PhoPepMass: A database and search tool assisting

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Accepted Manuscript PhoPepMass: A database and search tool assisting human phosphorylation peptide identification from mass spectrometry data Menghuan Zhang, Hui Cui, Lanming Chen, Ying Yu, Michael O. Glocker, Lu Xie PII:

S1673-8527(18)30125-5

DOI:

10.1016/j.jgg.2018.07.005

Reference:

JGG 631

To appear in:

Journal of Genetics and Genomics

Received Date: 11 January 2018 Revised Date:

9 July 2018

Accepted Date: 9 July 2018

Please cite this article as: Zhang, M., Cui, H., Chen, L., Yu, Y., Glocker, M.O, Xie, L., PhoPepMass: A database and search tool assisting human phosphorylation peptide identification from mass spectrometry data, Journal of Genetics and Genomics (2018), doi: 10.1016/j.jgg.2018.07.005. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT PhoPepMass: A database and search tool assisting human phosphorylation peptide identification from mass spectrometry data

Menghuan Zhanga,b,1, Hui Cuia,b,c,1, Lanming Chend, Ying Yue,*, Michael O Glockerf,*,

School of Life Science and Technology, Shanghai Tech University, Shanghai 201210,

China b

Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and

Technology, Shanghai 201203, China

Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Univer

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c

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a

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Lu Xieb,*

sity of Chinese Academy of Sciences, Shanghai 200031, China. d

College of Food Science and Technology, Shanghai Ocean University, Shanghai

201306, China e

Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical

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University, Tianjin 30007, China f

Proteome Center Rostock, University of Rostock, Rostock 18055, Germany

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* Corresponding author: Dr. Lu Xie, Tel: +86-21-20283705; Email: [email protected]

Correspondence may also be addressed to Dr. Michael O Glocker,

1

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[email protected], or to Dr. Ying Yu, [email protected]

These authors contributed equally to this work.

Abstract Protein phosphorylation, one of the most important protein post-translational modifications, is involved in various biological processes, and the identification of phosphorylation peptides (phosphopeptides) and their corresponding phosphorylation sites (phosphosites) will facilitate the understanding of the molecular mechanism and

ACCEPTED MANUSCRIPT function of phosphorylation. Mass spectrometry (MS) provides a high-throughput technology that enables the identification of large numbers of phosphosites. PhoPepMass is designed to assist human

phosphopeptide identification from MS

data based on a specific database of phophopeptide masses and a multivariate

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hypergeometric matching algorithm. It contains 244,915 phosphosites from several public sources. Moreover, the accurate masses of peptides and fragments with phosphosites were calculated. It is the first database that provides a systematic resource for the query of phosphosites on peptides and their corresponding masses.

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This allows researchers to search certain proteins of which phosphosites have been reported, to browse detailed phosphopeptide and fragment information, to match

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masses from MS analyses with defined threshold to the corresponding phosphopeptide, and to compare proprietary phosphopeptide discovery results with results from previous studies. Additionally, a database search software is created and a “two-stage search strategy” is suggested to identify phosphopeptides from tandem mass spectra of proteomics data. We expect PhoPepMass to be a useful tool and a

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source of reference for proteomics researchers. PhoPepMass is available at https://www.scbit.org/phopepmass/index.html.

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Keywords

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Phosphosite; phosphopeptide; phosphopeptide mass

1. Introduction

Post-translational modifications (PTMs) of proteins contribute to the greater diversity of the proteome as compared to the genome. Among the PTMs, reversible phosphorylation is the most frequent type. Phosphorylation of proteins change the physicochemical properties of proteins, affect the function of proteins, and modulate the cellular processes (e.g., metabolism, differentiation, motility, membrane transport, and immunity) (Cohen, 2000). Thus, it is of tremendous scientific interest to investigate phosphorylation sites (phosphosites) and to correlate these to certain biological functions and regulatory processes.

ACCEPTED MANUSCRIPT The most commonly used technology for identifying and studying phosphosites is mass spectrometry (MS). Phosphorylation is typically non-stoichiometric and often present in low abundance. Because of the specific physicochemical properties of phosphopeptides, the ion signals of phosphopeptides tend to be suppressed in the

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presence of non-phosphopeptides when recording mass spectra. Hence, analysis of phosphopeptides from complex mixtures by MS requires peptide enrichment, e.g., by affinity pull down, immobilized metal affinity chromatography, or titanium dioxide columns (Eickner et al., 2011). Enriched peptides are then separated by liquid

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chromatograph, ionized, and analyzed. Phosphosites are finally identified from mass spectra by using computational methods, where each ion signal represents a peptide or

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a peptide fragment (Riley and Coon, 2016).

However, the existing protein identification methods can only identify fewer than 50% of the proteins in a complex sample (McHugh and Arthur, 2008; Paradela and Albar, 2008). These methods can be categorized into two strategies: de novo sequencing and the database search. The de novo sequencing approach appears to be the only feasible

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method for deciphering unknown protein sequences, detecting novel amino acid mutations, or characterizing proteins from a proteome with no genome information, etc (Yefremova et al., 2015). Among the most widely used methods for identifying

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proteins in biological samples are database search programs such as SEQUEST (Eng et al., 1994), Mascot (Perkins et al., 1999), OMSSA (Geer et al., 2004), and X!Tandem (Craig and Beavis, 2004), which extract candidate peptides from a protein

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database using parent ion masses and possible cleavage specificity and then score the candidates using the ion signals observed in the tandem spectra. For the identification of modified peptides, the routine database search approach needs to be augmented. A protein or peptide modification shifts the parent ion mass of the respective protein or peptide, and presence of modified peptides increases the number of ion signals within a spectrum, affecting both the scoring phases and peptide identification success (Bern et al., 2007). To overcome such difficulties, SEQUEST (Eng et al., 1994) and Mascot (Perkins et al., 1999) expand the number of entries in the database to include anticipated modifications. When including many

ACCEPTED MANUSCRIPT types of modifications in the database, processing becomes slow and sensitivity on identifying the unmodified peptides diminishes (Chamrad et al., 2004) as the number of candidate masses increases. To improve the performance of the search process, Mascot (Creasy and Cottrell, 2002) and X!Tandem (Craig and Beavis, 2003) chose to

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build a small database containing only the proteins found by unmodified peptides and then only consider the protein modifications of this small database. However, this solution raises other limitations: it can only find anticipated modifications, it will miss a protein which is only represented by modified peptides, and it will be difficult to

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separate the true identifications from false positives (Bern et al., 2007).

Here in PhoPepMass, we attempt to identify phosphosites based on a specific

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database of phophopeptide masses and a multivariate hypergeometric matching algorithm. In our previous work, we developed a systematic resource for phosphorylation mediated signaling networks, along with information of phosphosites (Zhang et al., 2015). On this basis, we further expanded the number of phosphosites data to 244,915 from several public sources. Then, we calculated the masses of

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peptides and fragments with phosphosites. Through comparison of the masses from experiments with our calculated masses, phosphosites could be identified (Fig. 1). The PhoPepMass database allows researchers to search specific proteins of interest of

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which phosphosites have been reported, to browse their detailed peptide and fragment information, to match masses from MS analyses with defined threshold to the corresponding peptide, and to compare proprietary phosphopeptide discovery results

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with results from previous studies. In addition, a database search software is provided and a “two-stage search strategy” suggested to identify phosphopeptides from tandem mass spectra files in either the “mgf” or the “pkl” format. We expect PhoPepMass to be a useful tool that may serve as a reference to proteomics researchers, especially to phosphoproteomics researchers.

2. Results 2.1 Database contents and statistics PhoPepMass contains 244,915 phosphosites from 20,075 proteins. These are

ACCEPTED MANUSCRIPT equivalent to 734,745 peptides with phosphosites including all combinations due to sub-stoichiometric phosphorylation. Fig. 2 shows the workflow of peptide sequence selection.

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2.2 Data accessibility PhoPepMass consists of a relational database and a dynamic web interface. The framework of the database and web server is shown in Fig. 3. An online version of PhoPepMass is freely available (https://www.scbit.org/phopepmass/index.html). Users

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can browse the database through five query ways: protein query, tryptic peptide query, non-tryptic peptide query, mass query and mass list query.

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Protein query

Using “protein query”, users can input a protein name or gene name, and select mono-isotopic mass or average mass. The protein query result is returned in three sections (Fig. 4A). First, the protein sequence appears with highlighted phosphosites. Probing a site will yield the sequence position of this site (Fig. 4B). Second, detailed

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phosphosite information for the queried protein is shown, including domain information, their corresponding sources, and Pubmed IDs (Fig. 4C). Third, the phosphopeptides in the queried protein are shown, including completely cleaved

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peptides and their masses; peptides with one missed cleavage, by clicking which their masses can also be obtained in expanded information (Fig. 4D). Tryptic peptide query

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Users can input a peptide that was cleaved after K’ or ‘R’, and select mono-isotopic mass or average mass. The results of the “tryptic peptide query” include protein UniProt ID, phosphosites, the sequence position of this peptide and its corresponding mono-isotopic mass (Fig. S1A). Non-tryptic peptide query — If the peptide is not cleaved after ‘K’ or ‘R’, users can try ‘non-tryptic’ peptide query and select mono-isotopic mass or average mass. Results of the “non-tryptic peptide query” are protein entries and information about which sequences contain the queried peptides. Clicking on protein ID provides further information that will be displayed

ACCEPTED MANUSCRIPT separately (Fig. S1B). Mass query Users can input a peptide mass, then choose mono-isotopic mass or average mass, and type in a ‘ppm’ value which is given by the MS data. The result of “mass query” is a

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peptide list. Users can click on the masses for further display (Fig. 5A). Mass list query

This query is very useful if users need to map several masses to their corresponding peptide list. Similarly, one could input a peptide mass list and choose mono-isotopic

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mass or average mass, then type in ‘ppm’ value as given by the MS data. The result of “mass list query” is again a peptide list for your queried masses (Fig. 5B).

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Phosphopeptide sequence database

In our previous work, we developed a systematic resource PhoSigNet for phosphorylation mediated signaling networks, along with information of phosphosites (Zhang et al., 2015). Thus, a phosphopeptide sequence database has been provided in PhoSigNet, which includes phosphosite information to facilitate peptide modification

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detection in shotgun proteomics. Here, we further expanded the number of phosphosites data to 244,915 from several public sources. This data set of phosphopeptide

sequences

was

updated

and

can

be

downloaded

from

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https://www.scbit.org/phopepmass/download/sequence_all.csv.

2.3 Results of case study

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A set of real world MS raw data generated by Chinese researchers was employed to test the search tool function of PhoPepMass. Phosphosite assignments were compared after searching with canonical engines and by PhoPepMass. There were 7732 phosphosites identified by MaxQuant and 4076 phosphosites by X!Tandem (FDR=0.01). PhoPepMass identified 4820 phosphosites (FDR=0.01), of which 2524 sites (52.4%) and 2005 sites (41.6%) were also identified by MaxQuant and X!Tandem respectively (Table S1). The same sites identified by MaxQuant, X!Tandem and PhoPepMass are 1548 (Fig. S2), when FDR of 0.01 was set for each search tool. Of note, numbers of common and uniquely identified phosphosites vary

ACCEPTED MANUSCRIPT with the set FDR values (Fig. S3). From the applicants’ perspective, it may be advised to apply more than one search engine and more reliable phosphosite assignments may be obtained by focusing on the intersection results (common phosphosites) when different search tools were applied.

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In addition, since PhoPepMass matches experimentally determined masses of peptide ions to only the phosphopeptide masses that are contained in its data base, we experimented with a “two-stage search strategy”. We first searched a data set using a regular database (UniProt) with a canonical search engine (MaxQuant) and then listed

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the non-assigned entries of the mgf-file in a second mgf-file. In the first stage, all conventional peptide assignments are provided and the risk of false positive

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phosphopeptide assignments is thereby significantly reduced. In our case study, there are 7732 phosphosites identified by MaxQuant in the first stage. The second mgf-file which contains only the remaining unassigned entries from the first search, was then searched against our phosphopeptide database with our search engine (PhoPepMass) (Fig. 6). Thus, phosphosites can be identified in the first stage which are not contained

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in PhoPepMass, and some missed sites can be identified in the second stage by PhoPepMass with more confidence. In our case study, there are 1678 phosphosites

3. Discussion

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additionally identified by PhoPepMass in the second stage.

Phosphorylation is the most extensive post-translational protein modification and

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affects many biological processes. Hence, it is particularly important to accurately identify phosphosites. Current phosphosite identification can be broadly divided into two experimental methods. Low-throughput methods can identify specific phosphosites

using

an

antibody that

corresponds

to

the

site,

e.g.,

by

immunohistochemistry and/or Western blotting. High-throughput methods can identify sites of phosphorylation through phosphopeptide-enriched MS experiments, assisted with search identification software tools, like MaxQuant and Mascot. However, the high false positive rate of phosphosite identification is a persistent problem that needs to be addressed.

ACCEPTED MANUSCRIPT Evaluating relationship between a candidate sequence and an observed tandem mass spectrum is the key process for peptide identification, which can be accomplished by examining the m/z locations that should be occupied by fragment ions from the respective amino acid sequence. The preprocessing procedures for the currently used

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database search tools are different, resulting in diverse identification results. For example, in Sequest, only the 200 most intense ion signals are retained from each spectrum and are separated into ten zones according to their m/z ratios (Eng et al., 1994). In X!Tandem, the 50 most intense peaks from each tandem mass spectrum are

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employed by default for matching (Craig and Beavis, 2004). Therefore, peak filtering is a key preprocessing step to remove “noise”. Obviously, the peak filter should be

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neither too aggressive nor too weak, when applying such methods.

Here, we made an effort to identify phosphosites from high-throughput experiments using a different strategy. PhoPepMass stratifies mass peaks of a spectrum into a configurable number of intensity levels. Then, it introduces a multivariate hypergeometric distribution to calculate the random matching probability for each

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pair of candidate sequences and spectrum peaks. The scoring system tends to match intense ion signals rather than minor mass peaks, which is similar to that in MyriMatch (Tabb et al., 2007). Because of this pairwise scoring approach,

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PhoPepMass can process a large number of peaks for each spectrum. To improve identification confidence, phosphosites which have been identified by previous experiments were collected. From such a resource, the accurate masses of peptides

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and fragments with phosphosites were calculated. And then, phosphosites can be identified, through comparing the masses from new experiments with our calculated masses. Hence, this method can eventually provide higher identification accuracy and sensitivity due to the great number of entries of phosphosites in the database and because of less peak filtering need. In addition, a “two-stage search strategy” can be applied with this software, which can avoid the shortcoming of PhoPepMass’ not being able to identify new phosphosites. That is, new sites can be identified in the first stage, and still missed sites can be identified in the second stage. In conclusion, PhoPepMass is a database and search

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complementing general protein identification programs, especially in the field

of phosphorylation proteomics.

4. Materials and methods

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4.1 Defining masses of human phosphopeptides 4.1.1. Selection of phosphosites

Phosphorylation can occur at multiple sites in one protein, thus switching the signaling network (Cohen, 2000; Salazar and Hofer, 2009; Breitkreutz et al., 2010). In

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the current version of PhoPepMass, the information of phosphosites was retrieved from six databases (SysPTM 2.0 (Li et al., 2014), HPRD (Keshava Prasad et al.,

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2009), PhosphoSitePlus (Hornbeck et al., 2012), PhosphoELM (Diella et al., 2008), Swiss-Prot (Boeckmann et al., 2003), and dbPTM (Huang et al., 2016)). The site information in PhoPepMass will be updated when a new major database version of the six databases is released.

As different protein identifiers were used in different resource databases, to integrate

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heterogeneous data and avoid redundancy, protein identifiers were unified using Ensemble datasets. Protein IDs were downloaded from Biomart of Ensembl (Zerbino et al., 2018), then the proteins were uniformly mapped to their UniProt/SwissProt ID

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with redundancies removed.

4.1.2. Selection of peptide sequences Proteins were commonly digested into peptides using trypsin for MS analysis, since it

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has a well-defined specificity. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids arginine or lysine, except when followed by proline. In our study, a protein sequence was sheared into peptides based on the principle of trypsin digestion. The workflow of peptide sequence selection is shown in Fig. 2. First, amino acid sequences of proteins were cleaved at C-terminal to ‘K’ or ‘R’, except when P followed (‘KP’ or ‘RP’), for the collected proteins with phosphorylation. Then, only peptides with phosphosites were collected in our selection. The peptides contain sequences that were obtained either by complete cleavage, or by one missed cleavage either on the left side or the right side.

ACCEPTED MANUSCRIPT 4.1.3. Non-stoichiometric phosphorylation In most cases, phosphorylation is not stoichiometric. For all phosphosites on a protein, they do not always occur at the same time. Therefore, we should consider all the possibilities of which phosphosites occur simultaneously. If there is only one

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phosphosite in one peptide, there are two possibilities: the peptide is phosphorylated or not. However, if more than one phosphosite exists in a peptide, there will be many possibilities remaining. For example, if there are 4 phosphosites in one peptide, the number of combinations is 15 ([C(4,1) + C(4,2) + C(4,3) + C(4,4)] = 4+6+4+1 = 15).

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If there are more than 10 phosphosites in one peptide, the number of combinations is more than 1080. In our database, we eliminated those peptides with more than 11

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phosphosites to reduce the amount of computation time and memory. 4.1.4. Calculation of phosphopeptide masses

We calculated phosphopeptide masses using the following formula: protonated peptide ion mass = sum of the masses of its amino acid residues + number of phosphosites × the mass increment of PO3H + the mass of H2O + the mass of

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H+.

4.1.5. Calculation of fragment masses

If one charge (proton) is retained on the N terminal side of the fragment, the ion is

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classified as either a, b or c. If one charge (proton) is retained on the C terminal side of the fragment, the ion type is either x, y or z. Higher charged fragment ions are not calculated.

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Singly charged b fragment ion mass = sum of the masses of its amino acid residues + number of phosphosites × the mass increment of PO3H + the mass of H+. Singly charged y fragment ion mass = sum of the masses of its amino acid residues + number of phosphosites × the mass increment of PO3H + the mass of H2O + the mass of H+. a fragment ion mass = b fragment ion mass – mass of (-CO) c fragment ion mass = a fragment ion mass + mass of (-CO-NH3) z fragment ion mass = y fragment ion mass – mass of (-NH3) x fragment ion mass = z fragment ion mass + mass of (-CO-NH)

ACCEPTED MANUSCRIPT 4.2 Additional information Gene names or protein names from Biomart in Ensembl database are provided, including NCBI’s RefSeq, Ensembl, UniProt/Swiss-Prot, UniProt/TrEMBL, Entrez Gene, Gene name and aliases, which allow queries with the respective identifiers to

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be carried out in PhoPepMass. Functional information indicates Pfam domain from PFAM database, which allows users to allocate protein domain function. 4.3 System configuration

PhoPepMass consists of a dynamic web interface implemented with PHP technology

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and a relational database implemented by using MySQL5 (http://www.mysql.com/). (Fig. 3)

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4.4 Database search software

The PhoPepMass database search software is implemented with Python technology for high resolution and rapid identification of phosphopeptides. Users can download it from https://www.scbit.org/phopepmass/download/PhoPepMass.rar. The software reads files in the “mgf” or “pkl” format, which contain the mass, charge status,

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relative intensity of each precursor peptide; and the masses, relative intensities of its corresponding fragments.

The software mainly consists of three steps: 1) data preprocessing; 2) intensity

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classification; and 3) probability calculation. For the data preprocessing, the total ion current (TIC) for each spectrum is calculated by summing the fragment ion intensities. Then, users can customize the proportion of the TIC to be retained. The peaks are

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sorted in descending order of intensity. After removing a percentage of TIC, PhoPepMass generates a final peak list that reflects the intensity distribution in the original peaks. For the intensity classification process, users can customize the number of intensity classes during scoring. The number of peaks in these classes is different, and the ratio of adjacent class sizes is 2:1. The most intense class maintains the fewest peaks (Perkins et al., 1999). For example, if we set the TIC proportion to 95%, and the number of intensity classes is set to 3. The fragments in the top 95% of TIC are classified as “A” set (the most intense), “B” set (the intermediate intense), “C” set (the least intense) in a ratio of 1:2:4. And the fragments in the remaining 5% of

ACCEPTED MANUSCRIPT TIC are classified as “D” set (noise). In summary, according to the principle of intensity classification, the corresponding location of each predicted m/z value in the spectrum is tested to determine whether or not any peak is present, and if it is present, which class it belongs to. For the probability calculation process, the multivariate

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hypergeometric (MVH) distribution is employed to compute the probability of this random match (Tabb et al., 2007). t ) m p= T ( ) M

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∏(

where p is the probability of a random match, i is the number of intensity class, ti is

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the number of peaks from a particular intensity class in the spectrum, mi is the number of peaks matched to the theoretical phosphopeptide database from a particular intensity class, T is the sum of ti, and M is the sum of mi. 4.5 Case study

We used a public MS raw file as an example to identify phosphosites. The file was from

iProX,

named

“HeLa_TiO2_3_50per_F1_R1.raw”

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downloaded

(http://www.iprox.org//page/SDV015.html?subprojectId=IPX0000939002). The data were generated from the HeLa cell line sample, by combining titanium dioxide enrichment and tandem high-pH reverse phase for phosphor-proteome analysis in a

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high-throughput manner (Ren et al., 2018). The MS raw file was converted to ‘mgf’ file, using the Trans-Proteomic Pipeline (TPP) software (Deutsch et al., 2015).

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Phosphosites were identified with the PhoPepMass database search software. To compare PhoPepMass with canonical searching engines, we also used MaxQuant, X!Tandem to identify phosphosites. The parameters were set as 20 ppm for precursor tolerance, 0.5 Da for fragment tolerance, 95% for the proportion of the TIC to be retained, 3 for the number of intensity classes.

Figure Legends: Fig. 1. The strategy for identifying phosphosites of PhoPepMass. Conventional

ACCEPTED MANUSCRIPT phosphorylation identification process is to search a MS data set using a regular database (UniProt) with a canonical search engine (Mascot). In PhoPepMass, to improve identification confidence, phosphosites experimentally identified were collected. Accurate masses of peptides and fragments with phosphosites were

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calculated. And then, phosphosites can be identified, through comparing the masses from new experiments with our calculated masses by a statistical algorithm.

Fig. 2. The workflow of peptide sequence selection. Protein sequence is sheared to peptides based on the principle of trypsin digestion.

relational database and a dynamic web interface.

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Fig. 3. The framework of the database and web server. PhoPepMass consists of a

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Fig. 4. The protein query result. A: It is returned in three sections. B: The protein sequence with highlighted phosphosites. C: Detailed phosphosite information is shown, including domain information, their corresponding sources and Pubmed IDs. D: The phosphopeptides are shown, including completely cleaved peptides and peptides with one missed cleavage, also the corresponding masses.

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Fig. 5. Results of mass and mass list query. A: The result of mass query is a list of peptides, whose masses can be matched with the queried mass within the defined threshold. B: The result of mass list query is again a list of peptides obtained by batch

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matching methods.

Fig. 6. The “two-stage search strategy” for identifying phosphosites with

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PhoPepMass.

SUPPLEMENTARY DATA Fig. S1. Results of tryptic peptide query and non-tryptic peptide query. Fig. S2. The venn diagram of phosphosites identified by MaxQuant, X!Tandem and PhoPepMass. Fig. S3. The influence of differently set FDR value on common or unique phosphosite percentages identified by PhoPepMass compared to MaxQuant and X!Tandem. Table S1. Phosphosites identified by MaxQuant, X!Tandem and PhoPepMass.

ACCEPTED MANUSCRIPT Acknowledgments We would like to acknowledge Dr. Liangliang Ren, National Proteome Research Center (Beijing), for public access to their published phosphoproteomics data. We would also like to acknowledge Prof. H-J. Thiesen and Mr. H. Al-Bony, Institute of

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Immunology, University of Rostock, for providing the protein extract and Drs. C. Koy, C. Röwer, and S. Mikkat from the Proteome Center Rostock for providing proprietary phosphopeptide data sets for internal testing. This work was supported by National Key Research and Development Program of China (2016YFC0904101); Chinese

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Human Proteome Projects (CNHPP: 2014DFB30020, 2014DFB30030); Shanghai Municipal Science and Technology Commission of China (No. 17ZR1420300); and

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National Hi-Tech Program (2015AA020101).

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Hornbeck, P.V., Kornhauser, J.M., Tkachev, S., Zhang, B., Skrzypek, E., Murray, B., Latham, V., Sullivan, M., 2012. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res. 40, D261-270.

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Huang, K.Y., Su, M.G., Kao, H.J., Hsieh, Y.C., Jhong, J.H., Cheng, K.H., Huang, H.D., Lee, T.Y., 2016. dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins. Nucleic Acids Res. 44, D435-446. Keshava Prasad, T.S., Goel, R., Kandasamy, K., Keerthikumar, S., Kumar, S., Mathivanan, S., Telikicherla, D., Raju, R., Shafreen, B., Venugopal, A., Balakrishnan, L., Marimuthu, A., Banerjee, S., Somanathan, D.S., Sebastian, A., Rani, S., Ray, S., Harrys Kishore, C.J., Kanth, S., Ahmed, M., Kashyap, M.K., Mohmood, R., Ramachandra, Y.L., Krishna, V., Rahiman, B.A., Mohan, S., Ranganathan, P., Ramabadran, S., Chaerkady, R., Pandey, A., 2009. Human Protein Reference Database--2009 update. Nucleic Acids Res. 37, D767-772. Li, J., Jia, J., Li, H., Yu, J., Sun, H., He, Y., Lv, D., Yang, X., Glocker, M.O., Ma, L., Yang, J., Li, L., Li, W., Zhang, G., Liu, Q., Li, Y., Xie, L., 2014. SysPTM 2.0: an updated systematic resource for post-translational modification. Database (Oxford), 2014, bau025.

ACCEPTED MANUSCRIPT McHugh, L., Arthur, J.W., 2008. Computational methods for protein identification from mass spectrometry data. PLoS Comput. Biol. 4, e12. Paradela, A., Albar, J.P., 2008. Advances in the analysis of protein phosphorylation. J. Proteome Res. 7, 1809-1818.

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Perkins, D.N., Pappin, D.J., Creasy, D.M., Cottrell, J.S., 1999. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20, 3551-3567. Ren, L., Li, C., Shao, W., Lin, W., He, F., Jiang, Y., 2018. TiO2 with Tandem Fractionation (TAFT): An approach for rapid, deep, reproducible, and high-throughput phosphoproteome analysis. J. Proteome Res. 17, 710-721.

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Riley, N.M., Coon, J.J., 2016. Phosphoproteomics in the age of rapid and deep proteome profiling. Anal. Chem. 88, 74-94.

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Salazar, C., Hofer, T., 2009. Multisite protein phosphorylation--from molecular mechanisms to kinetic models. FEBS J. 276, 3177-3198. Tabb, D.L., Fernando, C.G., Chambers, M.C., 2007. MyriMatch: highly accurate tandem mass spectral peptide identification by multivariate hypergeometric analysis. J. Proteome Res. 6, 654-661.

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Yefremova, Y., Al-Majdoub, M., Opuni, K.F., Koy, C., Cui, W., Yan, Y., Gross, M.L., Glocker, M.O., 2015. "De-novo" amino acid sequence elucidation of protein G'e by combined "top-down" and "bottom-up" mass spectrometry. J. Am. Soc. Mass Spectrom. 26, 482-492.

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Zerbino, D.R., Achuthan, P., Akanni, W., Amode, M.R., Barrell, D., Bhai, J., Billis, K., Cummins, C., Gall, A., Giron, C.G., Gil, L., Gordon, L., Haggerty, L., Haskell, E., Hourlier, T., Izuogu, O.G., Janacek, S.H., Juettemann, T., To, J.K., Laird, M.R., Lavidas, I., Liu, Z., Loveland, J.E., Maurel, T., McLaren, W., Moore, B., Mudge, J., Murphy, D.N., Newman, V., Nuhn, M., Ogeh, D., Ong, C.K., Parker, A., Patricio, M., Riat, H.S., Schuilenburg, H., Sheppard, D., Sparrow, H., Taylor, K., Thormann, A., Vullo, A., Walts, B., Zadissa, A., Frankish, A., Hunt, S.E., Kostadima, M., Langridge, N., Martin, F.J., Muffato, M., Perry, E., Ruffier, M., Staines, D.M., Trevanion, S.J., Aken, B.L., Cunningham, F., Yates, A., Flicek, P., 2018. Ensembl 2018. Nucleic Acids Res. 46, D754-d761. Zhang, M., Li, H., He, Y., Sun, H., Xia, L., Wang, L., Sun, B., Ma, L., Zhang, G., Li, J., Li, Y., Xie, L., 2015. Construction and deciphering of human phosphorylation-mediated signaling transduction networks. J. Proteome Res. 14, 2745-2757.

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ACCEPTED Overlap MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

P-value 4.65E-23 1.11E-22 1.09E-20 4.48E-20 7.57E-20 1.79E-18 1.79E-18 4.64E-18 7.04E-18 1.54E-17 4.17E-17 4.41E-17 4.77E-17 5.53E-17 7.73E-17 1.32E-16 1.35E-16 1.53E-16 1.57E-16 1.90E-16 2.83E-16 3.13E-16 4.10E-16 6.80E-16 8.81E-16 1.07E-15 1.07E-15 1.22E-15 1.26E-15 1.35E-15 1.36E-15 1.66E-15 1.72E-15 1.72E-15 2.02E-15 2.51E-15 2.66E-15 3.09E-15 3.36E-15 3.51E-15 4.09E-15 5.18E-15 5.67E-15 5.86E-15 6.23E-15 6.42E-15 6.86E-15 7.07E-15 7.18E-15

EP

Site S95 S341 T795 S1114 S1276 S233 S234 S4626 T329 T1555 S419 S1328 S55 S149 S181 S198 S344 S240 S30 S2900 S1153 S647 S498 S4622 S2751 S774 S771 S390 S88 T4623 S116 T2397 S443 S444 S222 S892 S777 S182 S1754 S363 S1995 S723 S24 S1116 S185 T210 S532 S148 T992

AC C

Protein Q86U42 Q9NZN5 Q9Y597 Q13428 Q9P2E9 Q14151 Q15424 Q15149 Q8NC44 P18583 P46937 Q9H2Y7 P08670 Q9Y3C6 Q9BXB4 Q9UBK8 Q86WB0 Q9Y446 Q3KR37 P49792 A7E2V4 Q7Z460 P23588 Q15149 O75592 Q6IN85 Q6IN85 O15027 P38159 Q15149 Q15121 Q9UQ35 Q9BQF6 Q9BQF6 Q12888 Q6ZRV2 Q6IN85 P41227 Q9Y2I7 Q9H3P2 Q9HCK8 P98175 Q86WB0 Q9Y4G8 Q96CX2 Q9Y2W1 O94979 O15234 Q4ADV7

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TE D

7.52E-15 7.95E-15 8.37E-15 8.91E-15 8.99E-15 1.32E-14 1.33E-14 1.45E-14 1.79E-14 1.83E-14 1.85E-14 2.01E-14 2.12E-14 2.23E-14 2.29E-14 2.33E-14 2.46E-14 2.58E-14 3.23E-14 3.23E-14 3.30E-14 3.32E-14 3.54E-14 3.62E-14 3.90E-14 4.25E-14 4.54E-14 4.80E-14 4.93E-14 4.97E-14 5.35E-14 5.82E-14 5.86E-14 5.86E-14 5.86E-14 6.31E-14 6.37E-14 6.53E-14 6.84E-14 7.28E-14 7.47E-14 8.53E-14 8.60E-14 8.78E-14 9.78E-14 9.93E-14 9.98E-14 9.98E-14 1.01E-13 1.01E-13

EP

T363 S752 S234 S79 S338 T178 S1049 S214 S973 S77 S1405 S524 T37 S350 T510 S85 T215 S534 S478 S478 S369 S27 S366 S351 S1668 S168 T506 S157 S178 S1645 S154 S62 S119 S117 S113 S703 S796 S617 S29 S975 S240 S368 S2835 S271 T2889 S613 S777 T779 T154 T154

AC C

Q9NQW6 Q9NRA8 Q8IYB3 P26368 Q8WXI9 Q86TB9 P41252 Q7Z417 Q9UPQ0 O15169 Q13459 Q07866 P04075 Q9NYJ8 Q86V48 P16333 Q9BU76 Q86VM9 Q641Q2 Q9Y4E1 A8CG34 P52564 P46937 P42166 Q9C0D5 P42167 P43007 O76064 Q9BXB4 Q8IZH2 Q8IWS0 Q8NFG4 Q13247 Q13243 Q08170 P49756 Q6GYQ0 Q07157 P29966 Q9UPQ0 Q8IWW6 A8CG34 O75592 O75128 Q7Z6Z7 Q99590 Q9Y2H5 Q9Y2H5 P42167 P42166

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TE D

1.09E-13 1.09E-13 1.14E-13 1.19E-13 1.29E-13 1.32E-13 1.33E-13 1.43E-13 1.44E-13 1.52E-13 1.54E-13 1.55E-13 1.55E-13 1.72E-13 1.79E-13 1.80E-13 1.95E-13 1.99E-13 1.99E-13 2.06E-13 2.11E-13 2.32E-13 2.33E-13 2.36E-13 2.39E-13 2.41E-13 2.41E-13 2.49E-13 2.77E-13 2.82E-13 2.88E-13 2.90E-13 2.97E-13 3.12E-13 3.26E-13 3.26E-13 3.29E-13 3.30E-13 3.32E-13 3.32E-13 3.41E-13 3.58E-13 3.60E-13 3.77E-13 3.98E-13 4.12E-13 4.14E-13 4.41E-13 4.48E-13 4.49E-13

EP

S369 S375 T172 S28 S1100 S4613 S117 T207 S308 S795 S512 S399 S391 S2888 T681 S304 S177 S486 S650 T2412 S302 S1956 S2885 S2394 T1589 T28 S761 S56 T990 S746 S177 S25 S1417 S192 S305 T306 S74 S74 S617 S219 S2825 T619 S157 S113 T315 S3515 S1125 S1350 S197 S1665

AC C

P51812 P51812 Q9NZM1 Q9H2H9 Q13464 Q15149 Q6IN85 Q7Z589 Q9Y4H2 Q6GYQ0 Q86V48 P07900 P08238 Q7Z6Z7 O60237 Q9Y4H2 Q86TB9 Q8WUI4 Q9H4G0 Q9BZC7 Q86U70 P35580 Q5T4S7 Q9UQ35 Q8IVL1 P52564 P48634 Q6IAA8 Q8WWI1 Q8TEW8 Q9BXB4 Q9H2H9 Q8NI27 P21291 Q86U70 Q86U70 Q6P0Q8 Q6DCA0 Q9UPN6 Q8ND56 P15924 Q9UPN6 P49761 O43396 O15143 Q03164 Q12774 Q96SN8 Q6PID6 Q9C0D5

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TE D

4.78E-13 4.97E-13 5.02E-13 5.22E-13 5.24E-13 5.33E-13 5.52E-13 5.52E-13 5.56E-13 5.65E-13 5.74E-13 5.99E-13 6.23E-13 6.36E-13 6.44E-13 7.07E-13 7.90E-13 7.93E-13 8.00E-13 8.18E-13 8.66E-13 9.20E-13 9.23E-13 9.24E-13 9.26E-13 9.33E-13 9.39E-13 9.45E-13 9.49E-13 9.49E-13 1.01E-12 1.01E-12 1.01E-12 1.05E-12 1.08E-12 1.09E-12 1.09E-12 1.10E-12 1.12E-12 1.12E-12 1.18E-12 1.20E-12 1.21E-12 1.22E-12 1.22E-12 1.24E-12 1.26E-12 1.30E-12 1.32E-12 1.32E-12

EP

S17 T25 S740 S624 S732 T601 S3511 S3517 S214 S623 S535 S756 S97 S51 S263 S803 S1088 S607 S54 T116 S547 S1037 Y89 S409 S420 S433 S618 S235 S610 T609 S535 S137 S795 S107 S499 S2407 S362 S160 S518 S488 S979 S695 S279 S101 S315 S4538 T234 S891 S941 S563

AC C

Q8IVP5 Q6Y7W6 Q9H2P0 O95466 Q14684 P55265 Q03164 Q03164 Q9Y6D5 Q9HBL0 P25205 Q13263 P23193 Q07960 P07900 Q9H694 Q7Z460 Q14157 Q9BUR4 Q12982 Q9NPA5 Q5VUA4 O75376 Q13112 Q15326 P35658 Q13586 P78345 P51532 P51532 Q9BTA9 O43815 Q86VM9 O60841 P47736 Q9UQ35 Q7L8J4 O60231 Q14155 Q15052 Q9UK61 O14974 Q96RK0 O95155 Q9Y2W1 Q9NU22 P78345 O15027 P27816 Q5T5Y3

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TE D

1.34E-12 1.35E-12 1.36E-12 1.37E-12 1.37E-12 1.37E-12 1.45E-12 1.50E-12 1.54E-12 1.54E-12 1.55E-12 1.55E-12 1.55E-12 1.58E-12 1.59E-12 1.75E-12 1.76E-12 1.83E-12 1.84E-12 1.84E-12 1.86E-12 1.86E-12 1.88E-12 1.89E-12 1.91E-12 1.91E-12 1.92E-12 1.92E-12 1.92E-12 1.93E-12 1.94E-12 1.95E-12 1.97E-12 1.97E-12 2.02E-12 2.03E-12 2.03E-12 2.12E-12 2.14E-12 2.15E-12 2.18E-12 2.18E-12 2.19E-12 2.20E-12 2.21E-12 2.21E-12 2.33E-12 2.37E-12 2.39E-12 2.41E-12

EP

T163 S715 S1907 S598 S77 S175 S759 S464 T479 S484 S1549 S645 S647 S676 S330 S511 S2256 T983 S150 S1758 T63 S62 S120 T360 S1218 S963 T315 T1368 T1370 S115 S385 S89 S151 S863 T318 S96 S95 S1121 S94 S859 S350 T488 S439 S164 S41 T220 S343 S361 S1029 S289

AC C

Q7Z434 Q8IYB3 Q7Z6Z7 Q7Z460 Q96S55 Q7Z5L9 P48634 Q08AD1 Q86US8 Q86US8 O95071 P13807 P13807 Q8WWQ0 P49790 Q9BTA9 O95359 Q13428 Q9UBC1 Q12888 Q96E09 Q96E09 O95218 Q9BWW4 Q13017 Q14676 Q9UQ35 O75976 O75976 Q7Z309 Q9NYF8 P16333 Q96S55 Q8N122 P61073 Q9NQL2 Q9HB90 Q8WX93 O43847 Q8N122 Q9H814 P51114 Q8WWY3 Q9Y6M1 Q96EV2 Q8ND56 Q6WKZ4 Q6P6C2 Q9UHW9 Q6WCQ1

