Top Diseases and Functions. Hereditary Disorder, Skeletal and Muscular Disorders, Carbohydrate Metabolism. Cardiovascular System Development and ...
Table S3. Function of genes that changed transcription upon BORIS downregulation in K562 cells. Top Diseases and Functions Hereditary Disorder, Skeletal and Muscular Disorders, Carbohydrate Metabolism Cardiovascular System Development and Function, Organismal Development, Cellular Movement Cellular Function and Maintenance, Developmental Disorder, Hereditary Disorder Organismal Injury and Abnormalities, Reproductive System Disease, Endocrine System Disorders Embryonic Development, Organ Development, Organismal Development Cell-‐To-‐Cell Signaling and Interaction, Connective Tissue Development and Function, Cardiovascular Disease Cellular Assembly and Organization, Cellular Movement, Nervous System Development and Function Cell Morphology, Cellular Function and Maintenance, Cellular Assembly and Organization Cell Morphology, Connective Tissue Development and Function, Hematological System Development and Function Cardiovascular Disease, Cell Death and Survival, Connective Tissue Disorders Nervous System Development and Function, Organismal Development, Cell Morphology Organ Morphology, Organismal Development, Nervous System Development and Function Cell Signaling, Post-‐Translational Modification, Protein Synthesis Inflammatory Disease, Inflammatory Response, Organismal Injury and Abnormalities Cellular Assembly and Organization, Cellular Function and Maintenance, Cellular Compromise Cardiovascular Disease, Metabolic Disease, Lipid Metabolism Cell-‐To-‐Cell Signaling and Interaction, Organ Development, Reproductive System Development and Function Lymphoid Tissue Structure and Development, Tissue Morphology, Cellular Development Hematological Disease, Hereditary Disorder, Developmental Disorder Cell Morphology, Organ Morphology, Organismal Development Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking Cellular Development, Hematological System Development and Function, Hematopoiesis Lipid Metabolism, Small Molecule Biochemistry, Cardiovascular Disease Organismal Functions, Cell-‐To-‐Cell Signaling and Interaction, Hematological System Development and Function Nervous System Development and Function, Cell-‐To-‐Cell Signaling and Interaction, Small Molecule Biochemistry
