Microarray profile of circular RNAs identifies

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Shaoyan Zhang1, Xiaoli Zeng2, Ting Ding2, Lin Guo1, Yulong Li2, Songlei Ou1 ...... Guo, J. U., Agarwal, V., Guo, H. & Bartel, D. P. Expanded identification and ...
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Received: 22 November 2017 Accepted: 1 February 2018 Published: xx xx xxxx

Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer Shaoyan Zhang1, Xiaoli Zeng2, Ting Ding2, Lin Guo1, Yulong Li2, Songlei Ou1 & Hui Yuan2 Accumulating evidence has revealed that aberrant Circular RNAs (circRNAs) expression plays important roles in carcinogenesis and tumor progression. However, their role in non-small cell lung cancer (NSCLC) remains unclear. In this study, we first used circRNA microarrays to screen for tumour-specific circRNA candidates in between NSCLC (n = 3) and adjacent lung (n = 3) tissue. Among the circRNA expression profile, two circRNAs (hsa_circ_0014130 and hsa_circ_0016760) were selected for validation in ten pairs of NSCLC and adjacent non-cancerous tissues by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Only hsa_circ_0014130 exhibited significantly overexpressed in NSCLC tissues (P 

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