Figure S6-1 - PLOS

si on Amino acid metabolism

Genetic Information Processing

Metabolism of other amino acids Metabolism of cofactors and vitamins Transcription Translation

Environmental Information Processing

Folding, sorting and degradation Signal transduction

Membrane transport Signal transduction

Signaling molecules and interaction

Cellular Processes

Transport and catabolism Cell motility Cell growth and death Cellular community

Organismal Systems

Immune system

Endocrine system

Circulatory system Nervous system

Human Diseases

Development Cancers: Overview Cancers: Specific types

Immune diseases Neurodegenerative diseases

Cardiovascular diseases

Endocrine and metabolic diseases Infectious diseases: Parasitic

PA R G −P

PA X8

R R A -o v ES

A X EI F1

D IC ER 1

lik e

er ex

pr es Energy metabolism Lipid metabolism Nucleotide metabolism

KEGG pathway FATTY ACID METABOLISM CITRATE CYCLE TCA CYCLE PROPANOATE METABOLISM GLYCOLYSIS GLUCONEOGENESIS PYRUVATE METABOLISM GLYOXYLATE AND DICARBOXYLATE METABOLISM BUTANOATE METABOLISM OXIDATIVE PHOSPHORYLATION SPHINGOLIPID METABOLISM PURINE METABOLISM PYRIMIDINE METABOLISM VALINE LEUCINE AND ISOLEUCINE DEGRADATION TRYPTOPHAN METABOLISM ARGININE AND PROLINE METABOLISM ALANINE ASPARTATE AND GLUTAMATE METABOLISM GLUTATHIONE METABOLISM PORPHYRIN AND CHLOROPHYLL METABOLISM RNA POLYMERASE SPLICEOSOME RIBOSOME AMINOACYL TRNA BIOSYNTHESIS PROTEASOME MAPK SIGNALING PATHWAY CALCIUM SIGNALING PATHWAY WNT SIGNALING PATHWAY ABC TRANSPORTERS PHOSPHATIDYLINOSITOL SIGNALING SYSTEM VEGF SIGNALING PATHWAY MTOR SIGNALING PATHWAY ECM RECEPTOR INTERACTION CELL ADHESION MOLECULES (CAMS) CYTOKINE CYTOKINE RECEPTOR INTERACTION LYSOSOME PEROXISOME REGULATION OF ACTIN CYTOSKELETON CELL CYCLE P53 SIGNALING PATHWAY FOCAL ADHESION TIGHT JUNCTION GAP JUNCTION COMPLEMENT AND COAGULATION CASCADES CHEMOKINE SIGNALING PATHWAY NATURAL KILLER CELL MEDIATED CYTOTOXICITY INSULIN SIGNALING PATHWAY MELANOGENESIS GNRH SIGNALING PATHWAY PROGESTERONE MEDIATED OOCYTE MATURATION PPAR SIGNALING PATHWAY ADIPOCYTOKINE SIGNALING PATHWAY CARDIAC MUSCLE CONTRACTION VASCULAR SMOOTH MUSCLE CONTRACTION LONG TERM DEPRESSION LONG TERM POTENTIATION AXON GUIDANCE PATHWAYS IN CANCER SMALL CELL LUNG CANCER MELANOMA CHRONIC MYELOID LEUKEMIA GLIOMA PANCREATIC CANCER ACUTE MYELOID LEUKEMIA PROSTATE CANCER BLADDER CANCER ENDOMETRIAL CANCER RENAL CELL CARCINOMA SYSTEMIC LUPUS ERYTHEMATOSUS ASTHMA PARKINSONS DISEASE ALZHEIMERS DISEASE HUNTINGTONS DISEASE ARVC VIRAL MYOCARDITIS DILATED CARDIOMYOPATHY HCM TYPE II DIABETES MELLITUS LEISHMANIA INFECTION

R A S−

lik e Global and overview maps Carbohydrate metabolism

B R A F−

Category Metabolism

-log(q-value) 5

15