Figure S5 - PLOS

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0. -2 -1. TTT. |. -2 -1. R = 0.32 m = 0.67. R = 0.5 m = 0.51. R = 0.18 m = 0.09. TT. TTT. 2. 2. -2 -1 0 1 2. Exiqon. -2 -1 0 1. Exiqon. -2 -1 0 1. Illumina. **. *. 5. 5. 5. 0.

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S.I. P........K.G...F..N. .....PVN.S TIQEHAPLG. NLVNEHL... ...T...... .FD.S....L .. ... ....RH.A. TGHRNLOVL .DL.ADT. YG RKVVE.SI.AL. TEA.SOVI .CPPT..SS. RV.. 163.

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Onco- CIS. Z normal. Onco-CIS. Z tumor. Onco- CIS. Z combined. GISTICq. EIS normal. EIS tumor. PPP2CB. ZNF44. GLTSCR2. AGR2. INTS9. PTEN. CDKN2A.

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(TAF HAFTAFE A. GRY. A. T GA37. FACE "GUF2A-12 iana. FREEWARKCASR-KBkxco PATCH. FKBS RELAEREB FKBO'MAPKZPIK3CPRKCAK3d1GBE.

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Figure S5 - PLOS

Figure S5. - PLOS

0 0 0. IMAGES. AR Milliona. N N. Patient Q. -. @ zboj. - g. PARA. PRESEI deilding. 00. GOAeo e. 8. N. FGFR1 chr8 p11. LYN chr8 q12. EXT1 chr8 q24. PTK2.

Figure S5 - PLOS

Figure S5. - PLOS

Sba. Sca. Cgl. Kpo. Kla. Ago. Kwa. Cgu. Dha. Lel. Ctr. Cal. Cdu. Yli. Afl. Aor. Ate. Ang. Afu. Nfi. Acl. Ani. Cim. Ure. Hca. Fox. Fve. Gze. Tre. Cgo. Pan. Ncr. Mgr. Bci.

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Figure S5 - PLOS

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Owl monkey. Squirrel monkey. Tufted capuchin. White-throated capuchin. Black-handed spider monkey. Long-haired spider monkey. Common marmoset.

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Figure S5

bb bbb. b b bb b b bb bb b b b b b bbb b b. 0. 2. 4. 6. 8. 10. Z m. _1. Z m. _2. S b_1. S b_2. S b_3. Z m. _3. Z m. _4. S b_4. S b_5. S b_6. Z m. _5. Z m. _6. Z m. _7.

Figure S5

Normalized expression . Bcl2 MFI. 500-. 0.007. 0.00+. 0/. Bax. Bc12. Bc12111. Bid. Bmf. Mcl1. Inhibitor concentration (UM). AZD8835. Vehicle. AZD8835. Cal101.

Figure S5

NP_573118 Drosophila melanogaster. XP_003388253 Amphimedon queenslandica. NP_075571 CAPN10 Homo sapiens. NP_035926 CAPN10 Mus musculus.

Figure S5

AI607873. -8.980. 1.27E-04. 0.049. Clec5a. -3.200. 1.46E-04. 0.051. Sox9. -0.643. 1.52E-04. 0.051. Sall4. -5.330. 1.65E-04. 0.054. AW822252. -2.854. 1.78E-04.

Figure S5

3'. 3'. IVT (in vitro transcription). Circular ligase. G-tailing. AAAAA. VTTTTTT ... Reverse transcription and PCR. VTTTTTT. GGGGG. Illumina adaptor. PCR. 3. A. B.

Figure S5

Figure S5 LD mt LD mt - PLOS

Page 1. Figure S5. A. LD mt. LD mt. B.

Figure S5 - PLOS

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Karitiana. Piap oco. Ticuna (Arara). Ticuna (Tarapaca). Embera. Waunana. Arhuaco. Kogi. Guaymi. Cabecar. Zenu. Wayuu. Kaingang. Ojibwa. Cree. Chipewyan.

Na-Dene Northern Amerind Central Amerind Chibchan-Paezan Andean Ge-Pano-Carib Equatorial-Tucanoan

Huilliche

62

Ache Quechua

10 0

Aymara Mixe

98

29

Mixtec

91

Zapotec

20 26

50

Pima

55

Kaqchikel

71

Maya Inga

10

Surui

27

Guarani

15

Karitiana

60

Piapoco Ticuna (Arara) Ticuna (Tarapaca)

50 10 0

10 0 8

Embera

86

Waunana

84

83

73

Arhuaco

10 0

Kogi

76

Guaymi

10 0

Cabecar Zenu

67

Wayuu

10 0

Kaingang Ojibwa

10 0

Cree Chipewyan Tundra Nentsi

10 0

Yakut 0.05

0.05

Figure S5