International Eurasian Conference on
Science, Engineering and Technology (EurasianSciEnTech 2018) 22-23 November 2018 Ankara / Turkey
EurasianSciEnTech 2018 w w w. e u r a s a n s c e n t e c h . o r g
International Eurasian Conference on
Science, Engineering and Technology (EurasianSciEnTech 2018) November 22-23, 2018 / Ankara, Turkey www.EurasianSciEnTech.org
PROCEEDING BOOK
International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
Chairman of Conference Assoc. Prof. Dr. Muhittin DOĞAN
Gaziantep University, Turkey
General Coordinator Assist. Prof. Dr. Mustafa PEHLİVAN
Gaziantep University, Turkey
Organizing Committee Prof. Dr. Ahmet AKSOY
Akdeniz University, Turkey
Prof. Dr. Mehmet Rüştü KARAMAN
Ankara University, Turkey
Prof. Dr. Osman GÜLNAZ
Cukurova University, Turkey
Prof. Dr. Zeliha SELAMOĞLU
Niğde Ömer Halisdemir University, Turkey
International Scientific Committee* Prof. Dr. Adnan QADIR
NED University of Engineering & Technology, Pakistan
Prof. Dr. Ahmet ŞEKEROĞLU
Niğde Ömer Halisdemir University, Turkey
Prof. Dr. Alpaslan DAYANGAÇ
Osmaniye Korkut Ata University, Turkey
Prof. Dr. Ayşe AYDOĞDU
Gazi University, Turkey
Prof. Dr. Azhar RASUL
Government College University, Pakistan
Prof. Dr. Azize AYOL
Dokuz Eylül University, Turkey
Prof. Dr. Bengi USLU
Ankara University, Turkey
Prof. Dr. Berna DENGİZ
Baskent University, Turkey
Prof. Dr. Bushra MIRZA
Quaid-i-Azam University, Pakistan
Prof. Dr. Bülent AKAY
Ankara University, Turkey
Prof. Dr. Bülent YEŞİLATA
Harran University, Turkey
Prof. Dr. Cihangir DURAN
Ankara Yıldırım Beyazıt University, Turkey
Prof. Dr. Deniz UZUNSOY
Bursa Technical University, Turkey
Prof. Dr. Dilek ERDİRENÇELEBİ
Konya Technical University, Turkey
Prof. Dr. Ebru ŞENADIM TÜZEMEN
Cumhuriyet University, Turkey
Prof. Dr. Ebru ŞENEL
Ankara University, Turkey
Prof. Dr. Fakhru'l Razi bin AHMADUN
National Defence University Malaysia, Malaysia
Prof. Dr. Faruk KARADAĞ
Çukurova University, Turkey
Prof. Dr. Fatma Suna BALCI
Gazi University, Turkey
Prof. Dr. Ferruh ERDOĞDU
Ankara University, Turkey
Prof. Dr. Gıyasettin KAŞIK
Selçuk University, Turkey
Prof. Dr. Gul Majid KHAN
Quaid-i-Azam University, Pakistan
Prof. Dr. Hüseyin CANBOLAT
Ankara Yıldırım Beyazıt University, Turkey
Prof. Dr. Kerim KÜÇÜK
Dokuz Eylül University, Turkey
Prof. Dr. Mehmet SARI
Aksaray University, Turkey
Prof. Dr. Meltem SARIOĞLU CEBECİ
Cumhuriyet University, Turkey
Prof. Dr. Muhammad ANSAR
Quaid-i-Azam University, Pakistan
Prof. Dr. Mustafa ÇİĞDEM
Yıldız Technical University, Turkey
Prof. Dr. Neriman BAĞDATLIOĞLU
Celal Bayar University, Turkey
Prof. Dr. Nil TOPLAN
Sakarya University, Turkey
Prof. Dr. Nuri ÖZALP
Ankara University, Turkey
Prof. Dr. Osman GÜLNAZ
Çukurova University, Turkey
Prof. Dr. Oya BOZDAĞ DÜNDAR
Ankara University, Turkey
Prof. Dr. Ozan TEKİNALP
Middle East Technical University, Turkey
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
Prof. Dr. Sarwat JAHAN
Quaid-i-Azam University, Pakistan
Prof. Dr. Sibel YILDIZ
Karadeniz Technical University, Turkey
Prof. Dr. Siti Khairunniza bt. BEJO
Universiti Putra Malaysia, Malaysia
Prof. Dr. Şule UĞUR
Gazi University, Turkey
Assoc. Prof. Dr. Abd. Rahim Abu TALIB
Universiti Putra Malaysia, Malaysia
Assoc. Prof. Dr. Ahmet EKİCİBİL
Çukurova University, Turkey
Assoc. Prof. Dr. Aslıhan DEMİRDÖVEN
Tokat Gaziosmanpasa University, Turkey
Assoc. Prof. Dr. Aycan TOSUNOĞLU
Uludağ University, Turkey
Assoc. Prof. Dr. Ayla UYSAL
Süleyman Demirel University, Turkey
Assoc. Prof. Dr. Ayşe AVCI
Sakarya University, Turkey
Assoc. Prof. Dr. Ayşe BEDELOĞLU
Bursa Technical University, Turkey
Assoc. Prof. Dr. Bülent KABAK
Hitit University, Turkey
Assoc. Prof. Dr. Dian Darina Indah Binti DARUIS
Universiti Putra Malaysia, Malaysia
Assoc. Prof. Dr. Didem ÖZÇİMEN
Yıldız Technical University, Turkey
Assoc. Prof. Dr. Fatma MEYDANERİ TEZEL
Karabuk University, Turkey
Assoc. Prof. Dr. Mahmoud HAFEZİEH
Iranian Fisheries Sciences Research Institute, Iran
Assoc. Prof. Dr. Mohammad SUDAGAR
Gorgan University, Iran
Assoc. Prof. Dr. Muhammad Mohsin AMMAN
NED University of Engineering & Technology, Pakistan
Assoc. Prof. Dr. Nemanja KAŠIKOVIĆ
University of Novi Sad, Serbia
Assoc. Prof. Dr. Niyazi ŞAHİN
Ankara Yıldırım Beyazıt University, Turkey
Assoc. Prof. Dr. Rani Faryal Faheem TAHIR
Quaid-i-Azam University, Pakistan
Assoc. Prof. Dr. Roselina ARELHI
University of Nottingham, Malaysia
Assoc. Prof. Dr. Sadaf ZAIDI
Aligarh Muslim University, India
