S1 Table. - PLOS

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rs7737685. PDE4D. 5. 58289046 rs4700316. PDE4D. 5. 58294691 rs2968005. PDE4D. 5. 58318052 x rs1948651. PDE4D. 5. 58333340 x rs16889129. PDE4D.
Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma.

S1 Table. List of the 384 tag-SNPs in 53 candidate gene regions that were analysed in the GEIRD study. The 236 tag-SNPs included in the association study are reported.

SNP rs4147567 rs10857796 rs2247584 rs2427828 rs2494265 rs2427829 rs2275352 rs7542294 rs946259 rs2071579 rs7515776 rs4950928 rs10802971 rs1053183 rs3753216 rs616593 rs646355 rs3765813 rs3753219 rs587640 rs676750 rs3819981 rs10184597 rs3771199 rs17637748 rs11692230 rs17689452 rs12475055 rs12996772 rs12712142 rs10439410 rs6758936 rs1427680 rs11571315 rs4553808 rs16840252 rs207908 rs3821107 rs3770507 rs207939 rs207945

Gene region GSTM1 GSTM1 FCER1A FCER1A FCER1A FCER1A CHI3L1 CHI3L1 CHI3L1 CHI3L1 CHI3L1 CHI3L1 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 CHML / OPN3 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 IL18R1 / IL1RL1 / IL1R1 CTLA4 CTLA4 CTLA4 CTLA4 XRCC5 XRCC5 XRCC5 XRCC5 XRCC5

Chr 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1

Chr Pos (GRCh37.p1 assembly) 110232524 110235032 159259680 159273041 159275274 159282011 203150179 203151176 203152177 203153634 203155703 203155882 241739794 241758631 241766551 241768617 241768630 241772881 241775502 241790148 241796284 241800324 102802255 102806613 102841715 102855065 102864681 102878891 102947201 102960584 102990788 102991369 204729795 204730901 204731005 204731519 217015947 217031328 217031678 217042498 217045939

Included

x x x x

x x

x x x x x x x x x x x x x x x x x

x x x x x

Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs2161969 rs4674217 rs12466972 rs6729330 rs16858320 rs929936 rs987338 rs3791978 rs3791961 rs2042542 rs3791947 rs4674220 rs6729299 rs3828282 rs13022785 rs4672859 rs3791906 rs7597833 rs6721140 rs3795877 rs13411332 rs920251 rs164640 rs352139 rs352143 rs353547 rs2284659 rs699473 rs2536512 rs1799895 rs17552548 rs11944668 rs2276936 rs1870339 rs1379934 rs7674313 rs6830970 rs10049947 rs1458562 rs10008568 rs987314 rs2904259 rs1921681 rs6844655 rs1795739 rs1398942 rs1795721 rs11726569 rs2112047 rs2553434 rs2544425

TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 TNS1 SERPINE2 SERPINE2 SERPINE2 SERPINE2 SERPINE2 TLR9 TLR9 TLR9 TLR9 SOD3 SOD3 SOD3 SOD3 SOD3 FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A FAM13A INTS12 / GSTCD / NPNT INTS12 / GSTCD / NPNT INTS12 / GSTCD / NPNT INTS12 / GSTCD / NPNT

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4

2

218680570 218681575 218683907 218694296 218699505 218709145 218711738 218714686 218721834 218736292 218739125 218742002 218750154 218779144 218782820 218789397 218803329 224842150 224858643 224866177 224887191 224892945 52247314 52258372 52264907 52268866 24794797 24796803 24801315 24801834 24804722 89669852 89726283 89727656 89755842 89777061 89777081 89790593 89853598 89854192 89862169 89885714 89904124 89915359 89930313 89930392 89943473 106606608 106698700 106798457 106801279

x x x x x x x x x x x x x

x x x x x x x x x

x x

x x x x x x x x

Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs6811135 rs7677312 rs4635819 rs6817700 rs1489758 rs6537309 rs17721701 rs2087826 rs3763084 rs7737685 rs4700316 rs2968005 rs1948651 rs16889129 rs10061553 rs6867053 rs929820 rs6898374 rs10071163 rs13186012 rs13176475 rs2409629 rs8180396 rs9292197 rs11747104 rs153982 rs27548 rs28054 rs4699939 rs26709 rs10491352 rs27184 rs17780175 rs17780860 rs40122 rs1823066 rs433565 rs6874460 rs258129 rs2547918 rs17795596 rs16889903 rs16889907 rs1605275 rs37574 rs17797781 rs40216 rs294498 rs2069812 rs6871536 rs2240032

INTS12 / GSTCD / NPNT INTS12 / GSTCD / NPNT INTS12 / GSTCD / NPNT INTS12 / GSTCD / NPNT HHIP HHIP HHIP HHIP PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D PDE4D IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4