Molecules in Network AHNAK,C21orf33/LOC102724023,CD109,CDC42EP3,CDC42EP4,CDHR1,CHI3L1,DLL3,FAM50A,FXYD6,GABAR-‐A,GABRG1,GABRQ ACVR1,ACVRL1,AMHR2,ANGPTL4,BMP10,BRINP3,CD24,COL1A2,EHF,ELF3,EMILIN2,EPHB6,ETFA,IGFBP5,INHA,let-‐7,LTBP1,mir-‐ AChR,APBB3,ASAH1,ASAP2,CD36,CHRD,DHCR7,DLK1,DOCK8,F8,FCGR2C,FCRLA,GBP4,GPD1,IFITM3,IgG,IgG1,Igg3,IgG2a,IgG2b ACTR1B,amylase,CA1,CA2,CA8,Carbonic anhydrase,chymotrypsin,CTSB,DDAH2,ERBB,GYPA,HBE1,HID1,KCNMA1,KCNMB3,ND 14-‐3-‐3,ACP5,ARHGAP22,ARHGDIB,Calcineurin A,CILP,Ck2,CLEC11A,DHH,EPHX2,FHL1,FIG4,Gsk3,IL4R,KLF6,LBH,Nfat (family),N ABCG2,ADNP,APOE,ATG16L2,CAT,CCDC80,chemokine receptor,Collagen type I,GRN,GSN,IL10RA,KDM3B,LASP1,LDL,LRP,LRP1, ACE,ADAMTS14,ADCY6,ALDH2,APBA2,arginase,BCAM,COL5A1,Collagen type III,Collagen(s),CTCFL,CTSL,FDXR,GAL3ST1,GPIIB-‐I ADAM19,ADRB,ADRB2,Ap2 alpha,Calcineurin protein(s),caspase,CD48,DST,FAS,HAGH,HISTONE,HSPA7,IKK (complex),IKZF1,KI ABLIM3,Actin,ADD2,Adducin,AKAP,AKAP2,AKAP7,AKAP13,ANXA6,calpain,CAPN5,COTL1,CUL9,DES,DPYSL2,F Actin,Filamin,GA ALT,APOL6,C3,C1q,C3-‐Cfb,CCRN4L,CFH,CFHR4,CFI,CMPK2,COL7A1,Collagen type ix,Collagen type VII,CSRNP1,DDIT4,DUB,FAM Alpha tubulin,Calmodulin,CKAP4,CNTNAP2,CRAT,DNA-‐methyltransferase,Dynein,EPB41L2,GAD1,Hdac,HES1,Histone h3,ID3,JA AHSP,Cbp/p300,CDKN1A,CPVL,CYP26A1,estrogen receptor,GAL,H2AFZ,H6PD,histone deacetylase,Histone h4,Importin alpha,K C10orf10,CAPZB,CARD9,CENPW,CRYAB,CRYBA4,DNAJB2,DNAJB5,DNAJC12,DNAJC15,Endophilin,FGFR1,FGFRL1,Hedgehog,HSP 20s proteasome,26s Proteasome,ANKRD17,APC/APC2,BNIP3,C/ebp,CCL2,CLTCL1,Ctbp,GBP5,HDC,HLA-‐DR,IFI27,IFI35,Immuno Alpha Actinin,Alpha catenin,Arp2/3,ASB2,ATPase,CEACAM1,COBL,Cofilin,COL15A1,CSRP1,CSRP2,DOCK10,FEV,FLNB,FMNL2,G ACACB,Ahr-‐aryl hydrocarbon-‐Arnt,ALAS1,APOC1,ATP2A3,Caspase 3/7,CDKN1C,CES1,CLU,Ecm,FECH,Focal adhesion kinase,glu ADCY,AR,AREG,ARNTL2,Cg,chemokine,CISD2,Creb,EPAS1,ERMAP,FAM174B,FAM198B,FSH,GJA1,IKBKE,IL12 (family),Insulin,MT