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TE D

2.41E-12 2.46E-12 2.48E-12 2.48E-12 2.48E-12 2.50E-12 2.54E-12 2.54E-12 2.59E-12 2.61E-12 2.61E-12 2.65E-12 2.72E-12 2.72E-12 2.74E-12 2.74E-12 2.79E-12 2.80E-12 2.81E-12 2.84E-12 2.85E-12 2.87E-12 2.92E-12 2.93E-12 2.94E-12 2.95E-12 3.03E-12 3.07E-12 3.21E-12 3.24E-12 3.30E-12 3.34E-12 3.35E-12 3.40E-12 3.50E-12 3.52E-12 3.57E-12 3.57E-12 3.58E-12 3.58E-12 3.63E-12 3.64E-12 3.68E-12 3.72E-12 3.72E-12 3.80E-12 3.80E-12 3.84E-12 3.84E-12 3.87E-12

EP

S417 S1563 S394 S392 S85 S11 S288 T1531 S518 S1436 S612 S241 S1301 S2276 T358 S356 S67 T178 S12 S43 S242 S30 S2057 S22 S370 S475 S1387 T1469 S1219 T334 S534 S745 T158 S1915 S499 S2172 S233 S743 S1214 S1218 S264 T349 S395 S372 S7 T483 S485 S18 S18 S512

AC C

Q14247 Q8WWI1 Q06265 Q06265 Q9UHD8 P57740 P18206 Q9UQ35 Q9NQW6 P25054 Q9H694 P49916 Q7Z3J3 P49792 Q9H814 Q9H814 P19338 Q96CX2 P50443 Q96BD0 Q96FJ0 Q9H410 Q9Y618 O75569 Q86WB0 P05787 Q9UQ35 Q9BTC0 Q12888 Q9H330 Q6VY07 Q8TEW8 P42575 P46821 Q8NC56 Q96JM2 P63261 Q86YV5 Q9UQ35 Q9UQ35 Q9NYF8 Q9H814 Q14980 Q9H4L5 P10243 P51114 P51114 P07355 A6NMY6 O15231

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TE D

3.89E-12 3.92E-12 3.93E-12 3.93E-12 4.01E-12 4.16E-12 4.18E-12 4.22E-12 4.24E-12 4.25E-12 4.30E-12 4.32E-12 4.35E-12 4.37E-12 4.41E-12 4.52E-12 4.57E-12 4.60E-12 4.66E-12 4.67E-12 4.77E-12 4.77E-12 4.84E-12 4.85E-12 4.93E-12 4.96E-12 4.99E-12 5.18E-12 5.20E-12 5.28E-12 5.32E-12 5.32E-12 5.34E-12 5.36E-12 5.49E-12 5.50E-12 5.61E-12 5.65E-12 5.73E-12 5.80E-12 5.90E-12 5.91E-12 5.94E-12 5.94E-12 5.94E-12 5.95E-12 5.96E-12 6.17E-12 6.17E-12 6.30E-12

EP

T652 S393 S215 T214 S1358 S278 S605 S23 S241 T852 S557 S775 S135 S162 S1732 T1647 S403 S40 T221 S65 T35 T35 S99 S525 S457 S339 S208 S1012 S464 S940 S1067 S1068 S16 S2719 S725 S1966 S68 S23 S643 S355 T720 S1385 T159 T2022 T93 S446 T453 S603 S465 T295

AC C

Q9H4G0 Q9P0L2 Q86WR7 Q86WR7 Q7Z5J4 O94875 Q14157 Q9Y4F1 Q5T200 O95425 Q92613 Q6GYQ0 Q99959 Q96D71 Q96L91 Q12888 Q5JSH3 P80723 P23396 Q969E4 Q9H8S9 Q7L9L4 Q14739 O95365 Q53EL6 Q6WKZ4 P43243 O95785 Q9BZZ5 Q96ST3 Q12888 Q12888 P50443 Q5T4S7 Q8WXE0 P24928 Q9H307 Q9UNE7 Q86TC9 P51991 P10636 Q9C0C2 Q13765 E9PAV3 O15173 P18887 P53396 P51116 P35611 Q6WCQ1

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TE D

6.38E-12 6.40E-12 6.43E-12 6.44E-12 6.57E-12 6.61E-12 6.68E-12 6.79E-12 6.94E-12 7.07E-12 7.15E-12 7.15E-12 7.15E-12 7.22E-12 7.24E-12 7.35E-12 7.45E-12 7.71E-12 7.79E-12 7.88E-12 7.89E-12 7.93E-12 7.93E-12 7.96E-12 8.29E-12 8.30E-12 8.41E-12 8.48E-12 8.66E-12 8.69E-12 8.70E-12 8.89E-12 9.14E-12 9.31E-12 9.31E-12 9.39E-12 9.51E-12 9.59E-12 9.59E-12 9.62E-12 9.65E-12 9.76E-12 9.91E-12 9.97E-12 1.00E-11 1.01E-11 1.02E-11 1.02E-11 1.02E-11 1.03E-11

EP

T869 T515 S76 S59 S124 S649 S78 S258 S102 S1182 S1157 S953 S955 S151 S487 T250 S91 S164 S211 S1883 S356 S50 S49 S368 S2821 S32 T1035 S243 S434 S197 T836 S221 T942 S271 S283 S517 S619 T639 S365 T274 S32 S2020 S433 T715 S528 T899 T1396 T1393 S2098 T856

AC C

O60716 Q86V48 Q53EL6 Q9NQG6 Q9Y5J1 Q4L235 Q53EL6 Q15942 Q9H6F5 Q9NTI5 O43432 Q9H2P0 Q9H2P0 Q6UUV9 Q9UHB7 Q86TC9 P38159 O60841 Q96B36 Q13315 P51991 Q07960 Q07960 O75122 P15924 Q9H0W8 Q5VUA4 Q9Y2W1 Q9BVJ6 Q9NV56 Q5VYK3 Q15418 P27816 Q9UQ88 P21127 Q99567 O95453 Q86TC9 Q9UHB6 Q6IQ49 Q7L4I2 Q92614 Q8N1G0 Q6PJG2 Q96EN8 Q15811 P49792 P49792 Q03164 Q9UQ35

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TE D

1.03E-11 1.05E-11 1.05E-11 1.06E-11 1.07E-11 1.08E-11 1.09E-11 1.10E-11 1.10E-11 1.13E-11 1.13E-11 1.13E-11 1.13E-11 1.14E-11 1.14E-11 1.14E-11 1.15E-11 1.16E-11 1.18E-11 1.19E-11 1.20E-11 1.20E-11 1.23E-11 1.25E-11 1.28E-11 1.28E-11 1.30E-11 1.30E-11 1.31E-11 1.31E-11 1.33E-11 1.33E-11 1.33E-11 1.34E-11 1.35E-11 1.37E-11 1.38E-11 1.38E-11 1.39E-11 1.39E-11 1.40E-11 1.40E-11 1.40E-11 1.41E-11 1.41E-11 1.44E-11 1.44E-11 1.45E-11 1.46E-11 1.46E-11

EP

S40 S141 S5735 S706 S280 S736 S2003 S493 S1278 S1090 S1092 S1089 S446 S2129 S699 S861 S402 S1492 S288 S203 S97 S28 S193 S729 S351 S295 T219 S125 S54 S136 S206 S722 S3818 S179 S64 S448 S678 S677 S127 S762 S370 S371 S192 Y284 S119 S2581 S1589 S80 S234 S537

AC C

P46108 Q13177 Q09666 P16070 O14745 Q14684 Q14980 A0MZ66 Q96T58 Q9H6S0 Q9H6S0 Q9H6S0 P14859 P18583 Q15596 Q6GYQ0 Q9Y2U8 Q9Y6N7 P14921 Q92925 Q14498 Q9H410 Q00059 Q9UKV3 Q01831 P04049 Q9NQS7 Q99733 O00264 Q5VTR2 Q6WKZ4 Q71RC2 Q7Z6Z7 Q8NI08 Q96MG7 P14859 Q86TV6 Q86TV6 Q6P158 Q66K74 Q9H4L5 Q9H4L5 Q00587 Q9NYF8 Q7Z309 Q9UQ35 Q7Z401 Q14103 Q8NC51 Q15042

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.47E-11 1.49E-11 1.52E-11 1.52E-11 1.52E-11 1.54E-11 1.55E-11 1.55E-11 1.56E-11 1.57E-11 1.57E-11 1.59E-11 1.62E-11 1.62E-11 1.65E-11 1.67E-11 1.67E-11 1.67E-11 1.69E-11 1.70E-11 1.70E-11 1.71E-11 1.76E-11 1.77E-11 1.78E-11 1.78E-11 1.79E-11 1.79E-11 1.81E-11 1.84E-11 1.85E-11 1.85E-11 1.86E-11 1.86E-11 1.90E-11 1.90E-11 1.93E-11 1.95E-11 1.97E-11 1.97E-11 2.02E-11 2.05E-11 2.07E-11 2.07E-11 2.08E-11 2.08E-11 2.08E-11 2.14E-11 2.14E-11 2.14E-11

EP

S621 S345 T2314 T704 S700 S333 S721 S1350 S330 S269 S193 T453 S73 S99 S522 S92 T1256 S1212 S882 S851 S379 T226 S675 S308 S102 S491 S504 S3570 T328 S363 T1608 S284 S343 S250 S218 S12 S5737 S659 S625 S164 S521 S1179 S328 S486 S182 S183 S186 S315 T311 S1162

AC C

Q7KZI7 Q6WKZ4 O95359 Q6PJG2 Q6PJG2 P49790 P10636 Q13428 Q9H330 O60716 Q5HYJ3 Q08J23 O43583 Q8NFH5 Q9NPI6 Q9UK76 O60610 Q7Z4S6 O75151 Q9HCS7 P15923 Q9UN86 Q6AI39 Q96MU7 Q9BW71 Q9UHB7 Q8N5C8 Q96Q15 P08651 Q00613 Q14676 Q96JM3 P08651 P57682 Q9NQS7 Q13286 Q09666 Q8NFC6 P52948 Q9NQG5 Q92560 Q7Z6E9 O75909 Q7KZI7 O60841 O60841 O60841 Q99460 Q99460 Q9NTI5

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

2.14E-11 2.14E-11 2.18E-11 2.18E-11 2.19E-11 2.22E-11 2.22E-11 2.24E-11 2.25E-11 2.25E-11 2.25E-11 2.25E-11 2.27E-11 2.30E-11 2.30E-11 2.31E-11 2.36E-11 2.37E-11 2.41E-11 2.41E-11 2.43E-11 2.44E-11 2.44E-11 2.46E-11 2.47E-11 2.47E-11 2.48E-11 2.49E-11 2.53E-11 2.53E-11 2.57E-11 2.58E-11 2.61E-11 2.61E-11 2.69E-11 2.70E-11 2.72E-11 2.76E-11 2.76E-11 2.76E-11 2.78E-11 2.78E-11 2.79E-11 2.80E-11 2.89E-11 2.90E-11 2.94E-11 2.94E-11 2.95E-11 2.98E-11

EP

S637 S274 S824 T821 S2718 S638 S327 S151 S220 S217 T1399 S1400 S41 S249 S252 S428 S1251 S294 T449 S239 T450 S127 S132 S236 S489 S13 S307 S528 S773 T893 S360 S405 T895 S899 S690 S699 S31 S339 S342 T338 S166 S738 S2105 S69 T469 S470 S937 S933 T1003 S261

AC C

Q9NYL2 Q3KR37 Q6P0N0 Q6P0N0 Q5T4S7 Q96TA1 Q9H330 P40425 Q9BU76 Q9BU76 P49792 P49792 P49736 P0C1Z6 P0C1Z6 Q9Y6D9 Q7LBC6 O00712 Q14676 Q9H7N4 Q969V6 Q9C086 Q9C086 P18887 Q5T0N5 P07948 Q15464 Q6WKZ4 Q6GYQ0 Q9NYV4 Q8N6T3 Q99590 Q8IX03 Q8IX03 Q9H6R7 A0FGR8 Q00341 P12694 P12694 P12694 O43399 Q9UKJ3 P46013 Q96B23 Q86SQ0 Q3YEC7 Q9HAU0 Q9HAU0 Q12965 P08238

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

2.98E-11 2.98E-11 3.00E-11 3.01E-11 3.04E-11 3.05E-11 3.05E-11 3.07E-11 3.11E-11 3.12E-11 3.14E-11 3.14E-11 3.15E-11 3.18E-11 3.19E-11 3.19E-11 3.20E-11 3.21E-11 3.24E-11 3.25E-11 3.27E-11 3.30E-11 3.34E-11 3.41E-11 3.48E-11 3.48E-11 3.48E-11 3.51E-11 3.52E-11 3.66E-11 3.72E-11 3.72E-11 3.72E-11 3.72E-11 3.72E-11 3.76E-11 3.76E-11 3.77E-11 3.77E-11 3.80E-11 3.81E-11 3.82E-11 3.83E-11 3.84E-11 3.89E-11 3.91E-11 3.94E-11 3.98E-11 4.13E-11 4.14E-11

EP

S183 S65 S895 S167 S63 S229 T223 S389 S1481 S2100 T866 S320 S888 T79 S294 T149 S700 S1254 S347 T329 S217 S462 S311 S262 S644 S641 S26 S777 S2069 S24 S2251 S1276 S1275 S1275 S1276 S179 S476 S461 S911 S97 S392 S425 S610 T5824 S215 S903 S1219 S336 S435 T118

AC C

Q58FF8 Q13541 Q9HC35 Q8WUA4 O75496 O75533 O75533 Q8IYB3 Q15648 Q9UQ35 Q9UQ35 Q9NY61 Q92547 Q15029 Q6WCQ1 Q96E09 Q8NE01 O60610 P12694 Q12893 Q6WCQ1 Q7Z5L9 Q96SB4 Q9NYF8 P28290 P28290 P49736 Q8N4C8 Q9Y618 Q9BRS2 P49792 Q7Z3J3 Q99666 O14715 A6NKT7 Q96C57 Q14157 P53985 Q8WWQ0 Q9H7F0 Q96HA1 P23588 Q9H0B6 Q09666 Q5JTV8 Q14C86 Q92766 Q99569 P47712 Q3KQU3

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

4.15E-11 4.20E-11 4.23E-11 4.25E-11 4.28E-11 4.28E-11 4.31E-11 4.32E-11 4.36E-11 4.37E-11 4.39E-11 4.39E-11 4.47E-11 4.54E-11 4.56E-11 4.56E-11 4.57E-11 4.57E-11 4.57E-11 4.64E-11 4.64E-11 4.67E-11 4.69E-11 4.70E-11 4.71E-11 4.72E-11 4.74E-11 4.75E-11 4.77E-11 4.80E-11 4.80E-11 4.81E-11 4.85E-11 4.85E-11 4.85E-11 4.85E-11 4.85E-11 4.87E-11 4.91E-11 4.91E-11 4.92E-11 5.01E-11 5.02E-11 5.02E-11 5.03E-11 5.05E-11 5.05E-11 5.05E-11 5.05E-11 5.09E-11

EP

T316 S20 S513 S108 S44 S442 S82 S113 S351 T318 S154 S303 S343 T328 T14 T14 S406 T231 S516 S393 S391 S26 S348 S52 S1646 T185 S259 S1791 S653 S850 S849 S183 S238 S233 S353 S351 S437 S225 S193 S189 S2102 S460 T2583 S1165 S718 S306 S307 S301 S303 S515

AC C

Q9UQ35 Q6Y7W6 O60832 Q9Y580 P17096 Q9H0E3 Q96JP5 Q3KQU3 Q6ZS17 Q9UQ35 Q99959 Q9H4L5 P12694 Q92597 P24941 Q00526 O43237 Q8IWW6 Q9ULM3 Q8IYB3 Q8IYB3 Q9UPY5 Q08499 Q9H2H9 Q12888 P28482 P17535 Q92538 P49848 P46100 P46100 Q8NI08 Q6U841 Q9Y6M7 Q9UQ35 Q9UQ35 Q13535 Q9UN86 Q9BVC5 Q9BVC5 Q9UQ35 Q3KQU3 Q9UQ35 Q9NTI5 Q6P996 P35659 P35659 P35659 P35659 Q6PJT7

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

5.12E-11 5.19E-11 5.19E-11 5.20E-11 5.21E-11 5.21E-11 5.21E-11 5.21E-11 5.23E-11 5.24E-11 5.25E-11 5.25E-11 5.27E-11 5.32E-11 5.33E-11 5.35E-11 5.37E-11 5.45E-11 5.45E-11 5.53E-11 5.57E-11 5.58E-11 5.58E-11 5.64E-11 5.67E-11 5.68E-11 5.71E-11 5.76E-11 5.87E-11 5.89E-11 5.89E-11 5.89E-11 5.92E-11 5.96E-11 6.02E-11 6.04E-11 6.05E-11 6.06E-11 6.06E-11 6.06E-11 6.10E-11 6.16E-11 6.18E-11 6.18E-11 6.21E-11 6.21E-11 6.21E-11 6.22E-11 6.31E-11 6.31E-11

EP

S437 S366 S365 T228 S300 T1214 S1216 S1208 S321 S545 S85 T465 T71 S1535 S615 S1176 T39 S605 S607 S2042 S25 S452 S21 S31 S881 T448 S77 S660 S205 S107 S836 S839 S1760 S547 S743 S439 S1287 S331 T727 S726 S1268 S523 S786 S82 S357 S358 T359 S833 S171 S183

AC C

Q14004 Q6NZI2 Q6NZI2 Q15019 Q4G0J3 Q12888 Q12888 Q12888 Q9NY61 Q5JTD0 O15541 Q9H6S3 P15336 Q14839 Q9P2E9 Q9Y4H2 P17096 Q8IYB3 Q8IYB3 O75179 O00193 O14639 O00458 Q9UHB7 Q6ZRV2 Q14676 P82094 O14523 Q92925 Q96FF9 Q9C0C9 Q9C0C9 Q14980 Q9ULU4 Q8IZL8 Q14004 Q96T58 Q9UI08 Q92614 Q92614 Q9ULD2 Q9NPI6 Q8TEK3 P04792 Q9UQ35 Q9UQ35 Q9UQ35 Q5VYK3 Q96CX2 Q96CX2

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

6.31E-11 6.34E-11 6.35E-11 6.35E-11 6.37E-11 6.46E-11 6.46E-11 6.47E-11 6.47E-11 6.47E-11 6.51E-11 6.51E-11 6.56E-11 6.58E-11 6.68E-11 6.69E-11 6.78E-11 6.79E-11 6.79E-11 6.79E-11 6.80E-11 6.81E-11 6.81E-11 6.83E-11 6.85E-11 6.92E-11 6.93E-11 6.98E-11 6.98E-11 7.01E-11 7.01E-11 7.01E-11 7.03E-11 7.04E-11 7.05E-11 7.06E-11 7.06E-11 7.07E-11 7.09E-11 7.09E-11 7.19E-11 7.19E-11 7.22E-11 7.26E-11 7.27E-11 7.30E-11 7.35E-11 7.37E-11 7.40E-11 7.40E-11

EP

T65 S604 S439 S432 S631 S300 S298 S740 S763 S268 T739 T751 S1271 S363 T42 S43 S1026 Y15 Y15 Y15 T568 T985 S389 S519 S2479 S16 S122 S89 S447 S672 S216 S1249 S195 S466 S306 S729 S378 S240 S339 S78 S1360 S454 S296 S839 S548 S385 S119 S181 S500 S501

AC C

Q9H6F5 Q15424 Q66K14 Q66K14 Q6PKG0 P08559 P29803 Q8IYB3 Q8IW35 P18887 Q9UQ88 P21127 Q9HBL0 Q8N6T3 Q9H6F5 P62750 Q8WWI1 P06493 Q00526 P24941 Q96T37 Q5T200 Q9NYF8 Q9ULM3 P11717 Q9ULI0 P22392 Q9UKI2 P14859 O14920 Q9BU76 P20020 Q9NV56 Q9H6S3 Q06265 P46100 Q9NZT2 Q9UNX4 Q16643 Q9UPN4 Q5VZK9 Q969V6 O00499 Q9ULH1 Q01804 Q8NC44 Q8WW12 O96013 Q6WKZ4 Q6WKZ4

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

7.43E-11 7.45E-11 7.48E-11 7.50E-11 7.51E-11 7.57E-11 7.60E-11 7.68E-11 7.69E-11 7.75E-11 7.75E-11 7.75E-11 7.76E-11 7.89E-11 7.96E-11 7.96E-11 8.00E-11 8.12E-11 8.30E-11 8.30E-11 8.31E-11 8.31E-11 8.32E-11 8.37E-11 8.39E-11 8.39E-11 8.42E-11 8.43E-11 8.43E-11 8.43E-11 8.45E-11 8.45E-11 8.52E-11 8.53E-11 8.58E-11 8.61E-11 8.64E-11 8.66E-11 8.66E-11 8.70E-11 8.81E-11 8.81E-11 8.84E-11 8.84E-11 8.87E-11 9.04E-11 9.06E-11 9.19E-11 9.20E-11 9.23E-11

EP

S377 S321 S259 S538 S482 S55 S287 S1239 S2563 T629 S623 T620 S511 S1191 S564 T130 S471 S603 Y273 Y321 S363 S365 S147 S521 T51 S202 Y33 S288 S288 S1217 T287 T287 S761 S94 S386 S285 S236 T723 S438 S56 T202 T139 S2702 S2706 S19 S139 S846 T349 S162 S251

AC C

Q8WYQ5 P61073 O00443 Q14978 Q8NFC6 O43818 Q676U5 Q8WXG6 Q12802 Q96AE4 Q2M2I8 Q2M2I8 O00567 P38398 P27824 O95251 Q3YEC7 Q05209 Q9Y463 Q13627 Q96ST2 Q96ST2 P29966 Q07866 P30086 Q14244 Q9UJV9 Q641Q2 Q9Y4E1 Q76I76 Q9Y4E1 Q641Q2 A0FGR8 P05455 Q01813 O94888 Q9H7L9 P40818 O94804 O95251 Q13595 Q86W56 Q9UQ35 Q9UQ35 Q9UNE7 P50914 Q9UQ35 Q01831 Q9UNF1 Q9UHR4

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

9.23E-11 9.31E-11 9.35E-11 9.37E-11 9.39E-11 9.39E-11 9.40E-11 9.40E-11 9.42E-11 9.47E-11 9.53E-11 9.58E-11 9.60E-11 9.78E-11 9.81E-11 9.81E-11 9.84E-11 9.84E-11 9.91E-11 9.91E-11 9.93E-11 9.94E-11 9.94E-11 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.02E-10 1.02E-10 1.02E-10 1.03E-10 1.03E-10 1.03E-10 1.04E-10 1.04E-10 1.04E-10 1.06E-10 1.06E-10 1.08E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.10E-10 1.10E-10 1.11E-10 1.11E-10 1.12E-10

EP

T248 S33 T161 S1525 S1430 S1426 S406 T179 S354 T381 S314 S2041 S83 S658 T2125 T1726 S410 T414 S677 T678 S880 S131 S540 S250 S350 S361 S619 S1047 S956 S2518 S172 S758 S28 S455 S677 T1177 T1019 T198 S784 S272 S674 T252 S627 S391 S309 T1244 S1326 S227 S232 S935

AC C

Q9UHR4 Q92522 Q6UUV9 P11388 Q12888 Q12888 Q9ULU4 Q9H1E3 Q9UKS6 P12270 Q9NQS7 O75179 P31321 Q9NYF8 Q9UQ35 Q96L91 Q9UKV3 Q9UKV3 Q8WWQ0 Q8WWQ0 P07814 Q99959 Q63ZY3 Q9UPT5 Q01831 Q9Y2X7 Q7KZI7 Q86TC9 Q14683 Q9HCK8 P04920 Q99700 Q9NTJ3 O43318 Q9P227 Q9UQ35 Q7Z401 Q9NQX3 Q9H4G0 Q9UNZ2 Q86Y91 Q9UHR4 Q6PKG0 P20700 Q96AX9 P11388 Q9UQ35 P51812 Q9UK32 Q9HD20

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.12E-10 1.13E-10 1.13E-10 1.14E-10 1.14E-10 1.14E-10 1.14E-10 1.14E-10 1.15E-10 1.15E-10 1.15E-10 1.15E-10 1.15E-10 1.16E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.18E-10 1.18E-10 1.18E-10 1.18E-10 1.19E-10 1.19E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.22E-10 1.22E-10 1.22E-10 1.22E-10 1.22E-10 1.22E-10 1.23E-10 1.24E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.27E-10 1.27E-10 1.27E-10 1.29E-10 1.29E-10 1.30E-10 1.30E-10

EP

S2365 S1101 T51 T1756 S576 S578 S140 S322 T3573 S40 S73 T76 S113 S391 T294 S437 S452 S102 T246 S174 S1173 S1176 T96 S255 S127 S260 S264 S860 S141 S1854 S333 S361 S663 S683 S452 S704 S675 T383 S14 S310 S382 S386 T190 S605 S2121 T358 S325 S324 S648 S473

AC C

Q7Z6Z7 Q9UQ35 Q7Z309 Q12888 O15014 O15014 Q9UQC2 Q9UQ35 Q96Q15 P49736 P35251 P35251 Q86YP4 P27448 Q14677 P47712 Q8IYB3 Q96EI5 Q6ZW31 Q13153 Q13017 Q13017 P23193 Q9UHR4 Q96CB8 Q13595 P62995 Q6GYQ0 Q14181 Q9Y2F5 Q92597 Q8N6T3 Q15648 P49756 Q08J23 P16070 P49756 Q9UQ35 Q13286 Q14669 Q96JM3 Q96JM3 Q9NYF8 Q14966 Q9UQ35 Q8NI08 P61073 P61073 Q9H4G0 Q9NV70

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.31E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.33E-10 1.33E-10 1.33E-10 1.33E-10 1.33E-10 1.34E-10 1.34E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.36E-10 1.36E-10 1.36E-10 1.38E-10 1.38E-10 1.39E-10 1.40E-10 1.40E-10 1.40E-10 1.40E-10 1.40E-10 1.40E-10 1.42E-10 1.42E-10 1.42E-10 1.43E-10 1.44E-10 1.45E-10 1.47E-10 1.47E-10 1.48E-10 1.48E-10 1.51E-10 1.52E-10 1.52E-10 1.53E-10 1.54E-10 1.54E-10 1.55E-10

EP

S141 S102 S101 S717 S713 S442 S1995 S608 S606 S226 S223 S1068 S134 S285 S26 S26 S560 S1262 S11 S566 S563 T173 S297 S608 S691 Y5836 S208 S194 S475 S69 S66 S21 Y44 S107 S106 S103 S395 T914 S144 S105 S120 S499 S368 S864 S2011 T307 S1315 S470 S2005 S5851

AC C

P18858 P05387 P05386 Q8IYB3 Q8IYB3 Q9NZB2 P46100 Q05209 Q05209 Q7Z5K2 Q7Z5K2 Q9UDY2 Q9UGY1 Q8N2M8 P07355 A6NMY6 P12956 P46821 P45973 Q02447 Q02447 Q96D71 Q9NYF8 Q14157 Q96TA1 Q09666 Q5VV41 Q9NV56 Q9UMZ2 Q9H6F5 Q9H6F5 Q14134 Q9NQZ2 O60231 O60231 O60231 Q13506 Q16512 Q13523 O60361 P22392 Q9UQR0 Q9UHB6 Q13127 Q9H4A3 Q01518 Q8WWQ0 Q14157 Q9H4A3 Q09666

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.55E-10 1.55E-10 1.55E-10 1.55E-10 1.55E-10 1.55E-10 1.55E-10 1.56E-10 1.56E-10 1.57E-10 1.57E-10 1.57E-10 1.59E-10 1.59E-10 1.59E-10 1.59E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.61E-10 1.61E-10 1.62E-10 1.62E-10 2.36E-22 5.37E-22 7.51E-22 1.81E-20 2.13E-20 5.27E-20 3.55E-19 4.11E-19 1.02E-18 1.32E-18 1.43E-18 1.79E-18 1.79E-18 1.85E-18 1.89E-18 2.68E-18 5.86E-18 7.30E-18 8.62E-18 9.05E-18 1.34E-17 1.35E-17 1.60E-17

EP

S1479 S162 T8 S13 S14 S12 S150 S1413 S711 S94 S1378 S16 S826 T831 S802 S582 S66 S68 S390 S290 S142 S349 S401 S662 S36 S641 S649 S785 S793 S137 S183 S355 S159 S12 S983 S1156 S467 S144 S234 S235 S657 S2833 S113 S1257 S412 T330 T455 S328 S177 S956

AC C

Q15648 Q9Y6M1 P45973 P45973 P45973 P45973 Q6ZWE6 Q02880 Q9Y597 Q53EL6 Q13428 Q86U86 Q14687 Q14687 Q99590 Q86W92 Q9UJV9 Q9UJV9 P02545 Q8TF01 Q13523 O60716 Q99590 Q9H1B7 P17096 P13807 P13807 P19634 Q9Y597 Q96IF1 Q8IWC1 Q658Y4 Q96AC1 Q9UH99 Q9C0C2 A7E2V4 Q14157 Q9Y2U8 Q14151 Q15424 Q9H501 O75592 O60841 P20020 Q9UQR1 Q8NC44 Q14676 Q9Y608 Q09666 Q5T1M5

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

2.51E-17 2.68E-17 2.81E-17 3.26E-17 4.05E-17 4.22E-17 5.30E-17 5.41E-17 5.67E-17 6.00E-17 6.81E-17 8.67E-17 1.01E-16 1.01E-16 1.04E-16 1.07E-16 1.19E-16 1.27E-16 1.38E-16 1.47E-16 1.48E-16 1.75E-16 1.80E-16 1.96E-16 2.62E-16 2.93E-16 2.96E-16 3.20E-16 3.27E-16 3.32E-16 3.38E-16 3.86E-16 3.99E-16 4.06E-16 4.09E-16 4.22E-16 4.48E-16 4.51E-16 4.82E-16 5.21E-16 6.20E-16 6.92E-16 7.82E-16 7.82E-16 8.01E-16 8.05E-16 8.18E-16 8.27E-16 8.35E-16 8.67E-16

EP

S1556 S642 S196 S430 S244 S439 S446 S2372 S194 S56 S888 S123 S127 S126 S1547 S22 S98 S156 S516 S43 T420 S49 S527 S156 S740 S161 S183 S445 S358 S4396 S716 S77 S709 S2749 S18 S1387 S487 T139 S114 S233 S459 S1275 S497 S1267 S203 S200 S328 Y427 S344 S628

AC C

P18583 O43719 Q15424 Q9UBB4 Q9UDY2 O94887 P15056 Q7Z6Z7 O43237 P08670 P52948 P54725 Q14137 Q14137 Q14160 Q9UHR5 Q13895 Q8IVT2 Q9Y6G9 Q9Y5Q9 P23588 O95400 O94979 P07199 Q9UKJ3 Q6SPF0 O60271 Q8NHM5 P35611 Q15149 Q92738 Q7Z5K2 Q14671 O75592 Q9UHR5 O14646 Q15361 Q8WW12 Q12982 P07910 Q96JM3 Q9UPT8 P23588 Q9BQG0 Q96B36 P15408 P15336 P29353 P82094 Q92625

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

8.72E-16 9.01E-16 1.08E-15 1.10E-15 1.37E-15 1.39E-15 1.43E-15 1.48E-15 1.73E-15 1.81E-15 1.98E-15 1.99E-15 2.04E-15 2.07E-15 2.14E-15 2.26E-15 2.26E-15 2.40E-15 2.43E-15 2.47E-15 2.53E-15 2.57E-15 2.58E-15 2.61E-15 2.67E-15 2.70E-15 2.92E-15 3.06E-15 3.09E-15 3.34E-15 3.38E-15 3.47E-15 3.58E-15 3.81E-15 3.93E-15 3.95E-15 4.02E-15 4.07E-15 4.18E-15 4.37E-15 4.55E-15 4.59E-15 4.76E-15 4.84E-15 4.98E-15 5.34E-15 5.49E-15 5.52E-15 5.63E-15 5.63E-15

EP

S856 T36 S1385 S244 S187 S354 S542 S94 S266 T693 S27 S182 S1666 S135 S310 S750 S749 S661 S64 S133 S367 S1859 S3010 S485 S304 S81 S22 S1298 S592 S118 S240 S567 S1432 S153 S521 S202 S28 S160 S480 S1010 S1084 T1011 S429 S265 S624 S715 S169 S540 S697 S674

AC C

Q13045 P80723 O14646 Q7Z5L9 Q9Y520 Q96K21 Q96QC0 Q9GZR7 Q9Y385 P00533 P29966 Q96GY3 Q9C0C2 Q9UKM9 P53667 Q14147 Q14147 Q86YS7 Q9H3Q1 P29692 P46937 P27708 Q14789 Q8IWZ8 Q05655 Q9H410 Q8NE71 Q92538 Q9Y2X7 P29966 Q7Z5L9 Q5TCZ1 Q96N67 Q16666 Q9C0E2 Q86X95 Q05D32 Q02241 O60583 Q8WWI1 P21333 Q8WWI1 Q13112 Q9UNF1 P52756 P51812 O43598 Q9Y2J4 Q96HA1 A8CG34

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

5.67E-15 5.78E-15 5.78E-15 5.95E-15 6.06E-15 6.08E-15 6.18E-15 6.53E-15 7.25E-15 7.32E-15 7.52E-15 7.63E-15 7.68E-15 7.86E-15 8.83E-15 8.93E-15 9.98E-15 9.99E-15 1.02E-14 1.04E-14 1.09E-14 1.17E-14 1.22E-14 1.30E-14 1.39E-14 1.44E-14 1.46E-14 1.52E-14 1.53E-14 1.57E-14 1.61E-14 1.61E-14 1.62E-14 1.63E-14 1.72E-14 1.86E-14 1.98E-14 2.03E-14 2.06E-14 2.18E-14 2.25E-14 2.26E-14 2.40E-14 2.42E-14 2.49E-14 2.54E-14 2.57E-14 2.80E-14 2.80E-14 2.87E-14

EP

S152 S1621 S1620 S217 S649 S765 T563 S23 S601 S12 T364 S553 S427 S203 S168 S575 S102 S1423 S696 S619 T461 S278 S22 S1166 S20 S567 S727 S14 S440 S465 S332 S14 S468 S315 S365 S283 S306 S592 S1283 S630 S260 S1943 S110 S838 S828 S1155 S473 S326 T327 S362

AC C

Q9Y2D5 Q9C0C2 Q9C0C2 Q7L2J0 Q7Z460 Q8WUA4 Q9Y5B6 P13051 Q86W92 P02545 Q9NQW6 Q9NWH9 O95747 Q8NEF9 Q9BZ23 Q8IVT2 P54105 Q8WWI1 O14497 Q9HBL0 Q14157 Q6IQ49 Q9UBN7 P00533 P49840 Q8WUF5 P42224 O00458 Q13263 Q9BY89 Q66PJ3 Q5SW96 Q96D46 O00273 Q13501 Q12872 Q9Y4H2 Q9NYZ3 Q9NTI5 Q9UJA3 Q9HC77 P35579 Q13425 Q9UKV3 Q14008 Q15648 Q9HCH0 Q15345 Q15345 P35613

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

2.88E-14 2.91E-14 2.92E-14 3.07E-14 3.10E-14 3.15E-14 3.18E-14 3.18E-14 3.18E-14 3.20E-14 3.23E-14 3.24E-14 3.53E-14 3.58E-14 3.67E-14 3.76E-14 3.79E-14 3.82E-14 4.16E-14 4.23E-14 4.29E-14 4.44E-14 4.52E-14 4.54E-14 4.66E-14 4.69E-14 5.00E-14 5.00E-14 5.39E-14 5.42E-14 5.44E-14 5.54E-14 5.59E-14 5.64E-14 5.78E-14 5.78E-14 5.78E-14 5.83E-14 6.01E-14 6.05E-14 6.06E-14 6.15E-14 6.16E-14 6.27E-14 6.28E-14 6.34E-14 6.37E-14 6.41E-14 6.54E-14 6.59E-14

EP

S1348 S928 S596 S732 S1466 S736 S121 S121 S127 S968 S19 S1047 T19 S411 S879 S5110 S1038 S857 S2649 S207 S366 S439 S495 S507 S153 S268 S133 S545 S406 S912 S152 S1991 T1466 S1586 S775 S777 T778 S21 S1468 T1237 S621 S224 S530 S898 S2359 S584 S1017 S100 S97 S470

AC C

Q03468 Q86TC9 Q9Y2X7 P46087 Q02880 Q9H2P0 Q969E4 Q6IPX3 Q5H9L2 Q5VZK9 P10155 P41252 P49840 Q66K14 Q6P2E9 Q09666 Q5TCZ1 Q9Y6Q9 O75592 Q9Y2W1 Q13501 Q13263 P23588 P43007 Q96S55 Q9NYF8 P54725 Q9P206 Q9BTX1 Q02241 Q9Y618 P46100 Q14676 Q8WWI1 Q13111 Q13111 Q13111 Q8IUD2 Q9UIG0 Q8WXG6 Q8N3F8 O75376 Q96EN8 Q9BTC0 O95359 P46013 Q4ADV7 Q96SB3 Q9H910 O15047

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

6.59E-14 7.04E-14 7.04E-14 7.12E-14 7.20E-14 7.20E-14 7.31E-14 7.37E-14 7.38E-14 7.42E-14 7.48E-14 7.60E-14 7.66E-14 7.91E-14 7.92E-14 7.97E-14 7.98E-14 8.00E-14 8.11E-14 8.16E-14 8.50E-14 8.50E-14 8.53E-14 8.68E-14 8.95E-14 9.47E-14 9.57E-14 9.74E-14 9.74E-14 1.01E-13 1.01E-13 1.04E-13 1.06E-13 1.07E-13 1.07E-13 1.08E-13 1.09E-13 1.09E-13 1.09E-13 1.10E-13 1.13E-13 1.13E-13 1.15E-13 1.22E-13 1.23E-13 1.24E-13 1.29E-13 1.30E-13 1.31E-13 1.33E-13

EP

S1062 S209 T437 S856 S1448 S374 S363 S220 S18 S1228 S290 S216 S65 S805 S617 S653 S578 S181 S136 S1605 S1258 S243 S373 S1510 T1989 S109 S201 S1012 S315 S156 S156 S359 S445 S630 T711 S165 S2272 S201 S613 S1992 S558 S557 S212 S181 S611 S442 S421 S988 S101 S1690

AC C

Q12789 Q7Z589 P35658 Q5T5U3 Q14160 Q5VT52 Q15418 Q6L8Q7 O75569 Q13428 P18206 Q9UKV3 Q15154 Q8WWI1 Q5H9R7 Q96RL1 Q86UU1 Q5T4S7 Q8TB72 Q12873 Q63HN8 Q9UFC0 A8CG34 Q8WWI1 P46100 P46937 Q6ZUT6 Q8WWI1 Q5SQI0 P42166 P42167 Q9NQ55 Q96JM3 Q8WVC0 P98174 Q7Z434 Q9UQ35 Q9ULX3 P51532 P46100 Q9Y5B6 Q9Y5B6 Q86WR7 O00264 Q9UKN8 P48651 Q7L7X3 Q8WWI1 P29966 Q9Y5S2

