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Charitou et al_Supplemental Figure2. a-KG (nmols)/5x10" cells. 3 3 3. RPEshFOXO. RPEshFOXO. +doxy. RPEshFOXO. _IDH1 siRNA. **. **. RPEshFOXO.
Charitou et al_Supplemental Figure2.

B.

0,6

*

0,4

*

0,2

NADPH/NADP+ ratio

5 α-KG (nmols)/5x10 cells

A.

0

RPEshFOXO

RPEshFOXO _IDH1 siRNA

3,0 2,0

**

**

RPEshFOXO +doxy

RPEshFOXO IDH1 siRNA

1,0 0 RPEshFOXO

C.

RPEshFOXO +doxy

1.6

NADPH/NADP+ ratio

1.4 1.2 1 0.8 0.6 0.4 0.2 0

shLuc-

D.

shLuc +doxy

shFOXO

shFOXO +doxy

25 GSH/GSSG ratio

20 15

*

*

RPEshFOXO +doxy

RPEshFOXO _IDH1 siRNA

10 5 0 RPEshFOXO