Mar 1, 2016 - Xiao-Yun Zhang,1 Hua-Song Ma,2 Li Liu,1 Zhong-Quan Dai,3 Juan Du,1 Zheng Wu, ... cognitive functions may cause potential risks in space ... The entire .... reduction and recovering in bilateral thalamic NAA ... participant in the redox cycle (Danielsen and Ross, 1999). .... Inositol trisphosphate and calcium.
Pakistan J. Zool., vol. 48(2), pp. 575-581, 2016.
Longitudinal Metabolic Changes in the Thalamus of Macaque Brain During 42-Day Head Down Tilt Xiao-Yun Zhang,1 Hua-Song Ma,2 Li Liu,1 Zhong-Quan Dai,3 Juan Du,1 Zheng Wu,1 Xu-Sheng Huang4 and Yi-Ling Cai1,* 1 Department of Neurology, 306th Hospital of PLA. Beijing 100101, China 2 Department of Orthopedics, 306th Hospital of PLA. Beijing 100101, China 3 Department of Biomedical Engineering, the China Astronaut Research and Training Center. Beijing, 100101, China 4 Department of Neurology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China. Xiao-yun Zhang and Hua-song Ma have contributed equally to this work. AB STR ACT Basic changes in environmental conditions are fundamental to understanding brain mechanisms. Several studies have reported impairment of central nervous processes during weightlessness. In this study, neurobiological alterations during 6°head down tilt (HDT) were investigated longitudinally using non-invasive proton magnetic resonance spectroscopy (1H MRS) at 3T in region related to cognitive and movement, such as the thalamus. Scans were performed in five rhesus monkeys before HDT and at 7, 21 and 42 days after HDT. Spectra were processed using LC Model. Statistical analysis of the data obtained demonstrated no significant difference in the bilateral thalamus of macaques. Our MRS data showed reduced N-acetylaspartate (NAA) (p
