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ASHOK VERMA AND JORGE PARDO. 8. Neurologic Outcomes in HIV. Infection: Clinical Events and Surrogate. Markers / 95. CONSTANTIN T. YIANNOUTSOS.
The Spectrum of Neuro-AIDS Disorders Pathophysiology, Diagnosis, and Treatment

Edited by

Karl Goodkin. M.D.. Ph.D.• FAPA Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, and Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, California

Paul Shapshak. Ph.D. Ann Lowerey Murphey Laboratory, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida

Ashok Verma. M.D.• D.M. Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida

II ASM

PRESS

Washington, DC

Copyright © 2009

ASM Press American Society for Microbiology 1752 N Street, NW. Washington, DC 20036-2904

Library of Congress Cataloging-in-Publication Data The spectrum of neuro-AIDS disorders; pathophysiology, diagnosis, and treatment / edited by Karl Goodkin, Paul Shapshak, Ashok Verma. p. ;cm.

Includes bibliographical references and index.

ISBN 978-1-55581-369-7

1. Brain-Infections. 2. AIDS (Disease) 1. Goodkin, Karl. II. Shapshak, Paul. III. Verma, Ashok. [DNLM: 1. HIV Infections-eomplications. 2. AIDS-Related Opportunistic Infections. 3. Antiretroviral Therapy, Highly Active-adverse effects. 4. Central Nervous System Diseases-etiology. 5. Diagnostic Techniques, Neurological. 6. Mental Disorders-etiology. WC 503.5 S741 2009] RC359.5.S64 2009 616.97'92-dc22 2008039156 ISBN 1-978-1-55581-369-7

AU Rights Reserved Printed in the United States of America

10 9 8 7 6 5 4 3 2 1 Address editorial correspondence to: ASM Press, 1752 N St., N.W., Washington, DC 20036-2904, U.S.A. Send orders to: ASM Press, P.O. Box 605, Herndon, VA 20172, U.S.A. Phone: 800-546-2416; 703-661-1593 Fax: 703-661-1501 Email: [email protected] Online: estore.asm.org

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Contents

8. Neurologic Outcomes in HIV

Infection: Clinical Events and Surrogate

Markers / 95

Contributors / ix Preface / xiii

SECTION 1

_

DISORDERS DUE TO PRIMARY HIV-1 PATHOGENESIS AND THEIR TREATMENT / 1

CONSTANTIN T. YIANNOUTSOS

19)

Designing HIV gp120 Peptide Vaccines: '-Kt