MECHANISMS OF ACTION: PHYSIOLOGICAL

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Volume 36

April 1992

No. 4

MINIREVIEW Active Efflux Mechanisms for Antimicrobial Resistance

Stuart B.

Levy

695-703

MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Molecular Targets of 5-Fluoroorotate in the Human Malaria Parasite, Plasmodium falciparum Effects of Novel Fluoroquinolones on the Catalytic Activities of Eukaryotic Topoisomerase II: Influence of the C-8 Fluorine Group Bactericidal Activities of Five Quinolones for Escherichia coli Strains with Mutations in Genes Encoding the SOS Response or Cell Division The Lipid A Biosynthesis Mutation lpx42 of Escherichia coli Results in Drastic Antibiotic Supersusceptibility Iron Transport-Mediated Antibacterial Activity of and Development of Resistance to Hydroxamate and Catechol Siderophore-Carbacephalosporin Conjugates Lack of Effect of Carbonyl Cyanide mChlorophenylhydrazone on KB-5246 Accumulation by Staphylococcus aureus Relative 13-Lactamase- and Transpeptidase-Inhibitory Activities of the New Quinolone WIN-57273 in Staphylococcus aureus

Pradipsinh K. Rathod, Nilima Pai Leffers, and Robert D. Young Megan J. Robinson, Barbara Anne Martin, Thomas D. Gootz, Paul R. McGuirk, and Neil Osheroff

751-756

Laura J. V. Piddock and Ruth N. Walters

819-825

Riitta Vuorio and Martti Vaara

826-829

Albert A. Minnick, Julia A. McKee, E. Kurt Dolence, and Marvin J. Miller Yasuo Kotera, Yoshimasa Inoue, Masami Ohashi, Keizo Ito, and Matsuhisa Inoue Yves Xavier Furet, Christine Lucain, and Jean-Claude Pechere

840-850

704-711

883-885

894-897

MECHANISMS OF RESISTANCE Characterization of Two Plasmids from Campylobacterjejuni Isolates That Carry the aphA-7 Kanamycin Resistance Determinant Identification of a Streptomycin Resistance Gene and a Partial Tn3 Transposon Coding for a 1-Lactamase in a Periodontal Strain of Eikenella corrodens Characterization of the tet(M) Determinant of Tn916: Evidence for Regulation by Transcription Attenuation Overproduction of a Penicillin-Binding Protein Is Not the Only Mechanism of Penicillin Resistance in Enterococcus faecium Interaction of Vibrio cholerae Cells with 13-Lactam Antibiotics: Emergence of Resistant Cells at a High Frequency

Evidence for In Vivo Incorporation of D-Lactate into Peptidoglycan Precursors of Vancomycin-Resistant Enterococci Tet Determinants Provide Poor Protection against Some Tetracyclines: Further Evidence for Division of Tetracyclines into Two Classes

Fred C. Tenover, Cynthia L. Fennell, Linda Lee, and Donald J.

LeBlanc Jean-Michel Lacroix and Walker Yan A. Su, Clewell

712-716

Clay B.

740-743

Ping He, and Don B.

769-778

Ingo Klare, Arne C. Rodloff, Jutta Wagner, Wolfgang Witte, and Regine Hakenbeck Tapas K. Sengupta, Keya Chaudhuri, Sabita Majumdar, Anuradha Lohia, Anadi N. Chatterjee, and Jyotirmoy Das

788-795

Michel Arthur, Catherine Molinas,

867-869

Patrice Courvalin Brunello Oliva and Ian

876-878

Timothy D. H. Bugg, Gerard D. Wright, Christopher T. Walsh, and Chopra

783-787

Continued on following page

Continued from preceding page A Pneumococcal Clinical Isolate with High-Level Resistance to Cefotaime and Ceftriaxone Effects of Amino Acids on Expression of Enterococcal Vancoimycin Resistance

Agnes M. S. Figueiredo, James D. Connor, Anatoly Severin, Maria Vitoria Vaz Pato, and Alexander Tomasz Lana J. Zarlenga, Michael S. Gilmore, and Daniel F. Sahm

886-889

Julia A. Kiehlbauch, Carolyn N. Baker, and I. Kaye Wachsmuth M. S. Bartlett, T. D. Edlind, M. M. Durkin, M. M. Shaw, S. F. Queener, and J. W. Smith Kenneth E. Aldridge

717-722

Kenneth E. Aldridge, Denise D. Schiro, and Laura M. Varner Sheila K. Spangler, Michael R. Jacobs, and Peter C. Appelbaum

854-855

Helene Renaudin, Joseph G. Tully, and Christiane Bebear Martha L. Sanchez, Richard P. Wenzel, and Ronald N. Jones Kenneth V. I. Rolston, Hieu T. Nguyen, Dai H. Ho, Barbara LeBlanc, and Gerald P. Bodey Hosmin Anwar, Janice L. Strap, and J. William Costerton Maria Teresa Blanco, Ciro P6rez-Giraldo, Javier Blanco, Francisco J. Moran, Cipriano Hurtado, and Antonio C.

