Department ofSurgery, Royal Melbourne Hospital, Victoria, Australia. (Received 3 June 1974) ..... inhibition test is best established. This appears to give ...
Clin. exp. Immunol. (1975) 19, 289-299.
THYROGASTRIC AUTOIMMUNE DISEASE STUDIES ON THE CELL-MEDIATED IMMUNE SYSTEM AND HISTOCOMPATIBILITY ANTIGENS* SENGA WHITTINGHAM, URIWAN YOUNGCHAIYUD, I. R. MACKAY, J. D. BUCKLEY AND P. J. MORRIS Clinical Research Unit, The Walter and Eliza Hall Institute of Mcdical Research, and The Royal Melbourne Hospital, and the University of Melbourne Department of Surgery, Royal Melbourne Hospital, Victoria, Australia (Received 3 June 1974) SUMMARY
Cell-mediated immune responses were studied in autoimmune diseases of thyrogastric type, Hashimoto's thyroiditis and autoimmune pernicious anaemia-type gastritis. Specific cell-mediated immunity was investigated by the leucocyte migration inhibition procedure, and general cell-mediated immunity (T-cell performance) was studied by standard in vivo and in vitro tests. In thyrogastric autoimmune diseases inhibition of migration of leucocytes was induced by thyroglobulin and gastric parietal cell microsomes; under conditions of presumably low cellular sensitization, stimulation of migration was observed. There was no depression of general cellmediated immunity, in contrast to what occurs in systemic lupus erythematosus and related autoimmune diseases. A weak association of autoimmune gastritis with HL-A3 and HL-A7 (P