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.33E-13 1.34E-13 1.34E-13 1.36E-13 1.49E-13 1.49E-13 1.51E-13 1.51E-13 1.56E-13 1.57E-13 1.59E-13 1.59E-13 1.66E-13 1.70E-13 1.72E-13 1.72E-13 1.76E-13 1.76E-13 1.79E-13 1.80E-13 1.80E-13 1.80E-13 1.85E-13 1.87E-13 1.92E-13 1.95E-13 1.95E-13 1.97E-13 1.97E-13 2.02E-13 2.02E-13 2.03E-13 2.04E-13 2.08E-13 2.10E-13 2.29E-13 2.32E-13 2.33E-13 2.33E-13 2.38E-13 2.38E-13 2.59E-13 2.60E-13 2.66E-13 2.72E-13 2.74E-13 2.77E-13 2.82E-13 2.82E-13 2.86E-13

EP

S1693 T580 S1156 T389 S539 S4386 T255 S259 S209 S844 S522 S524 S222 S411 S2887 S255 S76 S74 S453 S290 S441 S441 S437 S439 T696 S280 S109 S21 S41 S287 S280 S467 S436 S125 S732 S646 Y598 S3808 T2884 S1174 S1114 S4986 S99 T2024 S762 S202 S991 S177 S1247 S203

AC C

Q9Y5S2 Q86UU1 Q15648 Q6PJT7 Q9Y4E1 Q15149 P17275 P17275 Q14244 Q8WY36 Q5VTR2 Q5VTR2 Q9NYF8 Q8IY17 Q7Z6Z7 Q9UBC2 Q96C19 Q96C19 Q8IU81 O14745 Q641Q2 Q9Y4E1 Q9BVJ6 O43318 O14974 O14757 Q8WXX5 O43399 Q13439 Q12857 Q12857 P53985 Q8IU81 Q8N8S7 O60271 Q96TA1 Q9Y2X7 Q7Z6Z7 Q5T4S7 Q9Y4H2 Q12888 Q09666 Q96SB3 E9PAV3 Q14566 Q6WKZ4 Q8WWI1 Q9NYF8 P11388 Q9H0H5

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

2.87E-13 3.02E-13 3.13E-13 3.15E-13 3.18E-13 3.29E-13 3.30E-13 3.36E-13 3.37E-13 3.50E-13 3.52E-13 3.60E-13 3.65E-13 3.67E-13 3.72E-13 3.79E-13 3.84E-13 4.11E-13 4.21E-13 4.27E-13 4.31E-13 4.35E-13 4.62E-13 4.67E-13 4.75E-13 4.77E-13 4.83E-13 4.85E-13 5.02E-13 5.15E-13 5.22E-13 5.27E-13 5.40E-13 5.44E-13 5.56E-13 5.57E-13 5.67E-13 5.70E-13 5.71E-13 5.82E-13 5.97E-13 5.98E-13 6.04E-13 6.11E-13 6.45E-13 6.59E-13 6.66E-13 6.70E-13 7.00E-13 7.11E-13

EP

S1040 S332 S112 S1222 T211 S225 S114 T646 S692 S1759 T1147 S380 S1233 S143 S315 S225 S315 S316 S520 S214 S833 S26 S210 S1080 T828 S1179 S218 S487 S738 S1063 S370 S289 S21 S1113 S227 S601 S1195 S1126 S407 S22 S425 S1783 S557 S3467 S314 S143 S2559 S817 S1837 S166

AC C

Q9BTC0 Q13501 Q7Z417 Q96T58 O15173 O75643 Q9P035 O15439 Q9UHB6 Q12888 Q14004 Q9C0B5 Q9UQ35 Q12792 Q9H788 P22626 Q9NZT2 P98082 O00567 Q5VUA4 O60524 Q6Y7W6 Q9UBB9 Q5JTH9 Q7Z3B3 Q9NRY4 Q9Y6D5 Q8WUI4 Q9H2P0 Q12789 A8CG34 P46937 Q6IQ22 Q12888 Q9Y6D5 Q9C0C2 Q13017 Q12774 P02545 P02545 Q7Z3K3 Q8WWQ0 O95453 O75592 P67809 Q5JTV8 Q9P2D1 Q9H7F0 Q03164 Q13765

M AN U

SC

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

7.14E-13 7.19E-13 7.27E-13 7.32E-13 7.32E-13 7.33E-13 7.63E-13 7.86E-13 7.92E-13 8.13E-13 8.20E-13 8.28E-13 8.32E-13 8.34E-13 8.60E-13 8.70E-13 8.71E-13 9.05E-13 9.08E-13 9.24E-13 9.32E-13 9.39E-13 9.89E-13 1.01E-12 1.02E-12 1.05E-12 1.06E-12 1.07E-12 1.08E-12 1.08E-12 1.10E-12 1.10E-12 1.13E-12 1.17E-12 1.21E-12 1.21E-12 1.21E-12 1.21E-12 1.23E-12 1.24E-12 1.24E-12 1.24E-12 1.26E-12 1.27E-12 1.29E-12 1.29E-12 1.34E-12 1.35E-12 1.36E-12 1.36E-12

EP

S22 S176 T110 S759 S230 S230 S185 S466 S758 S334 S434 T15 S1920 S2273 S641 S75 S214 T1885 S15 S155 S292 S236 S121 T796 S686 S332 S362 T165 S600 S31 S326 S212 S5763 S231 S1096 S215 S277 S278 S548 S503 S174 S176 S703 S445 S1644 S481 S21 S260 S161 S207

AC C

Q9BRS2 P55327 P46937 Q66K74 Q96B97 O60716 Q1KMD3 O60825 O75152 P49790 Q8TBZ3 P43487 P24928 Q63HN8 P35221 Q56NI9 Q9Y6Q9 Q13315 P04792 Q8IX90 Q6WCQ1 Q96G46 Q9Y5J1 Q86VM9 Q9UHB6 P78310 Q92597 Q1KMD3 Q7Z460 Q9NWW5 Q8ND76 Q96B36 Q09666 P07900 Q14C86 Q9Y618 Q96RK0 Q96RK0 Q9H7N4 Q9BY44 P67809 P67809 Q9UHB7 Q8NB49 Q9NQT8 Q8IZL8 Q96GN5 Q8IYB3 Q1KMD3 Q9Y6G9

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.37E-12 1.38E-12 1.39E-12 1.39E-12 1.39E-12 1.40E-12 1.41E-12 1.41E-12 1.43E-12 1.45E-12 1.45E-12 1.45E-12 1.47E-12 1.47E-12 1.49E-12 1.50E-12 1.51E-12 1.53E-12 1.62E-12 1.63E-12 1.63E-12 1.65E-12 1.66E-12 1.69E-12 1.70E-12 1.70E-12 1.71E-12 1.71E-12 1.71E-12 1.73E-12 1.75E-12 1.76E-12 1.76E-12 1.76E-12 1.81E-12 1.81E-12 1.84E-12 1.85E-12 1.90E-12 1.90E-12 1.90E-12 1.91E-12 1.94E-12 1.94E-12 1.98E-12 1.98E-12 2.02E-12 2.07E-12 2.11E-12 2.11E-12

EP

S139 S827 S224 S220 S329 S522 S226 S51 S196 S60 S118 S118 S448 T445 S733 S339 S557 S21 S231 S547 S229 S168 S1333 S244 Y114 S261 S90 S458 S929 S230 S425 S500 S498 S563 S144 S316 S199 S456 S97 S214 S131 S964 S307 S303 S1939 S137 S490 S494 S426 S120

AC C

P49736 Q7Z3B3 Q6WCQ1 Q6WCQ1 P21731 Q13330 A0JLT2 Q9ULG1 Q8IWE2 O00505 P18669 Q8N0Y7 Q9NPF5 Q9NPF5 O60271 P08651 Q9NPH3 Q6R327 Q13283 Q5TCZ1 Q13033 Q8TBN0 Q15021 Q16204 O95218 Q9NZ63 O15173 P02545 Q9P206 P15408 Q96GM8 Q9H7N4 Q9H7N4 P19338 Q53GA4 Q3B726 Q04323 Q9H4M9 Q96NY9 O60841 Q9NXV6 Q14676 Q9Y2I7 Q00613 O14578 P52701 Q9UKV3 Q9HCH0 Q2TB10 Q13105

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

2.11E-12 2.22E-12 2.22E-12 2.23E-12 2.27E-12 2.27E-12 2.29E-12 2.29E-12 2.31E-12 2.32E-12 2.33E-12 2.35E-12 2.35E-12 2.36E-12 2.36E-12 2.36E-12 2.40E-12 2.41E-12 2.42E-12 2.42E-12 2.49E-12 2.52E-12 2.53E-12 2.53E-12 2.57E-12 2.72E-12 2.73E-12 2.74E-12 2.74E-12 2.76E-12 2.76E-12 2.78E-12 2.84E-12 2.87E-12 2.88E-12 2.91E-12 2.92E-12 2.94E-12 3.01E-12 3.03E-12 3.04E-12 3.04E-12 3.08E-12 3.14E-12 3.20E-12 3.27E-12 3.31E-12 3.32E-12 3.36E-12 3.40E-12

EP

S294 S1330 S2449 S258 S51 S35 S51 S53 S878 S48 S480 S120 S717 S675 T521 S2029 S1193 S765 S354 S12 T207 T1101 T13 S14 S111 S420 S782 S100 S483 S608 S836 S85 S40 S230 S174 S916 S2065 S455 S320 S171 S677 S16 S1712 S902 S467 S546 S17 T106 S30 S393

AC C

Q96T37 Q15021 Q9UQ35 P05787 P18615 Q8TAD8 Q96MH2 Q96MH2 Q96HP0 Q9UKT5 Q9NR09 Q9BVV8 P10636 Q9H2J7 P27816 E9PAV3 P20020 Q96EV2 Q86WB0 P35611 P27361 Q13464 P43487 P43487 Q96HC4 Q96PE2 Q8TDD1 Q9H307 P42568 Q99590 Q9C0C2 P55884 Q96BD0 Q13283 Q5VV41 Q16512 Q9Y618 P53396 Q9Y2W1 Q8N9T8 P49756 Q13200 Q5T5U3 Q14C86 Q9UMZ2 Q01804 P53999 Q8NFH5 A2RU67 Q13547

M AN U

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RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

3.44E-12 3.48E-12 3.57E-12 3.62E-12 3.65E-12 3.66E-12 3.67E-12 3.75E-12 3.82E-12 3.84E-12 3.84E-12 3.84E-12 3.86E-12 3.99E-12 4.00E-12 4.05E-12 4.06E-12 4.11E-12 4.16E-12 4.25E-12 4.25E-12 4.25E-12 4.26E-12 4.30E-12 4.37E-12 4.47E-12 4.52E-12 4.57E-12 4.60E-12 4.63E-12 4.66E-12 4.67E-12 4.68E-12 4.69E-12 4.71E-12 4.71E-12 4.76E-12 4.81E-12 4.81E-12 4.81E-12 4.94E-12 4.97E-12 4.98E-12 4.98E-12 5.02E-12 5.05E-12 5.06E-12 5.08E-12 5.11E-12 5.12E-12

EP

S314 S292 S663 S2484 S443 S320 S121 S471 S874 S619 T19 T19 S269 S47 S181 S674 T674 T200 S868 S2398 S516 S2501 S397 S2068 S46 S996 S143 S70 S352 S1345 S66 S351 S1380 S119 T96 T97 S181 S294 S414 S744 S221 S156 S344 S1057 S41 S626 S268 S338 S190 S415

AC C

Q99569 Q96T37 Q9H501 P11717 Q9H307 O60716 Q9NR30 P48681 Q8IYB3 P19338 P07355 A6NMY6 O75128 Q9H6F5 Q9NZI8 Q8WWQ0 P25205 Q8NEY8 O75717 Q9UQ35 P10636 Q8NFC6 Q96BT3 Q9Y618 Q96TC7 O95785 Q8NEJ9 P10809 Q9UK58 Q96T23 Q9H307 Q96NB3 P51532 P55884 Q9HB90 Q9NQL2 Q96AC1 Q53SF7 Q9UHR4 Q8TEW8 Q7Z5K2 O95292 Q15942 Q8N1G0 Q9NTJ3 Q92625 O60716 Q86WB0 Q12906 Q9UER7

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

5.14E-12 5.18E-12 5.22E-12 5.26E-12 5.28E-12 5.30E-12 5.33E-12 5.33E-12 5.45E-12 5.46E-12 5.52E-12 5.59E-12 5.61E-12 5.66E-12 5.68E-12 5.70E-12 5.72E-12 5.83E-12 5.84E-12 5.88E-12 5.89E-12 5.89E-12 5.90E-12 5.93E-12 5.93E-12 5.95E-12 5.98E-12 6.01E-12 6.06E-12 6.07E-12 6.11E-12 6.17E-12 6.20E-12 6.21E-12 6.25E-12 6.25E-12 6.30E-12 6.31E-12 6.33E-12 6.34E-12 6.38E-12 6.40E-12 6.58E-12 6.59E-12 6.61E-12 6.61E-12 6.61E-12 6.61E-12 6.61E-12 6.74E-12

EP

S384 S1017 S180 S527 S323 S1138 S691 S693 S3205 S333 T2645 S312 S176 S366 S337 S662 S738 S331 S298 S868 S75 S79 S713 S33 S205 S930 S436 S893 S1377 S210 S367 S113 S347 S494 T510 S242 S462 S60 S37 S594 T514 T3716 S170 S564 S48 S48 S48 S48 S48 S727

AC C

Q8IU81 O95785 P0C1Z6 O60318 O75674 Q9C0C2 A0FGR8 A0FGR8 P78527 Q9H6Z4 O75592 O00273 Q96CX2 P20810 Q99569 O14523 Q9ULW0 O00499 O00499 Q8TD19 Q9H1E3 Q9H1E3 P10636 O95674 P80723 Q9BX63 Q86VR2 Q8WX93 P11388 Q9UKV3 P49768 Q15185 P50750 O60832 Q8N1G4 P49916 Q9BZZ5 O95361 P14618 Q8WWM7 Q86V48 Q09666 O75367 Q9C0I1 Q71U36 P68363 Q6PEY2 Q9BQE3 Q13748 P13807

M AN U

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RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

6.77E-12 6.78E-12 6.83E-12 6.92E-12 6.92E-12 6.97E-12 6.99E-12 7.06E-12 7.15E-12 7.15E-12 7.23E-12 7.33E-12 7.40E-12 7.41E-12 7.43E-12 7.43E-12 7.48E-12 7.54E-12 7.57E-12 7.73E-12 7.80E-12 7.80E-12 7.84E-12 7.94E-12 7.98E-12 8.00E-12 8.05E-12 8.07E-12 8.16E-12 8.16E-12 8.27E-12 8.33E-12 8.36E-12 8.38E-12 8.39E-12 8.50E-12 8.54E-12 8.63E-12 8.80E-12 8.93E-12 9.04E-12 9.08E-12 9.08E-12 9.16E-12 9.20E-12 9.28E-12 9.28E-12 9.28E-12 9.28E-12 9.28E-12

EP

S21 S15 S1217 S299 S298 T75 S1006 S21 S286 S1156 T701 S30 T196 S554 S410 S495 T9 S200 S713 T1845 S2209 S2211 S162 S56 T918 S970 S395 S62 S361 T503 S21 S854 T202 S1003 S25 S267 S48 S328 S96 S593 S1697 S187 S256 S138 S254 T160 S158 S159 T160 S159

AC C

Q9UJV9 P53999 Q13813 Q4G0J3 Q4G0J3 Q3MHD2 O43314 Q96CP2 Q04726 O43432 A0FGR8 Q15311 P80723 P27824 Q13112 Q9UER7 Q86U86 Q04323 Q12873 Q03164 P46821 P46821 Q5JSH3 Q9Y5S9 Q9BX63 Q6PD62 Q8IVT2 P52292 O76021 Q9UQR0 Q9BRS2 Q9UPP1 P27361 Q9ULJ3 Q53F19 Q8TF74 O76080 O00712 Q5JSH3 Q5VT52 P18583 P05549 Q15477 Q5VTR2 Q86TC9 P42167 P42166 P42166 P42166 P42167

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

9.28E-12 9.32E-12 9.35E-12 9.54E-12 9.59E-12 9.64E-12 9.67E-12 9.67E-12 9.67E-12 9.67E-12 9.71E-12 9.76E-12 9.80E-12 9.81E-12 9.95E-12 1.01E-11 1.01E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.04E-11 1.04E-11 1.04E-11 1.05E-11 1.05E-11 1.06E-11 1.07E-11 1.08E-11 1.08E-11 1.08E-11 1.08E-11 1.08E-11 1.09E-11 1.11E-11 1.12E-11 1.12E-11 1.13E-11 1.15E-11 1.15E-11 1.16E-11 1.17E-11 1.17E-11 1.17E-11 1.17E-11 1.18E-11 1.19E-11 1.19E-11 1.20E-11

EP

S158 S301 S164 S312 S362 S401 S438 S440 S555 S556 Y187 S1438 S340 S64 S201 S425 T417 S7 S52 S27 S137 S1443 S1241 S435 S790 S400 S130 S559 S2102 S1106 T1101 T49 S141 S38 S628 T390 S123 S897 S329 S2105 S116 T251 S526 S199 S104 S104 S334 S752 T2000 S1459

AC C

P42167 P04049 P80723 Q9H8G2 Q9UHB6 P98082 Q96ST2 Q96ST2 Q9NPH3 Q9NPH3 P28482 P46821 O75909 P13051 Q8NEY8 Q96IG2 Q96IG2 Q01105 P30086 Q6IAA8 O75396 P46821 Q9BQG0 Q66K14 Q4LE39 Q96ST2 Q9UDY2 Q8WWM7 Q01082 Q6BDS2 Q6BDS2 Q13620 Q5QJE6 P16949 Q8N9T8 P49841 Q01664 P29317 Q8ND30 Q9Y520 P55081 Q86TC9 O95365 Q6WKZ4 P31943 P55795 Q86SQ0 Q9UMZ2 Q14980 P21333

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.20E-11 1.21E-11 1.22E-11 1.22E-11 1.23E-11 1.24E-11 1.25E-11 1.27E-11 1.27E-11 1.29E-11 1.31E-11 1.32E-11 1.32E-11 1.33E-11 1.33E-11 1.34E-11 1.34E-11 1.34E-11 1.34E-11 1.35E-11 1.35E-11 1.37E-11 1.40E-11 1.41E-11 1.42E-11 1.46E-11 1.46E-11 1.46E-11 1.48E-11 1.48E-11 1.49E-11 1.49E-11 1.50E-11 1.51E-11 1.52E-11 1.53E-11 1.54E-11 1.54E-11 1.55E-11 1.56E-11 1.59E-11 1.60E-11 1.61E-11 1.64E-11 1.64E-11 1.65E-11 1.66E-11 1.66E-11 1.66E-11 1.68E-11

EP

S720 S504 S39 S39 S143 S374 T724 S1179 S221 S282 T2289 T440 S433 S29 S303 S62 S67 T203 S325 S214 S116 S67 S71 S233 T86 S631 S157 S156 S351 S266 S1220 S341 S234 S119 S2317 T161 S338 S1579 S3816 T5 S117 S27 S173 S265 T263 S490 T25 S114 S111 S89

AC C

Q86X10 P23588 B5ME19 Q99613 P26358 Q9UHB6 P46100 Q9UQ35 Q9UKX7 Q96JM3 Q9UQ35 Q86VR2 Q86VR2 Q13085 Q13247 P56211 O43768 Q8N684 Q14678 Q9H1E3 P98174 P46087 P35251 Q13428 Q15029 P42684 Q5JTV8 Q5JTV8 P22059 P18887 Q14160 Q6WKZ4 Q9H7L9 O14737 O95359 Q13765 P49790 Q69YN4 Q7Z6Z7 Q9BQA1 Q9BVV8 Q9NTJ3 O75367 Q5T200 Q5T200 Q9UHB6 Q16637 Q5T3F8 Q5T3F8 P98175

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.68E-11 1.71E-11 1.71E-11 1.74E-11 1.76E-11 1.78E-11 1.84E-11 1.85E-11 1.86E-11 1.86E-11 1.91E-11 1.91E-11 1.93E-11 2.00E-11 2.00E-11 2.01E-11 2.02E-11 2.03E-11 2.03E-11 2.03E-11 2.04E-11 2.07E-11 2.08E-11 2.08E-11 2.08E-11 2.08E-11 2.12E-11 2.13E-11 2.15E-11 2.15E-11 2.18E-11 2.18E-11 2.20E-11 2.20E-11 2.20E-11 2.20E-11 2.21E-11 2.22E-11 2.24E-11 2.25E-11 2.27E-11 2.28E-11 2.28E-11 2.28E-11 2.32E-11 2.33E-11 2.33E-11 2.35E-11 2.36E-11 2.37E-11

EP

T925 S1456 T227 S778 S431 S100 S64 S286 S333 S457 S214 S66 S506 S292 S531 S159 S678 S58 S61 S857 S226 S575 S335 S2032 S47 S48 S5731 T174 S662 S85 S354 S80 S132 S134 S492 S1002 S742 S641 S26 S1601 S271 S420 S416 S1586 S454 S1103 S43 S259 S50 S415

AC C

Q9UDY2 Q9BTC0 Q9UN86 Q8N4C8 O14639 Q9BW71 O75496 Q96JM3 P08651 Q7Z5L9 Q9P0L0 Q96B23 Q9BY44 Q04727 Q6VY07 Q92733 P35658 Q9H1E3 Q9H1E3 Q9UPP1 P08238 Q9Y2W1 Q5VSL9 Q9H4A3 Q9ULG1 Q9ULG1 Q09666 O75367 Q86XL3 P49023 Q9NZL4 P51608 Q9Y2K6 Q9Y2K6 Q6UN15 Q12965 Q6PJG6 Q96TA1 Q92466 Q12873 Q9BRD0 P85037 P85037 O75592 Q14157 Q9UQ35 Q9UHR5 Q15942 Q86U44 O14545

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

2.37E-11 2.37E-11 2.37E-11 2.38E-11 2.39E-11 2.40E-11 2.41E-11 2.42E-11 2.42E-11 2.43E-11 2.43E-11 2.43E-11 2.43E-11 2.43E-11 2.44E-11 2.44E-11 2.47E-11 2.47E-11 2.49E-11 2.50E-11 2.55E-11 2.56E-11 2.57E-11 2.57E-11 2.58E-11 2.58E-11 2.59E-11 2.62E-11 2.62E-11 2.62E-11 2.64E-11 2.67E-11 2.67E-11 2.68E-11 2.70E-11 2.70E-11 2.71E-11 2.72E-11 2.74E-11 2.76E-11 2.78E-11 2.80E-11 2.80E-11 2.81E-11 2.81E-11 2.82E-11 2.82E-11 2.82E-11 2.83E-11 2.83E-11

EP

S17 S295 S165 S197 S2044 S1203 S512 T163 T1438 S179 S178 S180 S448 S718 S77 S312 S211 S701 S1024 S248 S355 S473 S95 S979 S402 S364 S304 T366 S367 S208 S369 S2029 S2027 S212 S93 S2401 S415 S195 S828 S2101 S141 S67 T333 S52 S53 S2047 S18 S2016 T199 S229

AC C

Q96QD8 O00712 P67809 Q8TEA8 O75179 Q9ULD2 Q9NYF8 Q5JSH3 P25054 Q9UHB7 Q9UHB7 Q9UHB7 Q9H0D6 P40818 Q9NWB6 Q9NQS7 Q8TF01 O43150 Q01804 Q9BUA3 Q09028 Q13263 Q13425 Q9P206 Q99590 O60502 P17706 Q92597 Q92597 O15173 Q9UHB6 Q9H4A3 Q9H4A3 Q9UFC0 Q9GZR7 O75179 Q9Y5T5 O95400 Q7Z3C6 Q5VUA4 Q53GA4 Q96B23 Q8TD19 P55081 P55081 Q9UPU5 Q9H6F5 Q9Y618 Q8IWE2 Q96P48

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

2.84E-11 2.86E-11 2.87E-11 2.88E-11 2.89E-11 2.92E-11 2.92E-11 2.95E-11 2.95E-11 2.97E-11 2.97E-11 2.97E-11 2.97E-11 2.99E-11 2.99E-11 3.00E-11 3.00E-11 3.01E-11 3.01E-11 3.03E-11 3.05E-11 3.05E-11 3.08E-11 3.11E-11 3.11E-11 3.11E-11 3.13E-11 3.14E-11 3.15E-11 3.15E-11 3.16E-11 3.22E-11 3.25E-11 3.27E-11 3.27E-11 3.29E-11 3.30E-11 3.30E-11 3.33E-11 3.33E-11 3.35E-11 3.35E-11 3.38E-11 3.38E-11 3.38E-11 3.38E-11 3.41E-11 3.42E-11 3.45E-11 3.47E-11

EP

S308 S25 S761 S135 T25 S334 S333 S996 T762 S532 S536 S155 S1303 S242 S1166 T50 S51 S105 S1381 S1965 S163 S135 S786 S955 S630 S1377 S1779 S282 S461 T447 T186 S583 T227 S18 S218 S83 S2132 S69 S1709 S1717 S445 S181 S822 S823 S817 T819 T1156 S518 S245 T220

AC C

Q01518 Q13085 O75152 Q09666 O75167 Q8WXI9 Q8WXI9 Q6PJG2 O75152 Q9Y2L9 Q9Y2L9 Q96I25 O60293 Q5T200 Q9NTI5 P36915 P36915 P20042 Q9HBL0 P46821 Q9Y2U5 O60841 P46087 P49792 Q96AE4 P51531 P46821 Q96EZ8 Q6PJG2 O15231 Q8IWC1 P27824 O75533 Q96QD8 Q6WCQ1 Q9H5H4 Q9UQ35 P35251 Q5SRE5 Q5SRE5 P85037 P52594 Q8IWX8 Q8IWX8 Q8IWX8 Q8IWX8 P49792 Q03164 O95425 Q8IYB3

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

3.48E-11 3.49E-11 3.53E-11 3.54E-11 3.56E-11 3.56E-11 3.57E-11 3.59E-11 3.68E-11 3.69E-11 3.69E-11 3.69E-11 3.77E-11 3.77E-11 3.78E-11 3.78E-11 3.79E-11 3.81E-11 3.82E-11 3.83E-11 3.84E-11 3.86E-11 3.86E-11 3.86E-11 3.89E-11 3.92E-11 3.95E-11 3.96E-11 3.98E-11 4.00E-11 4.01E-11 4.02E-11 4.02E-11 4.03E-11 4.06E-11 4.07E-11 4.07E-11 4.09E-11 4.10E-11 4.13E-11 4.13E-11 4.13E-11 4.14E-11 4.18E-11 4.18E-11 4.18E-11 4.19E-11 4.20E-11 4.21E-11 4.23E-11

EP

S253 S5752 S464 S1858 S616 S466 S1086 S543 T329 S241 S119 S227 S2409 S659 S324 S898 S904 S396 S47 S609 S1834 S247 S427 S296 S1780 S93 T4100 S95 T933 S107 S738 T654 S657 T888 S425 S295 T302 S49 S886 T404 S6 S515 T285 T925 S307 S1075 S83 S30 S799 S434

AC C

P05787 Q09666 Q6GQQ9 Q03164 Q13586 Q9BWU0 Q14676 Q9ULH7 Q9H330 P18887 P29692 P52701 P11717 Q86V48 Q9H2K8 Q96N67 Q15811 Q96HA1 Q9UPN4 Q14157 Q9H7D0 Q9H3N1 O76021 Q99460 Q92538 Q15154 Q09666 O15258 Q9UDY2 Q86YP4 P98175 Q58WW2 Q58WW2 P07814 Q8IZT6 Q9GZR7 Q9GZR7 Q8TAD8 P07814 Q14676 Q96AY2 P40222 O95817 Q6PD62 Q00613 Q9UMZ2 P10644 Q6Y7W6 O94979 Q9ULJ3

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

4.23E-11 4.25E-11 4.25E-11 4.25E-11 4.28E-11 4.28E-11 4.28E-11 4.28E-11 4.32E-11 4.32E-11 4.32E-11 4.33E-11 4.39E-11 4.44E-11 4.46E-11 4.46E-11 4.46E-11 4.46E-11 4.46E-11 4.50E-11 4.50E-11 4.52E-11 4.53E-11 4.53E-11 4.53E-11 4.55E-11 4.55E-11 4.56E-11 4.57E-11 4.62E-11 4.62E-11 4.65E-11 4.75E-11 4.75E-11 4.84E-11 4.96E-11 5.01E-11 5.01E-11 5.01E-11 5.03E-11 5.03E-11 5.04E-11 5.04E-11 5.05E-11 5.11E-11 5.12E-11 5.13E-11 5.15E-11 5.15E-11 5.21E-11

EP

T431 S597 S1093 S1094 S1472 S1522 S1524 S1526 S171 S163 S114 S280 T470 S1265 S167 S84 S237 S102 Y73 S137 T275 S18 S1099 S166 S1374 S158 S29 S323 S132 T598 S615 S162 T1521 S1518 S239 S587 S284 S1004 S681 S57 S694 S1231 S302 S175 S281 S42 T60 S271 S691 S82

AC C

Q9ULJ3 Q8IYB3 Q5VZK9 Q5VZK9 O75376 Q02880 Q02880 Q02880 O00566 O00566 Q86YP4 O94888 Q96D46 P46821 O00566 O15541 Q9H7L9 O75351 Q15029 O60841 O75410 Q07666 Q5VT52 Q9NQG5 Q7Z5J4 O95292 Q15311 Q63ZY3 Q9UHB6 P51116 Q9Y6X9 P29692 O43149 O43149 O95671 Q96B97 Q6IBW4 Q9UKV3 Q8N163 O00264 Q9C0B5 Q04637 O94875 Q63ZY3 O43572 Q92917 P13051 Q5PRF9 Q12996 Q9GZR7

M AN U

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

5.21E-11 5.21E-11 5.22E-11 5.22E-11 5.22E-11 5.23E-11 5.23E-11 5.23E-11 5.25E-11 5.28E-11 5.28E-11 5.29E-11 5.31E-11 5.32E-11 5.35E-11 5.35E-11 5.36E-11 5.36E-11 5.37E-11 5.38E-11 5.39E-11 5.39E-11 5.45E-11 5.46E-11 5.46E-11 5.50E-11 5.54E-11 5.56E-11 5.60E-11 5.60E-11 5.63E-11 5.66E-11 5.69E-11 5.69E-11 5.70E-11 5.72E-11 5.73E-11 5.73E-11 5.74E-11 5.77E-11 5.78E-11 5.78E-11 5.80E-11 5.82E-11 5.82E-11 5.83E-11 5.87E-11 5.89E-11 5.89E-11 5.89E-11

EP

S660 S210 S397 S80 S435 S874 S316 T310 S738 S50 S232 S2151 S2567 S695 S166 S7 S499 S501 S194 S601 S498 S499 Y256 T453 S447 S1905 S334 S40 T270 S2229 S458 S212 S682 S280 S329 S292 S282 S766 S418 S27 T128 S185 S30 S646 S89 S83 S122 S30 S132 S133

AC C

Q68CZ2 Q9Y5J1 Q8IVT2 Q9Y3X0 O94776 Q9H7N4 Q9NY61 Q9NY61 Q5T5Y3 Q96AT1 Q13573 O75376 O95359 Q8IYB3 O60341 Q96AY2 Q9H0D6 Q9H0D6 Q9NQX3 P51116 Q8TCJ2 Q8TCJ2 O00401 P18887 P18887 O15027 Q9UGV2 Q5VUA4 O75475 Q9BV73 Q96NT5 Q7Z417 Q9Y2W1 P27816 O75909 Q03111 Q6IBW4 Q32MZ4 Q14247 P49736 O95251 Q86XP3 O75379 Q7Z460 P05114 Q96JP5 Q5VZL5 Q9UHD8 P51858 P51858

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

5.93E-11 5.93E-11 5.96E-11 5.96E-11 5.99E-11 5.99E-11 5.99E-11 6.01E-11 6.03E-11 6.03E-11 6.09E-11 6.12E-11 6.12E-11 6.14E-11 6.15E-11 6.16E-11 6.17E-11 6.17E-11 6.18E-11 6.18E-11 6.19E-11 6.22E-11 6.23E-11 6.27E-11 6.27E-11 6.31E-11 6.40E-11 6.46E-11 6.46E-11 6.47E-11 6.49E-11 6.49E-11 6.49E-11 6.50E-11 6.51E-11 6.52E-11 6.52E-11 6.53E-11 6.54E-11 6.57E-11 6.58E-11 6.70E-11 6.70E-11 6.72E-11 6.79E-11 6.81E-11 6.81E-11 6.81E-11 6.81E-11 6.83E-11

EP

S370 S1230 S528 S529 T872 S1032 S1035 S764 S41 S161 S1304 S17 S453 S781 T25 S525 S404 S406 S459 S2569 T285 S379 S335 S544 S545 S146 S77 S291 S293 S738 S2280 S1305 S1106 S33 S752 S675 S678 S298 S644 S107 S601 S1021 S145 S773 S226 S440 S437 S436 S435 S183

AC C

O75122 Q2KHR3 Q6VY07 Q6VY07 Q8IYB3 Q9UMN6 Q9UMN6 Q6NWY9 Q9Y2V2 Q5JSH3 O60293 P39687 O15231 Q8IYB3 Q96A57 Q9NPI6 P02545 P02545 P11274 O95359 Q02952 P12270 Q9UGV2 O60504 O60504 Q9HC35 Q9Y4B5 P29803 P08559 Q8IYB3 P49792 Q7Z3J3 P11388 A2RU67 P21127 Q8N163 Q8N163 Q9BTE3 Q86TC9 Q5VV41 Q92615 Q9UPP1 P29966 Q8IYB3 Q9UPQ0 Q9UQ35 Q9UQ35 Q9UQ35 Q9UQ35 Q9NYF8

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

6.85E-11 6.86E-11 6.86E-11 6.89E-11 6.94E-11 6.94E-11 6.95E-11 6.96E-11 6.98E-11 6.98E-11 7.00E-11 7.01E-11 7.06E-11 7.07E-11 7.07E-11 7.10E-11 7.18E-11 7.19E-11 7.19E-11 7.23E-11 7.28E-11 7.30E-11 7.31E-11 7.32E-11 7.34E-11 7.42E-11 7.43E-11 7.45E-11 7.51E-11 7.52E-11 7.53E-11 7.55E-11 7.55E-11 7.55E-11 7.55E-11 7.56E-11 7.58E-11 7.59E-11 7.61E-11 7.65E-11 7.65E-11 7.67E-11 7.68E-11 7.68E-11 7.72E-11 7.72E-11 7.73E-11 7.73E-11 7.77E-11 7.80E-11

EP

S151 S333 S31 S216 S766 S774 S694 S1300 T90 S218 S636 T219 S731 T111 S241 S2155 Y67 S237 S1784 S62 S63 S779 S90 S853 T899 S394 S172 S51 S484 S479 T469 S109 S105 T108 S461 S347 S75 S245 S63 S297 S295 S643 S187 S740 S405 T399 S240 S243 T358 S208

AC C

Q9BWH2 Q9UGV2 Q16637 Q13242 Q6PKG0 Q6PKG0 Q8IYB3 Q14160 Q9UKI2 Q15019 P02545 Q9BU76 P46100 Q8WUZ0 Q9UNX4 P12270 P06748 Q9BTK6 Q92538 A2RU67 Q9C086 Q7LBC6 Q6PKG0 Q7Z4S6 Q9HC35 Q8IVT2 Q63ZY3 Q99549 Q8NFC6 Q9H6S3 Q9H6S3 Q8NE71 Q8NE71 Q8NE71 Q86UU1 Q01831 Q6PKG0 Q14684 Q13442 Q9UQ35 Q9UQ35 Q6AI08 Q96CX2 Q9UQ88 Q14247 Q14247 Q9UKV3 Q9UKV3 O76021 Q9UKV3

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ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

7.80E-11 7.80E-11 7.85E-11 7.88E-11 7.95E-11 7.95E-11 7.98E-11 8.00E-11 8.00E-11 8.09E-11 8.12E-11 8.13E-11 8.14E-11 8.15E-11 8.18E-11 8.21E-11 8.27E-11 8.27E-11 8.31E-11 8.31E-11 8.33E-11 8.34E-11 8.35E-11 8.36E-11 8.36E-11 8.36E-11 8.41E-11 8.42E-11 8.45E-11 8.45E-11 8.45E-11 8.45E-11 8.45E-11 8.48E-11 8.51E-11 8.52E-11 8.54E-11 8.54E-11 8.60E-11 8.63E-11 8.66E-11 8.71E-11 8.73E-11 8.74E-11 8.79E-11 8.79E-11 8.82E-11 8.85E-11 8.87E-11 8.88E-11

EP

S52 S1073 S100 S78 S328 S330 S3527 S388 Y389 S144 S559 S311 S17 S269 S471 S203 S659 S662 S758 S755 T118 S1160 S854 S181 S393 S330 S113 S23 S1320 T1319 S284 S284 S877 S1370 S193 T753 S1797 S360 S247 S135 S45 S920 S210 S402 S332 S333 S571 S85 S692 S53

AC C

Q8TAD8 P27816 P23193 O95155 Q92922 Q92922 Q03164 Q5T0W9 Q5T0W9 Q9HC35 Q6VMQ6 Q8N5Y2 O00193 Q9UJU6 Q8IVT2 Q9H8G2 Q86YS7 Q86YS7 A0FGR8 A0FGR8 Q96T60 P49792 Q9UQ35 Q9H1E3 Q13425 Q8NC51 P46379 Q9UJV9 Q12888 Q12888 Q641Q2 Q9Y4E1 Q8N122 Q9H2Y7 P22059 A0FGR8 P46821 Q7Z5L9 P25490 Q8WXI9 Q8TAP8 Q9UDY2 Q09666 Q14676 O00712 O00712 P17812 Q9BUR4 Q8TEW0 O43818

M AN U

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RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

8.88E-11 8.88E-11 8.88E-11 8.88E-11 8.90E-11 8.95E-11 8.96E-11 8.96E-11 8.99E-11 9.03E-11 9.05E-11 9.12E-11 9.12E-11 9.13E-11 9.15E-11 9.17E-11 9.21E-11 9.24E-11 9.25E-11 9.25E-11 9.26E-11 9.28E-11 9.28E-11 9.28E-11 9.28E-11 9.28E-11 9.28E-11 9.29E-11 9.29E-11 9.32E-11 9.34E-11 9.35E-11 9.36E-11 9.36E-11 9.36E-11 9.40E-11 9.41E-11 9.41E-11 9.43E-11 9.49E-11 9.49E-11 9.50E-11 9.52E-11 9.53E-11 9.56E-11 9.58E-11 9.59E-11 9.59E-11 9.61E-11 9.61E-11

EP

S51 S50 T406 S402 S160 S15 S673 S669 S410 T1151 S696 S300 S206 S26 T150 S518 S394 S31 S88 S9 S4 S205 S206 S275 S273 S271 T272 S97 S337 S126 S455 S394 T329 S331 T332 S232 S725 S719 S1231 S240 T111 S354 S547 S397 S551 S2047 S125 S131 S66 S66

