These findings have profound implications for the biomedical role of HIF in gene regulation. ... Blouin, CC, Page, EL, Soucy, GM and Richard, DE. Hypoxic gene ...
Expression of hypoxia-inducible factor mRNA following injection of double-stranded RNA in the blue crab Callinectes sapidus ! "#$%!&'!()$*+,,+-)$./!"0%,%!123)%$45/!6%$)7!&0$7)885/!3#0+9!&0$7)885/!%7:!;%?0JK'( 0,( )*0!( 0,!)",3&( !5#&( 2&")D+&( 52( )*&( +&1D%")5+4( 2D,3)05,( 52( 9:;?< 0,-D3&-( !0%&,30,1B( ?%)&+,")0/&%4'( &6$&+0#&,)"%( 35,-0)05,!( I35,3&,)+")05,'( !"#$%0,1( )0#&'( &)3BJ( #"4( *"/&(7&&,(0,"$$+5$+0")&()5(-&)&3)(9:;(1&,&(!0%&,30,1'(",-()*&(3*",1&!(0,(9:;(#=>?(#01*)(7&($"+)(52( "(1&,&+"%(+&!$5,!&()5(0,8&3)05,(5+()0!!D&(-"#"1&B( (
8 7 6
24-Hour 48-Hour
5
*
4 3 2
*
1 0
Control
HIF dsRNA
* CG dsRNA
Treatment
;01D+&(LB((=&%")0/&(&6$+&!!05,(52(9:;?(&6$+&!!05,(0,()*&(8D/&,0%&(7%D&(3+"7(Callinectes sapidus 0,8&3)&-(.0)*(9:;?(5+($5%4
(
MD$$5+)&-( 74( ",( NO:PQ( >&.( :,/&!)01")5+( ?."+-( ",-( "( >R??S95%%0,1!( N"+0,&( Q"75+")5+4( T0!0)0,1(M3*5%"+(?."+-()5(>PF'(",-(",(>M;(1+",)(I:RP