International Eurasian Conference on
Science, Engineering and Technology (EurasianSciEnTech 2018) 22-23 November 2018 Ankara / Turkey
EurasianSciEnTech 2018 w w w. e u r a s a n s c e n t e c h . o r g
International Eurasian Conference on
Science, Engineering and Technology (EurasianSciEnTech 2018) November 22-23, 2018 / Ankara, Turkey www.EurasianSciEnTech.org
PROCEEDING BOOK
International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
Chairman of Conference Assoc. Prof. Dr. Muhittin DOĞAN
Gaziantep University, Turkey
General Coordinator Assist. Prof. Dr. Mustafa PEHLİVAN
Gaziantep University, Turkey
Organizing Committee Prof. Dr. Ahmet AKSOY
Akdeniz University, Turkey
Prof. Dr. Mehmet Rüştü KARAMAN
Ankara University, Turkey
Prof. Dr. Osman GÜLNAZ
Cukurova University, Turkey
Prof. Dr. Zeliha SELAMOĞLU
Niğde Ömer Halisdemir University, Turkey
International Scientific Committee* Prof. Dr. Adnan QADIR
NED University of Engineering & Technology, Pakistan
Prof. Dr. Ahmet ŞEKEROĞLU
Niğde Ömer Halisdemir University, Turkey
Prof. Dr. Alpaslan DAYANGAÇ
Osmaniye Korkut Ata University, Turkey
Prof. Dr. Ayşe AYDOĞDU
Gazi University, Turkey
Prof. Dr. Azhar RASUL
Government College University, Pakistan
Prof. Dr. Azize AYOL
Dokuz Eylül University, Turkey
Prof. Dr. Bengi USLU
Ankara University, Turkey
Prof. Dr. Berna DENGİZ
Baskent University, Turkey
Prof. Dr. Bushra MIRZA
Quaid-i-Azam University, Pakistan
Prof. Dr. Bülent AKAY
Ankara University, Turkey
Prof. Dr. Bülent YEŞİLATA
Harran University, Turkey
Prof. Dr. Cihangir DURAN
Ankara Yıldırım Beyazıt University, Turkey
Prof. Dr. Deniz UZUNSOY
Bursa Technical University, Turkey
Prof. Dr. Dilek ERDİRENÇELEBİ
Konya Technical University, Turkey
Prof. Dr. Ebru ŞENADIM TÜZEMEN
Cumhuriyet University, Turkey
Prof. Dr. Ebru ŞENEL
Ankara University, Turkey
Prof. Dr. Fakhru'l Razi bin AHMADUN
National Defence University Malaysia, Malaysia
Prof. Dr. Faruk KARADAĞ
Çukurova University, Turkey
Prof. Dr. Fatma Suna BALCI
Gazi University, Turkey
Prof. Dr. Ferruh ERDOĞDU
Ankara University, Turkey
Prof. Dr. Gıyasettin KAŞIK
Selçuk University, Turkey
Prof. Dr. Gul Majid KHAN
Quaid-i-Azam University, Pakistan
Prof. Dr. Hüseyin CANBOLAT
Ankara Yıldırım Beyazıt University, Turkey
Prof. Dr. Kerim KÜÇÜK
Dokuz Eylül University, Turkey
Prof. Dr. Mehmet SARI
Aksaray University, Turkey
Prof. Dr. Meltem SARIOĞLU CEBECİ
Cumhuriyet University, Turkey
Prof. Dr. Muhammad ANSAR
Quaid-i-Azam University, Pakistan
Prof. Dr. Mustafa ÇİĞDEM
Yıldız Technical University, Turkey
Prof. Dr. Neriman BAĞDATLIOĞLU
Celal Bayar University, Turkey
Prof. Dr. Nil TOPLAN
Sakarya University, Turkey
Prof. Dr. Nuri ÖZALP
Ankara University, Turkey
Prof. Dr. Osman GÜLNAZ
Çukurova University, Turkey
Prof. Dr. Oya BOZDAĞ DÜNDAR
Ankara University, Turkey
Prof. Dr. Ozan TEKİNALP
Middle East Technical University, Turkey
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
Prof. Dr. Sarwat JAHAN
Quaid-i-Azam University, Pakistan
Prof. Dr. Sibel YILDIZ
Karadeniz Technical University, Turkey
Prof. Dr. Siti Khairunniza bt. BEJO
Universiti Putra Malaysia, Malaysia
Prof. Dr. Şule UĞUR
Gazi University, Turkey
Assoc. Prof. Dr. Abd. Rahim Abu TALIB
Universiti Putra Malaysia, Malaysia
Assoc. Prof. Dr. Ahmet EKİCİBİL
Çukurova University, Turkey
Assoc. Prof. Dr. Aslıhan DEMİRDÖVEN
