RESEARCH ARTICLE
Fasting glucose and risk of colorectal cancer in the Korean Multi-center Cancer Cohort Hyeree Park1, Sooyoung Cho2, Hyeongtaek Woo2, Sue K. Park2,3,4, Hai-Rim Shin5, SoungHoon Chang6, Keun-Young Yoo2, Aesun Shin2,4* 1 Seoul National University College of Medicine, Seoul, Republic of Korea, 2 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, 3 Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea, 4 Cancer Research Center, Seoul National University, Seoul, Republic of Korea, 5 World Health Organization Regional Office for the Western Pacific, Manila, Philippines, 6 Department of Preventive Medicine, Konkuk University School of Medicine, Chungju, Republic of Korea
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OPEN ACCESS Citation: Park H, Cho S, Woo H, Park SK, Shin HR, Chang S-H, et al. (2017) Fasting glucose and risk of colorectal cancer in the Korean Multi-center Cancer Cohort. PLoS ONE 12(11): e0188465. https://doi.org/10.1371/journal.pone.0188465 Editor: Cheng Hu, Shanghai Diabetes Institute, CHINA Received: April 26, 2017 Accepted: November 7, 2017 Published: November 21, 2017 Copyright: © 2017 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Data are available from the Dryad Digital Repository (doi:10.5061/ dryad.f1858). Funding: This research was funded by the Seoul National University Hospital. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
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Abstract Previous cohort studies have demonstrated a positive association between diabetes mellitus (DM) and colorectal cancer (CRC). However, there are few comparisons between DM groups categorized by fasting glucose level. This study examined associations between diabetes as defined by fasting glucose level and self-reported history of DM and CRC risk among Korean adults. Data from the Korean Multi-center Cancer Cohort between 1993 and 2005 were analyzed. The study population comprised 14,570 participants aged 20 years or older. Participants were followed until December 31, 2012 (median follow-up: 11.9 years). Among participants with high fasting glucose (126mg/dL), the risk of developing CRC was significantly higher (HR: 1.51 [1.02–2.25]) than among participants with low fasting glucose (
