St Michael, F., J. Li, M. D. Howard, A. J. Duncan, T. J. Inzana, and A. D.. Cox. 2005 ...... Jones, P. A., N. M. Samuels, N. J. Phillips, R. S. Munson, Jr., J. A. Bozue, J.
Investigation of Haemophilus somnus Virulence Factors: Lipooligosaccharide Sialylation and Inhibition of Superoxide Anion Production By Michael D. Howard
Dissertation submitted to the faculty of the Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy In Veterinary Medical Science Thomas J. Inzana, Chair Gerhardt G. Schurig Thomas E. Toth
Virginia Buechner-Maxwell Eugene M. Gregory
April 5, 2005 Blacksburg, Virginia The United States of America Keywords: Haemophilus somnus, Histophilus somni, sialic acid, sialylation, superoxide anion, virulence factors, microbial immunity
INVESTIGATION OF HAEMOPHILUS SOMNUS VIRULENCE FACTORS: LIPOOLIGOSACCHARIDE SIALYLATION AND INHIBITION OF SUPEROXIDE ANION PRODUCTION By Michael D. Howard Chairman: Professor Thomas J. Inzana, Ph.D. Department of Biomedical Sciences and Pathobiology (ABSTRACT)
Virulent strains of the bovine opportunistic pathogen Haemophilus somnus (Histophilus somni) cause multi-systemic diseases in cattle. One of the reported virulence factors that H. somnus may use to persist in the host is resistance to intracellular killing. It is reported in this dissertation that H. somnus significantly (P