Tokat Gaziosmanpasa University, Turkey
Assoc. Prof. Dr. Aycan TOSUNOĞLU
Uludağ University, Turkey
Assoc. Prof. Dr. Ayla UYSAL
Süleyman Demirel University, Turkey
Assoc. Prof. Dr. Ayşe AVCI
Sakarya University, Turkey
Assoc. Prof. Dr. Ayşe BEDELOĞLU
Bursa Technical University, Turkey
Assoc. Prof. Dr. Bülent KABAK
Hitit University, Turkey
Assoc. Prof. Dr. Dian Darina Indah Binti DARUIS
Universiti Putra Malaysia, Malaysia
Assoc. Prof. Dr. Didem ÖZÇİMEN
Yıldız Technical University, Turkey
Assoc. Prof. Dr. Fatma MEYDANERİ TEZEL
Karabuk University, Turkey
Assoc. Prof. Dr. Mahmoud HAFEZİEH
Iranian Fisheries Sciences Research Institute, Iran
Assoc. Prof. Dr. Mohammad SUDAGAR
Gorgan University, Iran
Assoc. Prof. Dr. Muhammad Mohsin AMMAN
NED University of Engineering & Technology, Pakistan
Assoc. Prof. Dr. Nemanja KAŠIKOVIĆ
University of Novi Sad, Serbia
Assoc. Prof. Dr. Niyazi ŞAHİN
Ankara Yıldırım Beyazıt University, Turkey
Assoc. Prof. Dr. Rani Faryal Faheem TAHIR
Quaid-i-Azam University, Pakistan
Assoc. Prof. Dr. Roselina ARELHI
University of Nottingham, Malaysia
Assoc. Prof. Dr. Sadaf ZAIDI
Aligarh Muslim University, India
Assoc. Prof. Dr. Selma DÜZYOL
Konya Technical University, Turkey
Assoc. Prof. Dr. Sezgin AYDIN
Gazi University, Turkey
Assoc. Prof. Dr. Tayfun DEDE
Karadeniz Technical University, Turkey
Assoc. Prof. Dr. Tevfik AĞAÇAYAK
Konya Technical University, Turkey
Assist. Prof. Dr. Ali Osman AYAŞ
Adıyaman University, Turkey
Assist. Prof. Dr. Bilge İMER
Middle East Technical University, Turkey
Assist. Prof. Dr. Ebru SARALOĞLU GÜLER
Başkent University, Turkey
Assist. Prof. Dr. Halil İbrahim DEMİR
Sakarya University, Turkey
Assist. Prof. Dr. İbrahim ÇINAR
Karamanoğlu Mehmetbey University, Turkey
Assist. Prof. Dr. Mustafa AKYOL
Adana Science and Technology University, Turkey
Assist. Prof. Dr. Özge TUFAN ÇETİN
Akdeniz University, Turkey
Assist. Prof. Dr. Poonam AGARWAL
Jawaharlal Nehru University, India
Assist. Prof. Dr. Shahram DADGAR
Iranian Fisheries Sciences Research Institute, Iran
Dr. Aainaa Izyan NAFSUN
Universiti Putra Malaysia, Malaysia
Dr. Lim Kar SING
Universiti Malaysia Pahang, Malaysia
Dr. Tugay AYAŞAN
East Mediterranean Agricultural Research Institute, Turkey
*This list is arranged in alphabetical order. Conference Secretariats Assist. Prof. Dr. Demet DOĞAN
Gaziantep University, Turkey
Dr. Mustafa SEVİNDİK
Akdeniz University, Turkey
Dr. Celal BAL
Gaziantep University, Turkey
Serap ŞAHİN YİĞİT
Gaziantep University, Turkey
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
CONTENTS Page 1. INVAITED SPEAKERS
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2. FULL-TEXT PAPERS
8
2.1. ORAL PRESENTATIONS 2.2. POSTER PRESENTATIONS
8 2689
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
Pharmacological properties of Fomes fomentarius Celal Bal1*, Hasan Akgül2 *1
2
Gaziantep University, Oguzeli Vocational School, Gaziantep, Turkey. Akdeniz University, Science Faculty, Biology Department, Antalya, Turkey. *Corresponding author e-mail:
[email protected]
