Accepted Manuscript Case Report Ocular Metastasis of Colorectal Cancer: An Uncommon Presentation of a Common Malignancy Muhammad Rizwan Khawaja, John T. Minturn, A. John Spittler, E. Gabriela Chiorean PII: DOI: Reference:
S1658-3876(15)00024-2 http://dx.doi.org/10.1016/j.hemonc.2015.02.002 HEMONC 85
To appear in: Accepted Date:
21 February 2015
Please cite this article as: M.R. Khawaja, J.T. Minturn, A. John Spittler, E. Gabriela Chiorean, Ocular Metastasis of Colorectal Cancer: An Uncommon Presentation of a Common Malignancy, (2015), doi: http://dx.doi.org/ 10.1016/j.hemonc.2015.02.002
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Title: Ocular Metastasis of Colorectal Cancer: An Uncommon Presentation of a Common Malignancy
Authors: Muhammad Rizwan Khawaja1, John T Minturn2, A. John Spittler1, E. Gabriela Chiorean1,3
Affiliations: 1
Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis,
IN 2
Midwest Eye Institute, Indianapolis, IN
3
University of Washington, Seattle, WA
Corresponding Author: E. Gabriela Chiorean, MD, Associate Professor of Medicine, Division of Oncology, University of Washington 825 Eastlake Ave E, G4-833 Seattle, WA, United States Tel: 206-288-6248, Fax: 206-288-6681 E-mail:
[email protected]
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Table: Table 1. Summary of literature review of colorectal cancer with ocular metastasis Age Sex Time Initial site Other Ocular O-Surg (yr) from mets extent initial Dx Khawaja 60 F 4 yr Rectum Yes Choroid No et al Apte et 39 M 3 mo Cecum Yes Retina Excision al Howard 63 M 3 yr Ascending Yes Retina, Enucl et al colon choroid, orbit Kennedy 51 M Rectosigmoid No Choroid, Enucl et al macula Lin et al 43 M 8 yr Sigmoid Yes Choroid No
ORT
Chemo
Outcome
Yes Yes
FOLFOXB FOLFIRI
No
No
Died at 32mo Alive at 7mo Died at 16mo
No
No
Died at 9mo No i-B Died at 4mo Kuo et al 65 F 20 mo Colon Yes Choroid No No i-B Alive at 5mo Ward et 52 F NA Colon Yes Choroid No No No Diet at al b/l 1mo Hisham 32 F 10 mo Rectum Yes Orbit No Yes No Died at et al 2mo M:, male; F:, female; Yr:, years; Mo:, months; Dx:, Diagnosis; NA:, not available; Mets:, metastasis; b/l:, bilateral; O-Surg:, ocular surgery;; Enucl:, enucleation; O-RT:, ocular radiation therapy; B:, bevacizumab; i-B:, intravitreous bevacizumab
Conflicts of Interest: None declared.
