of oxygen restriction (called the Warburg effect), while also efficiently producing ATP by mitochondrial respiration (called the Pasteur effect) (5). The metabolic ...
INTERNATIONAL JOURNAL OF ONCOLOGY 47: 1009-1016, 2015
High-capacity glycolytic and mitochondrial oxidative metabolisms mediate the growth ability of glioblastoma Jungim Kim1*, Jeongsu Han1*, Yunseon Jang1, Soo Jeong Kim1, Min Joung Lee1, Min Jeong Ryu1,2, Gi Ryang Kweon2,4 and Jun Young Heo1,3 1
Department of Biochemistry, 2Research Institute for Medical Science, 3Brain Research Institute and 4 Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon 301-747, Republic of Korea Received May 23, 2015; Accepted July 6, 2015 DOI: 10.3892/ijo.2015.3101
Abstract. Among the primary brain tumors, glioblastoma multiforme (GBM) has a radical proliferation ability that complicates the therapeutic modulation of cancer progression. The majority of GBM patients have a low survival rate (
