Measurements Information on concomitant drug use was recorded with the ... exposed to methadone and concomitant drugs (median 5.0 days versus 6.0 days, ...
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RESEARCH REPORT
doi:10.1111/j.1360-0443.2012.03844.x
Methadone and perinatal outcomes: a prospective cohort study add_3844
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Brian J. Cleary1,2,3, Maeve Eogan4, Michael P. O’Connell1, Tom Fahey5, Paul J. Gallagher2, Tom Clarke4, Martin J. White1, Christine McDermott4, Anne O’Sullivan1, Deirdre Carmody6, Justin Gleeson6 & Deirdre J. Murphy1,3 Coombe Women and Infants University Hospital, Dublin, Ireland,1 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland,2 Department of Obstetrics and Gynaecology, School of Medicine,Trinity College, Dublin, Ireland,3 The Rotunda Hospital, Dublin, Ireland,4 HRB Centre for Primary Care Research, Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland5 and Addiction Services, Health Service Executive, Dublin, Ireland6
ABSTRACT Aims Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS). This study aimed to examine perinatal outcomes and NAS in relation to (i) concomitant drug use and (ii) methadone dose. Design Prospective cohort study. Setting Two tertiary care maternity hospitals. Participants A total of 117 pregnant women on methadone maintenance treatment recruited between July 2009 and July 2010. Measurements Information on concomitant drug use was recorded with the Addiction Severity Index. Perinatal outcomes included pre-term birth (
