Supplementary Table 1. Pathogenicity analysis with respect to the de novo mutations identified in the Epi4K project (Allen et al. (2013) De novo mutations in epileptic encephalopathies. Nature, 501, 217–221). For each method, we report the genes within the 25th percentile and highlight a subset of 17 genes identified in the Epi4K study that are predicted to be pathogenic by all methods (RVIS, Gene Constraint Score and EvoTol).