Supplementary Fig.2. Human GNMT gene sequence from promoter ...

-1320 -1260 -1200 -1140 -1080 -1020 -960 -900 -840 -780 -720 -660 -600 -540 -480 -420 -360 -300 -240 -180 -120 -60 1 61 121 181

aaccctgcag aggaggagag ccctgtaatt tttctgctgg ! cttgaacaaa tgaaaatgaa ctgttacatt ggatgaagta atatttcccg tctcctgctt cggagtcttg ARE ccgccttccc gcgcgtgtca gtttcaccgt cagaccagct cacacttcgg tccagtcctg attgctcccg gagggctccg gctaaaagga ggcgcccggc ggggctgtcg AGGCGCGGCG !+1 ! AAGGGCTCCC GAGACACCCG ACGGCTGCCA !!

ttgcttccat aggcagagag gagcagaaag ctggctcgcc ! ! caattggaca agtacactcc ttgtgagttt aagttacagt ttataactga cctgtgaaag ctctgttgcc II! gggttcaagc ccatgtccca gttaccgtgt ttacctccag tggcacaatc cccgcctggc cctctcctga agggtcctct cctagcccag ccaaagcccg gctgccagca CAGGATGGTG

gtttaggcgc tgcccaccaa gggtcccaag agagagagag agagagagag agagagaagc gaaagggaga aaaatgaatc ccaaactttg aaaatatgtt aacggtagag gatgtccagg ! ! ARE I! aaatgcacaa acaaagcaag aaaggaatga acagtgtggg agcgagcatg agcatagggg aaataccctc tacttggggt acaccctatg tacaaagtta ttaatggcgg gcatacgccc agtgtgaatt ggccttatgt tccctgtctc cagagggttt tgtttgtttt ttgctttttg caggctggag tgcagtggtg cactcggctc

gattctcctg gctaatcttt taccgtattc agactccccc tttgtttaga gctcagctct cccctctcgc cccgccgtgg gattgcgagg gcaggggcgt gtgcttatgc GACAGCGTGT ARE III GGACCAGTAC GCGGACGGGG CAGCCGCACC GCCGAGTACA GCGGGTGCTC GACGTAGCCT

gctcagcctc ctttattttt cagccgggct tgtcttccct tatgctgatg gcggatctca cttctcctcg gattgcacag cagcgccctc gtccgcgcgc tttaagtgcg ACCGGACCCG ! AGGCGGCGCG AGGCATGGCT GTGGCACTGG

cggagtagct agtagagacg ccgcccctgg gcaccggctg ccttccttcg ggggatggag agacccgggt agggctgggt cctgcagctg tcacctgcta gagcgggtgg CTCCCTGGGG

ttggaaagga! gcgagagcgg! ggcttacctc! ttcttggcat! aggattttat! ctcaaaggcc! taaatgaaga! tatggagagg ! tagaccctat! ttttttgaga! actgcaactt! aggactacag! tgttagccag! attcggtgga! actataccta! ctgggaacgg! tggcaatctc! taagtgggca! ccgcaggctg! gacagactcg! ttggccaggt! ctgcggagcc! GTGGCGGCCG!

CGTGTGGCAG CTGTATATCG! GCTTGGGCTG CTGCGCCAGC! gtgagcccag gccggggccg!

Supplementary Fig.2. Human GNMT gene sequence from promoter region – 1320 bp to + 240 bp (intron 1) is shown. The sequence was retrieved from the UCSC hg19 human genome assembly (http://genome.ucsc.edu). Boxes indicate the three predicted AREs. Exon 1 is shown in uppercase letters, with sequences 5’ to the transcription start and intron 1 sequences shown in lowercase letters. The 5’ untranslated region (UTR) is indicated in blue and the coding region in red. +1 indicates the transcription start site.