NRE220. Applications of FDG-PET and Arterial Spin Labeling MR Imaging in Quantification of Cerebral. Metabolic Activity and Blood Flow in Neurodegenerative ...
NRE220 Applications of FDG-PET and Arterial Spin Labeling MR Imaging in Quantification of Cerebral Metabolic Activity and Blood Flow in Neurodegenerative Diseases: Comparison of FDG-PET and ASL Education Exhibits Location: NR Community, Learning Center
Participants Sina Houshmand MD (Presenter): Nothing to Disclose Ali Salavati MD, MPH : Nothing to Disclose Benjapa Khiewvan : Nothing to Disclose Thomas J. Werner : Nothing to Disclose Sudipto Dolui PhD : Nothing to Disclose Abass Alavi MD : Nothing to Disclose
TEACHING POINTS To review applications of currently available FDG-PET quantification techniques in assessment of cerebral metabolic activity of Alzheimer's disease patients. To review and compare arterial spin labeled MR imaging with FDG-PET in diagnosis and characterization of Alzheimer's disease.
TABLE OF CONTENTS/OUTLINE Alzheimer's disease (AD) is a neurodegenerative disease associated with alterations in cerebral blood flow (CBF) in different regions of brain. These changes have been well correlated with cerebral metabolism abnormalities using 18F-fluorodeoxyglucose positron emission tomography (FDG PET). Arterial spin labeling (ASL) MRI which utilizes magnetically labeled blood water as a tracer for CBF quantification has shown to be a potential non-invasive biomarker for AD over the last several years. In this review we will discuss applications of these two modalities and compare their characteristic features and potential for diagnosis of AD and its spectrum. 1. FDG-PET i. Pathophysiology of changes in FDG-PET images ii. Pattern of changes iii. Correlation with clinical severity iv. Use as therapeutic endpoint v. Sensitivity and specificity vi. Quantitative methods 2. ASL MRI i. Technical aspects of ASL ii. Regions of hypoperfusion iii. Correlation with PET
