www.impactjournals.com/oncotarget/
Oncotarget, 2017, Vol. 8, (No. 45), pp: 79234-79247 Clinical Research Paper
Preoperative lymphocyte-to-monocyte ratio as a strong predictor of survival and recurrence for gastric cancer after radical-intent surgery Jun-Peng Lin1, Jian-Xian Lin1, Long-Long Cao1, Chao-Hui Zheng1, Ping Li1, Jian-Wei Xie1, Jia-Bin Wang1, Jun Lu1, Qi-Yue Chen1, Mi Lin1, Ru-Hong Tu1 and Chang-Ming Huang1 1
Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Correspondence to: Chang-Ming Huang, email:
[email protected] Keywords: gastric cancer, preoperative lymphocyte-to-monocyte ratio, nomogram, overall survival, recurrence Received: December 09, 2016 Accepted: March 20, 2017 Published: April 12, 2017 Copyright: Lin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT Objectives: To evaluate the predictive value of the preoperative lymphocyteto-monocyte ratio (LMR) for the prognosis of patients with gastric cancer (GC) after radical-intent surgery. Methods: We retrospectively analyzed 1,810 patients who underwent radical-intent gastrectomy for primary GC from December 2008 to December 2013. X-tile software was used to identify the optimal value for blood LMR. Nomograms were developed to predict overall survival (OS) and recurrence-free survival (RFS) after surgery. Results: LMR was significantly lower in patients with GC than in matched normal volunteers (P
