Exploiting extensive and lethal mitophagy as a

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Exploiting extensive and lethal mitophagy as a therapeutic cancer cell strategy. Amitriptyline. Mitochondrial dysfunction. Extensive. Mitophagy.
Exploiting extensive and lethal mitophagy as a therapeutic cancer cell strategy Amitriptyline

Amitriptyline Antioxidants: Protection and cell survival

ROS COMPLEX III

Mitochondrial dysfunction Autophagosome ROS

Extensive Mitophagy

Autophagolysosome accumulation

If mitophagy inhibition: Early apoptosis increases

ROS

ROS

ROS

ROS

ROS

ROS

Autophagolysosome permeabilization CATHEPSINS AND HYDROLYTIC ENZYMES

Apoptosis

CASPASE  ACTIVATION

Genes & Cancer, in press 2016

If caspase inhibition: Extensive mitophagy and necrosis