Prediction of sarcopenia using a combination of ...
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Prediction of sarcopenia using a combination of ...
May 15, 2018 - Hyun Bang2, Eun-Soo Kwon1, Kwang-Pyo Lee1,5, Sun Gun Chung2,4 & Ki-Sun Kwon1,6. Sarcopenia is a gradual loss of skeletal muscle ...
www.nature.com/scientificreports
OPEN
Received: 22 November 2017 Accepted: 15 May 2018 Published: xx xx xxxx
Prediction of sarcopenia using a combination of multiple serum biomarkers Ju Yeon Kwak1, Hyeoncheol Hwang2, Seon-Kyu Kim3, Jeong Yi Choi1, Seung-Min Lee1, Hyun Bang2, Eun-Soo Kwon1, Kwang-Pyo Lee1,5, Sun Gun Chung2,4 & Ki-Sun Kwon1,6 Sarcopenia is a gradual loss of skeletal muscle mass and function with aging. Given that sarcopenia has been recognized as a disease entity, effective molecular biomarkers for early diagnosis are required. We recruited 46 normal subjects and 50 patients with moderate sarcopenia aged 60 years and older. Sarcopenia was clinically identified on the basis of the appendicular skeletal muscle index by applying cutoff values derived from the Asian Working Group for Sarcopenia. The serum levels of 21 potential biomarkers were analyzed and statistically examined. Interleukin 6, secreted protein acidic and rich in cysteine, macrophage migration inhibitory factor, and insulin-like growth factor 1 levels differed significantly between the normal and sarcopenia groups. However, in each case, the area under the receiver operating characteristics curve (AUC) was