atherosclerosis independent of insulin resistance: the Guangzhou ... Lin Xu*,â , Chao Qiang Jiangâ , Tai Hing Lam*, Jie Ming Linâ , Xiao Jun Yueâ , Kar Keung ...
Clinical Endocrinology (2010) 73, 181–188
doi: 10.1111/j.1365-2265.2009.03760.x
ORIGINAL ARTICLE
The Metabolic syndrome is associated with subclinical atherosclerosis independent of insulin resistance: the Guangzhou Biobank Cohort Study-CVD Lin Xu*,†, Chao Qiang Jiang†, Tai Hing Lam*, Jie Ming Lin†, Xiao Jun Yue†, Kar Keung Cheng‡, Bin Liu†, Ya Li Jin†, Wei Sen Zhang† and G Neil Thomas‡ *Department of Community Medicine, School of Public Health, University of Hong Kong, Hong Kong, †Guangzhou No.12 Hospital, Guangzhou, China and ‡Public Health, Epidemiology, and Biostatistics, University of Birmingham, Birmingham, UK
Summary Objective We examined whether the association of the metabolic syndrome (MetS) and subclinical atherosclerosis is independent of insulin resistance in a Chinese community sample with no history of type 2 diabetes. Methods Five hundred and ninety-six men and 526 women from a substudy of the Guangzhou Biobank Cohort Study (GBCSCVD) had carotid intimal-medial thickness (IMT) measured by B-mode ultrasonography, and brachial-ankle pulse wave velocity (PWV) and ankle-brachial systolic blood pressure index (ABI) measured simultaneously by a noninvasive automatic waveform analyser. Results Fourteen percentage had MetS as defined by the International Diabetes Federation. Obesity indices, systolic and diastolic blood pressure and pulse pressure, lipids, fasting and postload glucose and insulin, homeostatic model assessment of insulin resistance, glycosylated haemoglobin A1c, leptin, high-sensitivity C-reactive protein, IMT and PWV increased and high-density lipoprotein-cholesterol, adiponectin and ABI decreased significantly with increasing number of MetS components after adjusting for age and sex (P for trend from 0Æ004 to
