Serological markers in fulminant hepatitis B

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Oct 11, 1982 - responses to all three hepatitis B virus antigens and more rapid clearance of the latter ... may cause an Arthus reaction inhepatic sinusoids.
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Gut, 1983, 24, 615-617

Serological markers in fulminant hepatitis B A

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E S GIMSON, R S TEDDER, Y S WHITE, L W F EDDLESTON, AND ROGER WILLIAMS

From The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London, and The Department of Virology, Middlesex Hospital Medical Sc0hool, London. SUMMARY Serological markers for hepatitis B virus infection have been examined in 34 patients with acute hepatitis B, 17 of whom developed fulminant hepatic failure. Hepatitis B surface antigen concentrations were significantly lower and hepatitis Be antigen was less frequently detectable in patients with fulminant hepatic failure compared with those with acute hepatitis (median 0O64 ,ug, range 16-0 and median 32 ,ug and range 100-4 ,ug respectively, p