Assoc. Prof. Dr. Selma DÜZYOL
Konya Technical University, Turkey
Assoc. Prof. Dr. Sezgin AYDIN
Gazi University, Turkey
Assoc. Prof. Dr. Tayfun DEDE
Karadeniz Technical University, Turkey
Assoc. Prof. Dr. Tevfik AĞAÇAYAK
Konya Technical University, Turkey
Assist. Prof. Dr. Ali Osman AYAŞ
Adıyaman University, Turkey
Assist. Prof. Dr. Bilge İMER
Middle East Technical University, Turkey
Assist. Prof. Dr. Ebru SARALOĞLU GÜLER
Başkent University, Turkey
Assist. Prof. Dr. Halil İbrahim DEMİR
Sakarya University, Turkey
Assist. Prof. Dr. İbrahim ÇINAR
Karamanoğlu Mehmetbey University, Turkey
Assist. Prof. Dr. Mustafa AKYOL
Adana Science and Technology University, Turkey
Assist. Prof. Dr. Özge TUFAN ÇETİN
Akdeniz University, Turkey
Assist. Prof. Dr. Poonam AGARWAL
Jawaharlal Nehru University, India
Assist. Prof. Dr. Shahram DADGAR
Iranian Fisheries Sciences Research Institute, Iran
Dr. Aainaa Izyan NAFSUN
Universiti Putra Malaysia, Malaysia
Dr. Lim Kar SING
Universiti Malaysia Pahang, Malaysia
Dr. Tugay AYAŞAN
East Mediterranean Agricultural Research Institute, Turkey
*This list is arranged in alphabetical order. Conference Secretariats Assist. Prof. Dr. Demet DOĞAN
Gaziantep University, Turkey
Dr. Mustafa SEVİNDİK
Akdeniz University, Turkey
Dr. Celal BAL
Gaziantep University, Turkey
Serap ŞAHİN YİĞİT
Gaziantep University, Turkey
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
CONTENTS Page 1. INVAITED SPEAKERS
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2. FULL-TEXT PAPERS
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2.1. ORAL PRESENTATIONS 2.2. POSTER PRESENTATIONS
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International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2018), November 22-23, 2018 Ankara, Turkey www.EurasianSciEnTech.org
The Importance of Poisonous Mushrooms in Pharmacological Studies Zeliha Selamoglu Department of Medical Biology, Faculty of Medicine, University of Nigde Ömer Halisdemir, Nigde, Turkey
[email protected]
Abstract Mushrooms that affect human health negatively due to the toxic compounds they contain are called ''poisonous mushrooms''. Mushrooms, which can cause serious health problems in consumers, can cause death. Although many negative health problems in humans, poisonous mushroom are medically important natural resources. Studies conducted by many researchers have identified antioxidant, antimicrobial, anticancer, antibacterial, antiviral and antiproliferative activities of poisonous mushroom. In these regards, the aim of this review was to evaluate the medical potential of poisonous mushroom. Keywords: Mushroom, Poisonous Mushrooms, Pharmacologia, Antioxidant, Antimicrobial. INTRODUCTION The worldwide diversity of mushroom species is roughly accounted as 140.000 . Of these, 14.000 are known and 7.000 are considered to have varying levels of edibility. More than 2.000 species are safe and 700 are documented to have considerable pharmacological properties (Akgul et al., 2017; Bal et al., 2017). Mushrooms are a recognized component of the human diet, with versatile medicinal properties. Some mushrooms are popular worldwide for their nutritional and therapeutic properties. Some species are well utilized for food and medicine due to the presence of pharmacologically active substances and essential nutrients. Because of these properties, mushrooms were described as popular remedies in ancient oriental documents and some of them became ingredients in traditional medicine (Sevindik 2018a; Sevindik et al., 2018a; Bal 2018). There are many thousands of mushroom species in the world, some are edible and some are poisonous due to containing significant toxins. The edible mushroom is a common food item with tempting flavour, taste and nutritive value; nowadays quite often grown at home and cultured with commercial marketing. A great variety of species was classified as poisonous and represents risks to health if ingested. Apart from mushrooms that contain psychoactive toxins, ingestion of toxic mushrooms is invariably accidental and caused by misidentification of species (Adejumo and Awosanya 2005; Jo et al., 2010; Sanchez, 2017; Sevindik 2018c). Mushrooms are a recognized component of the human diet, with versatile medicinal properties. Some mushrooms are popular worldwide for their nutritional and therapeutic properties. But, some species are dangerous because they cause toxicity. There are many data explaining the medicinal and/or toxic effects of these fungal species. Various substances belonging to poisonous mushrooms were already identified and are related with different symptoms and signs. Intoxications caused by commonly consumed mushrooms were already described, for this reason edible mushrooms and the ones having pharmacological potential must be carefully studied in order to identify the possibility of intoxications, so more studies have to be carefully conducted, clinical and experimental assays with medicinal species must investigate the side effects that may occur (Toth et al., 1989; Tomasi et al., 2004; Riede, 2011;
