Expression of mutant p53 protein and CD44 variant proteins in ...
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Expression of mutant p53 protein and CD44 variant proteins in ...
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Gut 1995; 36: 76-80
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Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis J W R Mulder, V J M Wielenga, M M Polak, F M van den Berg, G R Adolf, P Herrlich, S T Pals, G J A Offerhaus
Abstract
Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression ofthe tumour suppressor gene p53 and splice variants vS and v6 of the celi adhesion molecule CD44 by inmmunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n= 12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n=17). A statistically significant trend of increasing expression was seen for both p53 (p
