Supporting Information. Characterization of expression quantitative
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Supporting Information. Characterization of expression quantitative
2. 3. 0. 1. 2. 3. Expected âlog10(p). O b se rve d. â lo g. 10. (p. ) QQ plot of local association pâvalues for probe ILMN_3235246 q qq q qqqqqqqqqqqqqqqqqqqq.
Supporting Information. Characterization of expression quantitative trait loci in pedigrees from Colombia and Costa Rica ascertained for bipolar disorder. C. B. Peterson, S. K. Service, A. J. Jasinska, F. Gao, I. Zelaya, T. M. Teshiba, C. E. Bearden, R. M. Cantor, V. I. Reus, G. Macaya, C. López-Jaramillo, M. Bogomolov, Y. Benjamini, E. Eskin, G. Coppola, N. B. Freimer, and C. Sabatti.
QQ plot of local association p−values for probe ILMN_3235246
QQ p o o d s a assoc a on p−va ues or probe LMN_3235246
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S2 Fig QQ plots QQ plots for local vs distal association p-values obtained using Mendel for a randomly chosen probe and for all 34 030 probes genomewide Due to the large number of tests in the genomewide setting only p-values for local association < 0 05 for distal association < 0 001 were saved For the local and distal association analyses across all probes 7 and 13 p-values respectively were recorded as exactly 0 due to limited precision in Mendel these are omitted from the plots The QQ plot for local association for a specific probe (upper left) shows enrichment of small p-values vs what would be expected under the null (λGC = 1 15) this deviation makes sense however given that most genes are sub ect to some form of local regulation The QQ plot for distal association for a specific probe (upper right) shows that the distribution of test statistics is as expected under the null (λGC = 1 01) The genomewide distributions (lower left and right) suggest that there are a large number of non-null hypotheses for both local and distal regulation the deviation from expected values takes place much earlier in the local regulation plot however suggesting that the proportion of non-null hypotheses is indeed higher among local vs distal hypotheses