AC C

O43818 O43818 Q8IYB3 Q8IYB3 P54727 Q96AY2 Q9P206 Q9P206 Q6UUV7 Q9H792 Q8IYB3 Q5JTD0 P43243 Q6IAA8 P29966 Q86UU1 Q9UDY2 Q92522 Q9UK76 Q96AY2 P09651 Q9Y5J1 Q9Y5J1 O75475 O75475 O75475 O75475 Q17RY0 P12694 Q9H6Z4 O60832 Q92769 Q9UGV2 Q9UGV2 Q9UGV2 Q13283 Q9H7N4 Q9H7N4 Q2KHR3 Q16204 P20042 O60293 Q9H1B7 Q14978 Q9NWH9 O75179 Q07157 Q07157 P42167 P42166

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

9.62E-11 9.65E-11 9.78E-11 9.83E-11 9.94E-11 1.00E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.03E-10 1.04E-10 1.05E-10 1.05E-10 1.06E-10 1.06E-10 1.06E-10 1.06E-10 1.06E-10 1.07E-10 1.07E-10 1.07E-10 1.07E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.10E-10 1.11E-10 1.11E-10 1.11E-10 1.11E-10 1.13E-10 1.13E-10

EP

S362 T734 T745 S332 S132 S251 S346 S422 S87 S84 S85 S1329 S224 S652 S87 S149 S883 S1452 S188 S445 T443 T5839 S5841 S49 S37 S520 T267 S157 T522 S90 S153 S427 S1146 S575 S573 S1260 S775 T778 S777 S769 S859 T1867 S105 S1329 S149 S51 S47 S520 S332 S126

AC C

Q9H6X2 Q86X10 Q8IZL8 Q68CZ2 O15357 Q9BUA3 Q01831 P23588 Q96AY2 Q96AY2 Q96AY2 Q6T4R5 Q13573 Q7Z417 Q9UK76 Q9Y618 P07814 P51532 Q9NQX3 O14974 O14974 Q09666 Q09666 Q9Y3T9 Q9NQZ2 Q86UU1 P55081 Q92733 Q8N1G4 Q9BUR4 O95218 Q9Y4F1 Q53SF7 P17812 P17812 P46821 Q8IYB3 Q8IYB3 Q8IYB3 Q8IYB3 P35606 Q6ZNJ1 O95155 Q9UQ35 Q13283 Q9BTU6 Q9BTU6 Q8N1G4 Q9H330 Q9NRF2

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.13E-10 1.14E-10 1.14E-10 1.14E-10 1.14E-10 1.14E-10 1.14E-10 1.14E-10 1.15E-10 1.15E-10 1.15E-10 1.15E-10 1.16E-10 1.16E-10 1.16E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.18E-10 1.19E-10 1.19E-10 1.19E-10 1.19E-10 1.20E-10 1.20E-10 1.20E-10 1.20E-10 1.20E-10 1.20E-10 1.20E-10 1.21E-10 1.21E-10 1.21E-10 1.22E-10 1.22E-10 1.22E-10 1.22E-10 1.23E-10 1.23E-10 1.23E-10 1.23E-10 1.23E-10 1.23E-10 1.23E-10 1.23E-10 1.23E-10 1.24E-10 1.24E-10

EP

S310 S303 S171 S1133 S185 S138 S541 S323 S1023 S221 S100 S1002 T446 S67 S67 S60 S657 S15 S141 S450 S231 S498 S204 S214 S37 S56 S557 S166 S165 S658 S460 S455 S632 S128 S179 S330 S574 S772 S589 S1361 S366 S91 S506 S511 S1005 S1004 T1215 S1207 T400 S24

AC C

Q01518 O00499 Q8NI08 O75116 P61006 O75446 Q9ULH7 Q9UQ35 Q01804 O95425 Q86YP4 Q9NWH9 P35269 P42167 P42166 Q13442 Q9H1B7 O00193 Q9UQC2 Q8IYB3 Q6ZW31 Q9C0C2 Q96JM3 Q96JM3 O95674 Q9Y3T9 Q8WWM7 Q969G5 Q969G5 Q9H1B7 Q7Z5L9 Q7Z5L9 P02545 Q96CB8 Q86TB9 Q92597 P17812 Q8N1F8 Q9NRY4 Q9NTI5 P05455 Q9H6F5 Q3MII6 Q5F1R6 Q12965 Q12965 Q15648 Q15648 Q9UQ35 Q96A57

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.24E-10 1.24E-10 1.24E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.26E-10 1.26E-10 1.26E-10 1.27E-10 1.27E-10 1.27E-10 1.27E-10 1.27E-10 1.28E-10 1.28E-10 1.28E-10 1.28E-10 1.29E-10 1.29E-10 1.29E-10 1.29E-10 1.29E-10 1.29E-10 1.29E-10 1.29E-10 1.29E-10 1.31E-10 1.31E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.33E-10 1.33E-10 1.33E-10 1.33E-10 1.34E-10 1.34E-10 1.35E-10 1.35E-10

EP

S673 S672 S387 S468 Y204 S122 S121 S121 S155 S380 T175 S267 S1172 S2123 S12 S261 T257 T118 S122 S126 S460 S481 T213 S95 S1305 T412 S413 S411 S1114 S289 S861 S296 Y333 S105 S104 S24 S183 S621 S395 S398 S377 S906 S1990 S171 T176 T1274 S224 S4389 S427 S519

AC C

Q9Y3T9 Q9Y3T9 Q9UQ35 O15047 P27361 P41236 P41236 Q6NXS1 Q8TBF4 Q12888 O75367 Q92733 Q13136 Q9UQ35 Q9NP87 Q9UHR4 Q9UHR4 Q8WUZ0 Q8WUZ0 Q8WUZ0 Q9NSK0 P53396 Q7L2J0 Q96NY9 Q29RF7 Q6UUV7 Q6UUV7 Q6UUV7 Q9UPT8 Q9NWH9 Q15154 Q96RU3 Q68CZ2 P05387 P05386 O00193 Q6FI81 Q9HBL0 Q9UQ35 Q9UQ35 Q9UQ35 Q13428 P46100 Q63ZY3 Q63ZY3 Q7Z6E9 Q8WXE1 Q15149 Q96JM3 O00567

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.36E-10 1.36E-10 1.36E-10 1.36E-10 1.36E-10 1.36E-10 1.36E-10 1.36E-10 1.36E-10 1.37E-10 1.38E-10 1.38E-10 1.38E-10 1.38E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.40E-10 1.40E-10 1.40E-10 1.40E-10 1.40E-10 1.41E-10 1.41E-10 1.42E-10 1.42E-10 1.42E-10 1.42E-10 1.42E-10 1.43E-10 1.43E-10 1.43E-10 1.43E-10 1.43E-10 1.44E-10 1.44E-10 1.44E-10 1.44E-10 1.44E-10

EP

S92 S255 S177 S1256 S4521 S174 S170 S285 S216 S451 S453 S6 S695 S57 S376 S82 S83 S696 S638 S432 S398 S400 S70 S364 S211 S80 S119 S381 T120 S122 S129 S403 S2362 S1137 S1134 S216 S1163 S437 S628 S1179 S398 S25 S16 S1306 S1045 S253 S1471 S736 S78 S80

AC C

P05455 P08238 Q58FF8 P46821 Q9UPN3 Q96D71 Q96D71 Q9NYF8 Q8ND56 O60832 O60832 P09651 Q8TEW0 Q13442 Q8IVT2 Q14103 Q14103 Q96TA1 Q9NW82 Q8NDI1 Q9UDY2 Q9UDY2 P06748 Q92597 Q13242 Q15637 Q15390 Q13428 Q8WXI9 Q8WXI9 Q8WXI9 P02545 Q7Z6Z7 O75116 O75116 Q09666 Q9BQG0 Q13263 P02545 Q9Y4F5 Q96ST2 P16949 P16949 Q14160 Q9P2D0 O15541 P11388 P98175 P13861 P13861

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem

TE D

1.44E-10 1.45E-10 1.45E-10 1.45E-10 1.45E-10 1.46E-10 1.47E-10 1.48E-10 1.48E-10 1.48E-10 1.48E-10 1.48E-10 1.48E-10 1.49E-10 1.49E-10 1.49E-10 1.49E-10 1.49E-10 1.49E-10 1.49E-10 1.50E-10 1.51E-10 1.51E-10 1.51E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.53E-10 1.53E-10 1.53E-10 1.53E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.55E-10 1.55E-10 1.55E-10 1.56E-10 1.56E-10 1.56E-10 1.56E-10 1.56E-10 1.56E-10 1.56E-10 1.57E-10 1.57E-10

EP

S575 S616 T614 S1309 S1298 S190 S518 S284 S289 S312 S525 S1358 S511 T793 S258 S261 S579 S212 S787 S882 S118 T1003 T2409 S353 S2012 S2739 S436 S426 T74 T74 S135 S19 S1362 S357 S122 S477 T190 S416 T401 S1067 Y231 S304 S307 S307 S304 S986 S290 S287 T48 S250

AC C

Q68EM7 Q8IYB3 Q8IYB3 Q14160 Q14160 P22059 Q8N1G4 O95817 O95817 Q14669 Q14004 Q9NTI5 Q9UQR0 Q4LE39 Q4G0J3 Q4G0J3 Q86W92 Q09666 P27816 P07814 P55081 Q9UQ35 Q9UQ35 Q8N5D0 Q9H4A3 Q6ZNJ1 Q8NDI1 Q8NDI1 P42166 P42167 Q9BXS6 Q9H1E3 Q9NTI5 P46013 Q6NXS1 Q14157 P28482 Q659A1 Q14247 Q9UDY2 Q96P48 P05388 P05388 Q8NHW5 Q8NHW5 Q9UDY2 Q9NYF8 Q9NYF8 P36915 Q96ST2

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem MaxQuant;X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1.57E-10 1.57E-10 1.58E-10 1.58E-10 1.59E-10 1.59E-10 1.59E-10 1.59E-10 1.59E-10 1.59E-10 1.59E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.61E-10 1.61E-10 1.62E-10 1.62E-10 1.62E-10 1.62E-10 1.62E-10 1.62E-10 1.62E-10 1.63E-10 8.00E-20 9.87E-20 5.27E-19 7.58E-19 4.50E-18 5.57E-18 5.86E-18 5.87E-18 6.34E-18 8.58E-18 8.67E-18 9.05E-18 2.81E-17 3.97E-17 4.63E-17 4.63E-17 1.53E-16 2.53E-16 3.58E-16 4.33E-16 4.33E-16 5.09E-16 6.87E-16 8.24E-16 8.24E-16

EP

S248 S28 T157 S194 S333 S333 S36 S37 S36 S796 S165 S392 S400 S323 S82 S659 S52 Y13 S494 S143 S147 S1793 S14 S131 S59 S1691 S1277 S99 Y394 T351 Y11 S1242 S206 S214 Y401 S202 S453 S195 T9 S132 S133 S238 S474 S960 T1241 T1256 S447 S114 T245 T244

AC C

Q96ST2 Q16637 Q8IVT2 O95400 Q641Q2 Q9Y4E1 P10412 P16402 P16403 Q99590 P51858 P02545 Q99590 P08651 Q15637 Q9H1B7 Q8TAP8 Q9H1E3 Q9C0C2 Q96E09 Q96E09 P46821 Q02363 O75446 Q00839 Q9NQT8 Q9P2E9 Q5TAQ9 Q92560 Q658Y4 Q9UH99 Q01814 P19338 Q9Y232 Q92560 Q96GY3 Q14676 Q15424 Q9UH99 P55081 P55081 Q9Y446 Q9UJX6 Q5T1M5 Q01814 P20020 P15056 Q9NRR5 Q15424 Q14151

M AN U

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RI PT

ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1.46E-15 1.73E-15 1.75E-15 1.99E-15 2.23E-15 2.52E-15 2.97E-15 3.24E-15 3.32E-15 3.35E-15 5.43E-15 5.43E-15 5.95E-15 6.74E-15 7.18E-15 8.20E-15 8.20E-15 8.20E-15 8.27E-15 8.36E-15 9.44E-15 9.85E-15 1.08E-14 1.12E-14 1.28E-14 1.39E-14 1.93E-14 1.93E-14 1.93E-14 2.06E-14 2.20E-14 2.39E-14 2.39E-14 2.49E-14 2.49E-14 3.17E-14 3.70E-14 4.38E-14 4.57E-14 5.42E-14 7.31E-14 7.37E-14 7.57E-14 7.65E-14 7.77E-14 8.69E-14 8.69E-14 9.29E-14 9.41E-14 1.00E-13

EP

S15 T267 S576 S687 T832 S797 S169 S96 S347 T355 S245 S246 S216 S1384 T996 S423 S419 S420 S13 S1996 S545 S296 S246 S94 S276 S21 S403 S401 S404 S202 S856 S64 S757 T829 S830 S18 S112 S896 S444 T913 S369 S219 T266 Y89 S770 T109 S115 Y780 T679 S205

AC C

O00458 Q9Y385 Q14694 Q12959 Q14008 Q6GYQ0 Q9BZ23 Q86XP3 Q9BWW4 P42167 Q14151 Q15424 Q7L2J0 O14646 Q4ADV7 Q9P2I0 Q9P2I0 Q9P2I0 Q8IVP5 P46100 Q96QC0 O75808 Q9NVT9 Q9NQS1 O75410 P49840 Q8NBJ9 Q8NBJ9 Q8NBJ9 Q96B36 Q9H9J4 Q8WVB6 Q13263 Q14008 Q14008 Q5XUX1 Q9P287 Q96N67 Q08945 Q02241 Q15418 Q6L8Q7 O94906 P46100 Q8IW35 Q9P287 Q9P287 Q13111 Q68EM7 Q96EV2

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1.09E-13 1.13E-13 1.13E-13 1.24E-13 1.33E-13 1.44E-13 1.85E-13 2.00E-13 2.20E-13 2.20E-13 2.24E-13 2.42E-13 2.44E-13 2.56E-13 2.60E-13 2.68E-13 2.70E-13 2.74E-13 2.74E-13 2.77E-13 2.87E-13 2.87E-13 2.87E-13 3.08E-13 3.17E-13 3.18E-13 3.38E-13 3.81E-13 3.84E-13 3.94E-13 3.94E-13 3.95E-13 3.99E-13 4.12E-13 4.19E-13 4.19E-13 4.26E-13 4.30E-13 4.75E-13 4.85E-13 5.01E-13 5.01E-13 5.05E-13 5.08E-13 5.15E-13 5.22E-13 5.30E-13 5.32E-13 5.43E-13 5.52E-13

EP

S390 S355 S597 Y383 S1091 S456 S340 S203 T1231 S1232 S1591 S619 S440 S58 S282 T220 T5729 S2599 S2597 T602 S1082 S1083 S1084 S875 T24 Y210 S967 Y155 S50 S532 T531 S358 S114 T3510 S267 S263 T466 S174 S830 S525 Y717 S716 S883 S46 S156 S372 Y228 S446 S418 S3518

AC C

Q6PJT7 Q9BWW4 Q8WWM7 Q9Y2X7 Q7Z460 Q08J23 Q658Y4 Q9NYB0 Q9UQ35 Q9UQ35 Q8IVL1 Q8N3F8 O14578 Q8TF76 Q12872 Q5JTV8 Q09666 P21359 P21359 Q86W92 Q76FK4 Q76FK4 Q76FK4 Q6P2E9 Q9Y4F1 O15173 Q5VZK9 P49761 Q13610 Q9BTA9 Q9BTA9 P51991 P98174 Q03164 Q14202 Q14202 Q9UJX6 Q9NZM1 Q7Z3B3 Q5VTR2 P40818 P40818 Q01831 O95400 Q9P2K3 A8CG34 O60716 Q13428 Q659A1 Q03164

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

5.65E-13 5.93E-13 6.94E-13 7.54E-13 7.83E-13 7.86E-13 8.04E-13 8.28E-13 8.32E-13 8.45E-13 8.45E-13 8.61E-13 8.61E-13 8.88E-13 8.99E-13 9.99E-13 1.04E-12 1.09E-12 1.10E-12 1.12E-12 1.37E-12 1.40E-12 1.40E-12 1.45E-12 1.52E-12 1.53E-12 2.00E-12 2.13E-12 2.19E-12 2.20E-12 2.20E-12 2.23E-12 2.32E-12 2.32E-12 2.32E-12 2.36E-12 2.36E-12 2.44E-12 2.62E-12 2.83E-12 2.83E-12 2.92E-12 2.93E-12 2.93E-12 2.99E-12 3.17E-12 3.36E-12 3.38E-12 3.41E-12 3.51E-12

EP

S880 S428 S829 T1007 S370 S288 T526 T18 S1934 Y119 Y119 S310 S311 T1392 S861 S598 S1102 S1825 S1105 S1269 S264 S469 S21 S1015 S304 S368 Y219 S1757 S494 S372 S375 S830 S518 S519 S520 T674 T615 Y732 T261 S84 S83 S735 S883 S884 S438 S72 T26 S689 S38 S228

AC C

Q96HP0 Q13112 Q7Z3B3 Q8WWI1 Q5F1R6 O14745 Q6PKG0 P43487 P24928 Q8N0Y7 P18669 O15143 O15143 Q5SYE7 Q5T5U3 Q8WWM7 Q13464 Q5T011 Q13464 Q9HBL0 Q9UNF1 Q9UMZ2 P43487 Q7Z401 Q9H4L5 Q15018 Q9NYF8 Q14980 A0MZ66 Q15018 Q15018 Q5VYK3 Q13523 Q13523 Q13523 Q9H2J7 Q9UPN6 P98175 Q92733 O95155 O95155 Q7Z3C6 Q96HP0 Q96HP0 Q9NZN4 P41236 A2RU67 P49959 O43314 Q8NE71

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

3.66E-12 3.68E-12 3.73E-12 3.77E-12 3.79E-12 3.79E-12 3.79E-12 3.80E-12 3.83E-12 3.91E-12 4.06E-12 4.25E-12 4.63E-12 4.82E-12 4.82E-12 4.96E-12 5.07E-12 5.07E-12 5.16E-12 5.33E-12 5.48E-12 5.48E-12 5.52E-12 5.61E-12 5.74E-12 6.09E-12 6.09E-12 6.11E-12 6.13E-12 6.15E-12 6.20E-12 6.23E-12 6.26E-12 6.40E-12 6.73E-12 6.86E-12 6.91E-12 7.07E-12 7.07E-12 7.21E-12 7.31E-12 7.58E-12 7.98E-12 8.64E-12 9.19E-12 9.29E-12 1.03E-11 1.04E-11 1.11E-11 1.13E-11

EP

Y321 S704 S88 S2115 S629 S674 S676 S249 S32 S566 S672 Y850 Y441 S740 S432 S362 S246 S247 S431 S91 S284 S305 S2643 S274 S173 T1102 S1105 S366 S261 S137 S53 T434 S986 S142 S242 S393 S443 S1177 S1176 S296 T23 T277 S525 S259 S134 Y438 S286 S286 S759 S161

AC C

O60716 P25205 O75376 Q9UQ35 Q03701 Q68EM7 Q68EM7 Q8IU60 P35659 Q92613 P25205 O95425 Q08945 Q7Z6Z7 Q8TBZ3 Q9Y2X7 Q8IU60 Q8IU60 Q9C0C9 P16333 P08651 P08651 O75592 Q5PRF9 P04920 Q9UPN9 Q9UPN9 P49768 Q9Y2U8 Q86W56 P49736 P35658 Q5T200 Q8NEJ9 O00566 Q96HA1 Q96JM3 Q9NTI5 Q9NTI5 P04049 O43399 O94875 Q9BTA9 P22626 Q5M775 Q08945 P08651 Q8TF01 Q05682 Q9NVU0

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1.13E-11 1.16E-11 1.17E-11 1.17E-11 1.21E-11 1.26E-11 1.26E-11 1.29E-11 1.32E-11 1.34E-11 1.34E-11 1.38E-11 1.41E-11 1.44E-11 1.44E-11 1.45E-11 1.48E-11 1.50E-11 1.51E-11 1.54E-11 1.60E-11 1.68E-11 1.68E-11 1.70E-11 1.71E-11 1.72E-11 1.78E-11 1.96E-11 1.97E-11 2.00E-11 2.03E-11 2.07E-11 2.08E-11 2.34E-11 2.37E-11 2.56E-11 2.71E-11 2.73E-11 2.77E-11 2.87E-11 2.89E-11 2.96E-11 2.98E-11 3.00E-11 3.05E-11 3.06E-11 3.12E-11 3.15E-11 3.15E-11 3.17E-11

EP

S162 S255 S185 S154 S226 T966 S128 S396 S435 T114 S683 S1917 S681 T157 T2020 S1792 S394 S425 T24 S1168 Y305 S127 S125 S245 S4889 S336 S98 S135 Y161 S462 S395 S165 S428 S467 S167 S19 S620 S151 Y932 S759 S468 S17 S395 T38 S164 S857 S124 S726 S723 T147

AC C

Q9NVU0 Q86TC9 Q8IWC1 Q5JTV8 P78345 Q14676 O14730 Q9Y6D6 Q86VR2 P46937 Q6ZW31 P46821 Q6ZW31 Q13765 E9PAV3 P46821 Q9Y6D6 O95747 Q13200 Q8N3D4 Q9NY61 O14730 O14730 Q68CP4 Q9NU22 Q8IY81 Q9BW71 Q8NHG8 Q9NQG5 Q08AD1 Q92560 Q9NZN8 Q96GM8 Q6GQQ9 P67809 Q96QD8 P42684 Q15185 Q9UDY2 O75152 Q86SQ0 Q96AY2 Q13425 Q09666 Q9Y2U5 Q9UQ35 Q15185 Q99590 Q99590 P29692

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

3.22E-11 3.27E-11 3.28E-11 3.28E-11 3.32E-11 3.45E-11 3.46E-11 3.50E-11 3.53E-11 3.53E-11 3.56E-11 3.68E-11 3.68E-11 3.70E-11 3.71E-11 3.81E-11 3.87E-11 3.87E-11 3.95E-11 4.00E-11 4.09E-11 4.14E-11 4.15E-11 4.20E-11 4.21E-11 4.27E-11 4.30E-11 4.30E-11 4.39E-11 4.39E-11 4.45E-11 4.49E-11 4.49E-11 4.50E-11 4.50E-11 4.51E-11 4.58E-11 4.58E-11 4.83E-11 4.93E-11 4.93E-11 4.95E-11 5.14E-11 5.14E-11 5.18E-11 5.25E-11 5.25E-11 5.35E-11 5.35E-11 5.43E-11

EP

S1132 S125 S27 S25 T444 S688 S184 S429 S202 S352 S138 S194 S193 S399 S196 S395 S106 Y705 T87 S182 S54 S291 S314 Y446 T257 Y506 T89 Y708 S385 S391 S275 S97 S90 Y134 S44 S684 T428 S430 S205 S397 S148 S470 Y258 S259 S855 S740 Y80 S352 S60 S307

AC C

O75116 Q9HAF1 O60678 O60678 O43318 P49959 P19338 P16383 Q04323 P46013 Q53GA4 Q8NAV1 Q8NAV1 Q9UNF0 Q8TEA8 Q96HA1 P24534 P25205 O75376 Q8NI08 Q8TAD8 O95817 Q13769 O14974 Q4G0J3 Q9UQR0 P41236 P25205 P35269 P35269 Q5PRF9 Q9H5H4 Q9H5H4 O60841 Q9BTU6 Q9C0B5 P16383 P16383 Q8N684 Q9NYF8 Q15185 O60885 Q9Y2U8 Q9Y2U8 Q7Z4S6 Q5T5Y3 O15541 Q9BWW4 P0DJ93 Q13769

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

5.44E-11 5.44E-11 5.61E-11 5.61E-11 5.73E-11 5.98E-11 6.18E-11 6.27E-11 6.38E-11 6.43E-11 6.47E-11 6.79E-11 6.79E-11 6.79E-11 6.94E-11 7.06E-11 7.13E-11 7.20E-11 7.34E-11 7.36E-11 7.39E-11 7.39E-11 7.40E-11 7.40E-11 7.47E-11 7.51E-11 7.53E-11 7.59E-11 7.73E-11 7.73E-11 7.77E-11 7.84E-11 7.89E-11 8.00E-11 8.00E-11 8.00E-11 8.06E-11 8.16E-11 8.25E-11 8.40E-11 8.58E-11 8.61E-11 8.69E-11 8.69E-11 8.74E-11 8.91E-11 8.95E-11 9.03E-11 9.22E-11 9.25E-11

EP

Y804 Y137 S258 S260 S278 S155 T2571 S692 S5749 S342 S349 S153 S145 S225 S58 S622 Y509 S122 T897 S854 T441 S436 T124 S125 S250 Y480 S480 S114 T331 T331 T93 S622 T1028 T722 S711 T713 S312 T244 S1445 S1386 T343 S100 Y1325 T1331 S397 S157 S482 S1262 S459 S12

AC C

Q8WWI1 P49736 Q86VR2 Q86VR2 O94888 Q8IVT2 O95359 Q96TA1 Q09666 Q16643 Q9Y6D5 P19338 P19338 Q9UPQ0 P0DJ93 Q8N9T8 Q8N1G4 Q01831 Q9HC35 Q7Z4S6 Q9NPQ8 Q9NPQ8 Q9H6Z4 Q9H6Z4 P25788 Q8NFC6 Q9H6S3 Q8WUZ0 Q641Q2 Q9Y4E1 Q53EL6 Q92625 Q9UHW9 P25205 P25205 P25205 Q13769 P49916 Q14160 Q5SYE7 Q16643 Q8NFH5 Q15021 Q15021 Q14676 Q9UNF1 Q5T5U3 Q15154 Q9H6S3 Q96AY2

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

9.28E-11 9.34E-11 9.43E-11 9.48E-11 9.56E-11 9.58E-11 9.83E-11 1.00E-10 1.00E-10 1.00E-10 1.02E-10 1.02E-10 1.03E-10 1.03E-10 1.03E-10 1.04E-10 1.05E-10 1.05E-10 1.06E-10 1.06E-10 1.08E-10 1.11E-10 1.11E-10 1.11E-10 1.11E-10 1.12E-10 1.12E-10 1.13E-10 1.14E-10 1.14E-10 1.16E-10 1.16E-10 1.18E-10 1.19E-10 1.20E-10 1.20E-10 1.23E-10 1.25E-10 1.30E-10 1.30E-10 1.30E-10 1.33E-10 1.34E-10 1.34E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10 1.35E-10

EP

T204 S301 S1228 S1295 S550 S317 Y183 S181 S203 S202 S2519 S473 S234 S506 S934 S118 T156 S358 S14 T5845 S1317 S463 S335 S333 T1161 S1329 S1322 T335 S173 S170 S668 T445 T185 S504 S24 T73 T1370 S647 S585 S588 S87 S884 T848 S4390 S313 S312 T319 T311 S87 S1301

AC C

Q9Y5J1 Q13247 Q2KHR3 Q14160 Q9NWH9 Q8NBU5 Q86XP3 Q8NI08 Q6NZI2 Q6NZI2 Q9HCK8 Q9UMZ2 Q13573 Q8N5C8 Q9H0A0 Q9HAF1 Q9Y618 Q96HB5 Q2M2I8 Q09666 Q14669 Q9H6S3 Q8IY81 Q8IY81 Q9BQG0 Q14669 Q14669 Q8TD19 Q8NI08 Q8NI08 Q8N556 P35269 Q13153 Q9C0C2 O95361 P41236 Q9NTI5 Q71RC2 Q6ZRV2 Q6ZRV2 P41236 Q01831 Q9UQ35 Q15149 Q9H501 Q9H501 Q9H501 Q9H501 Q96GX9 O60293

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ACCEPTED MANUSCRIPT

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1.37E-10 1.37E-10 1.37E-10 1.38E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.40E-10 1.42E-10 1.44E-10 1.45E-10 1.45E-10 1.46E-10 1.46E-10 1.47E-10 1.47E-10 1.48E-10 1.48E-10 1.50E-10 1.51E-10 1.53E-10 1.53E-10 1.53E-10 1.53E-10 1.54E-10 1.56E-10 1.57E-10 1.57E-10 1.60E-10 1.61E-10 1.62E-10 2.36E-22 6.53E-22 1.36E-20 2.43E-20 2.44E-19 2.67E-19 3.12E-19 6.83E-19 6.83E-19 7.10E-19 7.69E-19 7.97E-19 8.10E-19 3.07E-18 4.42E-18 5.11E-18 6.04E-18 7.54E-18

EP

T162 S122 T120 S1779 T265 S1260 S1263 S1257 S2405 Y449 S733 T861 S263 S77 Y75 S528 Y238 S283 S1110 S1164 T128 T779 S350 T117 S129 T1587 S983 S274 S276 T31 S688 T501 S787 S136 S783 S788 S216 S175 S364 S1116 T1115 S223 S90 S1111 T159 T349 S2377 S984 S224 T1118

AC C

P54727 Q9HAF1 Q9HAF1 Q92538 Q96QF0 Q15154 Q15154 Q15154 O75179 Q13263 P98175 P35606 Q15059 P41236 P41236 Q8N1G4 Q9H7N4 O95817 Q9UPT8 Q86SQ4 Q9H6Z4 Q13111 Q9BYJ9 Q01831 Q01831 O75592 P78312 Q96ST2 Q96ST2 O95674 A0FGR8 Q9C0C2 P19634 Q96IF1 P19634 P19634 Q9Y232 O94964-2 Q658Y4 Q13428 Q13428 Q6L8Q7 Q86U42 Q13428 P54727 Q658Y4 Q7Z6Z7 Q9C0C2 Q6L8Q7 Q9UPT8

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ACCEPTED MANUSCRIPT

TE D

8.64E-18 1.15E-17 1.24E-17 1.34E-17 1.39E-17 1.47E-17 1.75E-17 2.48E-17 2.72E-17 2.92E-17 3.44E-17 3.79E-17 4.53E-17 4.53E-17 5.53E-17 6.53E-17 8.91E-17 9.08E-17 9.08E-17 9.08E-17 9.08E-17 9.08E-17 9.67E-17 1.31E-16 1.39E-16 1.71E-16 2.03E-16 2.16E-16 2.36E-16 2.36E-16 2.76E-16 2.77E-16 3.24E-16 3.32E-16 3.32E-16 3.32E-16 3.32E-16 3.37E-16 3.89E-16 4.23E-16 4.32E-16 4.44E-16 5.62E-16 6.65E-16 6.91E-16 7.48E-16 8.16E-16 8.27E-16 8.27E-16 8.27E-16

EP

S180 T1110 T164 S96 S133 S300 S165 S1155 S2831 S337 S197 S470 S4618 S4620 T147 T230 S243 S365 S271 S338 S346 S307 T979 S379 S166 S204 S242 S227 S622 S631 T200 S892 S891 S4259 S4245 S4263 S4286 Y611 Y436 S1078 T518 T199 Y53 T382 S185 S1300 S435 Y317 Y428 Y318

AC C

O94964-2 Q13428 P54727 Q9Y608-2 Q96IF1 Q9UQ35 O94964-2 A7E2V4 O75592 Q9NZN5 Q15424 Q9UJX6 Q15149 Q15149 Q9Y3C6 Q9Y232 Q7Z5L9 P10636-5 P10636-3 P10636-6 P10636-6 P10636-2 Q9C0C2 Q12888 P54727 Q96GY3 Q7Z5L9 Q15424 Q07866-6 Q07866-4 Q15424 Q01831 Q01831 Q15149-4 Q15149-9 Q15149-6 Q15149-2 Q59FC3 O94887 Q13428-6 Q9Y6G9 Q5SNT6 P08670 Q12888 O60271 Q92538 O94887 P29353-2 P29353-6 P29353-7

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8.27E-16 8.41E-16 8.80E-16 9.48E-16 9.60E-16 1.02E-15 1.03E-15 1.22E-15 1.22E-15 1.26E-15 1.37E-15 1.38E-15 1.38E-15 1.38E-15 1.39E-15 1.43E-15 1.52E-15 1.72E-15 1.72E-15 1.72E-15 1.73E-15 1.73E-15 1.73E-15 1.76E-15 1.99E-15 2.07E-15 2.14E-15 2.20E-15 2.31E-15 2.47E-15 2.47E-15 2.47E-15 2.52E-15 2.52E-15 2.53E-15 2.66E-15 2.92E-15 3.09E-15 3.10E-15 3.24E-15 3.28E-15 3.41E-15 3.58E-15 3.58E-15 3.62E-15 3.95E-15 4.09E-15 4.60E-15 4.66E-15 4.66E-15

EP

Y272 T194 T1549 S462 T107 S75 T416 S195 S568 T120 S190 S426 S196 S569 S286 T1545 S761 S378 S377 Y1121 S191 S189 S268 S471 T205 S135 S313 S12 S4616 S402 S499 T447 S976 S149 S351 S768 S22 S605 S214 T98 T515 T334 S1392 S1423 S887 T25 S310 S19 S172 S173

AC C

P29353-3 Q15424 Q14160 Q14157 P31943 A2RU67 Q9BW34 A4QN18 J3KNL6 P29966 Q9Y520 Q7L7X3 A4QN18 J3KNL6 Q96K21-3 Q14160 Q6IN85 Q9BQF6-5 Q9BQF6-5 Q9UPT8 Q9Y520 Q9Y520 Q9Y385 Q14157 Q96GY3 Q53GL6 P53667 Q15776 Q15149 Q9BW34 P29692-2 Q8NHM5 Q9C0C2 Q9Y2U8 P46937-2 Q6IN85 Q2L6I2 Q59FC3 Q6L8Q7 Q86XP3 Q9Y6G9 Q8NC44 Q96N67-3 Q96N67-2 Q6P2E9 P52564 O95218-2 Q9UH99 Q9Y6M5 Q9Y6M5

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5.18E-15 5.18E-15 5.37E-15 5.43E-15 5.48E-15 5.52E-15 5.72E-15 5.86E-15 6.24E-15 6.46E-15 6.66E-15 6.75E-15 6.82E-15 7.12E-15 7.17E-15 7.17E-15 7.24E-15 7.25E-15 7.88E-15 8.73E-15 9.21E-15 9.37E-15 9.66E-15 9.95E-15 9.95E-15 9.99E-15 1.06E-14 1.10E-14 1.14E-14 1.14E-14 1.15E-14 1.15E-14 1.16E-14 1.27E-14 1.35E-14 1.36E-14 1.36E-14 1.43E-14 1.53E-14 1.55E-14 1.64E-14 1.69E-14 1.69E-14 1.79E-14 1.80E-14 1.82E-14 1.87E-14 1.96E-14 1.98E-14 1.98E-14

AC C

Q7Z3D7 S788 P98175-2 S722 Q09666 S176 Q15424 S247 O60832 T496 Q8NEF9 S205 Q13501 S361 Q9Y4G8 T1119 P54725 S125 A2RU67 T79 Q96JM3 T458 Q658Y4 T362 P52756 S621 Q01831 T876 Q6WCQ1 T210 O60583 T479 P08670 Y61 Q86W92-2 S595 Q8IWZ8 S491 Q8NHM5 T444 P08670 S51 P27816 T282 Q8NE71 T21 Q2L6I2 S24 Q8NE71 S24 Q8WWI1 T1425 O95785 T998 Q9Y608 T331 P55317 S331 P43487 S32 P46937 T412 P46937-2 T396 Q8WVB6 S63 Q9UH99 S21 O14578 S436 P19634 T779 Q13045 S860 Q9NTI5 S1369 Q9UQR1 S415 Q9NQS1 T98 Q05655 S306 Q07866-4 S629 Q07866-6 S620 Q9UPQ0-3 S1357 Q92538 S1304 Q6L8Q7 S217 O60832 T497 Q9NYF8 T661 Q96RG5 S308 Q9Y2W1 S211

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2.10E-14 2.10E-14 2.11E-14 2.19E-14 2.20E-14 2.34E-14 2.41E-14 2.41E-14 2.45E-14 2.48E-14 2.52E-14 2.62E-14 2.65E-14 2.72E-14 2.76E-14 2.79E-14 2.87E-14 2.88E-14 2.92E-14 3.23E-14 3.34E-14 3.39E-14 3.44E-14 3.52E-14 3.64E-14 3.74E-14 3.74E-14 3.84E-14 3.96E-14 4.03E-14 4.37E-14 4.37E-14 4.40E-14 4.78E-14 4.78E-14 4.86E-14 4.93E-14 5.06E-14 5.13E-14 5.19E-14 5.19E-14 5.19E-14 5.28E-14 5.32E-14 5.33E-14 5.35E-14 5.40E-14 5.42E-14 5.42E-14 5.43E-14

EP

S167 S167 T132 S171 S1141 S130 T101 S98 S1081 T328 S278 S75 S154 S687 Y620 S1104 S246 T1347 S609 S390 S159 Y27 T357 Y14 S461 S323 Y324 T702 S1160 T651 T164 T164 T1320 S304 S302 S1225 T25 T325 S642 S410 S409 S407 S695 S26 S26 S155 S307 T809 S808 T2522

AC C

P42166 P42167 P54725 Q9BZ23 Q9C0C2 Q96IF1 Q9NRR5 Q9NRR5 P21333 Q9UQ35 Q5PRF9 O15169 Q9Y2D5 O60237 P52756 Q9UPT8 Q54A51 Q03468 Q59FC3 Q5SNT6 Q9Y2D5 Q05D32 P42167 Q9UHR5 P11274 Q14678 Q14678 O14974 A7E2V4 Q7Z460 P42167 P42166 Q9H2Y7 P08651 P08651 Q96T58 P49736 P15336 Q6AI08 P23497 P23497 P23497 P00533 Q2M2I8 P52564 Q8IWS0 Q05655 Q02241-2 Q02241-2 Q9HCK8

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5.56E-14 5.63E-14 5.68E-14 5.87E-14 6.06E-14 6.06E-14 6.13E-14 6.17E-14 6.19E-14 6.30E-14 6.37E-14 6.41E-14 6.41E-14 6.75E-14 6.98E-14 6.98E-14 7.04E-14 7.08E-14 7.28E-14 7.30E-14 7.91E-14 7.93E-14 8.08E-14 8.09E-14 8.25E-14 8.25E-14 8.25E-14 8.25E-14 8.68E-14 9.01E-14 9.24E-14 9.29E-14 9.42E-14 9.49E-14 9.93E-14 1.02E-13 1.05E-13 1.10E-13 1.14E-13 1.22E-13 1.24E-13 1.24E-13 1.24E-13 1.24E-13 1.24E-13 1.30E-13 1.30E-13 1.30E-13 1.33E-13 1.33E-13

AC C

Q9NRA8 S746 P07199 S168 Q92738 S714 Q9BQG0 T1269 A9CP04 S376 Q7KZI7-14 S376 Q92538 S314 Q8NHM5 S443 Q9Y6N7 T1494 Q9Y608 S332 Q14676 S1458 Q6IN85 S127 Q6IN85 S126 Q9Y2J4 S537 Q8WWI1 S994 Q8WWI1 S995 P35658 T439 Q14671 T711 Q9UPQ0-3 S1359 P35611 S355 Q8WWI1-3 S471 Q8N3F8 S620 Q99569 S335 P80723 T31 Q15149-2 Y4502 Q15149 Y4612 Q15149-6 Y4479 Q15149-4 Y4475 Q8WWI1-3 S1176 Q6P2E9 S890 P42167 S354 Q7Z6Z7 S2388 Q9NQS1 Y99 Q5UIP0 S2196 Q99590 S614 Q00839 S66 Q9Y6M5 S167 Q96IG2 S421 P54725 S136 Q6IB11 S181 Q59FC3 Y396 Q59FC3 S398 Q9Y2X7 S385 Q9Y2X7 S388 Q59FC3 S401 P24534 T88 Q9NVT9 T248 Q8WWI1-3 S654 Q02241 S155 P82094 S349

