Vira l lo a d. (c o p ie s p e. r m. L. ) Cell count (cells per mm. 3). B. gag. -2. 0. 2. 4. 6. 8. 10. 12. 14. 100. 101. 102. 103. 104. 105. 106. 107. F3. *** ***. -2. 0. 2. 4. 6.
A.
Diveristy Divergence Predicted X4 tropism
C2V5 F1 1.00
CD4 CD8 VL
* ART
F3
F2
2000
107
0.100
1800
106
0.075
0.75
1600
105
1400 1200
104
1000
0.050
0.50
0.00
1.00
0.50
0.25
0.00
1.00
0.75
800 600
102
0.025
400
101
0.000 -2
* 0
2
4
6
8
* * * *** 10
12
14 -2
0
2
4
F4
0.100
*** ***
* 6
8
10
14 -2
12
0
2
4
6
8
10
10 14
12
107 106
0.075
105 104
0.050 10
3
102
0.025
101
0.000 -2
0
2
4
6
* * ** 8
10
12
14 -2
0
2
4
6
F6
0.100
0
F5_variant2
F5_variant1
*
200
0
* * **
*
8
10
12
14 -2
0
2
4
6
*
8
10
10 14
12
2000 1800 1600 1400 1200 1000 800 600 400 200
0
0
F8
F7
2000
107
1800
106
0.075
1600
105
1400 1200
104
0.50
0.050
1000
10
0.25
3
800 600
102
0.025
400
101
0.000 -2
0.00
Cell count (cells per mm3)
0.75
3
Viral load (copies per mL)
Proportion of population with X4-tropic genotype
0.25
Genetic distance (mean pairwise nucleotide substitutions per site)
10
* 0
** 2
4
6
8
10
12
14 -2
0
2
4
6
8
10
14 -2
12
0
2
4
6
*
8
10
12
10 14
200
0
0
Years post seroconversion
B.
gag F2
F1
F3 107
0.075
2000 1800
106
0.060
105
0.045
104
1600 1400 1200 1000
103
0.030
102
0.015
0.000 -2
101
* 0
2
4
6
8
* * * *** 10
12
14
-2
0
2
4
F4
0.075
6
8
10
12
*** ***
14
-2
0
2
4
6
8
10
F6
F5
12
10 14
600 400
106
0
2000 1800 1600
105
1400
104
1200 1000
3
10
0.030
102
0.015
* 0
2
4
6
*
8
* * ** 10
12
14
-2
0
2
4
F7
0.075
6
8
0
10
12
F8
14
-2 7
10
106
0.045
0 2000 1800 1600
105
1400
104
1200 1000
3
10
0.030
102
0.015
101
800 600 400 200
2
4
6
8
10
12
14
-2
0
2
4
6
8
101
*
0.060
0
**
*
10
Years post seroconversion
0
12
10 14
0
2
4
6
8
10
12
10 14
800 600 400 200 0
Cell count (cells per mm3)
10
0.045
0.000 -2
0
7
0.060
0.000 -2
800
200
*
Viral load (copies per mL)
Genetic distance (mean pairwise nucleotide substitutions per site)