Abstract Mushrooms that have existed for centuries have spread all over the world. While mushrooms differ as poisonous and non-poisonous, it is possible to classify them as edible and non-edible mushrooms. Recently, many researches have been conducted on benefits and importance of many species of mushrooms. In this study, Fomes fomentarius mushroom, which is a medicinal mushroom was studied. Fomes mushrooms have been used for centuries for medicinal purposes. Medicinal mushrooms are widely used as food and herb medicine in China, Japan and other Asian countries. Medicinal mushrooms are a source of polysaccharide with anti-inflammatory and immune system stimulant properties and have antioxidant, anti-inflammatory and antidiabetic effect. In this study, the use of F. fomentarius mushroom as a natural source in pharmacological studies was evaluated. Keywords: Medicinal Mushroom, Fomes fomentarius, Antioxidant, Anti-inflammatory, Natural source. 1. INTRODUCTION Mushrooms, which are seen all over the world, are distributed in certain regions and some species are spread over geographically wide areas. Fungi usually spread in forest areas. In addition to this, it is possible to come across in open areas such as marshes, Park-Gardens, sawdust, garbage and pastures (Akgül et al., 2017; Sevindik 2018).
Edible mushrooms are our important food source. With its easily digestible and nutritious feature, it is widely used in today's tables. Because of their taste and flavour, the edible mushrooms are consumed as meals in addition to their consumption. Mushrooms are a rich source of protein, lipids, amino acids, glycogen, vitamins and minerals (Okhuoya et al., 2010; Rathore et al. 2017).
Nature has been our medical agent for centuries. In recent years, the problem of antibiotic resistance, bacterial and fungal pathogens against antimicrobial agents by developing numerous defense mechanisms; the new and more powerful of these agents was presented as an alternative to antibiotic therapy (Heleno vd., 2013). The interest in natural compounds has been a common point for most biotechnology companies to be used in the production of new antimicrobial drugs (Butler, 2004; Lam, 2007).
A lot of research has been done on medically edible fungi. In addition, non-edible mushrooms have been found to be of medical importance in recent years. Today, it is important to investigate alternative drugs and natural therapeutics for cancer treatment. In recent years, the active compounds of Fomes fungus have been studied extensively and most of their biological activities have been studied. Fomes species, which often cause decay and destruction of wood, often cause white decay on trees.
ORAL PRESENTATION
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In this study, the studies used as material of F. fomentarius, which has a medical effect, has been mentioned. 2. MACROSCOPIC AND MICROSCOPIC PROPERTIES Regnum: Fungi Divisio: Basidiomycota Classis: Agaricomycetes Ordo: Polyporales Familia: Polyporaceae Genus: Fomes Species: Fomes fomentarius (L.) Fr. Basidiocarps: 5-45 cm in diameter, 2-25 cm in height and is shaped like a horse nail (figure 1). Each year, there are different gray colored concentric zones with different thicknesses stacked on top of each other, gray-gray brown. When it is young, there is a white circular ring on the edge. The outer part is hard and woody. Trama: Hard, cinnamon brown, mature when poured in the form of lighter powder. The smell of fruit while fresh. Hymenium: Porous, round, 2-3 cm in mm, tubes 2-5 (8) mm long and gray brown. Spores: 5.5-6 × 18.5-19 µ, elliptic-cylindrical, flat, hyaline.