4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5

3

106830232 106851856 106858898 106891531 145574239 145605075 145618719 145639318 58272116 58289046 58294691 58318052 58333340 58349882 58352210 58365545 58393332 58396902 58409273 58427198 58428799 58478692 58481760 58501622 58505337 58520536 58527071 58531652 58552877 58568473 58573936 58575323 58589786 58623098 58628717 58675953 58681898 58701418 58711707 58717094 58722921 58782668 58785305 58815363 58832869 58834124 58836950 58876950 131879916 131969874 131977127

x

x x x x x

x x x x x x x x x x x

x x x x x x x x x x

x

x x x x

Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs1800925 rs20541 rs848 rs2243250 rs2070874 rs2243282 rs778584 rs2563298 rs2569190 rs2569193 rs4357026 rs2303064 rs2303065 rs3777143 rs1862439 rs2052532 rs11743440 rs7733401 rs6887366 rs4264931 rs17720733 rs867522 rs2910098 rs2964276 rs1042713 rs1042714 rs1042717 rs1042719 rs953569 rs1553318 rs6420075 rs2853694 rs730691 rs1736927 rs1063320 rs1610696 rs2523793 rs2735014 rs909253 rs2229094 rs1041981 rs1800630 rs1800629 rs3093662 rs3093665 rs2269425 rs10947233 rs3134603 rs3134950 rs2269423 rs3134945

IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4 IL5 / RAD50 / IL13 / IL4 CD14 CD14 CD14 CD14 SPINK5 SPINK5 SPINK5 SPINK5 SPINK5 SPINK5 SPINK5 HTR4 HTR4 HTR4 HTR4 HTR4 HTR4 HTR4 ADRB2 ADRB2 ADRB2 ADRB2 HAVCR1 HAVCR1 HAVCR1 IL12B IL12B HLAG HLAG HLAG HLAG HLAG TNFA / LTA TNFA / LTA TNFA / LTA TNFA / LTA TNFA / LTA TNFA / LTA TNFA / LTA AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2

5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6

4

131992809 131995964 131996500 132009154 132009710 132016554 140005212 140011315 140012916 140015495 147457939 147480080 147480112 147487479 147494931 147496307 147499080 147833281 147851270 147874556 147950478 147966246 147978253 147978978 148206440 148206473 148206646 148207447 156477400 156479323 156486120 158749088 158756227 29796115 29798749 29798803 29802550 29805809 31540313 31540556 31540784 31542476 31543031 31544189 31545391 32123639 32124424 32126002 32127477 32145707 32146492

x x

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x x x x x x x x x x x x x x

x x

Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs9469089 rs3132965 rs3130349 rs3134943 rs1035798 rs2070600 rs3131300 rs1800684 rs3129876 rs3129881 rs9268659 rs2213585 rs3129889 rs9268852 rs9268877 rs5020946 rs9269794 rs701831 rs2157337 rs9385992 rs1891308 rs9389986 rs11155242 rs17071756 rs898070 rs1419835 rs10241507 rs1419779 rs6462579 rs764269 rs10246825 rs10258734 rs1800783 rs1800779 rs1799983 rs3918227 rs3918188 rs1808593 rs7830 rs892248 rs1342326 rs3939286 rs928413 rs10975498 rs2006682 rs10815388 rs7019575 rs10975516 rs1330383 rs12000491 rs1927914

AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 AGER / PPT2 HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA HLADRB1 / HLADRA GPR126 GPR126 GPR126 GPR126 GPR126 NPSR1 NPSR1 NPSR1 NPSR1 NPSR1 NPSR1 NPSR1 NPSR1 NOS3 NOS3 NOS3 NOS3 NOS3 NOS3 NOS3 ANGPT1 IL33 IL33 IL33 IL33 IL33 IL33 IL33 IL33 IL33 IL33 TLR4

6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 8 9 9 9 9 9 9 9 9 9 9 9

5

32146657 32146997 32147696 32147761 32151222 32151443 32151934 32151994 32408012 32409484 32410941 32413150 32413545 32429594 32431147 32450089 32549249 32549395 32609122 142633627 142648235 142661114 142691549 142715195 34698865 34723920 34743478 34813308 34866287 34875729 34877034 34896123 150689397 150689943 150696111 150700946 150702781 150708302 150709571 108422946 6190076 6210099 6213387 6226688 6227045 6232242 6243935 6247693 6251507 6257367 120464725

x

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x x

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x x x

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Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs2770146 rs5030728 rs11536897 rs485411 rs3802604 rs376397 rs3802600 rs10905284 rs573122 rs547110 rs1441586 rs2847667 rs2583471 rs569108 rs174547 rs174548 rs968567 rs174579 rs6591251 rs762803 rs1695 rs749174 rs1138272 rs476391 rs651159 rs632009 rs11225442 rs7123600 rs2276109 rs5744280 rs549908 rs5744256 rs360722 rs795467 rs2043055 rs360718 rs757343 rs2248098 rs3819545 rs10875693 rs11168275 rs2254210 rs2238136 rs4760648 rs11168287 rs4334089 rs4760658 rs3024974 rs841718 rs3024957 rs324011