Ap1,BCL3,BCL6,CD3,CD44,CD3G,CNKSR3,COL14A1,EIF4E,GAB1,HBG1,HCK,Igm,IL7R,Immunoglobulin,Interferon alpha,KIAA043 AMIGO2,Angiotensin II receptor type 1,ARHGEF25,BEX2,BMP,CLIP2,DAP,DOK3,elastase,ETS,FAIM,Ferritin,FTH1,FUCA1,H2AF, C-‐C chemokine receptor,c-‐Src,CD53,CSK,EHD4,ERK,Fgfr,GDF15,growth factor receptor,HCLS1,Integrin alpha 3 beta 1,Integrin CCL24,Collagen Alpha1,Collagen type IV,Cr3,CTSH,Cyclin B,DLG5,EFEMP1,EID1,Eotaxin,Fibrin,FLT1,FNBP1,I kappa b kinase,Inte 3 beta HSD,AKR1B1,ASB9,CD84,CD164,CD300A,CLEC3B,Cpla2,Csf,CSF1,ETV6,Fc gamma receptor,Fcer1,Fgf,FGF13,FGFR4,GBA, alcohol group acceptor phosphotransferase,Aldose Reductase,ALOX5,AMPK,BCR (complex),CDK18,CHMP4B,COX7A1,CYB5A,c Adaptor protein 1,AP1S2,CRIP2,DIXDC1,EGR3,FEZ1,FNDC3B,GC-‐GCR dimer,HTATSF1,Ikb,Ikk (family),IL-‐1R,IL18RAP,IL1RL1,INTE ABCG2,ADAT2,ALKBH7,ANXA9,APP,ARHGEF40,C4orf46,C6orf106,CAPSL,CLDN3,COL4A6,DDAH1,DDX54,DUSP3,ESR2,EYA4,FAM
Molecules in Network A,FXYD6,GABAR-‐A,GABRG1,GABRQ,Glycogenin,GYG1,GYG2,IFI30,Inhibin,ITGBL1,NNMT,NRBP1,P2RX6,PDK2,SGSH,SLC16A9,SLC39A8,STAT TFA,IGFBP5,INHA,let-‐7,LTBP1,mir-‐19,mir-‐1908,MSMO1,NADPH oxidase,PARD3B,PLAGL1,RMDN3,SERPINE1,SIGLEC14,SMAD7,Smad2/3,Sm IFITM3,IgG,IgG1,Igg3,IgG2a,IgG2b,IL12RB2,IL13RA1,MHC II,MMR,MTHFD1L,PDCD1,PHLDA3,PLD2,PLEK,PTK2B,SERPINI1,SIGLEC9,SKAP2,SL HBE1,HID1,KCNMA1,KCNMB3,NDRG2,Neuropilin,NR2F2,PC,Pde4,PGF,PLXNA2,PRSS1,PRSS2,PRSS3,RAB3D,RCN3,REN,SERPINB1,STC1,TMP sk3,IL4R,KLF6,LBH,Nfat (family),NFATC4,phosphatase,PI3K (family),PPFIBP1,PPM1K,PPP3CA,PTCH2,PTPN6,PTPRJ,RPS6KA,SHIP,SIGLEC6,SI 10RA,KDM3B,LASP1,LDL,LRP,LRP1,Mek,MYL6,P-‐TEFb,PAICS,PDGF BB,PHLDA1,PLAT,PLAU,PLOD2,PPAT,PXN,Rap1,RILP,ROGDI,SORCS1,Sos,S CTCFL,CTSL,FDXR,GAL3ST1,GPIIB-‐IIIA,Integrin alpha V beta 3,Kallikrein,KIF1A,Laminin,mir-‐182,NAV1,P38 MAPK,PSAT1,SLC6A12,SSC5D,Syn ONE,HSPA7,IKK (complex),IKZF1,KIAA0141,KLHL6,LRFN1,MAPT,MYO1F,NMDA Receptor,PLC,PLCB1,RAC2,SELM,SQSTM1,TANC2,TP63,TRPM L9,DES,DPYSL2,F Actin,Filamin,GAS2,Lamin b,MAP1A,MICALL1,Mucin,Par6,PIWIL2,Pkc(s),POLD4,SCIN,Spectrin,SPTA1,SPTAN1,SPTB,STOM type VII,CSRNP1,DDIT4,DUB,FAM129A,farnesyl transferase,Fcer,Fcgr3,GM2A,GOT,IL1B,ITGAX,LAMB3,LAPTM5,NEO1,PDK1,PRF1,RAB27A