870-872 873-875

Frederick G. Hayden, Koen

727-732

Jonathan A. V. Coates, Nick Cammack, Helen J. Jenkinson, Amanda J. Jowett, Michael I. Jowett, Bridget A. Pearson, Charles R. Penn, Philippa L. Rouse, K. Claire Viner, and Janet M. Cameron Xiang-Bin Kong, Qing-Yu Zhu, Pedro M. Vidal, Kyoichi A. Watanabe, Bruce Polsky, Donald Armstrong, Michael Ostrander, Stanley A. Lang, Jr., Elizabeth Muchmore, and Ting-Chao Chou

733-739

902-905

SUSCEPTIBILITY In Vitro Susceptibilities of Aerotolerant Canylobacter Isolates to 22 Antimicrobial Agents Antimicrotubule Benzimidazoles Inhibit In Vitro Growth of

Pneumocysis caninii In Vitro Antistaphylococcal Activities of Two Investigative Fluoroquinolones, CI-960 and WIN 57273, Compared with Those of Ciprofloxacin, Mupirocin (Pseudomonic Acid), and Peptide-Class Antimicrobial Agents In Vitro Antistaphylococcal Activity and Testing of RP 59500, a New Streptogramin, by Two Methods Susceptibilities of Penicillin-Susceptible and -Resistant Strains of Streptcccus pxeuaoiae to RP 595W0, Vancomycin, Erythromydn, PD 131628, Sparfloxacin, Temafloxacin, Win 57273, Ofloxacin, and Ciprofloxacin In Vitro Susceptibilities of Mycopasma genitlium to

Antibiotics In V'itro Activity of Decaplanin (M86-1410), a New Glycopeptide Antibiotic In Vitro Activity of Ro 23-9424, a Dual-Action Antibacterial Agent, against Bacterial Isolates from Cancer Patients Compared with Those of Other Agents Kinetic Interaction of Biofihm Cells of Staphylooccus aureus with Cephalexin and Tobramycin in a Chemostat System In Vitro Studies of Activities of Some Antifungal Agents apinst didaabicans ATCC 10231 by the Turbidimetric Method

779-782

851-853

856-859

879-882 890-893 898-901

G6mez-Garcia

ANTIVIRAL AGENTS Saety and Efficacy of Intranasal Pirodavir (R77975) in Experimental Rhinovirus Infection

(-)-2'-Deoxy-3'-Thiacytidine Is a Potent, Highly Selective Vmus Type 1 and Inhibitor of Human Immunodewiciency Type 2 Replication In Vitro

Comparisons of Anti-Huma Immunodeficiency Vwrus Activities, Cellular Transport, and Plasma and Intracellular Pharmacokinetics of 3'-Fluoro3'-lDeoxythymidine and

3'-Azido-3'-Deoxythymidine

Andries, and Paul A. J. Janssen

808-818

Continued on following page

Continued from preceding page

EXPERIMENTAL THERAPEUTICS Identification of Factors Affecting In Vivo Aminoglycoside

Activity in an Experimental Model of Gram-Negative Endocarditis

In Vitro and In Vivo Antibacterial Activities of Levofloxacin (I-Ofloxacin), an Optically Active Ofloxacin

Gilles Potel, Jocelyne Caillon, Florence Le Gallou, Denis Bugnon, Philippe Le Conte, Jocelyne Raza, Jean-Yves Lepage, Denis Baron, and Henri Drugeon K. P. Fu, Stephen C. Lafredo, Barbara Foleno, D. M. Isaacson, J. F. Barrett, A. J. Tobia, and M. E. Rosenthale

744-750

860-866

CLINICAL THERAPEUTICS 4-Week Treatment of Streptococcal Native Valve Endocarditis with High-Dose Teicoplanin

Imipenem versus Gentamicin Combined with Either Cefuroxime or Cephalothin as Initial Therapy for Febrile Neutropenic Patients

Efficacy and Safety of Temafloxacin versus Those of Amoxicillin in Hospitalized Adults with Community-Acquired Pneumonia

Mario Venditti, Vincenzo Gelfusa, Pietro Serra, Camillo Brandimarte, Alessandra Micozzi, Pietro Martino J. J. Cornelissen, A. de Graeff, L. F. Verdonck, T. Branger, M. Rozenberg-Arska, J. Verhoef, and A. W. Dekker Claude Carbon, Paul Leophonte, Patrick Petitpretz, Jean Pierre Chauvin, and Jean Hazebroucq

723-726

801-807

833-839

PHARMACOLOGY Metabolism of S-1108, a New Oral Cephem Antibiotic, and Metabolic Profiles of Its Metabolites in Humans Phase I Clinical Studies of S-1108: Safety and Pharmacokinetics in a Multiple-Administration Study with Special Emphasis on the Influence on Carnitine Body Stores Pharmacokinetics of Cefpodoxime Proxetil and Interactions with an Antacid and an H2 Receptor Antagonist

Effects of Aluminum Hydroxide and Calcium Carbonate Antacids on the Bioavailability of Ciprofloxacin

Kyoichi Totsuka, Kihachiro

Shimizu, Masaharu Konishi, and

Sadao Yamamoto M. Nakashima, T. Uematsu, T. Oguma, T. Yoshida, K. Mizojiri, S. Matsuno, and S. Yamamoto Nina Saathoff, Hartmut Lode, Katharina Neider, Karl M. Depperman, Klaus Bomer, and Peter Koeppe R. Wayne Frost, K. C. Lasseter, A. J. Noe, E. C. Shamblen, and J. T. Lettieri

757-761 762-768

796-800

830-832

AUTHOR'S CORRECTION Immune Response to a Major Epitope of p24 during Infection with Human Immunodeficiency Virus Type 1 and Implications for Diagnosis and Prognosis

Blandine Janvier, Armelle Baillou, Philippe Archinard, Marcelle Mounier, Bernard Mandrand, Alain Goudeau, and Francis Barin

906