Sep 22, 2011 - The growth and lymph node metastasis of tumor cells, angiogenesis and .... prospect for targeted therapy of colorectal cancer. Materials and .... advancement of solid tumors, including those associated with colorectal ... This research was supported by Natural Science Foundation of Hebei province of.
Pathol. Oncol. Res. (2012) 18:315–323 DOI 10.1007/s12253-011-9447-y
RESEARCH
Recombinant Human Endostatin Endostar Inhibits Tumor Growth and Metastasis in a Mouse Xenograft Model of Colon Cancer Yitao Jia & Min Liu & Wangang Huang & Zhenbao Wang & Yutong He & Jianhua Wu & Shuguang Ren & Yingchao Ju & Ruichao Geng & Zhongxin Li
Received: 7 December 2010 / Accepted: 1 August 2011 / Published online: 22 September 2011 # The Author(s) 2011. This article is published with open access at Springerlink.com
Abstract To investigate the effects of recombinant human endostatin Endostar on metastasis and angiogenesis and lymphangiogenesis of colorectal cancer cells in a mouse xenograft model. Colon cancer cells SW620 were injected subcutaneously into the left hind flank of nude mice to establish mouse xenograft models. The mice were treated with normal saline or Endostar subcutaneously every other day. The growth and lymph node metastasis of tumor cells, angiogenesis and lymphangiogenesis in tumor tissue were detected. Apoptosis and cell cycle distribution were studied by flow cytometry. The expression of VEGF-A, -C, or -D in SW620 cells was determined by immunoblotting assays. Endostar inhibited tumor growth and the rate of lymph node metastasis (P