GAD1,Hdac,HES1,Histone h3,ID3,JAG2,KCNQ5,LDL-‐cholesterol,LEF1,LFNG,LRRTM1,Notch,OTOF,PDLIM5,RELN,RNF138,ROBO2,Secretase ga tylase,Histone h4,Importin alpha,KIAA0513,LOXL2,MAGEC1,MS4A3,MUC15,N-‐cor,NCOA2,Nr1h,NR5A2,PCDH1,PEPCK,PLRG1,Rar,RTKN2,R hilin,FGFR1,FGFRL1,Hedgehog,HSP,Hsp70,Hsp90,Hsp22/Hsp40/Hsp90,HSP90B1,HSPA6,IL12 (complex),KIAA1522,KIF23,KRT19,MHC Class 5,HDC,HLA-‐DR,IFI27,IFI35,Immunoproteasome Pa28/20s,Interferon-‐α Induced,KIR,KRT13,KRT79,MAGEA3/MAGEA6,MAP1LC3,MBOAT7,M SRP2,DOCK10,FEV,FLNB,FMNL2,G-‐Actin,ICAM1,IQGAP2,IQSEC1,LRCH2,Mac1,MICAL1,MIR124,NES,PLEKHG6,RBCK1,RHOG,RNF213,Rock,SO m,FECH,Focal adhesion kinase,glutathione transferase,GST,GSTA4,GSTO2,HDL,HDL-‐cholesterol,INSIG1,KLHL3,KNSTRN,LPL,METTL7A,MGST GJA1,IKBKE,IL12 (family),Insulin,MTORC1,PALM,PAPPA,PCLO,PI4K2A,PKP2,Pld,PLD6,POLR2H,PPIB,PRKAA,RNA polymerase II,S100A6,SLC38 oglobulin,Interferon alpha,KIAA0430,LITAF,MAP2K1/2,mir-‐146,MNDA,NFAT (complex),NFKBIA,ORAI3,p70 S6k,p85 (pik3r),PCDH9,Pdgfr,PLC ,FAIM,Ferritin,FTH1,FUCA1,H2AF,HBB,HBD,HBG2,HBZ,HFE,Ho,ICOSLG/LOC102723996,lymphotoxin-‐alpha1-‐beta2,Mac,MIP1,NCOR-‐LXR-‐Ox 1,Integrin alpha 3 beta 1,Integrin alpha 4 beta 1,Integrin alpha 5 beta 1,Integrin alpha 5 beta 3,Integrinα,ITGA3,ITGA10,ITGA2B,Iti,ITIH4,IT n,FLT1,FNBP1,I kappa b kinase,Integrin,ITGAM,ITGB3,LGALS1,LILRA2,MAD2L1,MAGEA1,MAGEB2,Mlc,MTORC2,PLAUR,Pro-‐inflammatory C eptor,Fcer1,Fgf,FGF13,FGFR4,GBA,Gm-‐csf,KIT,L3MBTL1,Mapk,PLA2,PLA2G3,PLA2G16,PLA2G12A,PLC gamma,PPT1,RAB27B,SCN9A,SHP,sph CDK18,CHMP4B,COX7A1,CYB5A,cytochrome C,cytochrome-‐c oxidase,DAPK1,EIF1,ERN1,glutathione peroxidase,GPX3,GPX5,HAUS2,Ldh (c (family),IL-‐1R,IL18RAP,IL1RL1,INTERLEUKIN,IRAK,Jnk,LRP5,MESDC2,N-‐Cadherin,NDE1,NfkB1-‐RelA,PAEP,PRKAC,Smad1/5/8,SOSTDC1,STX1 AH1,DDX54,DUSP3,ESR2,EYA4,FAM49A,ITPRIPL2,LIMCH1,LRP1B,NFATC4,PASD1,PDYN,PHYHD1,PTGIS,PTP4A1,PTPN5,Ptprd,RELN,SH3BGR
