Methods: Three wound models including incision, excision and dead space ... space wounds, percentage of wound contraction and period of epithelialization in ...
Asian Pacific Journal of Tropical Medicine (2010)783-787
783
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Document heading
Wound healing activity of aqueous extract of Crotalaria verrucosa in Wistar albino rats Meena Kumari, Eesha BR, Mohanbabu Amberkar*, Sarath babu, Rajshekar, Neelesh Kumar Department of Pharmacology, Kasturba Medical College, Manipal University, Karnataka, India
ARTICLE INFO
ABSTRACT
Article history: Received 19 June 2010 Received in revised form 27 July 2010 Accepted 1 September 2010 Available online 20 October 2010
Objective: To evaluate the wound healing effect of aqueous extract of Crotalaria verrucosa (C. verrucosa) in rats. Methods: Three wound models including incision, excision and dead space wounds were used in this study. The parameters studied were breaking strength in incision models, granulation tissue dry weight, breaking strength and hydroxyproline content in dead space wounds, percentage of wound contraction and period of epithelialization in excision wound model. Results: Two doses of the extract with and without dexamethasone showed significant increases in mean hydroxyproline, total protein content and dry weight of granulation tissue but it was higher with dose 800 mg/kg comparing with the control. The dexamethasone treated group showed a significant (P