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1.35E-13 1.36E-13 1.37E-13 1.38E-13 1.42E-13 1.42E-13 1.43E-13 1.43E-13 1.45E-13 1.46E-13 1.49E-13 1.49E-13 1.49E-13 1.49E-13 1.51E-13 1.55E-13 1.57E-13 1.67E-13 1.74E-13 1.80E-13 1.87E-13 1.89E-13 1.92E-13 1.99E-13 2.00E-13 2.02E-13 2.06E-13 2.06E-13 2.07E-13 2.11E-13 2.19E-13 2.22E-13 2.25E-13 2.26E-13 2.26E-13 2.29E-13 2.33E-13 2.37E-13 2.38E-13 2.39E-13 2.41E-13 2.44E-13 2.51E-13 2.51E-13 2.52E-13 2.61E-13 2.74E-13 2.74E-13 2.77E-13 2.77E-13

EP

T149 S589 S596 S190 Y106 T3013 T2073 T1869 S1094 S1227 S4249 S4253 S4235 S4276 S1541 S401 T270 S521 S1421 S353 T894 T1558 S1940 S21 T28 S477 T365 Y483 T436 S278 S536 S1476 T20 T37 Y244 Y247 S141 S1497 S1176 S1153 S749 S311 Y180 Y180 S222 T207 S2578 S2576 S148 S517

AC C

Q16666 Q5VT52 Q05209 Q6WKZ4 Q56P03 Q14789 Q9Y618 Q6ZNJ1 Q8TEU7 Q9UQ35 Q15149-4 Q15149-6 Q15149-9 Q15149-2 Q14160 Q12931 Q9UJU6 O94979 Q8WWI1 Q5SNT6 Q6ZRV2 Q14160 O14578 Q15149-4 Q86WB0 O60583 Q9H3P2 Q8IWZ8 P35658 P14859 Q86VM9 Q9UIG0 O75569 Q96BD0 P22626 P22626 Q9Y2U8 Q9Y6N7 Q96RG5 Q14004 P48634-2 Q96RG5 O00264 Q6IB11 Q6L8Q7 Q04323 P21359-2 P21359-2 Q6P0Q8 O95263

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2.77E-13 2.88E-13 2.88E-13 2.88E-13 2.92E-13 2.94E-13 3.03E-13 3.07E-13 3.07E-13 3.16E-13 3.17E-13 3.18E-13 3.39E-13 3.42E-13 3.43E-13 3.43E-13 3.43E-13 3.49E-13 3.52E-13 3.52E-13 3.55E-13 3.56E-13 3.63E-13 3.63E-13 3.63E-13 3.64E-13 3.69E-13 3.79E-13 3.84E-13 3.84E-13 3.87E-13 3.92E-13 3.92E-13 3.95E-13 4.03E-13 4.05E-13 4.10E-13 4.19E-13 4.19E-13 4.24E-13 4.25E-13 4.25E-13 4.34E-13 4.34E-13 4.39E-13 4.40E-13 4.64E-13 4.66E-13 4.68E-13 4.71E-13

AC C

Q86W92-2 T596 P07199 T169 Q14004-2 S1092 Q9BXB4 S179 Q86WB0 T352 Q9BTA9 S534 Q99733 T117 Q5H9L2 T124 Q969E4 T118 Q8IVT2 S400 Q12872 S279 Q6UUV9 S158 Q86WB0 T372 Q6P2E9 S892 P18858 S88 P18858 S98 P18858 T97 O95155 S86 Q14004 T1143 Q14004-2 T1087 Q9H8M2 S588 Q01804 Y541 Q7Z5J4 S1352 Q9UQ35 T1222 Q9UQ35 S1219 P07199 S165 Q99590 T602 P15336 T333 Q6PK21 S171 Q96IF1 S127 Q6IQ22 S25 Q56P03 S109 Q56P03 S111 P67809 Y162 Q9NYB0 S205 Q9UQR1 Y417 Q09666 S5762 A6NHB5 S269 A6NHB5 S265 Q96AC1 Y179 Q8WWI1-3 S660 Q8WWI1-3 S657 Q7Z309-3 S138 Q7Z309-3 S134 P07199 T150 Q14676 T1459 O95359 S2574 Q9HCK8 T1993 Q5JSL3 T1247 Q5VT52 S596

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4.75E-13 4.91E-13 4.94E-13 4.96E-13 4.98E-13 5.11E-13 5.12E-13 5.13E-13 5.13E-13 5.16E-13 5.20E-13 5.20E-13 5.32E-13 5.39E-13 5.51E-13 5.62E-13 5.82E-13 5.96E-13 6.08E-13 6.11E-13 6.14E-13 6.21E-13 6.40E-13 6.44E-13 6.50E-13 6.83E-13 6.83E-13 6.93E-13 7.03E-13 7.24E-13 7.51E-13 7.60E-13 7.60E-13 7.67E-13 7.75E-13 7.75E-13 7.77E-13 7.90E-13 8.09E-13 8.15E-13 8.28E-13 8.42E-13 8.42E-13 8.49E-13 8.61E-13 8.81E-13 8.88E-13 8.90E-13 9.03E-13 9.03E-13

AC C

Q9NQW6 S362 Q68EM7 S570 P53985 T466 Q6GYQ0 T798 P21359-2 S2580 P23588 S424 Q8NHM5 T449 P51991 Y360 O95155 S87 Q7LBC6 S778 P55265 S605 Q8NEF9 S208 Q66K14 S416 Q3KQU3 S112 P11274 S462 O43815 Y135 P02545 T24 Q9Y2D5 S155 Q9H410 S77 Q2M2I8 T27 Q9Y446 T235 Q02241-2 S807 Q7Z4S6 S1275 Q13393 S508 Q9H2Y7 T1372 Q641Q2 Y443 Q5SNT6 Y355 Q9UKV3 T840 O75376 S97 Q2KHR3 S1227 Q2KHR3 S1239 Q13501 T375 Q9C0C2 T607 Q99959 S132 Q9UHW9-2S42 Q9UHW9-2T47 P98174 T704 Q7Z460-3 S1083 P55265 T603 Q86W92-2 S593 Q8WVC0 T629 Q8WXI9 S340 Q9UMZ2 S756 Q15154 S68 Q15464 S310 Q14789 S3014 Q5SYE7 S1388 O15020 S2171 P60709 S235 Q6S8J3 S935

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9.03E-13 9.23E-13 9.40E-13 9.50E-13 9.66E-13 9.78E-13 9.99E-13 1.00E-12 1.01E-12 1.03E-12 1.05E-12 1.05E-12 1.05E-12 1.07E-12 1.08E-12 1.09E-12 1.10E-12 1.10E-12 1.11E-12 1.12E-12 1.12E-12 1.13E-12 1.15E-12 1.15E-12 1.16E-12 1.16E-12 1.19E-12 1.19E-12 1.19E-12 1.22E-12 1.22E-12 1.22E-12 1.24E-12 1.24E-12 1.25E-12 1.27E-12 1.27E-12 1.29E-12 1.30E-12 1.30E-12 1.30E-12 1.30E-12 1.31E-12 1.31E-12 1.33E-12 1.37E-12 1.37E-12 1.41E-12 1.43E-12 1.43E-12

AC C

P63261 S235 Q5T1M5 S962 Q7Z5K2 S81 Q99590 T799 Q14676 T1461 Q9HC35 T909 Q15154 S69 Q9NPQ8 T443 O43815 T143 Q13263 Y755 Q8IWE2 T185 Q13393 S505 Q12888 T214 Q969G5 S173 P46087 S734 Q5T011 S1819 Q7Z6Z7 T3822 Q14498 Y95 Q6PD62 S932 Q99733 S121 Q14155-1 S340 Q5VTR2 T526 Q08945 S437 Q8WXG6 S1241 Q9BTK6 S234 Q6P0Q8 S151 P52948 S623 P52948-2 S606 P46100 Y2002 Q8IZH2 S1638 Q9NRA8 T755 P13051 T31 Q86X95 Y199 Q9Y6G9 S523 Q9UHW9-2S45 O60524 S831 Q9Y232 T207 P46821 S541 Q13428 S375 Q9BTA9 T500 J3KNL6 S1069 A4QN18 S696 Q8IVT2 T577 Q15326 S421 P14859 S283 Q96S55 S75 Q96S55 S78 Q9Y2D5 S158 Q13439 T39 Q13439 S40

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1.44E-12 1.45E-12 1.46E-12 1.46E-12 1.50E-12 1.50E-12 1.52E-12 1.52E-12 1.53E-12 1.53E-12 1.54E-12 1.55E-12 1.58E-12 1.59E-12 1.60E-12 1.62E-12 1.65E-12 1.65E-12 1.68E-12 1.68E-12 1.70E-12 1.71E-12 1.71E-12 1.73E-12 1.76E-12 1.80E-12 1.82E-12 1.82E-12 1.85E-12 1.85E-12 1.85E-12 1.86E-12 1.86E-12 1.86E-12 1.87E-12 1.88E-12 1.89E-12 1.91E-12 1.91E-12 1.92E-12 1.93E-12 1.93E-12 1.95E-12 1.97E-12 1.99E-12 1.99E-12 2.02E-12 2.05E-12 2.07E-12 2.07E-12

EP

S1140 S747 T438 S114 S437 T461 S2652 T45 S21 S195 S217 S517 S591 T648 S16 S171 S1434 S1394 S206 S2867 S1542 S988 T79 T214 S1408 S1396 S83 S18 T64 T500 S478 S763 S328 S156 Y82 T1159 Y264 S9 S10 T322 T121 T77 S1274 T173 S42 S95 T430 Y283 S80 S2576

AC C

Q9C0C2 P48634-2 O94776 Q9H6T3 Q08AD1-2 Q08J23 O75592 Q9Y2V2 Q8N6M7 P80723 Q96JM3 O15320 Q9C0A6 O15439 Q5SW96 Q9NQG5 Q96N67 Q96N67-3 Q9H0H5 Q9NYQ6 P38398 Q9P206-2 O15169 Q9Y2W1 Q13459 O14646 P04792 Q2M2I8 P46087 P23588 P51114 Q66K74 Q13501 Q8IWS0-2 A2RU67 Q15648 O75410 Q9UHR5 Q9UHR5 Q13769 Q7Z309 Q6DCA0 Q7Z4S6 O43598 Q9BVU3 P24534 O95747 P14921 Q53EL6 O95359

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2.11E-12 2.13E-12 2.13E-12 2.13E-12 2.14E-12 2.15E-12 2.18E-12 2.20E-12 2.20E-12 2.27E-12 2.30E-12 2.31E-12 2.32E-12 2.41E-12 2.41E-12 2.42E-12 2.43E-12 2.43E-12 2.45E-12 2.46E-12 2.46E-12 2.46E-12 2.48E-12 2.52E-12 2.53E-12 2.74E-12 2.74E-12 2.77E-12 2.78E-12 2.78E-12 2.78E-12 2.79E-12 2.80E-12 2.80E-12 2.85E-12 2.87E-12 2.89E-12 2.90E-12 2.92E-12 2.92E-12 2.93E-12 2.94E-12 2.97E-12 2.97E-12 3.01E-12 3.01E-12 3.02E-12 3.03E-12 3.07E-12 3.07E-12

EP

T517 S422 T775 S2020 S333 S621 S302 Y377 T249 T457 T496 S534 S73 S1093 T234 T373 S222 S100 T39 S371 S355 T494 S380 S1108 S145 T353 S57 T454 S245 S95 S294 S257 S1461 S528 S326 T869 T143 S1176 S2071 S60 T464 S357 Y1421 T660 T1350 S752 S118 S313 T240 T470

AC C

Q92560 Q2TB10 Q9Y2H5 Q9H4A3 Q9Y608 Q13586 Q05655 Q15018 O95671 P18887 A0MZ66 O95235 Q9H1E3 Q7Z460 O95671 Q86WB0 O60841 P46379 P49736 P46937 P46937-2 Q6UN15 Q06265 Q13464 Q8IWS0 Q9H814 O95251 Q9H4M9 Q9UFC0 P55884 Q9NWH9 Q86TC9 Q02880 O00567 Q9Y2W1 P35606 O15234 Q9NRY4 Q9Y618 Q86U90 Q5JSH3 Q86WB0 Q02880 Q8NFC6 Q03468 P48634-2 Q15185 P98082 Q96G46 Q9BWU0

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3.08E-12 3.12E-12 3.12E-12 3.22E-12 3.22E-12 3.24E-12 3.29E-12 3.29E-12 3.29E-12 3.35E-12 3.35E-12 3.36E-12 3.42E-12 3.43E-12 3.44E-12 3.47E-12 3.54E-12 3.57E-12 3.57E-12 3.59E-12 3.60E-12 3.60E-12 3.65E-12 3.67E-12 3.73E-12 3.73E-12 3.74E-12 3.79E-12 3.80E-12 3.83E-12 3.84E-12 3.89E-12 3.89E-12 4.01E-12 4.01E-12 4.01E-12 4.02E-12 4.04E-12 4.04E-12 4.07E-12 4.09E-12 4.14E-12 4.16E-12 4.17E-12 4.19E-12 4.21E-12 4.22E-12 4.23E-12 4.25E-12 4.25E-12

EP

S83 T276 T513 S330 S291 S324 S337 S352 S517 S380 S157 S323 T143 S287 S131 T101 S133 Y218 S745 S206 S931 S232 T220 Y11 S1160 T213 T1064 T682 S265 S476 T3470 S298 S301 S767 S715 S900 T1005 S1345 S366 S365 T633 S789 S147 Y452 S332 T44 S987 S350 S105 S199

AC C

P55884 O15231-2 O15231 Q86SQ0 O14745 Q9H330 Q8NC44 O60293 Q9NQW6 Q14247-3 P42575 Q9Y2W1 P29966 Q9GZR7 P29966 P17544-2 Q86W56 P63261 Q86YV5 Q9NYB0 Q68DQ2 P15408 P23396 Q8IVP5 Q9NTI5 P19338 Q12789 Q68EM7 Q9HC77 O60583 O75592 P25440 P25440 Q66K74 P98174 Q14C86 Q9ULJ3 Q03468 Q9Y6M4-3 Q9Y6M4-3 Q07866-4 P27816 Q8WW12 Q08945 Q92597 Q9NTJ3 Q9C0C2 Q86WB0 P10636-3 P10636-8

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4.25E-12 4.25E-12 4.25E-12 4.25E-12 4.34E-12 4.39E-12 4.44E-12 4.46E-12 4.46E-12 4.46E-12 4.46E-12 4.61E-12 4.62E-12 4.66E-12 4.73E-12 4.76E-12 4.82E-12 4.92E-12 4.92E-12 4.96E-12 4.99E-12 5.02E-12 5.03E-12 5.05E-12 5.07E-12 5.07E-12 5.08E-12 5.08E-12 5.17E-12 5.23E-12 5.23E-12 5.25E-12 5.25E-12 5.26E-12 5.26E-12 5.33E-12 5.35E-12 5.35E-12 5.37E-12 5.42E-12 5.42E-12 5.42E-12 5.48E-12 5.52E-12 5.60E-12 5.64E-12 5.66E-12 5.67E-12 5.68E-12 5.70E-12

AC C

P10636-5 S199 O94776 S433 O95425-2 T426 O95425-2 Y424 Q9ULM3 T521 Q8WUI4 S493 Q9UKX7 S223 Q56P03 S17 Q56P03 S26 Q56P03 S25 Q56P03 S24 P67809 S313 P78345 T221 Q5JTV8 T147 Q3KQU3 S116 Q96AC1 S180 Q9HCN4 S338 Q86WB0 S359 Q86WB0 S358 Q59FC3 S375 A8MXP9 S208 Q9H6T3 S121 Q9H7N4 S552 P61073 S319 Q8IU60 S254 Q6SPF0 T157 Q07866-4 S600 Q07866-6 S591 O43598 T174 Q15326 S419 P43243 Y213 Q8WWI1-3 T1254 Q8WWI1 T1588 P11717 S2400 Q6BDS2 S1103 Q96AC1 S175 Q9Y2X7 T364 Q9C0B5 T696 Q8WY36 T849 Q9H6T3 S116 Q9H6T3 S119 Q9H6T3 T111 P08651 T293 Q8NB49 T438 Q9H7F0 S98 Q13428 S1227 Q6GYQ0 S799 Q96FF9 T115 Q5T4S7 S2900 P14859 T276

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EP

5.72E-12 5.80E-12 5.83E-12 5.84E-12 5.86E-12 5.86E-12 5.92E-12 5.93E-12 5.95E-12 5.96E-12 6.00E-12 6.01E-12 6.04E-12 6.06E-12 6.06E-12 6.07E-12 6.13E-12 6.15E-12 6.15E-12 6.15E-12 6.20E-12 6.20E-12 6.23E-12 6.25E-12 6.26E-12 6.33E-12 6.33E-12 6.33E-12 6.33E-12 6.41E-12 6.41E-12 6.42E-12 6.71E-12 6.74E-12 6.75E-12 6.76E-12 6.77E-12 6.83E-12 6.89E-12 6.90E-12 6.90E-12 6.90E-12 6.91E-12 6.91E-12 6.91E-12 7.09E-12 7.23E-12 7.28E-12 7.31E-12 7.36E-12

AC C

Q643R0 S738 O14497 S698 O00499-2 S300 O00499-10 S282 O15027 S1903 J3KNL6 S2081 Q9UBC2 S247 Q8NB49 T447 Q9BX63 Y921 P49023 Y88 Q14157 S458 Q14157 S453 Q92766 T1204 Q8WW12 T141 P11388-2 S1403 O60885 S469 Q6ZW31 T679 Q05682 S723 Q05682 T730 O14795 S367 Q9Y6G9 T513 P49736 T59 O75367 T178 Q8TEK3 S1104 Q9BVV8 T113 P35269 S221 P35269 S224 P35269 S218 P35269 S217 P17010 S274 P08048 S270 Q9ULH7 S546 Q02880 T1422 P14921 S285 Q02880 S1473 Q5TCZ1 Y553 Q9UJV9 T13 P42167 S360 Q9C0C9 T435 P24928 T1919 P24928 T1933 Q2L6I2 S109 Q01814 S1238 Q9BVJ6 S405 Q9BVJ6 S407 Q12873 T715 A0FGR8 S704 Q86TC9 T923 O00273 S310 O43237 S407

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EP

7.40E-12 7.44E-12 7.44E-12 7.46E-12 7.51E-12 7.55E-12 7.56E-12 7.57E-12 7.57E-12 7.70E-12 7.73E-12 7.74E-12 7.90E-12 7.92E-12 7.98E-12 8.01E-12 8.03E-12 8.08E-12 8.11E-12 8.15E-12 8.33E-12 8.35E-12 8.45E-12 8.48E-12 8.64E-12 8.64E-12 8.70E-12 8.70E-12 8.78E-12 8.79E-12 8.83E-12 8.83E-12 8.85E-12 8.87E-12 8.89E-12 8.90E-12 8.93E-12 8.95E-12 9.01E-12 9.01E-12 9.01E-12 9.01E-12 9.14E-12 9.16E-12 9.21E-12 9.32E-12 9.38E-12 9.41E-12 9.52E-12 9.52E-12

AC C

P80723 S194 P51114-3 Y392 P51114 Y477 Q9BWU0 Y464 Q4ADV7 S1015 P54725 S138 P55884 S78 Q9NVI1 S1120 P24534 S112 Q14676 S394 Q03164 T1839 O60716 S225 Q7Z3B3 S832 O94776 Y437 Q9BX63 S927 Q9UK58 S355 Q09666 S220 P55884 S81 P02545 T643 Q14244 T205 Q96SN8 S1354 P14921 S282 Q13428-6 T1072 Q92538 S1789 P02545 S618 P02545 S619 P17544-2 S100 P17544-2 S97 O95218 Y124 Q04656 T278 Q9UK61 S978 Q8WWY3 T440 Q9BYJ9 S346 Q96JM3 S462 O60502 T370 Q13428 S982 Q01804 S545 O94776 T439 O94875-5 S306 O94875-4 S306 O94875-12 S346 O94875-10 S439 Q92466 S24 Q8NB49 T450 Q4G0J3 T266 P04049 S294 Q76L83 S571 Q04726 T285 Q7Z4S6 S1271 Q7Z4S6 S1278

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TE D

9.53E-12 9.58E-12 9.59E-12 9.59E-12 9.61E-12 9.63E-12 9.71E-12 9.73E-12 9.76E-12 9.80E-12 9.85E-12 9.91E-12 9.92E-12 1.00E-11 1.01E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.03E-11 1.04E-11 1.04E-11 1.05E-11 1.05E-11 1.06E-11 1.07E-11 1.07E-11 1.07E-11 1.08E-11 1.08E-11 1.08E-11 1.09E-11 1.12E-11 1.12E-11 1.12E-11 1.14E-11 1.15E-11 1.15E-11 1.15E-11 1.16E-11 1.16E-11 1.17E-11 1.17E-11 1.19E-11 1.19E-11 1.19E-11

EP

S2391 S548 S363 S366 T13 T375 Y187 S1230 S1446 S90 S925 T432 S13 T538 S119 S210 S481 S270 S277 S279 S273 S272 T307 S294 S146 S427 T392 S684 S1053 Y592 T865 T857 S624 T31 S354 T535 T432 S124 Y23 T897 S288 S39 Y511 S765 Y2836 S163 S104 Y558 T111 S1073

AC C

Q7Z6Z7 Q96SN8 Q9UHB6-4 Q9UHB6-4 Q5XUX1 Q92597 Q1HBJ4 Q13428 P46821 P24534 Q5T5U3 Q8N1G0 O60573 Q9Y2L9 Q59EQ8 Q7Z589 Q92499 Q13428 Q13428 Q13428 Q13428 Q13428 P08651 P08651 Q9Y2D5 Q66K14 P49841 Q12959 Q9UDY2 Q5VT52 Q8N122 Q8N122 Q2M2I8 Q13620-1 P42166 Q8N1G4 Q13112 Q01664 P10155 Q15811 Q6IBW4 P04075 Q9NYF8 Q05682 O75592 Q5JTV8 G8JLB6 Q5TCZ1 Q96T60 Q13428-6

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TE D

1.20E-11 1.20E-11 1.20E-11 1.20E-11 1.23E-11 1.24E-11 1.27E-11 1.27E-11 1.27E-11 1.27E-11 1.28E-11 1.28E-11 1.28E-11 1.28E-11 1.29E-11 1.29E-11 1.30E-11 1.31E-11 1.31E-11 1.31E-11 1.31E-11 1.32E-11 1.33E-11 1.33E-11 1.33E-11 1.34E-11 1.35E-11 1.36E-11 1.39E-11 1.41E-11 1.41E-11 1.41E-11 1.42E-11 1.42E-11 1.44E-11 1.45E-11 1.45E-11 1.46E-11 1.46E-11 1.47E-11 1.48E-11 1.48E-11 1.48E-11 1.48E-11 1.49E-11 1.49E-11 1.52E-11 1.52E-11 1.53E-11 1.53E-11

EP

T1584 S513 S27 Y383 T424 S373 S751 Y762 S763 Y829 T286 T288 T289 T303 S1419 S253 S244 S54 T336 S331 T100 S520 S275 S276 S333 Y675 S871 S78 T69 S1708 S671 T112 T136 T440 T313 T1799 T55 S397 S164 T178 S2415 T461 S299 S228 T1548 S342 S709 T698 Y455 Y455

AC C

Q8WWI1 O00567 Q9H410 Q9NYF8 Q2TB10 Q9UHB6 Q9UQ88 P21127 P21127 Q6P0N0 Q9UQ35 Q9UQ35 Q9UQ35 P04049 Q8NI27 Q9UBC2 Q8NE71 Q6IB11 P15336 P21731 Q9H910 Q92560 Q13501 Q13501 O00499 Q6ZW31 Q6P2E9 P51608 P19338 Q5SRE5 Q6ZW31 Q7Z309 Q5QJE6 P18887 Q9H788 P46821 Q13610 Q5JSH3 Q5JTV8 O00264 O75179 Q9BZZ5 P46013 O95671 P38398 Q6WKZ4 Q6PJG2 Q6PJG2 A9UF02 P11274

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TE D

1.53E-11 1.53E-11 1.55E-11 1.55E-11 1.55E-11 1.55E-11 1.55E-11 1.56E-11 1.58E-11 1.58E-11 1.58E-11 1.58E-11 1.59E-11 1.59E-11 1.59E-11 1.59E-11 1.59E-11 1.60E-11 1.61E-11 1.61E-11 1.62E-11 1.62E-11 1.63E-11 1.64E-11 1.65E-11 1.65E-11 1.65E-11 1.65E-11 1.67E-11 1.67E-11 1.67E-11 1.68E-11 1.68E-11 1.68E-11 1.69E-11 1.70E-11 1.70E-11 1.71E-11 1.73E-11 1.74E-11 1.75E-11 1.75E-11 1.76E-11 1.76E-11 1.78E-11 1.78E-11 1.82E-11 1.82E-11 1.83E-11 1.83E-11

EP

T678 S115 S373 S315 S404 S279 S1312 S477 T52 T34 S1237 S1240 T124 S168 T143 S1106 T1114 S1019 S19 S21 S105 T695 S496 T895 S2106 S745 S782 T1648 T1403 S1395 T160 Y122 S130 S154 S301 S2054 S1750 T1709 T157 S741 S142 S253 T77 S3016 S104 S490 T111 T1122 T108 T253

AC C

Q9Y3T9 Q8TAP9 P10636-5 P10636-2 P10636-8 P10636-3 Q13428-6 P05787 Q13620 Q13620-1 Q5JSL3 Q5JSL3 Q9BVV8 Q1KMD3 Q13283 Q9UKP4 Q9UKP4 Q4ADV7 Q96B01 Q96B01 Q8NFH5 Q92974 Q6UN15 Q6ZRV2 Q01082 Q8N4C8-3 Q8N4C8 Q12888 Q02880 Q02880-2 Q8IVT2 O14730 Q9C086 Q7Z3D7 Q8N359 Q9Y618 Q14980 Q12888 Q9Y2D5 Q8N4C8-3 Q96PE2 Q9H3N1 Q9BUR4 Q14789 Q9BW71 Q9UHB7 Q99733 Q12888 P46379 Q9BUA3

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TE D

1.85E-11 1.88E-11 1.89E-11 1.90E-11 1.90E-11 1.90E-11 1.90E-11 1.91E-11 1.91E-11 1.91E-11 1.92E-11 1.93E-11 1.93E-11 1.94E-11 1.94E-11 1.96E-11 1.97E-11 1.98E-11 2.00E-11 2.01E-11 2.02E-11 2.02E-11 2.03E-11 2.05E-11 2.06E-11 2.06E-11 2.06E-11 2.06E-11 2.07E-11 2.08E-11 2.08E-11 2.08E-11 2.11E-11 2.11E-11 2.11E-11 2.13E-11 2.13E-11 2.13E-11 2.13E-11 2.15E-11 2.16E-11 2.16E-11 2.17E-11 2.17E-11 2.20E-11 2.22E-11 2.22E-11 2.22E-11 2.22E-11 2.23E-11

EP

S583 S930 S552 S55 S12 S84 S225 S462 S98 S611 S182 S979 T264 S1471 T4898 S135 Y165 S691 S216 S19 S420 S241 S713 T92 S1749 T862 S696 S695 S678 S774 S771 S190 S441 S429 T362 S128 S162 S348 T110 T1219 T234 S902 T107 T107 Y432 S1121 T651 S22 S1593 S32

AC C

Q86UU1 Q9HAU0 Q96QC0 P52292 Q9UBD8 P49023 Q8ND56 Q9BTU6 P56181-2 Q9H0B6 Q6FI81 Q9UDY2 Q5PRF9 Q9BTC0 Q9NU22 Q53GA4 Q9NQG5 Q92974 Q7Z417 P53999 Q66K14 Q9UFC0 Q14671 P41236 Q12888 Q7Z4S6 Q92974 Q92974-2 Q4KMP7 Q99590 Q99590 O60841 Q9C0C9 Q9C0C9 P05455 P54725 P07199 Q9BYJ9 Q96HC4 Q96T58 Q9H7N4 Q15811 P55795 G8JLB6 Q05519 Q9NVI1 Q96TA1 P07355 Q8WWI1 Q9UHB7

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TE D

2.24E-11 2.26E-11 2.26E-11 2.26E-11 2.26E-11 2.26E-11 2.27E-11 2.29E-11 2.33E-11 2.34E-11 2.37E-11 2.37E-11 2.37E-11 2.37E-11 2.38E-11 2.38E-11 2.39E-11 2.39E-11 2.40E-11 2.40E-11 2.41E-11 2.41E-11 2.42E-11 2.42E-11 2.43E-11 2.43E-11 2.46E-11 2.48E-11 2.50E-11 2.51E-11 2.52E-11 2.53E-11 2.53E-11 2.53E-11 2.54E-11 2.54E-11 2.54E-11 2.54E-11 2.54E-11 2.54E-11 2.54E-11 2.55E-11 2.55E-11 2.56E-11 2.56E-11 2.57E-11 2.57E-11 2.58E-11 2.60E-11 2.61E-11

EP

S766 S355 S498 S1103 S711 Y710 T446 S2138 Y251 S419 T414 Y20 S24 S2169 S869 S132 S219 S322 S1149 S450 T1150 T451 S185 S534 S324 S719 T536 T350 S211 S97 T396 S265 S58 T219 T2942 S2934 T2944 T2937 T2943 S464 S140 S79 T1217 T729 S22 S890 T886 S579 Y519 T1523

AC C

Q66K74 Q13501 P47736 Q14C86 Q92738 Q92738 O43318 Q01082 P25490 Q7Z3K3 O14545 Q96QD8 Q96QD8 Q96JM2 Q8TD19 P29966 P80723 P08651 Q9ULD2-2 Q9ULD2-6 Q9ULD2-2 Q9ULD2-6 Q6FI81 Q9Y2J4 Q8ND76 P40818 Q15042 Q08499 P43243 Q14739 P36507 Q4G0J3 Q9Y3T9 Q9UKX7 Q5T4S7 Q5T4S7 Q5T4S7 Q5T4S7 Q5T4S7 P35611 Q9Y2U8 Q9UK76 Q13017 P13807 Q96QD8 Q15147 Q15147 P46013 O15320 O43149

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TE D

2.64E-11 2.68E-11 2.70E-11 2.74E-11 2.74E-11 2.75E-11 2.75E-11 2.75E-11 2.76E-11 2.76E-11 2.76E-11 2.76E-11 2.76E-11 2.76E-11 2.77E-11 2.77E-11 2.77E-11 2.77E-11 2.77E-11 2.78E-11 2.79E-11 2.81E-11 2.81E-11 2.82E-11 2.82E-11 2.83E-11 2.83E-11 2.84E-11 2.84E-11 2.84E-11 2.84E-11 2.86E-11 2.87E-11 2.88E-11 2.88E-11 2.90E-11 2.90E-11 2.91E-11 2.91E-11 2.91E-11 2.91E-11 2.91E-11 2.91E-11 2.91E-11 2.93E-11 2.95E-11 2.96E-11 2.96E-11 2.96E-11 2.96E-11

EP

S371 S52 T705 S459 S471 T236 T225 T231 T75 T75 S370 Y345 S306 S311 S399 S395 S396 S397 S1148 S146 Y2147 S309 Y47 T23 S49 S202 S200 S293 S295 Y1363 S679 Y169 S2195 S335 S96 T468 S341 S177 S118 S112 S99 T185 S783 S718 S67 S768 T476 S1705 S1701 S1686

AC C

Q9UHB6 A2RU67 A0FGR8 P53396 Q13263 Q9UK32 Q15418 P51812 Q15300 P10644 Q13501 P12694 Q9NQS7 Q9NQS7 Q7Z4V5 Q7Z4V5 Q7Z4V5 Q7Z4V5 Q9Y4H2 Q68E05 O75376 Q9H4L5 P55081 Q9H6F5 P18615 Q8IWE2 Q8IWE2 P29803 P08559 Q96T23 Q8WWQ0 Q9Y2U5 Q5UIP0 Q86WB0 P46379 Q3YEC7 Q16643 Q96AC1 Q13247 Q08170 O95155 Q1HBJ4 Q7Z3D7 P98175 Q8IXQ3 O75152 O15047 Q12888 Q12888 Q12888

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TE D

2.96E-11 2.97E-11 2.97E-11 2.97E-11 2.97E-11 2.97E-11 2.97E-11 2.99E-11 3.00E-11 3.00E-11 3.00E-11 3.01E-11 3.04E-11 3.06E-11 3.06E-11 3.08E-11 3.09E-11 3.10E-11 3.15E-11 3.16E-11 3.17E-11 3.21E-11 3.22E-11 3.22E-11 3.26E-11 3.27E-11 3.27E-11 3.27E-11 3.27E-11 3.31E-11 3.31E-11 3.32E-11 3.32E-11 3.33E-11 3.33E-11 3.33E-11 3.34E-11 3.35E-11 3.36E-11 3.38E-11 3.40E-11 3.40E-11 3.40E-11 3.40E-11 3.41E-11 3.43E-11 3.44E-11 3.45E-11 3.46E-11 3.46E-11

EP

S759 S2796 S1315 S660 S155 T149 S864 S96 Y109 S110 S903 T778 S20 S901 S117 S200 T279 Y276 S41 T93 T513 T215 Y289 T1095 S618 S3827 S21 T69 S226 S80 S497 S604 S203 T24 S764 T778 S309 S1728 S693 T432 S464 S465 S467 S389 S116 T394 T326 S701 S660 T214

AC C

O14617 Q03164 Q9H2Y7 Q9NYF8 Q5W009 Q6UUV9 Q9UQ35 O43847 Q8WUF5 Q8WUF5 Q9HC35 Q6GYQ0 Q2M2I8 Q15811 P55884 P22059 O14757 P55081 O95674 P24534 P29692-2 Q9P0L0 P08559 Q7Z460 P42684 Q7Z6Z7 Q96QD8 O43583 Q6WCQ1 Q9H6F5 Q9UGU5 Q14157 Q14244 Q01105-2 O14617 O14617 Q96SB4 Q96L91 Q9C0B5 P17544 Q08AE8 Q08AE8 Q08AE8 P49841 Q9NU19 P02545 Q9UQ35 P49959 Q71RC2 P19338

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TE D

3.46E-11 3.47E-11 3.47E-11 3.50E-11 3.52E-11 3.52E-11 3.53E-11 3.54E-11 3.55E-11 3.55E-11 3.56E-11 3.57E-11 3.57E-11 3.59E-11 3.59E-11 3.59E-11 3.61E-11 3.63E-11 3.63E-11 3.65E-11 3.65E-11 3.66E-11 3.66E-11 3.69E-11 3.70E-11 3.70E-11 3.70E-11 3.76E-11 3.78E-11 3.78E-11 3.78E-11 3.80E-11 3.81E-11 3.81E-11 3.83E-11 3.83E-11 3.83E-11 3.83E-11 3.84E-11 3.88E-11 3.89E-11 3.90E-11 3.93E-11 3.93E-11 3.93E-11 3.94E-11 3.94E-11 3.94E-11 3.94E-11 3.94E-11

EP

T364 T700 T447 T292 T640 Y641 Y627 S306 S615 S41 T487 S312 Y243 T396 S63 S547 T762 S533 Y531 S1030 S757 T416 T412 S485 S403 S1721 S1710 S134 S890 S893 S34 S547 S1359 T1371 Y602 S609 S184 S122 S22 T1905 S153 S128 T658 S1598 S10 S1471 S5739 S1225 S233 S22

AC C

Q14247-3 O14974 Q969V6 Q53SF7 O00461 O00461 P52948 Q9P289 P50570 P46108 Q9UHB6 Q96AX9 Q8IWW6 Q9UNF0 P13051 Q9ULH7 O14617 Q6PJT7 Q6PJT7 Q8TEK3 Q9NRA8 Q9UHR4 Q9UHR4 P29692-2 Q9UNF0 Q76NI1 Q76NI1 Q8WXI9 Q8N3V7 Q8N3V7 Q99576-3 Q96SN8 Q96T23 Q96T23 Q14157 Q9H0B6 Q9BXB4 Q59EQ8 P50443 Q7Z6Z7 Q6UUV9 P29966 Q8NFC6 Q14643 P57740 Q02880 Q09666 Q92766 P15408 Q5XUX1

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TE D

3.94E-11 4.01E-11 4.01E-11 4.01E-11 4.01E-11 4.04E-11 4.06E-11 4.06E-11 4.07E-11 4.07E-11 4.11E-11 4.11E-11 4.11E-11 4.13E-11 4.13E-11 4.15E-11 4.18E-11 4.19E-11 4.22E-11 4.25E-11 4.26E-11 4.28E-11 4.28E-11 4.28E-11 4.30E-11 4.30E-11 4.31E-11 4.31E-11 4.31E-11 4.33E-11 4.33E-11 4.38E-11 4.39E-11 4.39E-11 4.41E-11 4.42E-11 4.42E-11 4.43E-11 4.44E-11 4.45E-11 4.45E-11 4.46E-11 4.47E-11 4.50E-11 4.52E-11 4.52E-11 4.53E-11 4.53E-11 4.55E-11 4.57E-11

EP

S25 S735 S732 S737 S42 T287 T122 S1220 Y18 S430 S520 T614 T54 S411 S514 T645 S900 S83 Y1930 S111 T1367 S44 S91 S17 S114 S884 S227 Y427 T172 Y301 Y299 T982 T389 S321 T235 S2412 S71 T1266 S1258 T581 S1162 S178 S21 S519 S117 S1475 T495 T129 S158 T118

AC C

Q01105-2 P98175-2 P98175-2 P98175-2 Q99576-3 P27816 Q96T60 Q9C0C9 Q8IVP5 P35658 Q13330 Q9UPN6 Q9BV40 Q14676 P40222 P35221 Q96N67 Q15300 P24928 Q9Y580 Q9NTI5 Q96TC7 Q9UK76 Q96CP2 Q96FF9 Q8N122 Q5JTV8 Q9Y6D9 Q96AC1 P08559 P29803 Q9UK61 P35269 O75674 Q8N0Z3 Q9UQ35 Q53EL6 Q9HBL0 P46821 P17812 P00533 O00566 Q2M2I8 P10636 Q07157 Q14160 P29692-2 P29692 Q53XM7 Q5VZL5

TE D

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EP

4.57E-11 4.59E-11 4.59E-11 4.59E-11 4.60E-11 4.62E-11 4.64E-11 4.65E-11 4.65E-11 4.65E-11 4.66E-11 4.71E-11 4.71E-11 4.71E-11 4.71E-11 4.72E-11 4.72E-11 4.74E-11 4.74E-11 4.79E-11 4.79E-11 4.79E-11 4.83E-11 4.83E-11 4.85E-11 4.86E-11 4.86E-11 4.88E-11 4.88E-11 4.88E-11 4.89E-11 4.92E-11 4.94E-11 4.98E-11 4.99E-11 5.00E-11 5.00E-11 5.00E-11 5.02E-11 5.03E-11 5.03E-11 5.04E-11 5.04E-11 5.04E-11 5.04E-11 5.04E-11 5.04E-11 5.09E-11 5.12E-11 5.12E-11

