Author query sheet
Queries for Author Journal: Annals of the Rheumatic Diseases Paper: annrheumdis-2015-207692 Title: Did the subjects and the controls have the same disease?
The proof of your manuscript appears on the following page(s). It is the responsibility of the corresponding author to check against the original manuscript and approve or amend these proofs. Please read the proofs carefully, checking for accuracy, verifying the reference order and checking figures and tables. When reviewing your page proof please keep in mind that a professional copyeditor edited your manuscript to comply with the style requirements of the journal. This is not an opportunity to alter, amend or revise your paper; it is intended to be for correction purposes only. The journal reserves the right to charge for excessive author alterations or for changes requested after the proofing stage has concluded. During the preparation of your manuscript for publication, the questions listed below have arisen (the query number can also be found in the gutter close to the text it refers to). Please attend to these matters and return the answers to these questions when you return your corrections. Please note, we will not be able to proceed with your article if these queries have not been addressed. A second proof is not normally provided.
Query Reference
Query
Q1
IMPORTANT: Corrections at this stage should be limited to those that are essential. Extensive corrections will delay the time to publication and may also have to be approved by the journal Editor.
Q2
Please note that alterations cannot be made after you have approved for publication, irrespective of whether it is Online First.
Q3
Author SURNAMES (family names) have been highlighted - please check that these are correct.
Q4
Please check all names are spelt correctly, and check affiliation and correspondence details, including departments.
Q5
Please update volume numbers and page ranges for references [1 and 3].
PE: SMM
CE: EPM
QC: MD
Author query sheet If you are happy with the proof as it stands, please email to confirm this. Minor changes that do not require a copy of the proof can be sent by email ( please be as specific as possible). Email:
[email protected] If you have any changes that cannot be described easily in an email, please mark them clearly on the proof using the annotation tools and email this by reply to the eProof email. We will keep a copy of any correspondence from you related to the author proof for six months. After six months, correspondence will be deleted.
Please respond within 48 hours
Correspondence 1 2
Q13 ¶4 Q2 ¶5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Q3
26
Q427 ¶
Did the subjects and the controls have the same disease?
2
Istanbul Physical Therapy Rehabilitation Training and Research Hospital, Istanbul, Turkey
65
Correspondence to Dr Romain J Forestier, Centre de Recherche Rhumatologique et Thermal, Aix-Les-Bains 73100, France;
[email protected]
67
66 68
1
The article by Roberts et al is important because it points to potential occurrence of side effects due to paracetamol, some of which are life-threatening. However, we have some doubts about the conclusions because it is not certain that they really show the responsibility of the drug itself in the adverse events mentioned. Although the authors well define methodological limitations of the article, we think that they didn’t take into account the main confounding factor. The major confounding factor seems to be the reason of paracetamol use, since it is important to know whether the disease treated in the controls is similar to the one in subjects. When rheumatic diseases are considered, we know that in rheumatoid arthritis, cardiovascular morbidity is higher than in general population, related to the disease activity.2 In osteoarthritis, where long-term paracetamol use is commonly prescribed, the disease is usually associated with metabolic syndrome and decreased physical activity that lead to increased cardiovascular morbidity.3 In a later article, it seems essential to have a more accurate assessment of the comparability of the groups in terms of risk factors. 1
Romain J Forestier, Fatma Begum Erol Forestier 1
Centre de Recherche Rhumatologique et Thermal, Aix-Les-Bains, France
70
Provenance and peer review Not commissioned; internally peer reviewed.
71 72 73 74 75
To cite Forestier RJ, Erol Forestier FB. Ann Rheum Dis Published Online First: [ please include Day Month Year] doi:10.1136/annrheumdis-2015-207692
76 77
Received 30 March 2015 Accepted 30 March 2015
78 79
Ann Rheum Dis 2015;0:1. doi:10.1136/annrheumdis-2015-207692
80 81 82
REFERENCES
83
1
84
2
3
2
69
Competing interests None declared.
Roberts E, Delgado Nunes V, Buckner S, et al. Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann Rheum Dis 2015. Solomon DH, Kremer J, Curtis JR, et al. Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity. Ann Rheum Dis 2010;69:1920–5. Liu SH, Waring ME, Eaton CB, et al. Association of objectively measured physical activity and metabolic syndrome among U.S. adults with osteoarthritis. Arthritis Care Res (Hoboken) 2015.
85
Q5 86 87 88 89 90 91
28
92
29
93
30
94
31
95
32
96
33
97
34
98
35
99
36
100
37
101
38
102
39
103
40
104
41
105
42
106
43
107
44
108
45
109
46
110
47
111
48
112
49
113
50
114
51
115
52
116
53
117
54
118
55
119
56
120
57
121
58
122
59
123
60
124
61
125
62
126
63
127
64
128
Ann Rheum Dis Month 2015 Vol 0 No 0
1
