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Modifying chemotherapy response by targeted ... - Semantic Scholar
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Modifying chemotherapy response by targeted ... - Semantic Scholar
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Tsc2
+/-Eμ-Myc.
Tsc2
+/-Eμ-Myc. shFLuc.1309. Mcl-1. shBim.764. shBim.825.
Tsc2
+/-Eμ-Myc. A. C. E. F. Fraction V iable Cell. Population. Supplemental Figure 3.
0.6 0.4
0.6 0.4
B
Tsc2+/-Eμ-Myc
1.2 1.0
Fraction Viable Cell Population
10 102 Hipp [nM]
103
shFLuc.1309 Mcl-1
0.6 0.4 0.2 10
102
Dox [nM]
103
0
10 102 Hipp [nM]
Tsc2+/-Eμ-Myc
1.2 1.0 0.8
103
0.8
shFLuc.1309 shBim.764 shBim.825
0.2 0
10
102
Dox [nM]
0.0
0
F
0.6 0.4 0.0
shFLuc.1309 shNoxa.870 shNoxa.1678
0.2
D
0.8
0
0.0
Fraction Viable Cell Population
0
1.2 1.0
Tsc2+/-Eμ-Myc
0.6 0.4
0.2
0.2
0.0
shFLuc.1309 shBim.764 shBim.825
0.8
0.8
0.0
1.2 1.0
E Fraction Viable Cell Population
shFLuc.1309 Mcl-1
Tsc2+/-Eμ-Myc
103
Fraction Viable Cell Population
1.2 1.0
Fraction Viable Cell Population
C
Tsc2+/-Eμ-Myc
Fraction Viable Cell Population
A
Supplemental Figure 3
10 102 Hipp [nM]
Tsc2+/-Eμ-Myc
1.2 1.0
103
shFLuc.1309 shNoxa.870 shNoxa.1678
0.8 0.6 0.4 0.2 0.0
0
10
102
Dox [nM]
103
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