speed, and body size (height, weight, leg length). ⢠Multivariate PCA and canonical ... Stride Length: Releasing the Constraint of Obstetric Selection. Anat. Rec.
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4Department of Psychology, Faculty of Education and Psychology, Free University of Berlin, Berlin, Germany. 5Division of Psychology and Language Sciences, ...
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RQ1: Which model best represents the interrelationship between visual imagery and emotions? The quality of felt emotion appears as one influential factor.
Aedine Peyou Ndi, Department of Cell Biology and Neuroscience,. Montana State University-Bozeman. Marlyse Peyou Ndi, PhD, MPH, Yaoundé, Cameroon.
Paul M. Chakalian1; Liza C. Kurtz; David M. Hondula. 1paul.chakalian@asu. ... [4] Snyder, Sympson, Ybasco, Borders, Babyak, Higgins, Geen, Russell. (1996).
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1University of Pennsylvania, Philadelphia, PA, United States, 2Nemours Biomedical Research A.I. duPont Hospital for Children, Wilmington, DE, United States,.
2 Universidade Agostinho Neto, Faculdade de Ciências, Av. 4 de Fevereiro, 71 Luanda, ANGOLA. * E-mail: [email protected]. Among the material identified ...
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Musical syntax in perception and action: an fMRI study [email protected]. ... [1] Koelsch, S. (2005) Current Opinion in Neurobiology, 15(2), 207â12. [2] Novembre ...
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Di culty turning while walking is common among in Parkinson's disease (PD) and may lead to significant disability, freezing of gait. (FoG), falls and reduced ...
Cortical correlates of dual-task turning with and without freezing of gait Martina Mancini , Valeria Belluscio , Samuel Stuart 1
1,2
1
1 Department of Neurology, Oregon Health & Science University, Portland, OR 2 Universita’ degli Studi di Roma - Foro Italico Balance Disorders Laboratory
Results
Introduction Difficulty turning while walking is common among in Parkinson’s disease (PD) and may lead to significant disability, freezing of gait (FoG), falls and reduced mobility. Turning deficits have been related to executive-attentional mechanisms through dual-task paradigms, where prefrontal cortex (PFC) activity maybe implicated. However, the role of the PFC during turning under single or dual-task and association with FoG is not clear. OBJECTIVE This study investigated the relationship between the PFC activity and turning characteristics with and without a dual-task in people with PD with and without FoG.
PD shows specific impairments in turning quality compared to healthy controls # of turns 30
Duration (s)
*
*
9
25
20
15
10
5
0
CTR
PD-FOG PD+FOG
*
*
8
Peak Velocity (degrees/s) * 180 * 160
7
140
6
120
5
100
4
80
3
60
2
40
1
20
0
0
CTR
PD-FOG PD+FOG
CTR
PD-FOG PD+FOG
FoG Ratio 0.8
Freezing severity was higher in people with PD and FoG
Methods
0.7
*
0.6 0.5 0.4
Participants - 8 healthy controls - 32 subjects with PD - 17 non freezers - 15 freezers
CTR Age 66.5±5.5 8 Total of participants 5 N of Participants (males) Disease Duration (years) MDS-UPDRS_Part III MoCa 26.6±1.9 FAB Clock 1 Clock 2 TMT_A TMT_B
p value 0.205 0.076 0.065 0.083 0.006 0.023 0.277 0.61 0.299 0.167 0.01
OUTCOMES fNIRS
Change in oxygenated hemoglobin (HbO2) while turning from baseline standing (proxy for cortical activity).
Inertial sensors:
- Turning duration - Turning Peak Velocity - Turning Jerkiness - FoG Ratio
TASKS - Turning in place, 120s, single-task (ST) - Turning in place, 120s, dual-task (DT, modified AX-CPT)
0
HbO2 change while turning is associated to FoG severity and visuospatial function in PD+FoG ST DT
TMT B-A MDS-UPDRS III
HbO2 change while turning is associated to # of turns in PD-FoG
0.8
0.8
TMT A
0.6 0.4
Turning Jerkiness
0.2
Clox
FoG Ratio
Percent Total Power
100 degrees/s
# turns Turning Duration Turning Velocity
20 2
4
6
8
10
Frequency (Hz)
Discussion
80 60
FoG Ratio=9.99
40 20 0
2
4
6
Frequency (Hz)
8
10
8s
PD+FoG shows poorer scores in the MDS-UPDRS Part III and executive function (Trail Making B) compared to PD-FoG PD+FoG showed higher PFC activation during turning consistently with an association between increased activity of the PFC and presence of FoG.
Results PFC Relative change in HbO2 (microM)
0.4
PFC activity while turning is higher in PD compared to healthy controls in ST, while showing opposite trends for DT condition
Clox
0
FoG Ratio=0.84
40
PD+FOG
Right 360 turn
0.4
Turning Jerkiness
Turning Velocity
8s
FoG
TMT A
0.6
Turning Duration
80 60
TMT B-A
# turns
PD-FOG
Trunk angular velocity (yaw) Right shin angular velocity Left shin angular velocity
PD-FOG PD+FOG
MDS-UPDRS III
B: Frequency-analysis
FoG
CTR
ST DT
FoG Ratio
0
PD+FOG
0.1
0
Percent Total Power
100 degrees/s
Right 360 turn
0.2
0.2
A: Time-analysis PD-FOG
0.3
ST DT
Visuospatial ability might be a contributor factor to FoG
0.3
0.2
0.1
0
-0.1
-0.2
-0.3
-0.4
CTR
PD-FoG
PD+FoG
Acknowledgements We thank our participants for generously donating their time to participate. Grants: NIH Career Development Award R00 HD078492 (Mancini), PCO Pilot Funding (Mancini)
