Figure S3 - PLOS

MOS14 hTRN-SR1 hTRN-SR2 dTRN-SR TSR1 MTR10a

1 1 1 1 1 1

----MEHQNAVKEALNALYHHPDDTVRVHADRWLQNFQGTLDAWQVADNLLHDSSS---N MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQ----D MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQ----D MD--TYSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKR----D --------------------------MGKPFFFFGNFGLKNPTICAIEHICHRGC----G --MDNLQVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILSKEDPTNAL


54 57 57 55 31 59

LETLIFCSQTLRSKVQRDFEELPPGAFQKLRQSLTTLLKKFHKGPP-KVRTQISIAVAAL VESCYFAAQTMKMKIQTSFYELPTDSHASLWDSLLTHIQNLKDLSP-VIVTQLALAIADL VESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADL LHANYFAAQTMRNKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADL SYAQIFIFHSKTCNFFHFFKFFCSRHGASAHDAQSEATS-----------TQLCLAIADL LELNIFAAQTLRNKVTYDLSQLEN-NLPQFKDSLLTLLLSHN---QKLIITQLNVALARL


113 116 116 115 80 115

AVHVPAADWGDGGIISWLRDEMHMHPEYVPGFLELLTVLPEETFNYKIAARPDRRR--QF ALQMPS--WK--GCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRT--EI ALQMPS--WK--GCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRT--EI ALLMAS--WR--EPINDLLVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRRE--EV YIQVPT--WNN-WIFELLNQCQALEGDRTVMTLTLLQVFPEEVEQIRG-VGENRRH--AI AIQFLE--WQN-----PIFEIISLLNSSPSILLNFLRILPEETLDIASTSLTEVEFNSRI


171 170 170 169 134 168

EKELTSQMEAALSILSACLKISELK----------EQVLEAFASWLRLRHGIPGTVLACH IEDLAFYSSTVVSLLMTCVEKAGTD------EKMLMKVFRCLGSWFNL-GVLDSNFMANN IEDLAFYSSTVVSLLMTCVEKAGTD------EKMLMKVFRCLGSWFNL-GVLDSNFMANN HKQLDASAECVLKFLCMCLQREDLDQ-----QRVWNAALRTYSAWLVI-HAFPVSHVYNN RNELAACEQPMITFLSHVLEKFHSN------ADVLKRVFKCLESNLQN-HQMRTDHFAAS HELIDPIAEDVLKFLVSCIDLLQNTDGNSSSSISLEQILRCLNSWSYE--FPVEQLLTVQ


221 223 223 223 187 226

PLVHAALSSLN------CDPLSEASVNVISELIHHTASPS-SGGISAQTPLIQVIVPQIL KLLALLFEVLQQDK--TSSNLHEAASDCVCSALYAIEN------VETNLPLAMQLFQGVL KLLALLFEVLQQDK--TSSNLHEAASDCVCSALYAIEN------VETNLPLAMQLFQGVL ALTQLAFRLLSLPE--TSGKLHDNATECVCALLSCINTRQ-DGASDPESSFEAQLFGAVC PLISMIFHVIASIDPIIPSCLHETATNCIVQALYRVED------LEMHRKLAEVVHRGVI PLINLVFETISNGNE-SDMEAFDSAIDCLCVILRESRDTTNEQLISALFHQLMLLQEKLL


274 275 275 280 241 285

SLQAHLRDSSKDEEDVKAIG--RLFADVGDSYVELIATGSDE------PMVIVHALLEVT TLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQG---LGDLRTLELLLICA TLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQG---LGDLRTLELLLICA MLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKP---HYSLKGLDLVLLCV SLVSAFEKAQQVEDFDRLQNIARIFVEMVESFYVQIVNEANPDPAAIGSLACFELLLLVA PTLFTDHPLNDEYDDDLLEGMTRLFVEAGEAWSVVISKNPDFF-----KPMVLVLLMLTC


326 332 332 337 301 340

AHPEF---------DIASMTFNFWHSLQLMLTKRESYSSLGSEASIEVERNRRLHIFQPA GHPQY---------EVVEISFNFWYRLGEHLYKTN--------------DEVIHGIFKAY GHPQY---------EVVEISFNFWYRLGEHLYKTN--------------DEVIHGIFKAY GHFDY---------EVAEITFHLWYKLSEDLFQRN--------------EDKLTVLFRPH KHHDWALKIAIFLLQLIEMSFNVWYRITEELFKYD--------------DDQYIGRFRPY KNEDL---------DVVSYTFPFWFNFKQSLVLPR--------------YQESRKAYSDI


377 369 369 374 347 377

YQSLVSLVGFRVQYPEDYQGLSYEDLKEFKQTRYAVADVLIDAALILGGDTTLKILYMKL IQRLLHALARHCQLEPDHEGVP-EETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTL IQRLLHALARHCQLEPDHEGVP-EETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTL IERLISALFRHSQMESDHDGLI-EENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHIL AEKFIQCLYEHCKLDADDVDDLLDETSEFGEFRLKAVEALRDVVFIVNSDKCIQMMHQKL FVKLINGIITHLQYPSGQFSSK-EEEDKFKDFRYHMGDVLKDCTAVVGTSEALSQPLIRI


437 428 428 433 407 436

LEANAQTGNNFQDWRPAEAILFCIWAISNYVSV--------------------------KEGNPP-------WEVTEAVLFIMAAIAKSVDPKKPFSNAACHHSLLFGQNITSEISNCE KEGNPP-------WEVTEAVLFIMAAIAKSVDP--------------------------QAPETT-------WESTEAALFIMQNVAKNILP--------------------------IECCHKPN---ASWEESESALFVMSAVVQNLLP--------------------------KSAIENNN----SWQIMEAPLFSLRTMAKEISL---------------------------