AC C

Q8IWW6 T230 P22626 Y262 O14617 S758 O14617 S788 P78310 T334 P20810 S364 Q9ULD2 T1247 P46100 S108 Q9BW34 S431 P29692-2 S528 Q9C0E2 S524 Q96C86 S24 Q96C86 T25 O60716 S232 Q86U44 T65 Q14676 S1095 Q8IVT2 S582 Q7Z401 T1590 P17535 S251 Q9Y6M4-3 T367 Q9P206 Y982 Q96E09 T64 Q8IXT5 S718 P11717 T2415 Q9H307 S441 Q9UK58 S342 Q9Y2W1 T324 Q9UJV9 S83 Q9UJV9 S86 Q9UDY2 T1054 Q9P206 S981 Q96PE2 S418 Q5T1M5 S964 Q96KB5 S59 O95639 S201 Q9H910 T102 Q9H910 S103 O95359 S2250 Q9NTI5 S1161 Q6IB11 S57 Q9UDY2 Y249 Q04637-8 S1232 Q04637-3 S1191 O94875-4 S420 O94875-12 S460 O94875-5 S420 O94875-2 S395 Q6AI08 S640 Q14004 S441 P42684 S602

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5.13E-11 5.13E-11 5.14E-11 5.17E-11 5.17E-11 5.25E-11 5.27E-11 5.32E-11 5.32E-11 5.32E-11 5.32E-11 5.32E-11 5.33E-11 5.33E-11 5.35E-11 5.35E-11 5.36E-11 5.37E-11 5.37E-11 5.41E-11 5.42E-11 5.44E-11 5.44E-11 5.44E-11 5.45E-11 5.50E-11 5.50E-11 5.50E-11 5.52E-11 5.52E-11 5.57E-11 5.64E-11 5.64E-11 5.64E-11 5.68E-11 5.72E-11 5.73E-11 5.74E-11 5.76E-11 5.77E-11 5.78E-11 5.78E-11 5.78E-11 5.81E-11 5.82E-11 5.85E-11 5.89E-11 5.89E-11 5.89E-11 5.90E-11

AC C

Q8TF74 S266 P13051 S67 P36915 S55 Q14677 Y293 Q8TF74 T269 O95639 S202 Q15464 S312 Q9Y4H2 S1153 Q9Y4H2 T1151 Q9Y4H2 S1162 Q6PKG0 T624 Q14839 S1537 A6NMY6 Y24 P07355 Y24 Q14643 S1767 Q96RG5 S1178 P24928 S1962 Q8IXT5 S710 Q9UPP1 S1024 Q7Z417 S113 P46379 S106 Q8WWI1-3 Y470 P11717 S2401 P28482 T181 Q8NHV4 S518 O15541 Y249 A4QN18 S1710 J3KNL6 S2083 O00712 S326 O00712 S325 P43007 S502 Q06265 T305 O43149 S1520 O43149 T1512 Q14676 T447 Q92733 S278 Q92613 T558 Q14247-3 S381 Q969V6 S449 Q9UBK8 S191 Q5VSL9 S339 O95251 S138 O95251 S136 Q7Z6E9 S1273 Q00613 T357 P15502 S641 Q9C0C9 T838 Q9C0C9 T834 Q13428-6 S1076 Q5VSY0 S25

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TE D

5.90E-11 5.90E-11 5.93E-11 5.95E-11 5.97E-11 5.97E-11 5.98E-11 5.99E-11 6.00E-11 6.04E-11 6.04E-11 6.09E-11 6.12E-11 6.12E-11 6.14E-11 6.14E-11 6.14E-11 6.14E-11 6.18E-11 6.20E-11 6.24E-11 6.24E-11 6.24E-11 6.27E-11 6.28E-11 6.28E-11 6.29E-11 6.32E-11 6.33E-11 6.39E-11 6.39E-11 6.43E-11 6.46E-11 6.47E-11 6.47E-11 6.50E-11 6.50E-11 6.51E-11 6.52E-11 6.52E-11 6.54E-11 6.54E-11 6.57E-11 6.59E-11 6.59E-11 6.61E-11 6.64E-11 6.72E-11 6.74E-11 6.75E-11

EP

S27 S23 S603 S73 S727 S726 T199 T881 Y351 T204 S436 S1298 S325 S216 S790 S784 S782 S778 S459 T622 S115 S1364 S1375 S203 S185 S393 S127 S420 S172 T726 S724 S1311 S200 S747 S749 Y22 S729 S188 S686 S687 Y23 S25 S684 T599 S168 S311 S471 S64 T941 S712

AC C

Q5VSY0 Q5VSY0 Q8NB74 P08670 Q7Z6Z7 Q7Z6Z7 Q9NQX3 A9Z1X7 P42167 Q6ZUT6 Q14004 O60293 Q9P289 O15231-2 A9Z1X7 A9Z1X7 A9Z1X7 A9Z1X7 A9UF02 Q6PKG0 Q96HC4 Q96T23 Q96T23 O60504-2 P05549 Q9BXF6 P41236 Q9UQ35 O60341 Q05682 Q05682 Q92538 Q9NQX3 A9Z1X7 A9Z1X7 A2RU67 Q5VZ89 Q9UHB7 Q8N163 Q8N163 P50443 P50443 Q9Y2W1 P42684 Q8TBF4 Q9H8G2 Q92917 Q86U44 O75372 Q12873

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6.76E-11 6.77E-11 6.77E-11 6.77E-11 6.79E-11 6.79E-11 6.80E-11 6.80E-11 6.80E-11 6.80E-11 6.81E-11 6.81E-11 6.82E-11 6.82E-11 6.87E-11 6.89E-11 6.92E-11 6.92E-11 6.93E-11 6.94E-11 6.94E-11 6.94E-11 6.94E-11 6.97E-11 6.98E-11 7.01E-11 7.01E-11 7.01E-11 7.02E-11 7.06E-11 7.07E-11 7.09E-11 7.09E-11 7.13E-11 7.13E-11 7.13E-11 7.13E-11 7.16E-11 7.17E-11 7.18E-11 7.18E-11 7.19E-11 7.20E-11 7.21E-11 7.21E-11 7.22E-11 7.22E-11 7.24E-11 7.27E-11 7.27E-11

AC C

P10071 S664 O15234 T141 P08727 S49 P08727 S46 Q9UPQ0-3 S66 Q9UPQ0-3 S67 Q9UPQ0-3 S72 Q86YS7-2 S648 Q86YS7 S657 Q9Y2W1 S584 Q5T200 T984 P49023 S83 Q9Y4E1 S544 Q9UGY1 T124 O75151 S879 P10809 S67 Q14247-3 Y384 Q14247 Y421 P22392-2 S237 Q9P289 S304 Q9P289 S309 Q9P289 S300 P0DJ93 S50 Q9NZL4 S359 Q9UKI2 S91 P20020 S1246 Q01814 S1234 Q01814 S1231 P0C1Z6 T172 Q6PK21 S234 Q5TDG3 S240 Q9Y6A5 S177 Q15311 T27 O75400 S935 O75400 S933 O75400 S938 O75400 T932 P46108 T42 O75410 S267 O96028 T544 Q13283 Y133 Q969V6 S446 Q9NWH9 S999 Q92538 S1788 Q14677 S299 O00499-10 S287 O00499-10 S280 Q63ZY3 T552 Q8WWM7 S563 Q53EL6 S82

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7.28E-11 7.29E-11 7.31E-11 7.39E-11 7.39E-11 7.42E-11 7.42E-11 7.42E-11 7.43E-11 7.46E-11 7.48E-11 7.49E-11 7.50E-11 7.53E-11 7.58E-11 7.67E-11 7.68E-11 7.69E-11 7.70E-11 7.70E-11 7.80E-11 7.80E-11 7.83E-11 7.86E-11 7.87E-11 7.89E-11 7.89E-11 7.90E-11 7.95E-11 7.95E-11 7.95E-11 7.96E-11 7.96E-11 7.97E-11 7.98E-11 8.00E-11 8.00E-11 8.01E-11 8.01E-11 8.03E-11 8.03E-11 8.03E-11 8.05E-11 8.06E-11 8.08E-11 8.11E-11 8.12E-11 8.12E-11 8.15E-11 8.15E-11

EP

S85 T733 S114 Y435 S236 S114 S117 S4 Y94 S1032 S195 S8 S368 T749 T90 S2561 Y750 S599 S882 S881 S4752 S4754 S40 T848 T562 T1194 T1196 S30 T158 T1091 T2065 S655 S135 S543 S474 S464 S682 S540 S546 T627 S605 S602 S227 T321 T1749 T327 S133 T598 T271 S273

AC C

Q96JP5 Q86X10 Q96T60 Q9NPQ8 P49916 Q59EQ8 Q59EQ8 Q53ET0 P09668 Q9UHW9 Q00059 Q01082-3 Q14247-3 Q8IZL8 Q15029 Q12802 Q9UQ88 Q5VT52 Q8N122 Q8N122 Q9NU22 Q9NU22 P13051 P35606 P27824 P38398 P38398 Q969E4 Q5JSH3 P46013 P46013 O60293 O95251 Q9Y566 Q8IVT2 Q3YEC7 Q9C0B5 Q9H4G0 Q9H4G0 P27816 P27816 P27816 Q8ND56 Q13769 Q14980 O00499 Q8NEY8 Q05209 Q9UJU6 Q9UJU6-2

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8.15E-11 8.15E-11 8.19E-11 8.22E-11 8.24E-11 8.24E-11 8.24E-11 8.24E-11 8.25E-11 8.25E-11 8.25E-11 8.26E-11 8.27E-11 8.27E-11 8.36E-11 8.37E-11 8.40E-11 8.41E-11 8.42E-11 8.43E-11 8.43E-11 8.45E-11 8.48E-11 8.54E-11 8.56E-11 8.56E-11 8.56E-11 8.61E-11 8.63E-11 8.64E-11 8.64E-11 8.64E-11 8.66E-11 8.66E-11 8.67E-11 8.68E-11 8.78E-11 8.78E-11 8.79E-11 8.83E-11 8.84E-11 8.85E-11 8.86E-11 8.96E-11 8.98E-11 9.02E-11 9.03E-11 9.03E-11 9.04E-11 9.07E-11

AC C

Q9UJU6-2 T272 Q9UJU6 S272 Q8IWC1 T193 Q9UBC2 T251 O94880 T287 O94880 S290 O94880 S280 Q04726 S289 Q9UKM9 T298 Q9UKM9-2 T282 Q53GL6 S289 P08651 S337 Q86YS7-2 S653 Q86YS7-2 S650 Q5VU21 S309 Q92615 S599 Q5SYE7 T1394 O15169 Y82 P36915 T57 Q5SNT6 S200 Q5SNT6 S196 Q12888 S1327 Q7Z6E9 S1277 P46821 Y1796 Q99590 T800 O15173 S94 Q92730 S184 Q8NFH5 T109 Q12788 S418 Q68CZ2 S337 P52292 T61 Q9H7L9 T244 Q9BY44 T512 P52701 T139 P29317 T898 O60318 S529 Q13439 T43 Q68CZ2 S662 Q5JSZ5 S1395 Q9P206 T932 Q15596 S698 Q12906 T188 O43237 T410 Q8WWI1 S1516 Q8WWM7 S589 Q9UQ35 S421 Q5T0N5-4 S430 Q5T0N5 S488 Q6IPH7 S139 Q9H6F5 S37

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TE D

9.07E-11 9.14E-11 9.14E-11 9.14E-11 9.17E-11 9.24E-11 9.25E-11 9.25E-11 9.27E-11 9.27E-11 9.27E-11 9.30E-11 9.31E-11 9.32E-11 9.43E-11 9.43E-11 9.47E-11 9.48E-11 9.48E-11 9.49E-11 9.50E-11 9.50E-11 9.51E-11 9.62E-11 9.73E-11 9.78E-11 9.79E-11 9.81E-11 9.81E-11 9.84E-11 9.87E-11 9.90E-11 9.94E-11 9.95E-11 1.00E-10 1.00E-10 1.00E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.01E-10 1.02E-10 1.02E-10 1.02E-10 1.02E-10 1.02E-10

EP

T39 S636 S632 S634 S306 T2373 T56 T215 S287 T294 S284 S588 Y211 S58 S30 S55 Y161 S418 S417 S47 T353 S53 S732 S25 S107 S50 T113 S2118 T1738 S475 S363 T224 Y130 S591 T255 S176 S23 T298 S43 T483 Y109 S585 S565 S539 S188 T197 Y1379 T1313 T1903 S957

AC C

Q9NTJ3 O14617 O14617 O14617 Q9GZR7 O95359 Q9UPQ0-3 Q9UPQ0 Q969R2 Q969R2 Q969R2 P51531 Q15019 Q9H6Z4-3 Q9H1E3 Q9BV40 Q96I25 Q9UQ35 Q9UQ35 O95674 O60293 Q13620 Q5VZ89 Q9UNE7 Q9Y580 Q9H6F5 Q96FF9 Q9UQ35 Q96L91 O60583 Q6P6C2 Q9ULR3 Q99959 P51531 Q9BUA3 Q14676 Q96A57 Q15007 P46108 Q9H6S3 Q9NQS1 Q7KZI7-14 Q7KZI7-4 A9CP04 P0C1Z6 Q6WKZ4 P51532 O94964 P24928 Q14683

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1.02E-10 1.02E-10 1.02E-10 1.02E-10 1.02E-10 1.03E-10 1.03E-10 1.03E-10 1.03E-10 1.03E-10 1.03E-10 1.03E-10 1.04E-10 1.04E-10 1.04E-10 1.04E-10 1.04E-10 1.05E-10 1.05E-10 1.05E-10 1.05E-10 1.05E-10 1.06E-10 1.06E-10 1.06E-10 1.06E-10 1.07E-10 1.07E-10 1.07E-10 1.07E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.08E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.09E-10 1.10E-10

AC C

Q13112 T433 Q9HCK8-2 S2239 Q9HCK8-2 S2240 P55265 S599 Q9UKZ1 S7 Q9Y4H2 S1149 Q9Y4H2 S1164 Q9HCK8 S1424 Q9HCK8 S1420 Q5VZ89 S989 Q07157 S622 O95639 S200 Q9UQ35 S2415 P38398 T1550 Q9UPT8 T1106 Q02880 S1457 Q12888 T548 Q9BUR4 T81 Q9UKS6 T347 Q5JSH3 S471 Q9UHW9-2S51 Q8TBN0 T165 Q8NI27 S1422 Q8NI27 S1421 Q96GM8 S420 Q8WWM7 S558 Q9NYF8 S217 Q9NQZ2 S42 Q9NQZ2 T41 Q8WW12 S142 Q86UU1 T522 Q92733 T165 O94979 Y804 Q9H4L5 S374 Q9H3H1 S431 Q9UNZ2 S271 Q9NPQ8 S528 Q9NPQ8 S524 Q9NPQ8 S523 Q5VZ89 S737 O94964 S1303 Q99590 S798 P49768 S365 Q6PKG0 Y633 P20700 S396 Q03252 S385 Q03252 S390 Q13610 S57 P53396 S478 P51636 S20

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1.10E-10 1.10E-10 1.10E-10 1.11E-10 1.11E-10 1.11E-10 1.12E-10 1.12E-10 1.12E-10 1.12E-10 1.12E-10 1.12E-10 1.13E-10 1.13E-10 1.13E-10 1.13E-10 1.13E-10 1.14E-10 1.15E-10 1.15E-10 1.15E-10 1.16E-10 1.16E-10 1.16E-10 1.16E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.17E-10 1.18E-10 1.18E-10 1.18E-10 1.18E-10 1.18E-10 1.19E-10 1.20E-10 1.20E-10 1.20E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10

AC C

Q6Y7W6-4 T367 Q6Y7W6 T373 P02545 S18 Q5VV17 S216 Q16649 S301 Q8WWI1 S1018 Q9UPP1 Y852 Q5JSH3 S472 Q5JSH3 S470 Q5JSH3 Y479 Q9BQG0 S1243 P46013 S296 Q9Y3T9 S60 Q7Z309 S50 Q8IZC6 T1040 Q9H788 S316 P53396 S457 O75446 T145 Q96Q15 T3569 Q9UDY2 S978 Q6ZSP3 S24 Q9H8S9 S38 Q7L9L4 S38 Q8NC51 T232 Q92917 T473 P00533 Y585 P25490 Y254 Q9BUR4 S87 P07814 S885 Q9UPT8 S1108 P47712 S434 Q01082-3 S10 Q8NHV4 S568 Q01082-3 S7 Q6ZW31 S247 Q5M775 S133 Q14157 S445 Q14157 T446 P12270 T2146 O95674 S35 O95361 S29 Q5M775 S810 P15336 T73 P46821 T1913 P62995 S266 Q13595 S262 Q6GYQ0 S864 Q2L6I2 S140 Q8NE71 S140 Q9UQ35 S1621

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1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.21E-10 1.22E-10 1.22E-10 1.22E-10 1.22E-10 1.23E-10 1.23E-10 1.24E-10 1.24E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.25E-10 1.26E-10 1.27E-10 1.27E-10 1.27E-10 1.27E-10 1.27E-10 1.28E-10 1.28E-10 1.28E-10 1.29E-10 1.29E-10 1.29E-10 1.30E-10 1.31E-10 1.31E-10 1.31E-10 1.31E-10 1.31E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.32E-10 1.33E-10 1.33E-10 1.33E-10 1.34E-10 1.34E-10

EP

S1618 S1616 S1620 S33 S149 Y1172 S66 S868 S188 S578 S92 S482 T327 T182 S14 T198 T649 S3525 S1089 S250 S41 T32 T330 T325 S338 S453 T1203 S113 T208 S175 Y596 S458 T19 S276 S270 S258 S1166 T634 T718 S633 S634 Y19 S18 S23 T384 Y453 S464 T890 S111 S196

AC C

Q9UQ35 Q9UQ35 Q9UQ35 Q05D32 Q14181 P00533 P54829 O60716 Q1KMD3 P17812 P13861 Q9NR09 Q8ND30 Q92730 Q9UBD8 P27361 Q71RC2 Q03164 Q5VZ89 Q9UBC2 Q9H2H9 Q9H2H9 Q9UK58 Q9UK58 Q9UK58 Q13263 P20020 Q8WUF5 Q7L2J0 Q96C57 Q8IYB3 Q9NV70-2 Q15149-4 Q9UJU6-2 Q9UJU6-2 P55081 Q9BQG0 P35221 Q8IYB3 P42684 P42684 P51636 P51636 P51636 Q9UQ35 Q9H4M9 Q9BTU6 Q01831 Q8WWM7 Q86X95

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1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.34E-10 1.35E-10 1.35E-10 1.36E-10 1.36E-10 1.36E-10 1.37E-10 1.37E-10 1.37E-10 1.37E-10 1.37E-10 1.38E-10 1.38E-10 1.38E-10 1.38E-10 1.38E-10 1.38E-10 1.38E-10 1.38E-10 1.39E-10 1.39E-10 1.39E-10 1.39E-10 1.40E-10 1.40E-10 1.40E-10 1.40E-10 1.41E-10 1.41E-10 1.41E-10 1.42E-10 1.42E-10 1.43E-10 1.44E-10 1.44E-10 1.44E-10 1.44E-10 1.44E-10 1.44E-10 1.45E-10 1.45E-10

EP

T26 S4257 S4256 S4280 S4253 S4252 S4238 S4239 S4279 S867 T429 T525 T177 S166 Y70 S649 T377 S599 S590 S136 S620 Y226 Y231 S221 S223 S277 S819 T409 T228 S428 Y214 S89 T1583 T104 T409 S23 T883 T588 S353 S58 T739 S224 S1497 S156 S50 S714 S270 S272 Y140 S2045

AC C

Q96CP2 Q15149-6 Q15149-6 Q15149-2 Q15149-4 Q15149-4 Q15149-9 Q15149-9 Q15149-2 P35606 O14639 O00567 Q96D71 Q96D71 Q13442 P21580 Q8IVT2 Q07866-4 Q07866-6 Q9HAF1 Q13586 P51812 Q9UK32 Q9ULR3 Q9ULR3 Q13501 P42684 Q9UHR4 Q9UKX7 Q8NDI1 Q13242 Q15637 Q8WWI1 Q14847 P02545 Q14134 Q8N122 Q8WWM7 Q9NZL4 Q5VV42 Q5VZ89 P23396 P11388-2 Q9NYF8 Q96TC7 Q14671 Q04656 Q04656 Q13523 O75179

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1.46E-10 1.46E-10 1.46E-10 1.47E-10 1.47E-10 1.47E-10 1.48E-10 1.48E-10 1.48E-10 1.49E-10 1.49E-10 1.49E-10 1.50E-10 1.51E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.52E-10 1.53E-10 1.53E-10 1.53E-10 1.53E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.54E-10 1.55E-10 1.55E-10 1.55E-10 1.55E-10 1.55E-10 1.56E-10 1.56E-10 1.57E-10 1.57E-10 1.58E-10 1.58E-10

AC C

Q9H3P2 S360 Q8WWI1 T1424 P22059 S198 Q01082-3 T6 Q01082-3 S14 P22392-2 S235 Q9P2K3 T163 Q9UKV3 T408 Q92538 S1781 Q4LE39 Y795 Q4G0J3 S254 Q09666 T218 Q86SQ4 S1165 O00499 T323 Q14643 S1764 Q14643 T1766 P35580 T1960 Q5VT52 S597 Q5VT52 T598 Q8NDI1 T427 Q01518 S301 P42167 S79 P42166 S79 Q16181 Y30 Q16181 Y41 Q8WVP7 S473 Q8WVP7 T472 P07814 Y872 Q92614 S728 Q86W92-2 S532 Q8IYB3 T693 Q6NXS1 S127 Q15300 S77 P10644 S77 Q8IVT2 S586 Q9H4A3 S2002 Q14684 S731 Q14684 S735 Q659A1 S421 Q6AI39 S674 Q14247 T411 Q8N3F8 S612 Q15648 S1482 Q6ZWE6 S152 Q96CB8 T125 Q15464 Y297 Q14980 T1744 Q86U44 S48 P43630 Y398 Q00613 S368

ACCEPTED MANUSCRIPT

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1.58E-10 1.58E-10 1.59E-10 1.59E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.60E-10 1.61E-10 1.61E-10 1.61E-10 1.61E-10 1.61E-10 1.62E-10 1.62E-10 1.62E-10

EP

TE D

T367 S860 S1551 S20 S288 S395 Y26 S131 T410 S955 T956 Y87 Y1316 S1051 S544 S47 T286 S295 S376 S373 Y151

AC C

Q00613 Q9Y6Q9 O95071 Q15149-4 Q9UKM9 P02545 Q9H1E3 Q13523 Q99590 P41594 P41594 Q15637 Q8WWQ0 P46019 P46821 Q8TAP8 Q9UKM9 Q9UKM9 Q8WVM8 Q8WVM8 O75446

TE D

RI PT

M AN U

SC

ACCEPTED Localization probility Overlap MANUSCRIPT 0.202781 PhoPepMass 0.231364 PhoPepMass 0.231364 PhoPepMass 0.240016 PhoPepMass 0.243589 PhoPepMass 0.25828 PhoPepMass 0.262518 PhoPepMass 0.263085 PhoPepMass 0.277779 PhoPepMass 0.295359 PhoPepMass 0.299111 PhoPepMass 0.304953 PhoPepMass 0.304953 PhoPepMass 0.308211 PhoPepMass 0.308211 PhoPepMass 0.311582 PhoPepMass 0.311582 PhoPepMass 0.312719 PhoPepMass 0.318683 PhoPepMass 0.320353 PhoPepMass 0.320353 PhoPepMass 0.321148 PhoPepMass 0.324736 PhoPepMass 0.327105 PhoPepMass 0.328879 PhoPepMass 0.330205 PhoPepMass 0.331273 PhoPepMass 0.332335 PhoPepMass 0.332335 PhoPepMass 0.332335 PhoPepMass 0.332507 PhoPepMass 0.33265 PhoPepMass 0.333162 PhoPepMass 0.333329 PhoPepMass 0.33333 PhoPepMass 0.333332 PhoPepMass 0.333332 PhoPepMass 0.333333 PhoPepMass 0.334375 PhoPepMass 0.336269 PhoPepMass 0.338169 PhoPepMass 0.344398 PhoPepMass 0.349632 PhoPepMass 0.349632 PhoPepMass 0.350603 PhoPepMass 0.351645 PhoPepMass 0.351645 PhoPepMass 0.358679 PhoPepMass 0.364199 PhoPepMass

EP

Site S442 S356 T358 S470 S1665 T316 S63 T318 S2885 S676 S1153 T349 S350 T1647 S1646 S446 S447 S343 T349 T515 S512 S330 S339 S369 T161 T130 T449 S302 S305 T306 S462 S647 T178 S236 S279 T226 S225 S740 T250 S752 S466 T338 S304 S308 S294 S726 T727 S1995 S197

AC C

Protein Q9NZB2 Q9H814 Q9H814 Q14157 Q9C0D5 Q9UQ35 O75496 Q9UQ35 Q5T4S7 Q8WWQ0 A7E2V4 Q9H814 Q9H814 Q12888 Q12888 P14859 P14859 P12694 Q01831 Q86V48 Q86V48 Q9H330 Q16643 A8CG34 Q6UUV9 O95251 Q14676 Q86U70 Q86U70 Q86U70 Q7Z5L9 Q7Z460 Q86TB9 Q9H7L9 Q96RK0 Q9UN86 Q9UN86 Q9H2P0 Q86TC9 Q9NRA8 Q9H6S3 P12694 Q9Y4H2 Q9Y4H2 O00712 Q92614 Q92614 P46100 Q9NV56

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.375031 0.376613 0.377828 0.378834 0.387264 0.387808 0.397511 0.399265 0.399265 0.402912 0.404591 0.41145 0.41145 0.411766 0.411766 0.418385 0.42132 0.424489 0.425871 0.426995 0.427211 0.43215 0.432934 0.433625 0.433625 0.436265 0.438587 0.438736 0.440012 0.440786 0.44204 0.446571 0.446849 0.448141 0.448141 0.449499 0.450392 0.451812 0.453283 0.453283 0.453652 0.453652 0.45518 0.455996 0.457181 0.459006 0.461187 0.461259 0.461822 0.461822

EP

T992 S357 S22 S368 T448 S659 S325 T159 T2022 S880 S608 S203 S205 S294 T295 S372 S240 T178 S5737 S5851 S195 S548 S2041 S107 S106 T723 S1116 S516 S360 S336 S241 T681 T219 T2889 S2888 S24 T506 S164 S370 S371 T678 S677 Y44 T76 S108 S895 T488 S147 S777 T779

AC C

Q4ADV7 Q9UQ35 O75569 Q9UHB6 Q14676 Q8NFC6 P61073 Q13765 E9PAV3 P07814 Q14157 Q92925 Q92925 Q6WCQ1 Q6WCQ1 Q9H4L5 Q9UNX4 Q96CX2 Q09666 Q09666 Q9NV56 Q01804 O75179 O60231 O60231 P40818 Q9Y4G8 Q9ULM3 Q8N6T3 Q99569 P49916 O60237 Q9NQS7 Q7Z6Z7 Q7Z6Z7 Q9BRS2 P43007 Q9NQG5 Q9H4L5 Q9H4L5 Q8WWQ0 Q8WWQ0 Q9NQZ2 P35251 Q9Y580 Q9HC35 P51114 P29966 Q9Y2H5 Q9Y2H5

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.463024 0.463575 0.464474 0.465135 0.46687 0.473104 0.473365 0.473478 0.47376 0.47376 0.4746 0.474665 0.477022 0.477174 0.477174 0.479239 0.479239 0.480078 0.483077 0.483077 0.483366 0.483872 0.485247 0.485314 0.485423 0.485423 0.487881 0.48801 0.488057 0.488246 0.488421 0.489387 0.489918 0.489918 0.490334 0.492016 0.492158 0.492704 0.49325 0.49325 0.493503 0.494377 0.496342 0.496388 0.496388 0.496743 0.49756 0.497939 0.498145 0.498788

EP

S351 S903 S3517 T198 S839 S504 S493 S363 T1256 S1254 S327 S350 S621 T836 S833 S795 S796 S745 S235 T234 S963 S677 T214 S217 S355 S356 T895 S127 T639 S1114 S271 S1268 T220 S219 S391 S452 T363 S2069 S775 S773 T318 S485 S393 T28 S27 T1003 S420 T453 T720 S643

AC C

Q01831 Q14C86 Q03164 Q9NQX3 Q9C0C9 Q8N5C8 A0MZ66 Q00613 O60610 O60610 Q9H330 Q01831 Q7KZI7 Q5VYK3 Q5VYK3 Q6GYQ0 Q6GYQ0 Q8TEW8 P78345 P78345 Q14676 Q86TV6 Q86WR7 Q6WCQ1 P51991 P51991 Q8IX03 Q96CB8 Q86TC9 Q13428 O75128 Q9ULD2 Q8ND56 Q8ND56 P27448 Q08J23 Q9NQW6 Q9Y618 Q6GYQ0 Q6GYQ0 P61073 P51114 Q9P0L2 P52564 P52564 Q12965 Q15326 P53396 P10636 Q86TC9

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.498881 0.499006 0.499014 0.499379 0.499379 0.499379 0.499379 0.499379 0.499404 0.499566 0.499765 0.499803 0.499803 0.499906 0.49992 0.499922 0.499935 0.499962 0.49997 0.499972 0.499972 0.499981 0.499985 0.499985 0.499997 0.499997 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.501113 0.502388 0.503776 0.505153 0.505153 0.506065 0.509039 0.512261 0.512821 0.512846 0.512952 0.512952 0.513167 0.515738

EP

S1239 T914 T329 S1276 S2251 S1275 S1276 S1275 S89 T116 S695 S366 S365 S1157 T1555 S795 T51 T942 S390 S501 S500 S434 T739 T751 S95 S96 T2583 S478 T1177 S140 S486 S1049 S368 S478 S94 S310 S3515 S638 S607 T609 S610 S392 S1218 S491 T51 T246 S251 T252 S216 S1400

AC C

Q8WXG6 Q16512 Q8NC44 Q7Z3J3 P49792 Q99666 A6NKT7 O14715 P16333 Q12982 O14974 Q6NZI2 Q6NZI2 O43432 P18583 Q86VM9 P30086 P27816 O15027 Q6WKZ4 Q6WKZ4 Q9BVJ6 Q9UQ88 P21127 Q9HB90 Q9NQL2 Q9UQ35 Q9Y4E1 Q9UQ35 Q9UQC2 Q8WUI4 P41252 O75122 Q641Q2 P05455 Q14669 Q03164 Q96TA1 Q14157 P51532 P51532 Q96HA1 Q9UQ35 Q9UHB7 Q7Z309 Q6ZW31 Q9UHR4 Q9UHR4 Q9BU76 P49792

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.516069 0.516684 0.516684 0.516803 0.517359 0.517613 0.518256 0.518734 0.519731 0.519859 0.520779 0.520956 0.521288 0.521337 0.521904 0.525103 0.528689 0.531231 0.532627 0.534416 0.53544 0.536074 0.53716 0.538359 0.538403 0.538434 0.538485 0.53895 0.540339 0.541341 0.541842 0.543209 0.546259 0.550857 0.551087 0.552071 0.552925 0.554003 0.554426 0.556026 0.557868 0.559784 0.559964 0.561189 0.561189 0.562509 0.562567 0.563628 0.563997 0.564234

EP

S717 S26 S26 S537 S115 T856 S3818 S54 S288 S1668 Y5836 T1608 S699 S2394 T228 S446 S41 S131 S743 T172 S956 S55 S1219 S1481 S1214 T173 S475 S613 T315 S218 S524 S476 S31 S258 S1251 S25 S560 S691 S92 S40 S535 S208 S68 T1756 S1758 S619 T483 S77 S215 S1100

AC C

Q8IYB3 A6NMY6 P07355 Q15042 Q7Z309 Q9UQ35 Q7Z6Z7 O00264 P14921 Q9C0D5 Q09666 Q14676 A0FGR8 Q9UQ35 Q15019 P18887 P49736 Q99959 Q86YV5 Q9NZM1 Q14683 O43818 Q12888 Q15648 Q9UQ35 Q96D71 Q9UMZ2 Q99590 Q9UQ35 Q9NQS7 Q07866 Q14157 Q9UHB7 Q15942 Q7LBC6 O00193 P12956 Q96TA1 Q9UK76 P46108 Q9BTA9 P43243 Q9H307 Q12888 Q12888 Q7KZI7 P51114 Q96S55 Q5JTV8 Q13464

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.564434 0.564622 0.566239 0.566518 0.56678 0.567841 0.568891 0.570263 0.571397 0.572184 0.572766 0.573407 0.57461 0.577113 0.577591 0.580183 0.582746 0.584335 0.584889 0.585382 0.586107 0.588172 0.588322 0.588758 0.589148 0.589348 0.589952 0.591142 0.592408 0.593002 0.593995 0.594521 0.595029 0.595804 0.596993 0.599428 0.599457 0.59969 0.599836 0.601981 0.603241 0.604898 0.605101 0.605536 0.606564 0.607268 0.607802 0.609277 0.609826 0.609826

EP

T334 S2835 S525 S417 T39 T1399 T381 S975 S933 S512 S262 T42 S2518 S11 S12 T79 S1090 S361 T453 S179 S1125 S623 S172 S4626 T190 T149 S498 S343 S836 S406 S521 S499 S341 S699 S233 T465 S762 S1276 S582 S43 S16 S1791 S743 S339 S154 S358 T1589 S99 S233 S234

AC C

Q9H330 O75592 O95365 Q14247 P17096 P49792 P12270 Q9UPQ0 Q9HAU0 O15231 Q9NYF8 Q9H6F5 Q9HCK8 P45973 P45973 Q15029 Q9H6S0 Q9Y2X7 Q08J23 Q96C57 Q12774 Q2M2I8 P04920 Q15149 Q9NYF8 Q96E09 P23588 Q6WKZ4 Q9C0C9 O43237 Q92560 P47736 Q9NZN5 Q15596 P63261 Q9H6S3 Q66K74 Q9P2E9 Q86W92 Q96BD0 Q86U86 Q92538 Q8IZL8 P12694 Q8IWS0 Q9UQ35 Q8IVL1 Q8NFH5 Q14151 Q15424

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.610928 0.612694 0.612713 0.612751 0.613239 0.614817 0.616352 0.616407 0.616669 0.618427 0.619787 0.619989 0.624606 0.624606 0.62523 0.625703 0.629823 0.630232 0.630438 0.631257 0.631556 0.638098 0.638232 0.638543 0.639118 0.639943 0.640932 0.645508 0.648174 0.650531 0.650531 0.653048 0.654178 0.654874 0.655441 0.655441 0.656562 0.658165 0.659708 0.661921 0.663209 0.666665 0.666667 0.667965 0.670857 0.672291 0.674049 0.674661 0.676389 0.676772

EP

T629 S366 S746 S454 S370 S598 S435 S134 S623 S339 S217 S382 S117 Y89 S113 T985 S1208 S178 S5735 S50 S566 S23 S644 S97 S21 S40 S29 S307 S386 S18 S18 S168 S4622 S223 S470 S471 S107 S675 S523 S759 S612 S300 S69 S56 S151 S1760 S297 T990 S211 S17

AC C

Q96AE4 P46937 Q8TEW8 Q969V6 Q86WB0 Q7Z460 P47712 Q9UGY1 Q9HBL0 Q6WKZ4 Q9BU76 Q96JM3 Q6IN85 O75376 O43396 Q5T200 Q12888 Q9BXB4 Q09666 Q07960 Q02447 Q9Y4F1 P28290 Q9H7F0 O00458 P49736 P29966 Q15464 Q96JM3 P07355 A6NMY6 P42167 Q15149 Q7Z5K2 Q3YEC7 Q3YEC7 Q96FF9 P49756 Q9NPI6 P48634 Q9H694 Q4G0J3 Q96B23 O95251 Q6UUV9 Q14980 Q9NYF8 Q8WWI1 Q96B36 Q8IVP5

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.676817 0.677412 0.679137 0.683475 0.683486 0.688619 0.691042 0.692225 0.694452 0.694576 0.694816 0.695295 0.695975 0.697481 0.699603 0.701156 0.702818 0.703319 0.7038 0.705165 0.706388 0.706391 0.706826 0.707405 0.712788 0.715295 0.716093 0.717421 0.718477 0.719862 0.719862 0.720893 0.723488 0.724457 0.724505 0.726099 0.727239 0.729364 0.730287 0.731106 0.731242 0.731242 0.734264 0.734271 0.735787 0.736251 0.736526 0.738923 0.739325 0.740116

EP

S162 T1726 S3511 S511 S677 S863 Y284 S1162 S605 S202 S736 S2005 S650 S102 S756 S215 S700 S401 S363 S1271 S13 S518 S26 S428 S1492 S2042 S56 S295 S610 T1214 S1216 T294 S452 S255 S137 T383 S14 S2100 S777 S439 T287 T287 T71 S311 S678 T360 S278 T983 S721 S846

AC C

Q9Y6M1 Q96L91 Q03164 O00567 Q9P227 Q8N122 Q9NYF8 Q9NTI5 Q14157 Q14244 Q14684 Q9H4A3 Q9H4G0 Q9BW71 Q13263 Q86WR7 Q6PJG2 Q99590 Q8N6T3 Q9HBL0 P45973 Q9NQW6 P49736 Q9Y6D9 Q9Y6N7 O75179 Q6IAA8 P04049 Q9H0B6 Q12888 Q12888 Q14677 O14639 Q9UHR4 O43815 Q9UQ35 P45973 Q9UQ35 Q8N4C8 Q66K14 Q9Y4E1 Q641Q2 P15336 Q96SB4 Q86TV6 Q9BWW4 O94875 Q13428 P10636 Q9UQ35

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.741753 0.741859 0.742106 0.74325 0.745596 0.7469 0.749173 0.749352 0.751238 0.751363 0.754266 0.75435 0.754999 0.755422 0.75549 0.756096 0.756429 0.757358 0.758541 0.759831 0.76144 0.761619 0.763045 0.763071 0.764212 0.764563 0.767852 0.768063 0.768825 0.770403 0.772197 0.774972 0.775298 0.775343 0.775931 0.778975 0.780685 0.781097 0.784467 0.785559 0.785814 0.785978 0.787249 0.788885 0.789485 0.789673 0.790027 0.791772 0.792238 0.794057

EP

S732 S519 S2365 Y33 S220 T1469 T63 T359 S113 S183 S328 S179 S973 S40 S1589 S663 S521 T652 T210 S368 S2581 S940 T93 S465 S439 S33 S704 T795 S763 T4623 S648 T118 T510 T163 S1436 S342 S1182 S405 S1262 S937 S1067 T221 S194 S20 S460 S647 S333 S1089 S941 S738

