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Table 1 (1) B - MDPI

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Exon 1. Mixed. Loss of dense core granule. Unchanged. Normal. Unchanged. Unchanged. Wijesekara et al. (2010). Pancreatic Î²-cell specific. (Ins2Cre). Exon 1.

Table 1. Summary of ZnT8-KO mouse studies

Study

Deletion location

Deletion strategy

Genetic background

Crystalization of insulin Loss of granules dense core

Proinsulin concentration

Glucose intolerance

Glucose-stimulated insulin secretion

Insulin level in vivo

Unchanged

Impaired (only males)

Increased

Impaired

Nicolson et al. (2009)

Whole body

Exon 1

Mixed

granule/ rod-shaped cores

Pound et al. (2009)

Whole body

Exon 3

Mixed

Not examined

Not examined

Normal

Decreased

Impaired

Lemaire et al. (2009)

Whole body b-cell Exon 1 Pancreatic specific (Ins2Cre) Exon 1

Mixed

Loss of dense core granule Loss of dense core

Unchanged

Normal

Unchanged

Unchanged

Mixed

granule/ rod-shaped cores

Increased

Impaired

Decreased

Unchanged

C57BL/6J

Unchanged

Decreased

Impaired

Decreased

Unchanged

Tamaki et al. (2013)

Whole body b-cell Exon 3 Pancreatic specific (Ins2Cre) Pancreatic b-cell Exon 5

C57BL/6J

Loss of dense core granules Loss of dense core

Increased

Impaired

Increased

Impaired

Mitchell et al. (2016)

specific (Ins1Cre)

C57BL/6J

granule/ rod-shaped cores

Not examined

Impaired

Unchanged

Impaired

Wijesekara et al. (2010) Pound et al. (2012)

Exon 1