Table S1 - Plos

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Table S1. Symbol. Refseq. Fold Change p-value. Apoptosis. Atm. NM_007499. 1.14. 0.2595. Brca1. NM_009764. 1.21. 0.2001. Mbd4. NM_010774. 1.17. 0.0576.
Table S1 Old vs young Fold Change p-value

Symbol

Refseq

Atm Brca1 Mbd4 Mgmt Mlh1 Prkdc Rad21 Trp53

NM_007499 NM_009764 NM_010774 NM_008598 NM_026810 NM_011159 NM_009009 NM_011640

1.14 1.21 1.17 1.03 1.11 1.18 0.92 0.99

0.2595 0.2001 0.0576 0.4526 0.0717 0.1651 0.1796 0.7870

Chek1 Gadd45a Hus1 Msh2

NM_007691 NM_007836 NM_008316 NM_008628

1.04 0.85 1.04 1.03

0.4769 0.0673 0.4726 0.2917

Cell Cycle Checkpoint

Brca2 Pinx1 Rad1 Rad9 Smc1a

NM_009765 NM_028228 NM_011232 NM_011237 NM_019710

1.10 1.04 1.00 1.04 1.09

0.3299 0.5702 0.9954 0.7445 0.1296

Cell Cycle Related

Atm Chaf1a Rad21 Rbbp4 Smc3 Terf1 Tlk1

NM_007499 NM_013733 NM_009009 NM_009030 NM_007790 NM_009352 NM_172664

1.14 1.03 0.92 0.94 0.99 1.09 1.04

0.2595 0.8364 0.1796 0.4231 0.8595 0.3338 0.4788

Double-Strand Break repair

Brca1 Brca2 Dmc1 Fen1 H2afx Lig4 Mre11a Prkdc Rad21 Rad50 Rad51 Rad51c Rad51l1 Rad51l3

NM_009764 NM_009765 NM_010059 NM_007999 NM_010436 NM_176953 NM_018736 NM_011159 NM_009009 NM_009012 NM_011234 NM_053269 NM_009014 NM_011235

1.21 1.10 1.20 1.07 0.97 0.86 1.08 1.18 0.92 1.11 1.08 1.00 1.16 1.08

0.2001 0.3299 0.5257 0.3573 0.6551 0.0768 0.3193 0.1651 0.1796 0.0594 0.3403 0.9577 0.1862 0.4290

Apoptosis

Cell Cycle Arrest

Rad52 Rad54l Xrcc2 Xrcc3 Xrcc4 Xrcc5 Xrcc6

NM_011236 NM_009015 NM_020570 NM_028875 NM_028012 NM_009533 NM_010247

1.15 0.88 1.09 1.03 0.98 0.88 1.01

0.0933 0.2520 0.1849 0.7082 0.8000 0.1674 0.7755

Damaged DNA Binding

Brca1 Ercc1 H2afx Msh2 Msh3 Rad1 Rad51 Rad51c Rad51l1 Trpc2 Xpa Xpc Xrcc1 Xrcc2 Xrcc3

NM_009764 NM_007948 NM_010436 NM_008628 NM_010829 NM_011232 NM_011234 NM_053269 NM_009014 NM_011644 NM_011728 NM_009531 NM_009532 NM_020570 NM_028875

1.21 0.96 0.97 1.03 1.06 1.00 1.08 1.00 1.16 1.24 1.10 0.96 0.89 1.09 1.03

0.2001 0.5727 0.6551 0.2917 0.2798 0.9954 0.3403 0.9577 0.1862 0.1598 0.1260 0.7057 0.0354 0.1849 0.7082

Base Excision Repair

Apex1 Apex2 Ccno Lig3 Mbd4 Mpg Mutyh Neil1 Neil2 Neil3 Nthl1 Ogg1 Parp1 Parp2 Parp3 Polb Smug1 Tdg Ung Xrcc1

NM_009687 NM_029943 NM_001081062 NM_010716 NM_010774 NM_010822 NM_133250 NM_028347 NM_201610 NM_146208 NM_008743 NM_010957 NM_007415 NM_009632 NM_145619 NM_011130 NM_027885 NM_011561 NM_011677 NM_009532

1.05 1.13 1.37 1.03 1.17 1.02 1.08 0.96 1.14 0.86 1.04 1.04 0.99 1.14 1.28 0.86 0.95 0.95 1.06 0.89