AC C

Q14684 Q9ULM3 Q7Z6Z7 Q9UJV9 Q9BU76 Q9BTC0 Q96E09 Q9UQ35 Q3KQU3 Q96CX2 O75909 Q8NI08 Q9UPQ0 P80723 Q7Z401 Q15648 Q07866 Q9H4G0 Q9Y2W1 A8CG34 Q9UQ35 Q96ST3 O15173 P35611 Q8WWY3 Q92522 P16070 Q9Y597 Q8IW35 Q15149 Q9H4G0 Q3KQU3 Q86V48 Q7Z434 P25054 P12694 Q9NTI5 Q99590 P46821 Q9HAU0 Q12888 P23396 Q9NV56 Q6Y7W6 Q3KQU3 P13807 P49790 Q9H6S0 P27816 Q9UKJ3

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.794447 0.795324 0.795523 0.795698 0.795966 0.796624 0.803439 0.803716 0.805439 0.806381 0.80788 0.809296 0.809414 0.809952 0.811982 0.812331 0.812624 0.814434 0.816167 0.816466 0.819354 0.819463 0.819527 0.820718 0.821332 0.823284 0.825629 0.825902 0.828439 0.83184 0.832891 0.832897 0.833795 0.838193 0.845395 0.845688 0.846867 0.847666 0.84847 0.852298 0.854248 0.855629 0.855629 0.856045 0.856082 0.856981 0.864867 0.865177 0.865696 0.865869

EP

S473 S62 S625 S409 S2172 S30 S269 S2563 T1244 S306 S183 T2125 S150 T25 S49 S1092 S82 S73 S979 S1883 S197 T450 S30 S675 S264 S303 T139 S284 T899 S268 S861 S91 T158 T315 S660 S240 S88 S229 S113 S206 S148 S97 T96 S617 S860 S324 S31 S774 S402 S777

AC C

Q9NV70 Q96E09 P52948 Q13112 Q96JM2 Q3KR37 O60716 Q12802 P11388 Q06265 Q8NI08 Q9UQ35 Q6ZWE6 Q6Y7W6 Q07960 Q9H6S0 Q96JP5 P35251 Q9UK61 Q13315 Q6PID6 Q969V6 Q9H410 Q6AI39 Q9NYF8 Q9H4L5 Q86W56 Q96JM3 Q15811 P18887 Q6GYQ0 P38159 P42575 O15143 O14523 Q9Y446 P38159 O75533 Q86YP4 Q6WKZ4 O15234 P23193 P23193 Q9UPN6 Q6GYQ0 P61073 Q00341 Q6IN85 Q9Y2U8 Q6IN85

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.866579 0.867853 0.868617 0.871302 0.871787 0.871787 0.871868 0.872051 0.872906 0.873391 0.874246 0.875468 0.876795 0.876881 0.877918 0.878701 0.879546 0.880665 0.883803 0.884005 0.884604 0.887391 0.887494 0.888169 0.889042 0.89125 0.891927 0.894137 0.895494 0.895735 0.897085 0.899085 0.90063 0.900814 0.903139 0.903801 0.904677 0.904828 0.905276 0.90713 0.907237 0.908222 0.909554 0.91027 0.910456 0.910682 0.910864 0.913819 0.915346 0.915874

EP

S95 S437 S1218 S77 S120 S105 S786 S177 T215 S455 S2256 S461 S43 S28 S171 S649 T704 S641 S362 S2821 S363 S1191 S608 T414 S1217 S348 S1479 S361 S150 S528 S771 S77 S236 T2397 S534 T1370 S522 S389 T1019 S78 S528 S2057 S89 T469 S322 S222 S185 S484 T8 S177

AC C

Q86U42 Q13535 Q13017 P82094 P22392 O60361 Q8TEK3 Q86TB9 Q9BU76 O43318 O95359 P53985 P62750 Q9H410 Q96CX2 P13807 Q6PJG2 P28290 Q7L8J4 P15924 Q9H3P2 P38398 Q05209 Q9UKV3 Q76I76 Q08499 Q15648 Q8N6T3 Q9UBC1 Q96EN8 Q6IN85 O15169 P18887 Q9UQ35 Q6VY07 O75976 Q9NPI6 Q9NYF8 Q7Z401 Q53EL6 Q6WKZ4 Q9Y618 Q9UKI2 Q86SQ0 Q9UQ35 Q12888 Q96CX2 Q86US8 P45973 Q9BXB4

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.916416 0.917358 0.918051 0.919213 0.920009 0.921115 0.921553 0.923172 0.924215 0.924276 0.924376 0.925021 0.92643 0.927936 0.927936 0.929999 0.929999 0.930606 0.931163 0.931206 0.93145 0.931458 0.931732 0.93272 0.933286 0.934359 0.934857 0.934947 0.934947 0.935148 0.936909 0.937054 0.937901 0.939205 0.93996 0.940538 0.941015 0.941957 0.942542 0.942963 0.944166 0.944757 0.945193 0.945526 0.945762 0.946435 0.946449 0.946786 0.947328 0.948071

EP

S2003 S85 T866 S1219 S433 S2825 S242 S1732 S285 S864 S489 T328 S729 S25 S28 S283 S271 S28 S55 S51 S1165 S193 S761 S59 S899 S296 T207 S839 S1385 S425 S80 S1430 S690 S379 T37 S448 S433 S618 S164 T831 S557 S606 S1088 S290 S198 S1358 T358 S499 S11 S2719

AC C

Q14980 O15541 Q9UQ35 Q92766 P35658 P15924 Q96FJ0 Q96L91 O94888 Q13127 Q5T0N5 P08651 P46100 Q9H2H9 Q9H2H9 P21127 Q9UQ88 Q9NTJ3 P08670 Q07960 Q9NTI5 Q00059 A0FGR8 Q9NQG6 Q8IX03 O00499 Q7Z589 Q9ULH1 Q9C0C2 P23588 Q14103 Q12888 Q9H6R7 P15923 P04075 P14859 Q8N1G0 Q13586 Q9Y6M1 Q14687 Q92613 Q05209 Q7Z460 Q8TF01 Q9UBK8 Q7Z5J4 Q8NI08 Q8NC56 P57740 Q5T4S7

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.948126 0.948908 0.950959 0.951537 0.952394 0.953463 0.953629 0.954194 0.954867 0.955063 0.955512 0.955672 0.956075 0.956542 0.956743 0.956786 0.956877 0.958752 0.959194 0.959498 0.959622 0.959974 0.961068 0.962312 0.962386 0.96296 0.963041 0.963385 0.963478 0.963536 0.963933 0.965318 0.96558 0.965917 0.966037 0.96641 0.967088 0.967302 0.967974 0.968402 0.970169 0.970567 0.9706 0.971109 0.971623 0.971623 0.971676 0.972674 0.973265 0.974147

EP

S892 S83 T231 S603 S181 S314 S545 S241 S315 S16 S1176 S351 S1249 S259 S888 S272 S350 S21 S1995 S73 S564 S385 S287 S627 S419 S1047 S437 S672 S288 T65 S1378 S354 S78 T1396 S3570 S1037 T620 S23 S1915 S1068 S338 S464 S330 S535 S2276 S1301 S85 S718 S369 S2718

AC C

Q6ZRV2 P31321 Q8IWW6 Q05209 Q9BXB4 Q9NQS7 Q5JTD0 Q5T200 Q9Y2W1 P50443 Q9Y4H2 Q6ZS17 P20020 P17535 Q92547 Q9UNZ2 Q9NYJ8 Q14134 Q9HCK8 O43583 P27824 Q9NYF8 Q676U5 Q6PKG0 P46937 Q86TC9 P47712 O14920 P18206 Q9H6F5 Q13428 Q9UKS6 Q9UPN4 P49792 Q96Q15 Q5VUA4 Q2M2I8 Q9UNE7 P46821 Q12888 Q8WXI9 Q9BZZ5 P49790 P25205 P49792 Q7Z3J3 Q9UHD8 Q6P996 P51812 Q5T4S7

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.974165 0.97423 0.97423 0.97423 0.974943 0.975806 0.975806 0.975918 0.976184 0.976184 0.976184 0.976527 0.976537 0.976672 0.977037 0.977603 0.977684 0.977846 0.97813 0.978251 0.978415 0.978452 0.980052 0.980193 0.980244 0.980471 0.980707 0.981121 0.981316 0.981448 0.98177 0.982165 0.982213 0.982862 0.982948 0.982995 0.983163 0.983242 0.983273 0.983273 0.983353 0.984229 0.984296 0.984474 0.984606 0.984723 0.985108 0.985311 0.985393 0.985627

EP

T248 S227 S221 S232 S99 S394 S392 T601 S119 S113 S117 S321 S1012 S1101 S2098 S119 S125 T619 S345 S14 S44 S1173 S7 S76 S234 S403 S141 T1368 S761 S1350 T2314 S240 S132 S151 S193 S1956 S52 S637 T154 T154 S94 S74 S547 S725 S141 S1563 S442 S67 T223 S331

AC C

Q9UHR4 P51812 Q15418 Q9UK32 Q14739 Q06265 Q06265 P55265 Q13247 Q08170 Q13243 P61073 O95785 Q9UQ35 Q03164 Q7Z309 Q99733 Q9UPN6 Q6WKZ4 Q13286 P17096 Q13017 P10243 Q53EL6 Q8IYB3 Q5JSH3 Q14181 O75976 P48634 Q96SN8 O95359 Q8IWW6 Q9C086 P40425 Q9BVC5 P35580 Q9H2H9 Q9NYL2 P42166 P42167 O43847 Q6DCA0 Q9ULU4 Q8WXE0 Q13177 Q8WWI1 Q9H0E3 P19338 O75533 Q9UI08

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.985683 0.985847 0.985967 0.986147 0.986347 0.986984 0.986992 0.987397 0.98757 0.98823 0.988419 0.988709 0.988813 0.988943 0.989206 0.989558 0.989589 0.990114 0.99049 0.990635 0.99089 0.9915 0.991524 0.991909 0.992143 0.992399 0.992612 0.992723 0.992827 0.993057 0.993088 0.993645 0.993657 0.993969 0.994271 0.994324 0.994391 0.994415 0.994434 0.994434 0.994764 0.994951 0.995129 0.995335 0.995394 0.995559 0.995627 0.995726 0.995956 0.995972

EP

S162 S802 S2020 S214 S122 S803 S2121 T1035 S162 S351 T274 T869 S149 T2412 S1405 S534 S135 S66 S4613 S617 T479 S65 S2102 S181 S674 S432 S186 T1393 S102 S1315 S1549 S377 S2011 S645 S1029 S289 S239 S234 S288 S288 S662 S1417 S333 S1966 S349 S1426 S94 S250 T3573 S12

AC C

Q9UNF1 Q99590 Q92614 Q7Z417 P22392 Q9H694 Q9UQ35 Q5VUA4 Q96D71 Q9UQ35 Q6IQ49 O60716 Q9Y3C6 Q9BZC7 Q13459 Q86VM9 Q99959 Q9H6F5 Q15149 Q07157 Q86US8 Q13541 Q9UQ35 O96013 Q86Y91 Q66K14 O60841 P49792 Q9H6F5 Q8WWQ0 O95071 Q8WYQ5 Q9H4A3 P13807 Q9UHW9 Q6WCQ1 Q9H7N4 Q8NC51 Q641Q2 Q9Y4E1 Q9H1B7 Q8NI27 Q92597 P24928 O60716 Q12888 Q53EL6 P57682 Q96Q15 P50443

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.996108 0.996161 0.996213 0.996213 0.996292 0.996377 0.99655 0.996687 0.996852 0.996948 0.996995 0.997117 0.997118 0.997178 0.997333 0.997372 0.997409 0.997496 0.997512 0.997536 0.997586 0.997642 0.997647 0.997669 0.997692 0.997703 0.997741 0.997741 0.997814 0.99786 0.997946 0.997983 0.997983 0.998192 0.998192 0.998198 0.998223 0.998235 0.998248 0.998274 0.998417 0.998484 0.998548 0.998792 0.998796 0.998808 0.998812 0.998814 0.998933 0.998958

EP

S375 S578 S320 S321 S532 S174 T307 S437 S390 T328 S486 S1907 S499 T329 T893 S487 S1360 S1068 S1854 S13 S127 S439 S391 T202 S85 S475 T35 T35 S1387 S214 S563 S859 S410 S32 T715 S406 S36 S347 S1328 S1535 S482 S166 S361 S353 S641 S64 S142 S715 S82 S66

AC C

P51812 O15014 Q9NY61 Q9NY61 O94979 Q13153 Q01518 Q14004 P02545 Q92597 Q7KZI7 Q7Z6Z7 Q9UQR0 Q12893 Q9NYV4 Q9UHB7 Q5VZK9 Q9UDY2 Q9Y2F5 P07948 Q9C086 Q14004 P20700 Q13595 P16333 P05787 Q7L9L4 Q9H8S9 Q9UQ35 Q9Y6D5 Q02447 Q8N122 Q9UKV3 Q7L4I2 Q6PJG2 Q9ULU4 P17096 P12694 Q9H2Y7 Q14839 Q8NFC6 O43399 Q6P6C2 Q9UQ35 P13807 Q96MG7 Q13523 Q8IYB3 P04792 Q9UJV9

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.998958 0.999 0.999135 0.999138 0.999205 0.999245 0.999249 0.999271 0.999367 0.999378 0.999385 0.999419 0.999426 0.999489 0.999541 0.999609 0.999635 0.999646 0.999649 0.999657 0.99968 0.999695 0.999724 0.999726 0.999753 0.999765 0.999771 0.999772 0.999804 0.999825 0.999843 0.999843 0.999864 0.999869 0.999869 0.99988 0.999887 0.999891 0.999891 0.9999 0.999903 0.999906 0.999916 0.99992 0.999927 0.99993 0.999932 0.999942 0.999942 0.999943

EP

S68 S120 S882 S631 S1026 S189 S1326 S4538 S101 S309 S603 T311 S344 S1645 S183 S1176 S2129 S157 S12 S723 S16 S208 S658 S619 S74 S97 S351 T185 S192 T1531 S391 S399 S2407 S740 S19 S102 S24 S167 S69 S54 S576 S182 S285 S226 S144 T821 S615 Y273 Y321 S300

AC C

Q9UJV9 O95218 O75151 Q6PKG0 Q8WWI1 Q9BVC5 Q9UQ35 Q9NU22 O95155 Q96AX9 P51116 Q99460 Q86WB0 Q8IZH2 O60841 Q13017 P18583 P49761 Q13286 P98175 Q9ULI0 Q5VV41 Q9NYF8 O95453 Q6P0Q8 Q14498 P42166 P28482 Q00587 Q9UQ35 P08238 P07900 Q9UQ35 Q8IYB3 Q9UNE7 Q96EI5 Q86WB0 Q8WUA4 Q9H6F5 Q9BUR4 O15014 O60841 Q8N2M8 Q7Z5K2 Q13523 Q6P0N0 Q9P2E9 Q9Y463 Q13627 P08559

TE D

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

RI PT

ACCEPTED MANUSCRIPT PhoPepMass

0.999943 0.999948 0.999948 0.999959 0.999966 0.999968 0.999973 0.999976 0.999978 0.999979 0.999979 0.99998 0.999986 0.999986 0.999986 0.999988 0.999988 0.99999 0.99999 0.99999 0.99999 0.999992 0.999993 0.999996 0.999996 0.999997 0.999997 0.999997 0.999997 0.999997 0.999998 0.999998 0.999998 0.999999 0.999999 0.999999 0.999999 1 1 1 1 1 1 1 1 1 1 1 1 1

EP

S298 S824 S250 S343 T179 S784 S119 T852 S881 S464 S649 S2751 Y15 Y15 Y15 S547 S1287 S260 S1754 S264 S700 S653 S1413 S274 S826 S2900 S2105 S683 S605 S1179 S62 S488 S518 S395 S1278 S1212 S107 S1525 T5824 S32 S193 S607 S26 S124 S711 S443 S444 S378 S563 S308

AC C

P29803 Q6P0N0 Q9UPT5 P08651 Q9H1E3 Q9H4G0 Q8WW12 O95425 Q6ZRV2 Q08AD1 Q4L235 O75592 P06493 P24941 Q00526 Q9NPA5 Q96T58 Q13595 Q9Y2I7 P62995 Q8NE01 P49848 Q02880 Q3KR37 Q14687 P49792 P46013 P49756 Q8IYB3 Q7Z6E9 Q8NFG4 Q15052 Q14155 Q14980 Q96T58 Q7Z4S6 O60841 P11388 Q09666 Q9H0W8 Q5HYJ3 Q8IYB3 Q9UPY5 Q9Y5J1 Q9Y597 Q9BQF6 Q9BQF6 Q9NZT2 Q5T5Y3 Q96MU7

SC

M AN U

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass

EP

T568 S65 S517 S953 S955 S151 S2479 S154 S713 S1121 S139 S729 S395 S238 S263 S538 S515 S605 T14 S935 S160 S365 S849 S175 S393 S391 S315 S386 S259 S452 S891 S192 S127 S911 S457 S301 S303 S306 S307 S261 S182 S385 S164 S243 S363 S365 S157 S233 S513 S706

AC C

Q96T37 Q969E4 Q99567 Q9H2P0 Q9H2P0 Q96S55 P11717 Q99959 Q8IYB3 Q8WX93 P50914 Q9UKV3 Q13506 Q6U841 P07900 Q14978 Q6PJT7 Q14966 P24941 Q9HD20 O60231 Q9UHB6 P46100 Q7Z5L9 Q8IYB3 Q8IYB3 Q99460 Q01813 O00443 Q8IYB3 O15027 P21291 Q6P158 Q8WWQ0 Q53EL6 P35659 P35659 P35659 P35659 P08238 P41227 Q8NC44 O60841 Q9Y2W1 Q96ST2 Q96ST2 O76064 Q9Y6M7 O60832 P16070

M AN U

SC

PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0.24523 0.267931 0.269349 0.269349 0.269349 0.274897 0.274897 0.277779 0.281672 0.311292 0.313464 0.313464 0.314117 0.318538 0.3194 0.320353 0.321148 0.325375 0.325375 0.326947 0.326962 0.327105 0.329645

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass

EP

T14 S103 S116 S604 S79 S280 S141 S2702 S2706 S136 S183 S758 S540 S249 S722 S850 S41 S624 S102 S1350 S511 S703 S389 S851 S101 S438 S252 S878 S78 S161 S162 T163 S14 T15 T2884 S828 S64 S18 S17 S1012 S244 S267 T514 T329 T1011 S1010 S439 S4386 S370 T13

AC C

Q00526 O60231 Q15121 Q15424 P26368 O14745 P18858 Q9UQ35 Q9UQ35 Q5VTR2 Q58FF8 Q99700 Q63ZY3 P0C1Z6 Q71RC2 P46100 Q96EV2 O95466 P05387 Q13428 Q9BTA9 P49756 Q8IYB3 Q9HCS7 P05386 O94804 P0C1Z6 Q96HP0 O95155 Q5JSH3 Q5JSH3 Q5JSH3 P43487 P43487 Q5T4S7 Q14008 O75496 Q96QD8 Q96QD8 Q8WWI1 Q7Z5L9 Q8TF74 Q86V48 Q9H330 Q8WWI1 Q8WWI1 Q13263 Q15149 A8CG34 P43487

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.33265 0.333207 0.33333 0.33333 0.333332 0.333333 0.349404 0.349404 0.350372 0.350372 0.368105 0.368105 0.377695 0.382483 0.398771 0.408969 0.409043 0.412528 0.413023 0.418564 0.418741 0.418741 0.418855 0.419738 0.420781 0.420784 0.42132 0.423784 0.425939 0.427002 0.427002 0.434463 0.4357 0.438623 0.439092 0.439627 0.439978 0.441155 0.441155 0.450392 0.450907 0.451207 0.45285 0.458416 0.461157 0.465721 0.47188 0.472357 0.472423 0.47247

EP

S649 T333 S277 S278 T227 S48 T19 S20 S827 T828 S1361 S1362 S433 T199 S6 S1990 S24 S437 T49 T90 S522 S524 T25 Y73 T778 T174 S241 S2567 T175 S411 T412 S1298 T190 S529 T461 S367 S518 S199 S200 S507 S141 S231 S2068 S616 S171 T888 S1156 S220 T420 S777

AC C

Q7Z460 Q8TD19 Q96RK0 Q96RK0 Q9UN86 Q9UKT5 P49840 P49840 Q7Z3B3 Q7Z3B3 Q9NTI5 Q9NTI5 Q86VR2 Q8IWE2 Q96AY2 P46100 O00193 Q13263 Q13620 Q9UKI2 Q5VTR2 Q5VTR2 Q96A57 Q15029 Q13111 O75367 Q9UNX4 O95359 O75367 Q6UUV7 Q6UUV7 Q14160 P28482 Q6VY07 Q14157 Q92597 Q03164 Q04323 Q04323 P43007 Q53GA4 Q13283 Q9Y618 Q13586 Q8NI08 P07814 Q15648 Q6WCQ1 P23588 Q8IYB3

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.477929 0.478475 0.479246 0.479246 0.479496 0.480078 0.480268 0.481424 0.483366 0.487535 0.487535 0.487973 0.48801 0.489335 0.49189 0.492559 0.494141 0.494714 0.494714 0.496688 0.496743 0.496918 0.496918 0.497179 0.497819 0.497824 0.498061 0.498421 0.498421 0.498881 0.499014 0.49914 0.499722 0.499877 0.499922 0.499935 0.499972 0.499978 0.499995 0.499996 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.500836 0.500836

EP

S207 S1241 S555 S556 S364 S744 S619 S181 S964 T157 S156 S292 S128 S296 S1586 S468 S626 S388 Y389 S333 S1002 S1005 S1004 S778 S171 S172 Y333 S578 T580 T1237 T330 S367 T1147 S410 T796 S52 S120 S15 S88 S506 T447 S1203 S326 S141 S487 S332 S333 S126 S47 S48

AC C

Q9Y2W1 Q9BQG0 Q9NPH3 Q9NPH3 Q92597 Q8TEW8 Q9HBL0 Q96AC1 Q14676 Q8IVT2 Q8IVT2 Q6WCQ1 Q96CB8 Q99460 O75592 O15047 Q92625 Q5T0W9 Q5T0W9 Q8WXI9 Q12965 Q12965 Q12965 Q8N4C8 Q63ZY3 Q63ZY3 Q68CZ2 Q86UU1 Q86UU1 Q8WXG6 Q8NC44 P46937 Q14004 Q13112 Q86VM9 P30086 Q13105 O00193 Q9UK76 Q9BY44 O15231 Q9ULD2 Q15345 Q9UQC2 Q8WUI4 O00712 O00712 Q9NRF2 Q9ULG1 Q9ULG1

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.501829 0.502037 0.51052 0.510594 0.510698 0.511395 0.518028 0.52596 0.527908 0.528262 0.528652 0.530615 0.53302 0.533095 0.534843 0.534909 0.534909 0.535628 0.536116 0.537259 0.539625 0.541191 0.544363 0.545118 0.545255 0.545713 0.547015 0.547015 0.547041 0.547143 0.547598 0.550358 0.551435 0.551435 0.552028 0.552622 0.553129 0.553149 0.555946 0.557414 0.558514 0.558981 0.560123 0.560677 0.563295 0.564258 0.564407 0.569391 0.57186 0.572881

EP

S775 T2289 S442 S214 T389 S302 S1063 T1989 S1133 S218 T1274 S462 S1547 S436 S426 S752 S740 S912 S879 S432 S333 S57 T522 T510 S27 S56 S441 S441 S83 T358 S765 S1156 S1992 S1991 T332 T9 T455 S92 S176 T1101 S208 S365 S1113 T1521 S448 S271 S12 S99 S203 S205

AC C

Q13111 Q9UQ35 P48651 Q9P0L0 Q6PJT7 O94875 Q12789 P46100 O75116 Q6WCQ1 Q7Z6E9 Q9BZZ5 Q14160 Q86VR2 Q2TB10 P21127 Q9UQ88 Q02241 Q6P2E9 Q8NDI1 Q9UGV2 Q13442 Q8N1G4 Q8N1G4 Q9NTJ3 P08670 Q641Q2 Q9Y4E1 Q14103 O76021 Q8WUA4 A7E2V4 P46100 P46100 Q9UGV2 Q86U86 Q14676 P05455 Q96CX2 Q13464 O15173 Q13501 Q12888 O43149 Q9NPF5 Q5PRF9 Q9UH99 Q96SB3 Q96B36 Q9Y5J1

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.573057 0.573221 0.576154 0.576511 0.579265 0.579416 0.579479 0.583546 0.584083 0.587104 0.587536 0.589063 0.589326 0.590154 0.590493 0.591766 0.592624 0.593085 0.594469 0.595039 0.597319 0.600834 0.601353 0.601353 0.60148 0.602284 0.605713 0.606351 0.607092 0.609308 0.610837 0.611754 0.612246 0.614273 0.615278 0.615731 0.618175 0.619432 0.621024 0.62105 0.622878 0.62342 0.623696 0.625495 0.62607 0.627379 0.627732 0.627805 0.629424 0.632369

EP

T1466 T443 S1387 S284 S1793 S230 S178 S94 S621 S196 S85 S266 T469 S464 T933 S1126 T446 T128 S694 S1920 S15 T207 T19 T19 S265 S1579 S495 S713 S823 S1939 S273 S27 S400 Y13 T503 S37 T165 S822 S100 S232 S695 S168 S220 S2317 T176 S271 T272 S179 S334 T200

AC C

Q14676 O14974 O14646 O95817 P46821 P15408 Q9UHB7 Q9GZR7 Q8N3F8 Q15424 P55884 Q9Y385 Q9H6S3 Q6GQQ9 Q9UDY2 Q12774 P35269 O95251 Q8IYB3 P24928 P53999 P27361 A6NMY6 P07355 Q9UNF1 Q69YN4 P23588 Q12873 Q8IWX8 O14578 O75475 P29966 Q9UDY2 Q9H1E3 Q9UQR0 O95674 Q1KMD3 Q8IWX8 Q9BW71 Q13283 Q8IYB3 Q8TBN0 Q6L8Q7 O95359 Q63ZY3 O75475 O75475 Q9UHB7 Q8WXI9 Q8NEY8

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.632759 0.633316 0.636288 0.637515 0.63792 0.639024 0.639214 0.64413 0.645441 0.647932 0.648746 0.656516 0.657414 0.657424 0.658502 0.660808 0.664852 0.666202 0.666593 0.666664 0.666664 0.666667 0.667979 0.668216 0.668718 0.671032 0.672838 0.673602 0.677337 0.678066 0.678591 0.680029 0.681191 0.681658 0.683067 0.686429 0.686709 0.690062 0.691613 0.693447 0.694173 0.695521 0.697645 0.700441 0.701375 0.701718 0.703921 0.705012 0.705098 0.706255

EP

S1306 S503 T327 T50 T762 T270 S528 Y598 S406 S447 S114 S531 S920 Y67 S854 S413 S269 Y114 S658 S299 S298 S67 S301 S853 S143 S332 S1837 S440 S477 T563 S295 S97 T1101 S2569 S169 S546 T1885 T701 S26 S516 S557 S122 S414 S316 S740 S328 S400 S66 S50 S373

AC C

Q14160 Q9BY44 Q15345 P36915 O75152 O75475 Q6VY07 Q9Y2X7 P02545 P18887 Q86YP4 Q6VY07 Q9UDY2 P06748 Q9UQ35 Q6UUV7 O75128 O95218 Q9H1B7 Q4G0J3 Q4G0J3 Q96B23 P04049 Q7Z4S6 P26358 Q9H330 Q03164 Q13263 Q14157 Q9Y5B6 O00712 Q96NY9 Q6BDS2 O95359 O43598 Q01804 Q13315 A0FGR8 Q6IAA8 P10636 Q8WWM7 Q8WUZ0 Q9UHR4 Q9NY61 Q9UKJ3 P15336 Q99590 Q96B23 Q86U44 A8CG34

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.70674 0.707941 0.712213 0.712639 0.712852 0.716996 0.717757 0.719291 0.720332 0.721485 0.722296 0.722932 0.724691 0.724857 0.725145 0.725699 0.727055 0.730607 0.730607 0.731003 0.73451 0.735598 0.736371 0.739138 0.739414 0.739998 0.740337 0.740575 0.741175 0.741564 0.741615 0.741691 0.743557 0.745191 0.746005 0.74637 0.746414 0.747236 0.747646 0.74868 0.749299 0.749432 0.750672 0.751607 0.752892 0.75392 0.754157 0.754847 0.755206 0.75649

EP

S445 S323 S206 T196 S2044 S174 S311 S17 T734 S520 S133 S236 S526 S1329 S467 S114 S165 S697 S674 S573 S283 S312 S991 S732 S418 S354 S18 S51 S1047 T445 S692 S427 T5839 S404 S758 S312 T329 T25 S226 S208 T364 S282 S4396 T1151 S210 S338 S183 S314 S60 T390

AC C

Q8NHM5 O75674 P43243 P80723 O75179 Q96D71 Q8N5Y2 P53999 Q86X10 Q8N1G4 P54725 Q96G46 O95365 Q6T4R5 Q9UMZ2 Q5T3F8 P67809 Q96HA1 A8CG34 P17812 Q12872 O00273 Q8WWI1 O60271 Q14247 Q9NZL4 Q9UHR5 Q9ULG1 P41252 Q9NPF5 Q9UHB6 O95747 Q09666 P02545 A0FGR8 Q9NQS7 Q9UGV2 O75167 Q9UPQ0 Q9UKV3 Q9NQW6 Q6IBW4 Q15149 Q9H792 Q9UKV3 Q86WB0 Q6FI81 P67809 O95361 P49841

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.758124 0.758504 0.759363 0.760364 0.760379 0.76049 0.76072 0.761621 0.76184 0.761855 0.76273 0.763804 0.76391 0.764011 0.766766 0.767311 0.768556 0.769296 0.769747 0.769851 0.770536 0.771773 0.772041 0.773986 0.774253 0.774537 0.775357 0.775518 0.77628 0.777667 0.780105 0.78023 0.780445 0.780871 0.781099 0.781568 0.78189 0.782142 0.782449 0.782775 0.783578 0.783636 0.783972 0.784282 0.784711 0.784735 0.785907 0.78672 0.787654 0.787915

EP

S1330 S696 S194 S396 S111 S40 S781 S427 S465 S410 S131 S22 S480 S402 S694 S230 T724 S341 S329 S398 S1518 S1114 S793 S266 S551 S1172 S85 T399 S354 T674 S470 S543 T275 S201 S1134 S435 S1385 S416 S983 S123 S187 S229 S720 S675 S727 T1156 S143 S1380 T778 S395

AC C

Q15021 Q8IYB3 O95400 Q96HA1 Q96HC4 Q96BD0 Q8IYB3 O76021 Q9BY89 Q6UUV7 Q07157 P02545 O60583 Q99590 Q9C0B5 Q13283 P46100 Q6WKZ4 O75909 Q9UQ35 O43149 Q12888 Q9Y597 P18887 Q9NWH9 Q13136 P49023 Q14247 O60293 P25205 O15047 Q9ULH7 O75410 Q8NEY8 O75116 Q66K14 O14646 Q659A1 Q9C0C2 P54725 Q96CX2 Q96P48 Q86X10 Q9H2J7 P13807 P49792 Q12792 P51532 Q8IYB3 Q9UQ35

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.787924 0.788081 0.78826 0.78965 0.790247 0.791283 0.791389 0.791414 0.791669 0.791954 0.792041 0.796144 0.796163 0.796942 0.799209 0.799906 0.801748 0.806833 0.807319 0.807994 0.80842 0.809358 0.811056 0.8111 0.812018 0.812171 0.81368 0.81584 0.817845 0.817962 0.818673 0.819214 0.819368 0.819452 0.820191 0.822774 0.824752 0.825147 0.825602 0.826349 0.826769 0.826842 0.827242 0.828378 0.829705 0.82987 0.830793 0.831399 0.831501 0.83261

EP

S334 T310 S1267 S362 S661 S398 S758 S675 S883 S518 S290 S1103 T285 S630 S254 S152 T302 T598 S173 S143 S882 S886 S1228 S160 S15 S1556 S355 S202 S175 S82 S331 S14 S394 S777 S335 S1138 S354 S738 T1319 T106 S27 S857 S183 S119 S868 T400 S1156 S176 S630 S158

AC C

Q9UGV2 Q9NY61 Q9BQG0 Q92597 Q86YS7 Q9UDY2 O75152 Q8N163 P07814 Q8N1G4 P18206 Q9UQ35 Q02952 Q96AE4 Q86TC9 Q9Y2D5 Q9GZR7 P51116 O75367 Q8NEJ9 P07814 P07814 Q13428 Q02241 Q96AY2 P18583 Q658Y4 Q86X95 Q63ZY3 Q14103 O00499 O00458 Q8IVT2 Q13111 Q9UGV2 Q9C0C2 Q86WB0 Q9H2P0 Q12888 Q8NFH5 Q6IAA8 Q9UPP1 Q8IWC1 P55884 Q8TD19 Q9UQ35 O43432 P67809 Q8WVC0 P42167

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.83261 0.833273 0.833524 0.834909 0.838002 0.838449 0.839946 0.840203 0.841517 0.843556 0.843765 0.849983 0.850716 0.851285 0.851592 0.855392 0.856104 0.85692 0.856925 0.857364 0.858103 0.858914 0.859403 0.860193 0.860264 0.86245 0.862849 0.863168 0.865551 0.865878 0.86608 0.867139 0.869025 0.870636 0.873261 0.874059 0.874317 0.874964 0.8775 0.877621 0.878631 0.878907 0.879673 0.880057 0.880225 0.880493 0.881749 0.882116 0.882268 0.882417

EP

S158 S51 S1423 T251 S41 S53 S479 S2027 S367 S376 S854 S766 S201 S137 S571 T118 S395 S461 S955 T186 S30 S425 S180 S18 S1163 T111 T925 S323 S329 S286 T110 S256 S168 S736 S135 S696 S366 S2398 S1094 S1759 S166 S643 S144 S3527 S630 S439 S1329 S787 S123 S2029

AC C

P42166 P36915 Q8WWI1 Q86TC9 Q13439 O43818 Q9H6S3 Q9H4A3 P49768 Q8IVT2 Q9UPP1 Q32MZ4 Q6ZUT6 Q96IF1 P17812 Q8WUZ0 Q8IVT2 Q86UU1 P49792 Q8IWC1 Q15311 Q96IG2 Q9UHB7 Q07666 Q9BQG0 Q8WUZ0 Q9UDY2 Q63ZY3 P21731 Q96JM3 P46937 Q15477 Q9BZ23 Q9H2P0 Q8WXI9 O14497 Q13501 Q9UQ35 Q5VZK9 Q12888 Q9NQG5 Q6AI08 Q53GA4 Q03164 Q9UJA3 O94887 Q9UQ35 P27816 Q01664 Q9H4A3

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.88418 0.884641 0.885012 0.88513 0.885787 0.88591 0.886488 0.887061 0.88728 0.888547 0.888616 0.889885 0.89173 0.892863 0.892934 0.893248 0.894086 0.894317 0.895902 0.895902 0.896473 0.897337 0.89743 0.898444 0.89912 0.900706 0.900823 0.902046 0.903933 0.904132 0.905122 0.905871 0.906589 0.908431 0.908561 0.909632 0.909721 0.911673 0.912128 0.912247 0.912526 0.912956 0.913389 0.913716 0.91455 0.915041 0.915656 0.916359 0.916535 0.916895

EP

T203 S1233 S1320 S471 S145 S1257 S332 S898 S304 T139 S337 S93 S717 S628 S80 S785 S187 S644 T160 T160 S1300 S621 S4 S52 S156 Y231 S323 S242 S1260 S542 T366 T219 S212 S559 S1709 S732 S137 S9 S251 S308 S659 S541 S237 S411 S856 T711 S64 S259 S2887 S5763

AC C

Q8N684 Q9UQ35 Q12888 P48681 P29966 P20020 Q13501 Q96N67 Q05655 Q8WW12 P12694 Q9GZR7 P10636 Q92625 P51608 P19634 Q9Y520 Q86TC9 P42167 P42166 Q14160 Q9HBL0 P09651 Q8TAD8 Q5JTV8 Q96P48 Q9UQ35 P49916 P46821 Q96QC0 Q92597 Q9BU76 Q09666 Q8WWM7 Q5SRE5 P46087 P52701 Q96AY2 Q9BUA3 Q01518 Q9H1B7 Q9ULH7 Q9H7L9 Q66K14 Q5T5U3 P98174 P13051 Q15942 Q7Z6Z7 Q09666

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.920226 0.921483 0.923297 0.923335 0.923819 0.925415 0.925622 0.926256 0.926274 0.926957 0.927703 0.928428 0.928749 0.928827 0.929775 0.930287 0.931383 0.931383 0.932571 0.932599 0.932827 0.932891 0.933428 0.933708 0.934547 0.934746 0.935901 0.936107 0.936107 0.936305 0.936452 0.936897 0.93705 0.937279 0.937673 0.937739 0.937883 0.938399 0.939357 0.94108 0.94166 0.942215 0.943263 0.943455 0.943698 0.943698 0.943998 0.944526 0.944917 0.944983

EP

S415 S504 S557 S446 S558 S596 S76 S1093 S49 S435 S160 S183 S574 S100 S312 S117 S21 S22 S540 S692 T646 S575 S125 S212 S290 S74 S1179 S159 S159 S693 S69 S242 S494 S2372 S331 S2032 S7 S197 S662 S195 S3808 S659 S467 S434 S234 S235 S3816 S163 S392 S17

AC C

O14545 P23588 Q9Y5B6 P15056 Q9Y5B6 Q9Y2X7 Q96C19 Q5VZK9 Q8TAD8 O94776 P54727 O60271 P17812 Q96SB3 Q9H8G2 Q9BVV8 Q9BRS2 Q9BRS2 Q9Y2J4 Q8TEW0 O15439 P17812 Q07157 Q86WR7 Q9NYF8 Q96C19 Q9UQ35 P42166 P42167 A0FGR8 P35251 Q5T200 O60832 Q7Z6Z7 Q9UGV2 Q9H4A3 Q96AY2 Q8TEA8 O14523 O95400 Q7Z6Z7 Q86YS7 P53985 Q8TBZ3 Q14151 Q15424 Q7Z6Z7 Q9Y2U5 P02545 O00193

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.94519 0.946746 0.947054 0.947802 0.948005 0.948207 0.948243 0.948272 0.948575 0.948723 0.949775 0.950382 0.950873 0.951101 0.951568 0.951727 0.951897 0.952064 0.952097 0.952491 0.952937 0.953273 0.953386 0.953654 0.95437 0.954635 0.955245 0.956245 0.957118 0.957825 0.958226 0.958236 0.958567 0.958932 0.95931 0.959741 0.960597 0.960747 0.96091 0.960958 0.961555 0.961709 0.961962 0.96201 0.962476 0.962518 0.963276 0.963479 0.963635 0.963992

EP

T745 S1035 T285 S33 S628 S485 S695 S968 S2649 S29 S1586 S1003 S1693 S403 S25 S369 S1443 S1834 S147 S425 S761 S156 S289 S248 S691 S290 S525 S1690 S4389 S764 S545 S196 S292 S18 S165 S559 S874 S182 S1222 S209 S459 S45 S979 S624 T918 S337 S40 S280 S547 S231

