Interference of cell cycle progression by zidovudine and lamivudine in ...

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Sep 15, 2008 - Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells. Jia-Long Fang*, Lynda J. McGarrity1 and Frederick.
Mutagenesis vol. 24 no. 2 pp. 133–141, 2009 Advance Access Publication 20 October 2008

doi:10.1093/mutage/gen059

Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells

Jia-Long Fang*, Lynda J. McGarrity1 and Frederick A. Beland Division of Biochemical Toxicology and 1Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA

Zidovudine (3#-azido-3#-deoxythymidine; AZT) and lamivudine [(2)2#,3#-dideoxy-3#-thiacytidine; 3TC] are nucleoside reverse transcriptase inhibitors used to treat and prevent human immunodeficiency virus-1 infections. In short-term incubations (

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