0.5033 0.0219 0.1940 0.6610 0.0576 0.5221 0.2340 0.5825 0.6499 0.1348 0.7094 0.6372 0.7098 0.1927 0.3461 0.0306 0.4557 0.5535 0.4679 0.0354

Atxn3

NM_029705

0.95

0.3230

Nucleotide-excision Repair

Mismatch Repair

DNA repair Related

Brip1 Ccnh Cdk7 Dclre1a Ddb1 Ddb2 Ercc1 Ercc2 Ercc3 Ercc4 Ercc5 Ercc6 Ercc8 Fancc Lig1 Mms19 Nthl1 Pnkp Poll Rad23a Rad23b Rpa1 Rpa3 Slk Xab2 Xpa Xpc

NM_178309 NM_023243 NM_009874 NM_018831 NM_015735 NM_028119 NM_007948 NM_007949 NM_133658 NM_015769 NM_011729 NM_001081221 NM_028042 NM_007985 NM_010715 NM_028152 NM_008743 NM_021549 NM_020032 NM_009010 NM_009011 NM_026653 NM_026632 NM_009289 NM_026156 NM_011728 NM_009531

1.03 0.98 0.80 1.23 0.85 1.13 0.96 1.04 0.89 1.11 0.90 0.72 0.92 1.10 1.02 0.97 1.04 0.91 0.92 1.03 1.15 1.05 0.93 1.08 1.01 1.10 0.96

0.6550 0.7194 0.1612 0.1280 0.0348 0.2722 0.5727 0.5775 0.2093 0.1298 0.1929 0.2485 0.6078 0.2320 0.4081 0.6422 0.7094 0.1243 0.2330 0.6359 0.2510 0.4996 0.2431 0.0424 0.8596 0.1260 0.7057

Mlh1 Mlh3 Msh2 Msh3 Msh4 Msh5 Msh6 Pms1 Pms2 Pold3 Trex1

NM_026810 NM_175337 NM_008628 NM_010829 NM_031870 NM_013600 NM_010830 NM_153556 NM_008886 NM_133692 NM_011637

1.11 1.15 1.03 1.06 1.50 0.91 0.90 1.08 1.21 1.14 1.42

0.0717 0.0109 0.2917 0.2798 0.2275 0.2441 0.1180 0.1300 0.0202 0.0164 0.0236

Atm Atr Atrx Chaf1a Cry2

NM_007499 NM_019864 NM_009530 NM_013733 NM_009963

1.14 0.85 1.13 1.03 1.09

0.2595 0.3628 0.3379 0.8364 0.2835

Exo1 Fancg Fen1 Gtf2h1 Gtf2h2 Lig1 Mgmt Mif Pold1 Pole Polh Poli Polk Pttg1 Rad18 Rad21 Rad50 Rad9 Rad9b Rbbp4 Rbm4 Rev1 Rfc1 Smc1a Smc3 Srd5a2 Sumo1 Tdg Top3a Top3b Ube2a Ung Wrn Wrnip1 Xrcc6bp1 Xrn2

NM_012012 NM_053081 NM_007999 NM_008186 NM_022011 NM_010715 NM_008598 NM_010798 NM_011131 NM_011132 NM_030715 NM_011972 NM_012048 NM_013917 NM_021385 NM_009009 NM_009012 NM_011237 NM_144912 NM_009030 NM_009032 NM_019570 NM_011258 NM_019710 NM_007790 NM_053188 NM_009460 NM_011561 NM_009410 NM_011624 NM_019668 NM_011677 NM_011721 NM_030215 NM_026858 NM_011917

0.58 1.00 1.07 1.09 1.06 1.02 1.03 1.03 1.10 1.04 1.01 1.06 1.15 1.64 1.06 0.92 1.11 1.04 1.21 0.94 0.94 1.11 0.98 1.09 0.99 0.90 1.07 0.95 2.35 0.92 1.08 1.06 1.15 1.03 0.86 1.04

0.3763 0.9358 0.3573 0.1117 0.3269 0.4081 0.4526 0.6745 0.3742 0.5916 0.5991 0.5399 0.1116 0.0109 0.3365 0.1796 0.0594 0.7445 0.1261 0.4231 0.1597 0.3661 0.7513 0.1296 0.8595 0.4235 0.1292 0.5535 0.3662 0.2535 0.3856 0.4679 0.0140 0.7933 0.3459 0.5769