Chart (copyright holder: authors) is based on a summary of recent publications: 1. Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal ...
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Chart (copyright holder: authors) is based on a summary of recent publications: 1. Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal ...
Time-Series Whole Genome Expression Data
CP Down-
UP-regulation
log(Fold change from ti to tj)
Check: SOC Control
Check: Disappearance of Criticality
Genes around CP Functional & Pathway analysis
Expression Regulation
Key Biological Processes?
Divergent region
Cell-fate change log(Expression)
Validation
Genome-State Change When
Scaling-Divergent Behavior: Critical Point (CP) log(1-nmsf)
log(Expression)
Sandpile Critical Behavior: Diverging UP- and Down- regulations at the CP
Phase Transitions of Higher Order Structures Critical Transition Region
Epigenetic Codes & Role of Non-coding RNAs?
Mapping: 3D Genome Structure
Genomic Mechanism?
Chart (copyright holder: authors) is based on a summary of recent publications: 1. Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal Development of Global Phase Transition Revealed in a Cancer Cell Line (2015) 2. Self-Organizing Global Gene Expression Regulated Through Criticality: The Mechanism of Cell Fate Change (2016)
