Lung stress and strain during mechanical ventilation: any difference ...

Lung stress and strain during mechanical ventilation: any difference between statics and dynamics? Alessandro Protti, Davide T. Andreis, Massimo Monti, Alessandro Santini, Cristina C. Sparacino, Thomas Langer, Emiliano Votta, Stefano Gatti, Luciano Lombardi, Orazio Leopardi, Serge Masson, Massimo Cressoni, Luciano Gattinoni.

Online Data Supplement

Figure E1. Study design.

CT: computed tomography. * One animal, initially assigned to the VT 25% and VPEEP 75% group, did not even initiate the study as it could not tolerate 24 cmH2O of positive endexpiratory pressure, required per protocol, due to major hemodynamic instability.

Table E1. Lung weight and 54-hour mortality.

Initial lung weight (g)

VT 100% VPEEP 0%

VT 75% VPEEP 25%

VT 50% VPEEP 50%

VT 25% VPEEP 75%

334±38

283±36

325±23

314±55

p

0.03 Final lung weight (g)

658±99§

559±309§

489±189

277±46*†

Lung wet-to-dry weight ratio (n=19)

7.2±0.4

7.5±1.7

6.1±1.1

5.6±0.6

0.05

100%

20%

0%

20%