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In vivo confocal microscopy of conjunctival goblet cells in patients with Sjögren's syndrome dry eye Jiaxu Hong, Wenqing Zhu, Hong Zhuang, et al. Br J Ophthalmol 2010 94: 1454-1458 originally published online December 2, 2009
doi: 10.1136/bjo.2009.161059
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Clinical science
In vivo confocal microscopy of conjunctival goblet cells in patients with Sjo¨gren’s syndrome dry eye Jiaxu Hong, Wenqing Zhu, Hong Zhuang, Jianjiang Xu, Xinghuai Sun, Qihua Le, Gang Li, Yan Wang Department of Ophthalmology, Eye & ENT Hospital, School of Shanghai Medicine, Fudan University, Shanghai, PR China Correspondence to Dr Jianjiang Xu, Department of Ophthalmology, Eye & ENT Hospital, School of Shanghai Medicine, Fudan University, 83 Fenyang Road, Shanghai 200031, PR China;
[email protected] Accepted 14 October 2009 Published Online First 2 December 2009
ABSTRACT Background To study the morphology and the density of conjunctival goblet cells (GC) in patients with Sjo¨gren’s syndrome dry eye with in vivo laser scanning confocal microscopy (LSCM), and to explore its correlation with the GC density detected by impression cytology. Methods A total of 43 Sjo¨gren’s syndrome dry eye patients were recruited. All were required to fill in the Ocular Surface Disease Index Questionnaires. The tear break-up time was measured, followed by corneal fluorescein staining examination and Schirmer I test. The images of conjunctiva were taken by the Heidelberg retina tomography (HRT-II)/Rostock cornea module. Finally, the specimens for impression cytology were obtained. SPSS V.13.0 software was used to analyse the data. Results Tear film function test showed that all patients had moderate to severe dry eye. The GC in LSCM images was characterised as a large hyper-reflective oval-shape cell with relatively homogeneous brightness. Though GC density assessed by LSCM (3326137) cells/mm2 was higher than that measured by impression cytology (2006141) cells/mm2, they showed a significant positive correlation, r¼0.908 (p
