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Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma TAKAHIRO NODA1,2, TAKASHI KUMADA3, SHINJI TAKAI1, RIE MATSUSHIMA-NISHIWAKI1, NAOKI YOSHIMI5, EISUKE YASUDA1,2, KANEFUSA KATO6, HIDENORI TOYODA3, YUJI KANEOKA4, AKIHIRO YAMAGUCHI4 and OSAMU KOZAWA1 1
Department of Pharmacology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194; Departments of 2Imaging Diagnosis, 3Gastroenterology and 4Surgery, Ogaki Municipal Hospital, 4-86 Minaminokawa-Cho, Ogaki, Gifu 503-8502; 5Tumor Pathology, University of the Ryukyus Faculty of Medicine, 207 Nishihara-Cho, Okinawa 903-0215; 6Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-Cho, Kasugai, Aichi 480-0392, Japan Received December 12, 2006; Accepted February 14, 2007
Abstract. Heat shock protein (HSP) 20, a low-molecularweight HSP, is constitutively expressed in various tissues, such as smooth muscle, skeletal muscle, and liver. However, the characteristics and function of HSP20 have not been precisely understood. In the present study, we investigated correlations of expression levels of HSP20 in hepatocellular carcinoma (HCC) tissues and the surrounding tissues with clinical and pathologic characteristics in 53 resected HCC specimens. Although HSP20 was detected in all 53 HCC tissues, the expression levels were reduced compared with those in the adjacent non-tumor tissues. The expression levels of HSP20 were inversely correlated with tumor stage by TNM classification (p