Ecology: In hardwood wood bodies (especially birch and beech), it causes white rotting, living alone or with more than one species. It has a thick rigid body. Life style is parasitic and saprotrophic.
Figure 1: Fomes fomentarius (L.) Fr 3. MEDICINAL PROPERTIES In studies on F. fomentarius, different methods are practiced, different dissolvent of mushrooms are used and various pharmacologic effects are determined. In the related studies on species, it is found that F. fomentarius have significant effects such as antioxidant enzyme activity, enzymatic activity, antimicrobial activity, antifungal ORAL PRESENTATION
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
activity, Anti-inflammatory effect, antioxidant activity, cytotoxicity, Antitumor, Antiviral activity, Antibacterial activity, DNA protective activity, Antioxidant and Oxidant activities (Table 1). Table 1: Pharmacological effects of F. fomentarius. References Lee, 2005 Water Sánchez-Santillán et al., Enzymatic activity Agar-malt extract 2015 Dresch et al., 2015; Bösiger et al., 2017; Antimicrobial activity Dundar et al., 2016; Ethanol, aqueous, methanol, polysaccharide Wasko et al., 2014 Dresch et al., 2015; Antifungal activity Ethanol Vazirian et al., 2014 Anti-inflammatory effect Aqueous Vazirian et al., 2014; Mircea et al., 2018; Antioxidant activity Mircea et al., 2015; Dundar et al., 2016; Bal Aqueous, Methanol, Ethanol et al., 2017 Kim et al., 2015; Water, hexane, dichloromethane, methanol, Kolundžić et al., 2016; Cytotoxicity aqueous, Ethanol Dundar et al., 2016; Bal et al., 2017 Chen et al., 2008 Antitumor Polysaccharide Aoki et al., 1993, Antiviral activity Polysaccharide Kolundžić et al., 2016; Antibacterial activity Hexane, dichloromethane, methanol, aqueous Bal et al., 2017 DNA protective activity Ethanol Antioxidant and Oxidant Bal et al., 2017 activities Ethanol Activity Antioxidant enzyme activity
Extracts
4. CONCLUSION In this study, the biological activities of Fomes fomentarius which are not edible but have medicinal properties were investigated. As a result of the researches, it was determined that the fungus has medical potential and it can be used as a natural resource for pharmacological researches. REFERENCES Akgul, H., Sevindik, M., Coban, C., Alli, H., & Selamoglu, Z. (2017). New approaches in traditional and complementary alternative medicine practices: Auricularia auricula and Trametes versicolor. J Tradit Med Clin Natur, 6(239), 2. Aoki, M., Tan, M., Fukushima, A., Hieda, T., Kubo, S., Takabayashi, M., ... & Mikami, Y. (1993). Antiviral substances with systemic effects produced by Basidiomycetes such as Fomes fomentarius. Bioscience, biotechnology, and biochemistry, 57(2), 278-282. Bal, C., Akgul, H., Sevindik, M., Akata, I., & Yumrutas, O. (2017). Determination of the anti-oxidative activities of six mushrooms. Fresenius Envir Bull, 26(10), 6246-6252. Bösiger, P., Fortunato, G., Schwarze WMR, F. (2017). Antibacterial Activity of Aqueous Fungal Extracts Derived From Basidiomycetes. Mod Appl Bioequiv Availab. 2 (5), 1-3.
