Flow Chart .pptx

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Chart (copyright holder: authors) is based on a summary of recent publications: 1. Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal ...
Time-Series Whole Genome Expression Data

CP Down-

UP-regulation

log(Fold change from ti to tj)

Check: SOC Control

Check: Disappearance of Criticality

log(Expression)

Validation Flux Analysis How

Global Perturbation

Critical States Genome Engine

Genome Computing? Rewritable Self-organized Memory?

Genes around CP Functional & Pathway analysis

Expression Regulation

Key Biological Processes?

Divergent region

Cell-fate change

Genome-State Change When

Scaling-Divergent Behavior: Critical Point (CP) log(1-nmsf)

log(Expression)

Sandpile Critical Behavior: Diverging UP- and Down- regulations at the CP

?: Project Targets

Coherent dynamics

Distinct Response Domains

Clustering of genes on karyotype based on critical states

Barcode Genes kbp~Mbp ?

?

Topology Associating Domains(TADs)

Phase Transitions of Higher Order Structures

Critical Transition Region

Epigenetic Codes & Role of Non-coding RNAs?

Mapping: 3D Genome Structure

Genomic Mechanism?

Chart (copyright holder: authors) is based on a summary of recent publications: 1. Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal Development of Global Phase Transition Revealed in a Cancer Cell Line (2015) 2. Self-Organizing Global Gene Expression Regulated Through Criticality: The Mechanism of Cell Fate Change (2016)