TBI / MT TBI / CB - Plos

TGFB R 2

Smo

R1

Cytoplasm

TGF B

Neurotrophin/TRK Signaling

Hh

GPCR

Extracellular space

SMAD3

DCC

CNG

CALM1 2.135

PLC

Gα13

PTCH Gαi

Ca2+

Gαi Gαq

/ Sa li n

SMAD4

TBI

Ca2+

Netrin-1

TGF-β

NGFR

Gαs

AC

MEKK1

SMAD4

IKK α

AC

Gβ

2/4/7

IκB

NFKBIA 2.993

Gli3

DAG MEK 1/2

ATP

Proteosomal degradation

cAMP B-Raf

c-RaF

AKAP

PDE

AKAP4 2.086

PKAr

BAD

PKA AC9

Metabolic energy

14-3-3

CAMK2

IP3

PIP2

1/5/6

YWHAH 2.135

Calcineurin

PKC

NFκB NF-κB Signaling

cAMP

PLCD3 2.106

Gγ

AC

AC

ATP

CALM

PLCG1 2.118

RhoA

SMAD3

e

cAMP

Up Down No change

Neurotransmitters, hormones, stress and inflammatory stimuli

Hypoxia, ischemia and heat shock

AKAP10 2.300

PKAc

ERK 1/2

Rap1

PTP

RAP1B 2.038

PKA

Cell survival

HSL

GRK 1/7

Lipolysis

DCC

T

BI

/

CNG

PLC

Rhodopsin Gα13

CB

Gαq Gαs

SMAD4

PLCG1 -1.030

RhoA

SMAD3

AC

MEKK1

SMAD4

IKK α

AC

Gβ

2/4/7

PLCD3 1.857

AC9 DAG

1/5/6

MEK 1/2 ATP

cAMP

AKAP4 1.492

PKAr

BAD

B-Raf

c-RaF

AKAP

PDE

14-3-3

CAMK2

IP3

PKC

NFκB

YWHAH 1.312

Calcineurin PIP2

Metabolic energy NF-κB Signaling

ATP

CALM

Gγ

AC

IκB

NFKBIA 1.547

cAMP

CALM1 -1.052

Ca2+

Gαi

PKAc

ERK 1/2

Rap1

AKAP10 2.175

RAP1B 1.534

PKA

Cell survival

HSL

GRK 1/7

Lipolysis

Smo

Rhodopsin DCC

PLC

TB I

Gαi Gαs

PLCG1 -1.255

RhoA SMAD3

MEKK1

SMAD4

AC

IKK α

AC

Gβ

2/4/7

NFKBIA -1.117

AC9 DAG

1/5/6

MEK 1/2

PKAr

BAD

PKAc

HSL Lipolysis Rhodopsin

Phospholipase C, gamma 1

PLC

Phospholipase C

CALM S30,S31 Calmodulin CALM1 S32 Calmodulin 1

GRK 1/7

B-Raf

c-RaF

AKAP4 1.067 AKAP10 1.769

PKA

Cell survival

S36,S37

cAMP

AKAP

PDE

YWHAH -1.318

PLCG1 S29

ATP

CAMK2

IP3

PKC

NFκB

NF-κB Signaling

Calcineurin PIP2

Gγ

AC

IκB

PLCD3 1.014

Rap1 RAP1B 1.129

Gαi ATP

CALM

Metabolic energy

14-3-3

PTCH

Gαq

T M /

cAMP

CALM1 -1.809

Ca2+

ERK 1/2 PTP