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Butler, M. S. (2004). The role of natural product chemistry in drug discovery. Journal of natural products, 67(12), 2141-2153. Chen, W., Zhao, Z., Chen, S. F., & Li, Y. Q. (2008). Optimization for the production of exopolysaccharide from Fomes fomentarius in submerged culture and its antitumor effect in vitro. Bioresource technology, 99(8), 31873194. Dresch, P., Rosam, K., Grienke, U., Rollinger, J. M., & Peintner, U. (2015). Fungal strain matters: colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus. AMB Express, 5(1), 4. Dundar, A., Okumus, V., Ozdemir, S., Celik, K. S., Boğa, M., & Ozcagli, E. (2016). Determination of cytotoxic, anticholinesterase, antioxidant and antimicrobial activities of some wild mushroom species. Cogent Food & Agriculture, 2(1), 1178060. Heleno, B., Thomsen, M. F., Rodrigues, D. S., Jørgensen, K. J., & Brodersen, J. (2013). Quantification of harms in cancer screening trials: literature review. Bmj, 347, f5334. Kim, S. H., Jakhar, R., & Kang, S. C. (2015). Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom Fomes fomentarius in human lung carcinoma cell line. Saudi journal of biological sciences, 22(4), 484-490. Kolundžić, M., Grozdanić, N. Đ., Dodevska, M., Milenković, M., Sisto, F., Miani, A., ... & Kundaković, T. (2016). Antibacterial and cytotoxic activities of wild mushroom Fomes fomentarius (L.) Fr., Polyporaceae. Industrial Crops and Products, 79, 110-115. Lam, K. S. (2007). New aspects of natural products in drug discovery. Trends in microbiology, 15(6), 279-289. Lee, J. S. (2005). Effects of Fomes fomentarius supplementation on antioxidant enzyme activities, blood glucose, and lipid profile in streptozotocin-induced diabetic rats. Nutrition research, 25(2), 187-195. Mircea, C., Cioanca, O., Bild, V., Iancu, C., Stan, C. Ă. T. Ă. L. I. N. A., & Hancianu, M. (2018). IN VIVO ANTIOXIDANT PROPERTIES OF SOME MUSHROOM EXTRACTS IN EXPERIMENTALLY INDUCED DIABETES. FARMACIA, 66(2), 257-261. Mircea, C., Cioanca, O., Iancu, C., Tataringa, G., & Hancianu, M. (2015). In vitro antioxidant activity of some extracts obtained from Agaricus bisporus brown, Pleurotus ostreatus and fomes fomentarius. Farmacia, 63(6), 927-933. Okhuoya, J., Akpaja, E., Osemwegie, O., Oghenekaro, A., & Ihayere, C. (2010). Nigerian mushrooms: underutilized non-wood forest resources. Journal of Applied Sciences and Environmental Management, 14(1). Rathore, H., Prasad, S., & Sharma, S. (2017). Mushroom nutraceuticals for improved nutrition and better human health: a review. PharmaNutrition, 5(2), 35-46. Sánchez-Santillán, P., Meneses-Mayo, M., Miranda-Romero, L., Santellano-Estrada, E., & Alarcón-Zúñiga, B. (2015). Fribrinolytic activity and gas production by Pleurotus ostreatus-IE8 and Fomes fomentarius-EUM1 in bagasse cane. Revista MVZ Córdoba, 20, 4907-4916. Sevindik, M. (2018). Investigation of Antioxidant/Oxidant Status and Antimicrobial Activities of Lentinus tigrinus. Advances in Pharmacological Sciences, 2018. https://doi.org/10.1155/2018/1718025 Vazirian, M., Dianat, S., Manayi, A., Ziari, R., Mousazadeh, A., Habibi, E., ... & Amanzadeh, Y. (2014). Antiinflammatory effect, total polysaccharide, total phenolics content and antioxidant activity of the aqueous extract of three basidiomycetes. Research Journal of Pharmacognosy, 1(1), 15-21. Wasko, S.J., Brenner, M.V., Cartier, S.F. (2014). Crystalline Metabolites of the Tinder Polypore (Fomes fomentarius). Journal of the North Carolina Academy of Science, 130(1), 16-22.
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