©2005 FASEB
The FASEB Journal express article 10.1096/fj.04-3583fje. Published online April 29, 2005.
Hydrogen sulfide is a novel mediator of lipopolysaccharideinduced inflammation in the mouse Ling Li,* Madhav Bhatia,* Yi Zhun Zhu,* Yi Chun Zhu,† Raina Devi Ramnath,* Zhong Jing Wang,* Farhana Binte Mohammed Anuar,* Matthew Whiteman,‡ Manuel Salto-Tellez,§ and Philip K. Moore* *Department of Pharmacology, National University of Singapore, Singapore 117597; Department of Physiology and Pathophysiology, Key Laboratory of Molecular Medicine of The Ministry of Education, Fudan University Shanghai Medical College; Shanghai 200032, People’s Republic of China, ‡Department of Biochemistry, National University of Singapore, Singapore 117597; and §Department of Pathology, National University Hospital, Singapore 119074 †
Corresponding author: Professor P. K. Moore, Department of Pharmacology, National University of Singapore, Block MD2, 18 Medical Drive, Singapore 117597. E-mail:
[email protected] ABSTRACT Hydrogen sulfide (H2S) is synthesized in the body from L-cysteine by several enzymes including cystathionine-γ-lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin-induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)- and time (6 and 24 h)-dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 ± 0.7 µM to 40.9 ± 0.6 µM (n=6, P