PDK2,SGSH,SLC16A9,SLC39A8,STAT1/3/5 dimer,TAX1BP3,TGFB1,TNFRSF8,TTC28,VAT1,VCX/VCX3A,XYLT1,ZNF862 NE1,SIGLEC14,SMAD7,Smad2/3,Smad2/3-‐Smad4,SORD,SRC (family),TBX20,TGFBI,TGFBR,TYROBP ,PTK2B,SERPINI1,SIGLEC9,SKAP2,SLAMF1,SLC25A13 3D,RCN3,REN,SERPINB1,STC1,TMPRSS15,TPP1,trypsin,Trypsinogen,Vegf PN6,PTPRJ,RPS6KA,SHIP,SIGLEC6,SIGLEC8,SOCS3,STRA6,STS,TBX3,TLE6 PXN,Rap1,RILP,ROGDI,SORCS1,Sos,SPARC,TMCC2,UNC5B 8 MAPK,PSAT1,SLC6A12,SSC5D,Syntaxin,SYT1,SYT3,TNFRSF9,TRIO,TUBA3C/TUBA3D,tubulin (family),VGF,VTN,WISP3 2,SELM,SQSTM1,TANC2,TP63,TRPM7,tubulin (complex),UBE2D3,Ubiquitin,WDFY3,YWHAB,ZNF395,ZNF676 pectrin,SPTA1,SPTAN1,SPTB,STOM,TANC1,UTRN,WIPF3 LAPTM5,NEO1,PDK1,PRF1,RAB27A,SCARF1,sPla2,UAP1,USP13,USP44 ,RELN,RNF138,ROBO2,Secretase gamma,SGK223,SLC4A11,SP6,SPAG11B,TCF,TCF/LEF,TLE2,UNC13A,ZEB1 PCDH1,PEPCK,PLRG1,Rar,RTKN2,Rxr,SLC7A8,SLC9B2,SLFN5,TFF1,TGM2,thymidine kinase,TJP3,TMEM176A KIAA1522,KIF23,KRT19,MHC Class II (complex),Mmp,P2RX1,PARD3,Proinsulin,SH3GL3,SH3KBP1,SLC6A19,Tlr,VIL1,ZNF572 A3/MAGEA6,MAP1LC3,MBOAT7,MHC CLASS I (family),MLF1,MYOZ1,NEBL,Proteasome PA700/20s,PSMA4,PSMB1,PSMB2,PSME1,TMEM1 KHG6,RBCK1,RHOG,RNF213,Rock,SORBS1,Tni,TNS1,TPM1,Tropomyosin,Troponin t KLHL3,KNSTRN,LPL,METTL7A,MGST1,MME,Nuclear factor 1,Pias,PRKCA,S100A11,SIAH2,Srebp,SSH1,SYP,VLDL-‐cholesterol,ZNF175 A,RNA polymerase II,S100A6,SLC38A5,SLC7A4,SMARCD3,TSPAN13,Wnt 70 S6k,p85 (pik3r),PCDH9,Pdgfr,PLCG2,SMOX,SPINK4,TCR,TH2 Cytokine,TSH,ZBTB20 ha1-‐beta2,Mac,MIP1,NCOR-‐LXR-‐Oxysterol-‐RXR-‐9 cis RA,NFkB (complex),NfkB-‐RelA,NLRX1,PARP10,Stat3-‐Stat3,TMOD2,TNFAIP2,TRIM38,U α,ITGA3,ITGA10,ITGA2B,Iti,ITIH4,ITIH5,JINK1/2,L1CAM,LAMA4,LAMB1,LAMB2,Lfa-‐1,PIK3CB,PITX1,PRSS8,SPINT2,SPRED1,Talin,ZDHHC2,ZF MTORC2,PLAUR,Pro-‐inflammatory Cytokine,PROCR,Raf,Ras homolog,Rho gdi,RHOV,SELPLG,TMCO4,TNIP1,TSPAN3 mma,PPT1,RAB27B,SCN9A,SHP,sphingomyelinase,SPRY4,SYK/ZAP,TEC/BTK/ITK/TXK/BMX,VAV roxidase,GPX3,GPX5,HAUS2,Ldh (complex),LPCAT2,MAPK6,Mitochondrial complex 1,MS4A6A,PARP,PARP16,Ppp2c,PRKAR1A,Rab5,Rac,RC P,PRKAC,Smad1/5/8,SOSTDC1,STX11,TAC3,TMSB4,Tnf receptor,TNFRSF21,TSC22D3,VANGL2,VitaminD3-‐VDR-‐RXR,VLDL TP4A1,PTPN5,Ptprd,RELN,SH3BGRL3,SLC5A7,TCP11L2,TMEM51,TSPAN13,ZSCAN18
lr,VIL1,ZNF572 PSMB1,PSMB2,PSME1,TMEM173,TNNI3,TRIM63,UPP1
DL-‐cholesterol,ZNF175
at3,TMOD2,TNFAIP2,TRIM38,UBA7 PINT2,SPRED1,Talin,ZDHHC2,ZFP36L1
6,Ppp2c,PRKAR1A,Rab5,Rac,RCN2,Rsk,Sapk,TINAGL1,ZNF433,ZNF671
