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Journal of Applied Pharmaceutical Science 02 (06); 2012: 140-144
ISSN: 2231-3354 Received on: 12-05-2012 Revised on: 22-05-2012 Accepted on: 09-06-2012 DOI: 10.7324/JAPS.2012.2610
Effects of Calliandra Portoricensis Extracts on the Haematological Indices of Wistar Rats Challenged With Venom of Echis Ocellatus Onyeama HP, Ebong PE, Eteng MU, Igile GO, Ibekwe HA and Atangwho IJ
ABSTRACT Onyeama HP National Veterinary Research Institute, Vom, Plateau State, Nigeria.
Ebong PE, Eteng MU, Igile GO, Atangwho IJ Department of Biochemistry College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
Ibekwe HA Department of Animal Science, Cross River University of Technology, Calabar, Obubra Campus, Cross River State, Nigeria.
Effect of whole ethanolic and selective solvent extracts of C. portoricensis plant was carried out in wistar rats to ascertain their efficacy in ameliorating or attenuating the haemotoxicity of venom of carpet viper. A total of 30 wistar rats were used, divided into 6 rats per group of control, venom, venom/flavonoid-rich, venom/polyphenol-rich and venom/whole ethanolic extracts. The control was given nothing while the other groups were given 200μg venom/rat and 0.5 ml 100mg/100g body weight (b.w.) of rat as “anti-dote” concentration. This “antidote” was given intramuscularly 4-6 hours after the administration of the venom. The result obtained showed significant increase (P