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Ruthes et al., 2013; Chelela et al., 2014; Poyraz et al., 2015; Tel et al., 2015; Akgul et al., 2016; Sevindik et al., 2017; Sevindik et al., 2018b; Sevindik 2018c; Colak et al., 2018). Mushrooms are of particular interest owing to the limited knowledge of mushroom toxins at the present time giving opportunities for further investigative studies. Mushrooms play a great part in numerous cuisines across the world. All mushrooms that are considered poisonous have been classified as such; the classification is actually done following hospital admissions of individuals who, after consuming mushrooms, have suffered symptoms of poisoning. Moreover, it is possible that many of mushrooms will contain toxins which have not yet been scientifically analysed and identified. Especially, when a mushroom was labelled as poisonous, scientists were rarely interested in identifying the hazardous chemical constituents. The lack of interest in the fungi kingdom caused many gaps in our current knowledge about mushrooms, fungi and their toxins (Toth et al., 1989; Tomasi et al., 2004; Riede, 2011; Fiedziukiewicz 2013; Ruthes et al., 2013; Chelela et al., 2014; Poyraz et al., 2015; Tel et al., 2015; Akgul et al., 2016; Sevindik et al., 2017; Sevindik et al., 2018b; Sevindik 2018c; Colak et al., 2018). Mushrooms are enriched with great quantities of complex polysaccharides possessing broad spectrum of therapeutic capacities. They are also rich in vitamins and minerals with excellent bioprotective properties. The amino acid content is well balanced and contains most of the essential amino acids required for normal functions in the body. Also, they have large amounts of trace elements required for major metabolic reactions. Mushrooms have been considered as an important source of bioactive natural compounds and many of the metabolites have shown to possess biological properties and potent health benefits (Adejumo and Awosanya 2005; Jo et al., 2010; Sanchez, 2017; Sevindik 2018b). Finally, we can suggest that natural compounds such as natural products including mushrooms which are exploited for drug development must be evaluated for the presence of toxicity and other physiological effects (Toth et al., 1989; Tomasi et al., 2004; Riede, 2011; Ruthes et al., 2013; Chelela et al., 2014; Poyraz et al., 2015; Tel et al., 2015; Akgul et al., 2016; Sevindik et al., 2017; Sevindik et al., 2018b; Sevindik 2018c; Colak et al., 2018). CONCLUSION Toxicity investigations of mushroom species have showed that mushroom poisoning can cause adverse effects such as liver failure, bradycardia, chest pain, seizures, gastroenteritis, intestinal fibrosis, renal failure, erythromelalgia, and rhabdomyolysis. Different materials responsible for the fatal signs and symptoms of mushroom toxicity have been identified from various poisonous mushrooms. No adequate database exists to estimate the worldwide exposure and fatality due to mushroom poisoning. Correct categorization and better understanding are essential for the safe and healthy consumption of mushrooms as functional foods as well as for their medicinal use. Most important factor is not to eat wild or uncultivated mushrooms as it is very difficult to correctly identify edible from poisonous mushrooms. Although many negative health problems in humans, poisonous mushrooms are medically important natural resources. REFERENCES Adejumo TO, Awosanya OB 2005. Proximate and mineral composition of four edible mushroom species from South Western Nigeria. African Journal of Biotechnology, 4(10): 1084-1088 Akgül H, Nur AD, Sevindik M, Doğan M 2016. Tricholoma terreum ve Coprinus micaceus’un bazı biyolojik aktivitelerinin belirlenmesi. Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi, 17(2): 158162.
