Dec 14, 2016 - should and what should not be done. Vahid Nasiri. Department of Parasitology, Razi Vaccine and Serum Research Institute, Agricultural ...
THE 25th IRANIAN CONGRESS ON INFECTIOUS DISEASE AND TROPICAL MEDICINE 10-14 Dec 2016
P150
Tissue repair and wound healing in cutaneous leishmaniasis lesions: what should and what should not be done Vahid Nasiri Department of Parasitology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Alborz, Iran Background and Aim: Leishmaniases are neglected tropical diseases that cause human infections varying from self-healing cutaneous lesions to mucosal diffuse cutaneous and visceral forms. It is generally accepted that control of Leishmania within the host is mediated by innate and adaptive immune responses. Materials and methods: The interplay of Leishmania and human host response is manifest not only in terms of the clinical or subclinical outcome of infection but also the rate of spontaneous healing and recurrent disease. Either an excess or a deficit of the immune response can lead to chronic, therapeutically challenging disease presentations. Either increased or diminished immune response can lead to a chronic disease and make challenges in the treatment. Results: It can be said that the outcome of the leishmaniases is results of interaction of Leishmania parasite and tissue substrate of host, especially the host immune system cells and therefore the role of the immune system and wound healing should be considered and treated in accordance with the strategy to be adopted in order to strengthen it. In the pre-treatment of the survival and active proliferation parasite in the tissues, particularly in the fibroblasts and the macrophages, the use of ointments and injectable drugs containing immune stimulating elements such as Angipars and Rejoderm ointment, not only healing the lesion, but sometimes have a negative effect by stimulating local immune cells that provide fertile ground for the proliferation of the parasite and causes the lesion to be worsening. Conclusions: Thus, first we must use the appropriate treatment procedure, which can include thermotherapy, cryotherapy, laser therapy and the use of appropriate available chemical drugs to kill the parasites in the area and after the preliminary treatment process, performs the immunotherapy using the right tools to stimulate the immune system and improve the performance of our injury and tissue repair. Keywords: Leishmania major, cutaneous leishmaniasis, treatment.
