EFFECTS OF EXERCISE TRAINING DURING NORMOBARIC HYPOXIC CONFINEMENT ON HORMONAL APPETITE REGULATION AND OXIDATIVE STRESS Tadej Debevec1, Vincent Pialoux2, Elizabeth J. Simpson3, Ian A. Macdonald3, Ola Eiken4, Grégoire P. Millet5, Igor B. Mekjavic1 1
Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia; Center of Research and Innovation on Sports, University Claude Bernard Lyon 1, Villeurbanne, France 2 MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham Medical School, School of Life Sciences, Queen's Medical Centre, Nottingham, United Kingdom; 3Department of Environmental Physiology, Royal Institute of Technology, Stockholm, Sweden 4 ISSUL, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland e-mail:
[email protected]
3
Background High altitude sojourns are frequently associated with weight loss and increased physical activity levels. Both, hypoxia and exercise have been shown to influence appetite and oxidative status. We aimed to discern the effects of moderate exercise training during continuous hypoxic exposure on select markers of hormonal appetite regulation and oxidative stress. Methods Fourteen healthy males participated in a continuous 10-day exposure to normobaric hypoxia (PIO2=88.2±0.6 mmHg; simulated altitude ~4000 m) either combined with moderate intensity exercise training (Exercise group, n=8; two 60-min exercise sessions·day-1 at 50% of altitude-specific maximal aerobic power) or without any exercise (Sedentary group, n=6). To quantify fasting and postprandial plasma concentrations of selected appetite-related hormones a meal tolerance test was performed before (Pre) and just prior to the end of confinement (Post). The oxidative stress and antioxidant markers were assessed at Pre, Post and 24-hrs after confinement cessation (Post+1). Results No differences between Pre and Post or between groups were noted in fasting and postprandial concentrations of total ghrelin, peptide YY, glucagon-like peptide-1, and leptin. Augmented advanced oxidation protein products and nitrotyrosine levels at Post indicate increased oxidative stress levels in the Sedentary group only. On the other hand, antioxidant markers (superoxide dismutase and catalase) were only increased at Post in the Exercise group (p