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Akgul H, Sevindik M, Coban C, Alli H, Selamoglu Z 2017. New approaches in traditional and complementary alternative medicine practices: Auricularia auricula and Trametes versicolor. J Tradit Med Clin Natur, 6(2): 239. Bal C 2018. A study on antioxidant properties of Gyrodon lividus. Eurasian Journal of Forest Science, 6 (2): 40-43. Bal C, Akgul H, Sevindik M, Akata I, Yumrutas O 2017. Determination of the anti-oxidative activities of six mushrooms. Fresenius Envir Bull, 26(10): 6246-6252. Chelela BL, Chacha M, Matemu A 2014. Antibacterial and antifungal activities of selected wild mushrooms from Southern Highlands of Tanzania. American Journal of Research Communication, 2(9): 58-68. Çolak OF, Rasul A, Sevindik M 2018. A study on Paxillus involutus: total antioxidant and oxidant potential. Turkish Journal of Life Sciences, 3(2): 244-247. Fiedziukiewicz M 2013. Mushroom Toxins-The Meixner Test (Doctoral dissertation, University of York). Jo WS, Hossain MA, Park SC 2014. Toxicological profiles of poisonous, edible, and medicinal mushrooms. Mycobiology, 42(3): 215-220. Poyraz B, Güneş H, Bahar TÜL, Sermenli HB 2015. Antibacterial and Antitumor Activity of Crude Methanolic Extracts from Various Macrofungi Species. Biyoloji Bilimleri Araştırma Dergisi, (1): 510. Riede I 2011. Tumor therapy with Amanita phalloides (Death Cap): stabilization of mammary duct cancer. TANG, 1(1): 32-34. Ruthes AC, Carbonero ER, Córdova MM, Baggio CH, Sassaki GL, Gorin PAJ, Iacomini M 2013. Fucomannogalactan and glucan from mushroom Amanita muscaria: Structure and inflammatory pain inhibition. Carbohydrate polymers, 98(1): 761-769. Sánchez C 2017. Reactive oxygen species and antioxidant properties from mushrooms. Synthetic and systems biotechnology, 2(1): 13-22. Sevindik M 2018a. Investigation of Oxidant and Antioxidant Status of Edible Mushroom Clavariadelphus truncatus. Mantar Dergisi, 9 (2): 165-168. Sevindik M 2018b. Investigation of Antioxidant/Oxidant Status and Antimicrobial Activities of Lentinus tigrinus. Advances in Pharmacological Sciences, 2018. https://doi.org/10.1155/2018/1718025 Sevindik M 2018c. Heavy metals content and the role of Lepiota cristata as antioxidant in oxidative stress. J Bacteriol Mycol Open Access, 6(4):237‒239. Sevindik M, Akgül H, Bal C 2017. Determination of Oxidative Stress Status of Ompholatus olearius Gathered from Adana and Antalya Provinces in Turkey. Sakarya University Journal of Science, 21 (3): 324-327. Sevindik M, Bal C, Akgül H 2018a. Comparison of Antioxidant Potentials of the Wild and Cultivated Forms of Edible Pleurotus ostreatus and Agaricus bisporus Mushrooms. Türk Yaşam Bilimleri Dergisi, 3 (2): 263-266. Sevindik M, Akgul H, Korkmaz AI, Sen I 2018b. Antioxidant Potantials of Helvella leucomelaena and Sarcosphaera coronaria. J Bacteriol Mycol Open Access, 6(2): 00173. Tel G, Ozturk M, Duru ME, Turkoglu A 2015. Antioxidant and anticholinesterase activities of five wild mushroom species with total bioactive contents. Pharmaceutical biology, 53(6): 824-830. Tomasi S, Lohezic-Le Devehat F, Sauleau P, Bezivin C, Boustie J 2004. Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 59(4): 290-293.
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Toth B, Patil K, Taylor J, Stessman C, Gannett P 1989. Cancer induction in mice by 4hydroxybenzenediazonium sulfate of the Agaricus xanthodermus mushroom. In vivo (Athens, Greece), 3(5): 301-305.
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