TCL1 (T cell leukemia/lymphoma 1). Marc-Henri Stern. Unité INSERM ... Mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL. Cytogenetics.
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS
Gene Section Short Communication
TCL1 (T cell leukemia/lymphoma 1) Marc-Henri Stern Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France Published in Atlas Database: March 1998 Online updated version: http://AtlasGeneticsOncology.org/Genes/TCL1ID66.html DOI: 10.4267/2042/37411 This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 1998 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Cytogenetics Associated with i(8q) in T-PLL. Hybrid/Mutated Gene None. Abnormal Protein None. Oncogenesis Over expression of TCL1 is considered as critical in the oncogenetic mechanism.
Identity Location: 14q32.1
DNA/RNA Description 4 exons; telomere - exon 1 to 4 - centromere orientation.
Transcription
t(7;14)(q35;q32.1)/T-cell malignancies → TCRB/TCL1
1.3 kb transcripts.
Protein
Disease Mainly T-cell prolymphocytic leukemia. Cytogenetics Associated with i(8q). Hybrid/Mutated Gene None. Abnormal Protein None. Oncogenesis Over expression of TCL1.
Description 114 amino acids; one domain with a b-barrel topology.
Expression Immature T and B lymphoid cells.
Localisation Cytoplasm.
Function Unknown.
References
Homology MTCP1 (38 structure).
%
identity,
similar
tridimentional
Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G. Chromosome walking on the TCL1 locus involved in T-cell neoplasia. Proc Natl Acad Sci USA 1993 Oct 15;90(20):92759.
Implicated in
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM. Characterization and localization of the TCL-1 oncogene product. Cancer Res 1994 Dec 15;54(24):6297-301.
t(14;14)(q12;q32.1) or inv(14)(q12q32.1)/T-cell malignancies → TCRA/D/TCL1
Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G. Identification of the TCL1 gene involved in T-cell malignancies. Proc Natl Acad Sci USA 1994 Dec 20;91(26):12530-4.
Disease Mainly T-cell prolymphocytic leukemia (T-PLL); Tcell NHL; T-cell ALL.
Atlas Genet Cytogenet Oncol Haematol. 1998;2(2)
Narducci MG, Virgilio L, Isobe M, Stoppacciaro A, Elli R, Fiorilli M, Carbonari M, Antonelli A, Chessa L, Croce CM, et al. TCL1
49
TCL1 (T-cell leukemia/lymphoma 1)
Stern MH
oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia. Blood 1995 Sep 15;86(6):2358-64.
Tcl1 oncogene: embryonic and lymphoid cell expression. Oncogene 1997 Aug 18;15(8):919-26.
Thick J, Metcalfe JA, Mak YF, Beatty D, Minegishi M, Dyer MJ, Lucas G, Taylor AM. Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. Oncogene 1996 Jan 18;12(2):379-86.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H. Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. Structure 1998 Feb 15;6(2):147-55.
Narducci MG, Stoppacciaro A, Imada K, Uchiyama T, Virgilio L, Lazzeri C, Croce CM, Russo G. TCL1 is overexpressed in patients affected by adult T-cell leukemias. Cancer Res 1997 Dec 15;57(24):5452-6.
This article should be referenced as such: Stern MH. TCL1 (T-cell leukemia/lymphoma 1). Atlas Genet Cytogenet Oncol Haematol.1998;2(2):49-50.
Narducci MG, Virgilio L, Engiles JB, Buchberg AM, Billips L, Facchiano A, Croce CM, Russo G, Rothstein JL. The murine
Atlas Genet Cytogenet Oncol Haematol. 1998;2(2)
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