TLR4 TLR4 TLR4 GATA3 GATA3 GATA3 GATA3 GATA3 MS4A2 MS4A2 MS4A2 MS4A2 MS4A2 MS4A2 FADS1 / FADS2 FADS1 / FADS2 FADS1 / FADS2 FADS1 / FADS2 GSTP1 GSTP1 GSTP1 GSTP1 GSTP1 MMP12 MMP12 MMP12 MMP12 MMP12 MMP12 IL18 IL18 IL18 IL18 IL18 IL18 IL18 VDR VDR VDR VDR VDR VDR VDR VDR VDR VDR VDR STAT6 STAT6 STAT6 STAT6

9 9 9 10 10 10 10 10 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12

6

120473338 120474282 120480010 8093185 8102272 8103298 8108812 8115362 59844919 59846718 59856028 59859609 59861814 59863104 61570783 61571348 61595564 61605613 67344689 67352256 67352689 67353253 67353579 102735030 102736419 102738499 102739319 102741968 102745791 112016514 112020916 112022848 112026703 112031080 112031624 112034739 48239675 48253356 48265006 48269650 48272275 48273714 48277713 48280665 48285414 48286015 48296486 57492745 57492996 57498035 57502182

x x

x

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x

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x x x x

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x

Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs167769 rs12298170 rs17119494 rs1732886 rs1168771 rs1168774 rs1168757 rs1732877 rs1152888 rs2111059 rs11177072 rs11177073 rs2069718 rs2069716 rs1861493 rs9658490 rs12830203 rs11068428 rs4766842 rs733334 rs7295972 rs1483757 rs545654 rs11635145 rs7181878 rs9302242 rs4776890 rs7163381 rs11636161 rs2118610 rs745103 rs2289263 rs10152544 rs744910 rs7183244 rs12708492 rs3784681 rs3743343 rs11639224 rs1964678 rs8043227 rs647041 rs578776 rs2869546 rs8042059 rs1878399 rs11636605 rs2297516 rs11080344 rs4795067 rs944725

STAT6 STAT6 STAT6 IRAK3 IRAK3 IRAK3 IRAK3 IRAK3 IRAK3 INFG INFG INFG INFG INFG INFG NOS1 NOS1 NOS1 NOS1 NOS1 NOS1 NOS1 NOS1 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 SMAD3 IREB2 IREB2 IREB2 CHRNA5 / CHRNA3 / CHRNAB4 CHRNA5 / CHRNA3 / CHRNAB4 CHRNA5 / CHRNA3 / CHRNAB4 CHRNA5 / CHRNA3 / CHRNAB4 CHRNA5 / CHRNA3 / CHRNAB4 CHRNA5 / CHRNA3 / CHRNAB4 NOS2 NOS2 NOS2 NOS2

12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 17 17 17 17

7

57503775 57515363 57516933 66583762 66588836 66591487 66594116 66599144 66605228 68541671 68542541 68542895 68550162 68550815 68551196 117670298 117688499 117693817 117720130 117732689 117747368 117761540 117777049 67370121 67389161 67389412 67393045 67414055 67418104 67428334 67435075 67439207 67444747 67446785 67461311 67467541 67472185 67486775 78753371 78754000 78768871 78880481 78888400 78907345 78907859 78912003 78928878 26095730 26104511 26106675 26109571

x x x x x x

x

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Accordini S, et al. An Interleukin 13 Polymorphism is Associated with Symptom Severity in Adult Subjects with Ever Asthma. rs4795400 rs12603332 rs3744246 rs7207600 rs8065126 rs7212938 rs921651 rs2241718 rs4803455 rs1800470 rs1800469 rs2317130 rs2241713 rs677044 rs2280091 rs2853209 rs3918395 rs511898 rs3918392 rs2853210 rs487377 rs570269 rs554743 rs3918249 rs2274755 rs17576 rs2236416 rs9607267 rs11912889 rs84460 rs228945 rs2072861 rs2072862 rs228963 rs228966 rs3218264 rs3218258

ORMDL3 / GSDMB / GSDMA ORMDL3 / GSDMB / GSDMA ORMDL3 / GSDMB / GSDMA ORMDL3 / GSDMB / GSDMA ORMDL3 / GSDMB / GSDMA ORMDL3 / GSDMB / GSDMA ORMDL3 / GSDMB / GSDMA TGFB1 TGFB1 TGFB1 TGFB1 TGFB1 TGFB1 ADAM33 ADAM33 ADAM33 ADAM33 ADAM33 ADAM33 ADAM33 ADAM33 ADAM33 ADAM33 MMP9 MMP9 MMP9 MMP9 HMOX1 HMOX1 IL2RB IL2RB IL2RB IL2RB IL2RB IL2RB IL2RB IL2RB

17 17 17 17 17 17 17 19 19 19 19 19 19 20 20 20 20 20 20 20 20 20 20 20 20 20 20 22 22 22 22 22 22 22 22 22 22

8

38067020 38082807 38084350 38091660 38099035 38122680 38133922 41829606 41851509 41858921 41860296 41861674 41869468 3649431 3650234 3651472 3653149 3655085 3655219 3658211 3658931 3659647 3662142 44638136 44639692 44640225 44640575 35781207 35783617 37525731 37525880 37528362 37528606 37535948 37537514 37541998 37544245

x x x x x

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x

x

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