AC C

Q8IZL8 Q9UMN6 O95817 O95674 P02545 Q8IWZ8 Q8TEW0 Q5VZK9 O75592 Q15311 Q8WWI1 Q9ULJ3 Q9Y5S2 P02545 Q13085 Q9UHB6 P46821 Q9H7D0 Q96E09 Q96GM8 O75152 O95292 O95817 Q9BUA3 A0FGR8 O14745 Q9NPI6 Q9Y5S2 Q15149 Q6NWY9 O60504 Q8IWE2 Q04727 O75569 Q7Z434 Q6VMQ6 Q9H7N4 Q96GY3 Q96T58 Q7Z589 Q96JM3 Q8TAP8 Q9P206 P52756 Q9BX63 Q99569 Q5VUA4 O14757 Q5TCZ1 Q6ZW31

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.964228 0.964529 0.964591 0.964733 0.964877 0.96569 0.965813 0.966424 0.966613 0.967365 0.967396 0.967532 0.967688 0.968514 0.968808 0.969342 0.969513 0.969563 0.969596 0.969633 0.969759 0.969816 0.970184 0.970256 0.970532 0.97057 0.971038 0.971659 0.971976 0.971985 0.972179 0.972244 0.972422 0.972609 0.972754 0.972806 0.972973 0.973189 0.973319 0.974191 0.974228 0.974431 0.974458 0.974868 0.974952 0.975921 0.976017 0.976026 0.976029 0.976143

EP

S1155 S157 S387 S466 S82 S12 S861 S185 S736 S426 S1348 S71 S779 S415 S217 S516 S1160 S212 S929 S454 S203 S310 S397 S460 S1032 S144 S1370 S1905 T440 S326 T48 S1333 S956 T1438 S24 S459 T753 T793 S434 T227 S57 T86 S47 S93 S206 S268 T899 S455 S674 S278

AC C

Q15648 Q5JTV8 Q9UQ35 Q9BWU0 Q15637 Q9NP87 Q15154 Q86XP3 P98175 Q8NDI1 Q03468 P35251 Q7LBC6 Q9UER7 Q7L2J0 Q9Y6G9 P49792 Q96B36 Q9P206 Q14157 Q8NEF9 Q01518 Q8IVT2 Q7Z5L9 Q9UMN6 Q9HC35 Q9H2Y7 O15027 Q86VR2 Q8ND76 P36915 Q15021 Q5T1M5 P25054 Q96A57 P11274 A0FGR8 Q4LE39 Q9ULJ3 O75533 O00264 Q15029 Q9H6F5 Q15154 Q9Y5J1 O60716 Q9HC35 P53396 Q8WWQ0 Q6IQ49

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.976175 0.976199 0.976242 0.976667 0.977148 0.977304 0.977457 0.977729 0.977911 0.978061 0.978254 0.978511 0.97871 0.978735 0.978912 0.978941 0.979107 0.979246 0.979334 0.979641 0.979823 0.979845 0.980278 0.980347 0.980467 0.981143 0.981176 0.981258 0.981265 0.981364 0.981567 0.981589 0.981614 0.981747 0.981808 0.982182 0.982305 0.982503 0.982657 0.98268 0.982878 0.983047 0.983145 0.983174 0.98335 0.983367 0.983723 0.983744 0.983754 0.983808

EP

S185 S916 S1258 S28 S77 S287 S429 S1466 S366 S329 S17 T118 S930 S1179 S443 S232 S96 S1166 S775 S280 S431 S183 S22 S646 S897 S467 S84 S511 S222 S738 S752 S258 T75 S316 S440 T36 S306 S75 S65 S250 S755 S370 S41 S525 S902 S2739 S363 S33 T401 S421

AC C

Q1KMD3 Q16512 Q63HN8 Q05D32 Q9NWB6 Q9NYF8 Q13112 Q02880 P20810 Q8ND30 P39687 Q96T60 Q9BX63 Q9NRY4 Q9H307 Q13573 Q5JSH3 P00533 Q8IYB3 O94888 O14639 Q9NYF8 Q8NE71 Q7Z460 P29317 Q14157 O15541 Q5F1R6 Q9NYF8 P98175 Q9UMZ2 Q4G0J3 Q3MHD2 P98082 Q9UQ35 P80723 Q9Y4H2 Q9H1E3 Q15154 Q96ST2 A0FGR8 O75122 Q9NTJ3 Q14004 Q14C86 Q6ZNJ1 Q15418 A2RU67 Q14247 Q7L7X3

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.984174 0.984195 0.984475 0.984595 0.984642 0.985027 0.985044 0.985358 0.985408 0.985422 0.985473 0.985706 0.985754 0.985885 0.986206 0.986406 0.986788 0.986907 0.986969 0.98703 0.987365 0.987438 0.987557 0.987727 0.987893 0.987973 0.987991 0.988024 0.988032 0.988053 0.988071 0.98817 0.988391 0.988441 0.988485 0.988525 0.988748 0.988829 0.988949 0.989168 0.98926 0.989555 0.989694 0.98971 0.98973 0.989808 0.989808 0.990011 0.990068 0.990068

EP

S194 T437 S2047 T819 S557 S1780 S122 S119 S593 S1303 S90 S589 S77 S135 S126 S833 S1114 S202 S457 S113 S609 S131 S662 S725 S515 S379 S218 S51 S118 S731 S494 S323 T693 S455 S126 S107 S21 S1166 S1002 S520 S1230 S575 S613 S12 S407 T97 T96 S332 S749 S750

AC C

Q9NQX3 P35658 O75179 Q8IWX8 Q9NPH3 Q92538 Q5VZL5 P29692 Q5VT52 O60293 O15173 Q9NRY4 Q7Z5K2 O60841 Q8WUZ0 O60524 Q9UPT8 Q6WKZ4 Q7Z5L9 P46379 Q14157 Q9NXV6 Q86YS7 Q9H7N4 P40222 P12270 Q9Y6D5 P18615 P29966 P46100 Q9HCH0 P08651 P00533 Q7Z5L9 Q9H6Z4 Q86YP4 Q96CP2 Q9NTI5 Q9NWH9 Q86UU1 Q2KHR3 Q8IVT2 P51532 P35611 P02545 Q9NQL2 Q9HB90 P78310 Q14147 Q14147

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.990102 0.990125 0.990147 0.990163 0.990204 0.990244 0.990557 0.990662 0.990732 0.990804 0.990831 0.99092 0.990924 0.991005 0.991073 0.991301 0.991308 0.991315 0.991357 0.991419 0.991432 0.991454 0.991468 0.991726 0.991802 0.991831 0.991885 0.991912 0.99193 0.992015 0.992052 0.992159 0.99216 0.99229 0.99229 0.99229 0.99229 0.99229 0.992403 0.992499 0.992602 0.992642 0.992676 0.992686 0.992766 0.992884 0.992888 0.992888 0.992945 0.993036

EP

S22 S62 S303 S21 S120 S344 T696 S996 S25 S738 S179 S62 S141 S52 S3010 S1797 S420 S221 S709 S129 S445 S83 S988 S838 S199 S14 S174 S1784 S380 S601 S27 T213 S1062 S48 S48 S48 S48 S48 S904 T257 S1304 S286 S601 S215 S716 S646 S2280 S1305 S333 S1084

AC C

Q9UHR5 P52292 O00499 O43399 Q9BVV8 P82094 O14974 O95785 Q53F19 Q5T5Y3 Q86TB9 A2RU67 Q5QJE6 Q8TAP8 Q14789 P46821 Q96PE2 Q9UKX7 Q14671 Q8WXI9 Q96JM3 Q96JP5 Q8WWI1 Q9UKV3 Q6WKZ4 Q5SW96 P67809 Q92538 Q12888 Q86W92 P49736 Q7L2J0 Q12789 Q71U36 Q13748 P68363 Q9BQE3 Q6PEY2 Q15811 Q9UHR4 O60293 Q04726 P51116 Q9Y618 Q92738 Q96TA1 P49792 Q7Z3J3 P08651 P21333

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.993056 0.993145 0.993276 0.993408 0.99343 0.993435 0.993525 0.993566 0.993603 0.993802 0.993855 0.993861 0.993933 0.994056 0.994202 0.994244 0.994257 0.994265 0.994278 0.994278 0.994289 0.994306 0.994365 0.994375 0.994397 0.994412 0.994512 0.994666 0.994776 0.99496 0.99507 0.99507 0.995099 0.99511 0.995122 0.995126 0.995164 0.995274 0.995276 0.995342 0.99541 0.995542 0.99555 0.995553 0.99556 0.995578 0.995604 0.995638 0.995649 0.995691

EP

S1448 S158 S374 S56 S332 S347 S346 S575 S275 S83 S114 S315 S718 T1845 S445 S102 S240 S50 S293 S291 S116 S1146 S292 S214 S177 S30 S1712 S212 S49 S312 S118 S118 S51 S600 S37 S26 S460 S2065 S330 S678 S2123 Y427 S522 S170 S1298 S1231 S817 S221 S60 S310

AC C

Q14160 O95292 Q9UHB6 Q9Y3T9 Q68CZ2 Q01831 Q01831 Q68EM7 O75475 Q9H5H4 Q12982 Q9H788 P40818 Q03164 Q8NB49 O75351 Q7Z5L9 O43818 P08559 P29803 P98174 Q53SF7 Q03111 Q5VUA4 Q09666 A2RU67 Q5T5U3 Q7Z417 O95400 Q14669 P18669 Q8N0Y7 O43818 Q7Z460 Q9NQZ2 Q6Y7W6 Q9NSK0 Q9Y618 Q8NC51 Q8N163 Q9UQ35 P29353 Q13330 Q96D71 Q92538 Q2KHR3 Q8IWX8 Q7Z5K2 Q13442 P53667

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.9957 0.995757 0.995763 0.995768 0.995915 0.995936 0.995978 0.995993 0.996136 0.996243 0.996244 0.996247 0.996292 0.996307 0.996308 0.996315 0.996343 0.996374 0.996391 0.996541 0.996564 0.996623 0.996648 0.996685 0.996705 0.996809 0.99685 0.996916 0.997112 0.997131 0.997135 0.997173 0.997218 0.997242 0.99725 0.997304 0.997365 0.997383 0.997417 0.997422 0.997481 0.997496 0.997516 0.997522 0.997566 0.997647 0.997715 0.997784 0.997785 0.997825

EP

S567 S31 T2645 S703 S1432 S46 S224 S641 S95 S696 S143 S657 S773 S97 S608 S260 S243 S95 S282 S146 S497 S187 S166 S87 S66 S285 S660 S328 S1021 S628 S230 S584 S490 S520 S31 S592 S137 S548 S102 S521 T431 S1067 S567 T453 S237 S579 S214 T202 S111 T2409

AC C

Q8WUF5 Q92522 O75592 Q9UHB7 Q96N67 Q96TC7 Q8WXE1 Q96TA1 O15258 Q96TA1 Q5JTV8 Q9H1B7 Q8IYB3 Q17RY0 Q99590 Q9HC77 Q9UFC0 Q96NY9 Q96JM3 Q9HC35 P23588 P05549 O60341 Q9UK76 Q9H307 Q9NYF8 Q68CZ2 O00712 Q9UPP1 Q8N9T8 O60716 P46013 Q9UHB6 O00567 Q9NWW5 Q9NYZ3 O60841 Q9H7N4 P54105 Q9C0E2 Q9ULJ3 Q9UDY2 Q5TCZ1 P18887 Q9BTK6 Q86W92 Q96JM3 P27361 Q5T3F8 Q9UQ35

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.997837 0.99785 0.99785 0.997912 0.997932 0.997958 0.997985 0.998011 0.998024 0.998051 0.99815 0.998184 0.998206 0.998329 0.99838 0.998401 0.998413 0.998424 0.998463 0.998493 0.998514 0.998514 0.998571 0.998581 0.998587 0.998618 0.99866 0.998702 0.998704 0.998721 0.998722 0.998747 0.99876 0.998766 0.998766 0.998794 0.998798 0.998811 0.998823 0.998824 0.998859 0.99886 0.998871 0.998875 0.998893 0.998931 0.998988 0.999016 0.999047 0.999065

EP

S2012 T161 T2024 S295 S165 S37 T1867 S594 S412 S663 T1215 S6 S166 S686 S681 S536 S89 S255 S334 S759 T74 T74 S159 S427 S856 S80 S844 S56 S325 S307 S480 S1137 S190 S67 S62 S898 S2401 S320 S90 T25 S5752 S1717 S234 S47 S133 S487 S21 S445 S786 S233

AC C

Q9H4A3 Q13765 E9PAV3 Q9GZR7 Q969G5 P14618 Q6ZNJ1 Q8WWM7 Q9UQR1 Q9H501 Q15648 P09651 Q969G5 Q9UHB6 Q8N163 Q9Y2L9 P98175 Q9UBC2 P49790 Q66K74 P42166 P42167 Q92733 Q9Y4F1 Q13045 Q15637 Q8WY36 Q9Y5S9 Q14678 Q9Y2I7 Q9NR09 O75116 Q12906 O43768 P56211 Q9BTC0 O75179 O60716 Q9BUR4 Q16637 Q09666 Q5SRE5 Q9H7L9 Q9UPN4 P29692 Q15361 Q9UJV9 O14974 P46087 Q13428

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.999083 0.9991 0.99912 0.999132 0.999176 0.999213 0.999228 0.999239 0.99925 0.999279 0.99931 0.99931 0.999326 0.999332 0.999332 0.999332 0.999355 0.999361 0.999393 0.999413 0.999438 0.999459 0.999459 0.999459 0.999468 0.999469 0.999519 0.999534 0.999535 0.999536 0.999547 0.99957 0.999591 0.999596 0.9996 0.999601 0.999606 0.999613 0.999621 0.999625 0.999639 0.999647 0.99967 0.99967 0.999678 0.999679 0.999707 0.999712 0.999717 0.999732

EP

S1256 S597 T150 S592 S224 S216 S527 S157 S1179 S28 S166 S2029 T654 S121 S127 S121 S334 S519 S394 S636 S269 S303 S733 S1858 S14 S2833 S180 S105 S532 S657 S518 S347 S530 S1965 S673 S1471 S859 S713 S738 S268 S171 S437 S284 S284 S144 S97 S790 S5841 S453 S296

AC C

P46821 Q8IYB3 P29966 Q9Y2X7 Q6WCQ1 Q09666 O60318 Q92733 Q9Y4F5 Q16637 Q13765 E9PAV3 Q58WW2 Q969E4 Q5H9L2 Q6IPX3 Q86SQ0 O00567 Q9UDY2 P02545 Q9UJU6 Q13247 O60271 Q03164 Q02363 O75592 P0C1Z6 O95155 Q9Y2L9 Q58WW2 Q86UU1 P50750 Q96EN8 P46821 Q9P206 P11388 P35606 P10636 Q9ULW0 Q9NYF8 Q8N9T8 Q9UQ35 Q641Q2 Q9Y4E1 Q9Y2U8 Q9H910 Q4LE39 Q09666 O15231 Q96RU3

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.999735 0.999735 0.999738 0.999752 0.999756 0.999762 0.999764 0.999766 0.999775 0.999807 0.999812 0.999813 0.99983 0.999836 0.999839 0.99984 0.999843 0.99985 0.999858 0.999859 0.99987 0.999873 0.999884 0.999885 0.999886 0.999891 0.999891 0.999891 0.999892 0.999894 0.999898 0.999898 0.999898 0.999899 0.999899 0.999903 0.999913 0.999913 0.999913 0.999913 0.999914 0.999915 0.999916 0.999916 0.999917 0.999918 0.99992 0.999921 0.999923 0.999924

EP

S153 S377 S281 S471 S81 S105 S21 S393 S320 S294 S112 S857 S492 S261 S152 S772 S456 S498 S80 S21 S996 S1017 S2229 S406 S436 S104 S104 S2362 S601 S31 S1075 S282 S1697 S422 S448 S632 S2359 T2000 S22 S5731 S85 S48 S672 S1174 Y187 S247 S137 S796 S438 S742

AC C

Q16666 Q9UQ35 O43572 Q8IVT2 Q9H410 P20042 Q8IUD2 Q13425 Q9Y2W1 Q53SF7 Q7Z417 Q9Y6Q9 Q6UN15 Q4G0J3 Q9Y618 Q8N1F8 Q9H4M9 Q9C0C2 Q9Y3X0 Q6IQ22 Q6PJG2 Q4ADV7 Q9BV73 Q9BTX1 Q9UQ35 P55795 P31943 Q7Z6Z7 Q9C0C2 Q16637 Q9UMZ2 Q96EZ8 P18583 P23588 Q9H0D6 P02545 O95359 Q14980 Q9UBN7 Q09666 Q9BUR4 O76080 Q9Y3T9 Q9Y4H2 P28482 Q9H3N1 O75396 Q99590 Q96ST2 Q6PJG6

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.999927 0.999929 0.99993 0.99993 0.999932 0.999933 0.999934 0.999938 0.999939 0.99994 0.999941 0.999943 0.999943 0.999945 0.999945 0.999946 0.999948 0.999949 0.999953 0.999955 0.999956 0.99996 0.99996 0.999961 0.999964 0.999964 0.999965 0.999965 0.999966 0.999966 0.999969 0.999971 0.999972 0.999973 0.999973 0.999974 0.999976 0.999976 0.999977 0.999978 0.999978 0.999978 0.999979 0.999979 0.999979 0.999981 0.999982 0.999983 0.999983 0.999983

EP

S673 S214 S247 S330 T211 S226 S339 S642 Y204 S1106 S47 S333 S333 S109 S328 S43 S210 S411 S29 S466 S42 S1080 S601 S877 S70 S59 S63 S682 S280 S244 S437 S1381 S1038 S298 S1096 S397 S190 S155 S1377 S193 S216 S430 S203 S209 S1023 S557 S481 S544 S494 S1024

AC C

Q9Y3T9 O60841 P25490 Q92597 O15173 A0JLT2 P08651 O43719 P27361 Q6BDS2 Q9BTU6 Q9Y4E1 Q641Q2 P46937 Q9Y608 Q9UHR5 Q09666 Q8IY17 Q13085 O60825 Q92917 Q5JTH9 Q92615 Q8N122 P10809 Q00839 Q9C086 Q9Y2W1 P27816 Q9UDY2 Q9BVJ6 Q9HBL0 Q5TCZ1 O00499 Q14C86 Q96BT3 P22059 Q8TBF4 P11388 P22059 Q13242 Q9UBB4 Q9H0H5 Q14244 Q01804 O95453 P53396 O60504 Q9C0C2 Q01804

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.999985 0.999985 0.999985 0.999985 0.999987 0.999987 0.999989 0.999989 0.999989 0.999989 0.99999 0.99999 0.99999 0.999991 0.999991 0.999991 0.999991 0.999991 0.999991 0.999992 0.999992 0.999992 0.999992 0.999992 0.999992 0.999992 0.999993 0.999994 0.999994 0.999994 0.999995 0.999995 0.999995 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997

EP

S473 T417 S420 S75 S2273 S762 S1472 S181 S425 S170 S727 S481 S3205 S156 S203 S1045 S156 S126 S41 S2749 T3716 S156 T111 S353 S631 S766 S53 S500 S1017 S1275 S468 S1358 S89 S164 S662 S587 S2559 S295 S435 S415 S769 S527 S127 S70 S2449 S83 S161 S1309 S495 S381

AC C

Q9HCH0 Q96IG2 P85037 Q56NI9 Q63HN8 Q14566 O75376 Q5T4S7 Q7Z3K3 O75367 P42224 Q8IZL8 P78527 P42166 Q9H8G2 Q9P2D0 P42167 Q14137 Q9Y2V2 O75592 Q09666 P07199 P20042 Q8N5D0 P42684 Q6PKG0 P55081 Q9H7N4 O95785 Q9UPT8 Q96D46 Q9NTI5 P05114 P80723 Q86XL3 Q96B97 Q9P2D1 Q9UQ35 Q9UQ35 Q9Y5T5 Q8IYB3 O94979 Q14137 P06748 Q9UQ35 P10644 Q6SPF0 Q14160 Q9UER7 Q13428

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999

EP

S121 S297 S64 S205 S39 S181 S1438 S289 S248 S121 S221 S39 S484 S1220 S113 S1265 S43 S122 S138 S2016 S402 S30 S23 S122 T404 S439 S512 S314 S267 S364 S67 S60 S261 S355 S171 S143 S362 S67 S66 S2102 S774 S258 S66 S67 S241 S216 S2047 S122 S352 T521

AC C

P41236 Q9UQ35 Q9H3Q1 P80723 B5ME19 O00264 P46821 P46937 Q96ST2 Q6NXS1 O95425 Q99613 Q8NFC6 Q14160 O60841 P46821 Q9Y5Q9 P41236 O75446 Q9Y618 Q14676 Q6Y7W6 Q9UJV9 Q6NXS1 Q14676 O43318 Q9NYF8 Q99569 Q92733 O60502 P46087 O00505 Q9NZ63 Q09028 O00566 Q96E09 Q9UHB6 P42166 P42166 Q01082 Q6PKG0 P05787 P42167 P42167 P18887 Q8ND56 Q9UPU5 Q8WXI9 Q9UK58 P27816

TE D

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

RI PT

ACCEPTED MANUSCRIPT PhoPepMass;X!Tandem

0.999999 0.999999 0.999999 0.999999 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

EP

S210 S52 S100 S151 S255 S162 S2209 S149 S328 S7 S1231 S18 S616 S132 S227 T470 S260 S135 S402 S416 S21 S130 S1452 S394 S225 S401 S121 S119 S287 S280 S216 S359 S564 S78 S114 S615 S204 S611 S211 S132 S888 S506 S384 S25 S335 S1247 S358 T220 S2155 S212

AC C

Q9UBB9 P55081 P23193 Q9BWH2 P08238 P29692 P46821 Q9Y618 Q92922 Q01105 Q04637 Q9H6F5 Q8IYB3 P51858 Q9Y6D5 Q96D46 Q8IYB3 Q9UKM9 Q8IYB3 P85037 Q96GN5 Q9UDY2 P51532 Q92769 P22626 P98082 Q9Y5J1 Q15390 Q12857 Q12857 Q9UKV3 Q9NQ55 Q9C0I1 P13861 Q9P035 Q9Y6X9 Q96JM3 Q9UKN8 Q8TF01 Q9Y2K6 P52948 Q3MII6 Q8IU81 P16949 Q5VSL9 P11388 P35611 Q8IYB3 P12270 Q9UFC0

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass;X!Tandem

EP

S425 S12 S181 S61 S239 S315 S307 S304 S427 S547 S91 S498 S499 S782 S245 S332 S583 S2501 S229 S292 S294 S233 S344 S132 S135 S153 S50 S265 S210 S1510 S188 S101 S107 S836 S87 S738 S181 S354 S986 S177 S214 S139 S4521 S4986 S1086 S53 S51 S35 S225 S765

AC C

Q8IZT6 P02545 Q9NZI8 Q9H1E3 O95671 Q9NZT2 Q8NHW5 Q8NHW5 Q96JM3 Q9H1B7 Q9H6F5 Q8TCJ2 Q8TCJ2 Q8TDD1 Q14684 Q66PJ3 P27824 Q8NFC6 Q13033 Q96T37 Q96T37 P07910 Q15942 Q9UHB6 Q09666 Q96S55 Q96AT1 Q5T200 Q9Y5J1 Q8WWI1 Q9NQX3 P29966 Q5VV41 Q9C0C2 Q96AY2 Q8IYB3 Q9H1E3 Q96K21 Q9UDY2 Q58FF8 Q9H1E3 P49736 Q9UPN3 Q09666 Q14676 Q96MH2 Q96MH2 Q8TAD8 O75643 Q96EV2

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass;X!Tandem

EP

S240 S244 S5110 S1522 S1524 S1526 T255 S817 S1859 S619 S194 S361 S165 S23 S351 S37 S1459 S1468 S82 S1006 S868 S366 S1666 S617 S1283 S174 T263 S436 T267 S501 S490 S445 S1057 S104 S1099 S1040 S131 T60 S201 S109 S200 S1456 S2105 S374 S211 S338 S440 S1621 S1620 S1601

AC C

Q16204 Q16204 Q09666 Q02880 Q02880 Q02880 P17275 Q9H7F0 P27708 P19338 O43237 O76021 P51858 P13051 Q96NB3 P16402 P21333 Q9UIG0 Q9GZR7 O43314 O75717 P05455 Q9C0C2 Q5H9R7 Q9NTI5 Q5VV41 Q5T200 Q8NDI1 P55081 Q9H0D6 Q9UKV3 P85037 Q8N1G0 P05386 Q5VT52 Q9BTC0 O75446 P13051 Q9ULX3 Q8WXX5 P15408 Q9BTC0 Q9Y520 Q5VT52 Q13242 P49790 Q96ST2 Q9C0C2 Q9C0C2 Q12873

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass;X!Tandem

EP

S1605 S1783 S2211 S450 S799 S669 S119 S224 Y256 S455 S451 S453 S227 T406 S357 S132 S330 S121 T872 S458 S300 S19 S253 S400 S405 S63 S1779 S511 S16 S545 S970 S1195 S397 S2101 S1305 S38 S30 S207 S1217 S2409 S906 S1943 S226 S30 S271 S333 S100 T4100 S289 S51

AC C

Q12873 Q8WWQ0 P46821 Q8IYB3 O94979 Q9P206 O14737 O75376 O00401 O60832 O60832 O60832 P52701 Q8IYB3 P46013 O15357 Q92922 Q9NR30 Q8IYB3 P02545 Q5JTD0 P10155 P05787 Q96ST2 Q14247 Q13442 P46821 Q9UQR0 P16949 Q9P206 Q6PD62 Q13017 Q14978 Q5VUA4 Q29RF7 P16949 O75379 Q9Y6G9 Q13813 P11717 Q13428 P35579 P08238 Q9UHD8 Q9BRD0 Q9H6Z4 Q9H307 Q09666 Q9NWH9 Q99549

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass;X!Tandem

EP

S458 S805 S715 S177 S261 S563 S701 S80 S135 S284 T1003 S36 S3467 S677 S691 S240 S243 S653 S1004 S95 S149 S652 S461 S316 S2151 S134 S483 S253 S298 S214 S113 S155 S828 S1377 S159 S231 S118 S116 S21 S380 S2484 S307 S303 S641 S874 S109 S105 S436 T108 S49

AC C

Q96NT5 Q8WWI1 P51812 Q9NYF8 Q9UHR4 P19338 O43150 P13861 Q9BXS6 Q6IBW4 Q9UQ35 P10412 O75592 P49756 Q12996 Q9UKV3 Q9UKV3 Q96RL1 Q9UKV3 Q13425 Q13283 Q7Z417 Q6PJG2 Q3B726 O75376 Q9Y2K6 P42568 O15541 Q9BTE3 Q9Y6Q9 Q15185 Q8IX90 Q7Z3C6 P51531 Q96AC1 P07900 P55081 P55081 Q6R327 Q9C0B5 P11717 Q00613 Q00613 P35221 Q8IYB3 Q8NE71 Q8NE71 Q8IU81 Q8NE71 Q9Y3T9

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass;X!Tandem

EP

S304 S307 S928 T120 S153 S659 S163 S167 S1374 S58 S453 S340 S553 S176 S259 S1644 S138 S218 S133 S155 S79 S2272 S362 S499 S1073 S575 S351 S185 S315 S2132 S51 S245 S1345 S181 S498 S393 S398 S84 S85 S362 S19 S90 S473 S893 S1106 S1193 T614 S36 S230 S657

AC C

P05388 P05388 Q86TC9 Q8WXI9 O95218 Q86V48 O00566 O00566 Q7Z5J4 Q9H1E3 Q8IU81 O75909 Q9NWH9 P55327 P17275 Q9NQT8 Q5VTR2 Q15019 P51858 Q96I25 Q9H1E3 Q9UQ35 Q9H6X2 Q9H0D6 P27816 Q9Y2W1 P22059 P61006 O00273 Q9UQ35 Q9BTU6 O95425 Q96T23 P52594 Q9H7N4 Q13547 Q96ST2 Q96AY2 Q96AY2 P35613 Q9H1E3 Q6PKG0 Q13263 Q8WX93 P11388 P20020 Q8IYB3 P16403 Q96B97 Q9H501

M AN U

SC

PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem PhoPepMass;X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0.196178 0.196178 0.227317 0.227317 0.23823 0.243589 0.262565 0.269594 0.269625 0.280289 0.280289 0.280289 0.291502 0.307105 0.325375 0.328069 0.329088 0.329088 0.332852 0.332852 0.332852 0.333138 0.333138 0.333273 0.333333

RI PT

ACCEPTED MANUSCRIPT 1 PhoPepMass;X!Tandem

EP

T5 S554 S136 S324 S110 S638 T925 S161 S15 S105 S77 S224 S315 S125 S100 S304 S360 S98 S16 S1207 S75 S678 S539 S719 S26 S323 S322 T1542 T1545 S248 S1663 S268 S995 S3503 S571 T570 T569 S572 T994 S1009 S27 S181 S182 S298 S296 S297 S292 S291 S682 S173

AC C

Q9BQA1 P27824 Q8TB72 Q9H2K8 Q13425 Q9NW82 Q6PD62 Q1KMD3 P04792 P05387 Q9Y4B5 Q13573 Q5SQI0 Q8N8S7 Q86YP4 P17706 Q7Z5L9 Q13895 Q13200 Q15648 Q6PKG0 P35658 Q9Y4E1 Q9H7N4 Q92466 P50552 P50552 Q14839 Q14839 Q9HB20 Q9C0D5 Q9Y6Y0 Q14676 Q03164 Q92841 Q92841 Q92841 Q92841 Q9H7N4 Q8WWI1 Q9UN81 Q9Y478 Q9Y478 P08240 P08240 P08240 Q8IVH2 Q8IVH2 Q9P275 Q96KQ7

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.333333 0.333333 0.333333 0.366979 0.370202 0.380144 0.381407 0.382003 0.384011 0.384206 0.384208 0.388038 0.391972 0.395225 0.401503 0.406701 0.411948 0.41331 0.413824 0.413824 0.417629 0.417629 0.421736 0.423722 0.424319 0.432477 0.43292 0.435275 0.436036 0.437315 0.439092 0.440003 0.442006 0.442506 0.443648 0.445547 0.446178 0.448424 0.451385 0.451385 0.452765 0.452765 0.453544 0.456253 0.456253 0.462689 0.465024 0.465024 0.465024 0.466212

EP

T46 T47 S1219 S1885 S362 S469 S475 T273 S352 T1315 S1316 S180 S31 T271 S1201 S1850 S751 S372 S50 S51 S363 S364 S547 T350 S31 S197 S270 S271 T341 T272 S460 S596 S48 S14 S1889 S184 S13 S12 S998 S997 T1650 S1651 T220 T178 T179 S509 S850 S849 S848 S5

AC C

Q9UKT5 Q9UKT5 Q9C0J8 Q9BYW2 P09651 Q9UPQ0 Q14157 Q96G46 Q92538 Q12888 Q12888 Q9Y478 O95361 Q96G46 Q9H6S0 P24928 O60343 Q27J81 Q9P258 Q9P258 P09651 P09651 Q9GZU1 O75533 O95155 Q32P44 Q9Y6Y0 Q9Y6Y0 Q8N556 Q9Y6Y0 Q14157 Q13263 O14686 Q86U86 Q96SN8 O43741 Q86U86 Q86U86 Q9H7N4 Q9H7N4 Q9Y4I1 Q9Y4I1 Q96HH9 Q96A73 Q96A73 Q8N5C8 Q99700 Q99700 Q99700 Q5JSH3

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.471747 0.475999 0.477996 0.477996 0.478085 0.47812 0.479478 0.479757 0.481965 0.486139 0.489109 0.489776 0.492868 0.492868 0.492913 0.493294 0.493762 0.494758 0.495028 0.495028 0.496797 0.497191 0.497333 0.497362 0.497399 0.497762 0.497795 0.498289 0.498318 0.498318 0.498869 0.498974 0.499213 0.499323 0.499492 0.499805 0.499937 0.49996 0.49997 0.499981 0.499981 0.499995 0.499999 0.499999 0.5 0.5 0.5 0.5 0.5 0.5

EP

S124 S209 S100 S99 S687 T686 S565 S620 S1291 S168 S1587 S8 T32 S31 S38 S589 S134 S337 S289 S288 S129 S1161 S633 S9 S944 S272 S190 S19 S1574 S1573 S105 S1552 S162 S106 S385 S2515 S863 T1286 S391 S194 S195 S19 S237 T238 T835 S2 S477 T1204 S689 T3

AC C

O95251 Q86YC2 O95251 O95251 Q8N556 Q8N556 O15047 Q9Y4H2 Q5VZK9 Q14134 Q7Z401 Q9NWV8 O14874 O14874 O43491 Q27J81 Q9UIF9 Q16643 Q99959 Q99959 Q5TAQ9 Q5T1M5 P49790 P17096 Q9Y2F5 Q96G46 Q9UNF1 Q6Y7W6 Q9BY89 Q9BY89 Q7Z422 Q9C0C2 Q9BUL9 Q6P1L5 Q69YQ0 P21359 O75420 Q9NZN5 O15027 O95817 O95817 P40222 Q8TDY2 Q8TDY2 Q9Y4E1 P07355 P12956 Q9ULD2 Q15398 A6NMY6

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.501528 0.50186 0.50437 0.512021 0.517901 0.529457 0.529547 0.530067 0.540658 0.540953 0.542231 0.548814 0.549676 0.550488 0.554013 0.554086 0.554339 0.555193 0.556372 0.557023 0.557088 0.558626 0.559391 0.559391 0.560294 0.561818 0.563356 0.570638 0.57264 0.574446 0.575213 0.577147 0.583154 0.585729 0.588515 0.591478 0.591855

RI PT

ACCEPTED MANUSCRIPT 0.5 X!Tandem

EP

S140 S141 T479 S14 S836 T479 T363 S125 S834 T3 T837 S2 S690 S85 T875 S601 S29 S987 S937 S1215 S5784 S600 S124 S486 S671 S349 S1100 T68 S201 S1082 S269 S151 S60 S57 S343 T119 T116 S184 S2917 T203 S10 S1065 S183 S475 S782 S51 S1026 S460 S391 S205

AC C

P24534 P24534 Q9Y4E1 Q9GZR2 Q641Q2 Q641Q2 Q9Y4H2 Q9NRF2 Q9Y4E1 P07355 Q641Q2 A6NMY6 Q15398 Q99549 Q6ZU35 Q13263 Q12797 Q4ADV7 Q8WYL5 P39880 Q09666 Q13263 P31749 Q9NUL3 Q8N163 O75533 Q99569 Q6PKG0 Q14244 Q9NYV4 Q9Y6Y0 Q92667 P51798 Q7L2J0 P49585 P05187 P10696 Q9HB19 Q7Z6Z7 Q8N573 Q86U86 Q9UQE7 Q96A73 P12956 Q12888 Q9UP95 P00533 Q9BTU6 Q8N3F8 Q8NEY8

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.596958 0.602685 0.604556 0.606078 0.6101 0.611105 0.613401 0.615198 0.61915 0.620769 0.622214 0.623286 0.62388 0.625581 0.625766 0.630034 0.636215 0.636707 0.637026 0.639515 0.642321 0.642573 0.644691 0.646905 0.647054 0.651009 0.65215 0.654736 0.654736 0.662687 0.663569 0.66616 0.668209 0.67007 0.670838 0.670952 0.674189 0.676208 0.67955 0.680528 0.692285 0.693607 0.696548 0.696842 0.702008 0.702529 0.706194 0.706501 0.706877 0.708014

EP

T402 S778 S257 S183 S518 S79 S183 S509 S650 S413 S2 S113 S269 S277 S557 S615 S1374 S629 S534 S1906 T599 S512 S598 S96 S598 S128 S860 T400 T394 S790 S652 S3175 S998 S56 S893 S71 S1763 T689 S372 T2381 S209 S1765 T382 S1671 S7 S198 S1218 T572 S1042 S935

AC C

Q9NYF8 Q13435 P10398 Q9NYB9 P49790 O95155 P48382 Q9UQ84 Q9UKJ3 Q9Y4P8 P67870 Q6VMQ6 Q96A49 Q96G46 Q7Z460 Q7Z2K8 P11388 Q13393 O15047 P24928 Q13263 Q3MIN7 P46100 O15344 Q13263 P46013 P55201 Q15139 O94806 Q8N137 Q96JM3 P49454 P07814 O60503 Q8WUA4 O43493 P42694 Q8N556 O94763 Q9UQ35 Q9NXV6 Q15154 Q6Y7W6 Q5T5U3 Q99733 Q9BZL6 P39880 Q96PK6 P00533 Q9UMZ2

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.709014 0.709935 0.712296 0.713653 0.714678 0.716181 0.716534 0.718937 0.719175 0.720207 0.721704 0.721946 0.721956 0.721956 0.72371 0.727086 0.72834 0.730128 0.73269 0.73415 0.737186 0.737332 0.738439 0.738466 0.740985 0.741865 0.742173 0.744533 0.746559 0.746969 0.749568 0.752779 0.755325 0.757207 0.757999 0.759446 0.760077 0.761233 0.762842 0.763578 0.763913 0.7642 0.766655 0.767008 0.768379 0.769468 0.769984 0.770157 0.770828 0.773331

EP

S594 S1000 S642 S327 S598 S242 T1041 S231 S1279 S39 S300 S30 Y352 Y361 S17 S804 S1554 S1181 S342 S863 S65 T521 S453 S75 S860 S1690 S428 S50 S302 S691 S156 S240 S265 S15 S754 S4108 T47 S467 S233 S106 S1317 T411 S34 T24 S222 S13 S1917 S784 T360 S16

AC C

Q13263 P07814 Q8NCD3 Q9NQA3 Q6NZY4 Q9NYB9 P00533 Q9UPQ0 Q9C0J8 Q9Y657 Q12857 P05783 Q86Z02 Q9H2X6 Q6UB98 Q9UPP1 Q9C0C2 O43933 Q8N556 O75448 Q9NS39 Q16555 Q9H7N4 Q8TDD1 P43246 Q8NG31 P10636 O95251 P49023 O60303 Q5SSJ5 Q86TN4 Q8N556 Q6UB98 O60343 Q8WXH0 Q96AQ6 O15014 Q9UPQ0 P49023 Q12888 Q9C0B5 O95361 Q9H2V7 Q96I25 O14579 P24928 P46100 Q5T4S7 Q9H814

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.776687 0.776938 0.77842 0.780505 0.781278 0.784947 0.785351 0.787387 0.787874 0.788302 0.791355 0.791893 0.793522 0.794824 0.795876 0.796123 0.799197 0.802273 0.803521 0.804098 0.804458 0.805316 0.807796 0.80831 0.808954 0.809174 0.811456 0.813316 0.814517 0.816441 0.817486 0.819029 0.824029 0.825365 0.829605 0.833097 0.833529 0.835957 0.842719 0.844212 0.845325 0.845859 0.845862 0.849058 0.850115 0.850742 0.852791 0.856546 0.860204 0.860513

EP

T11 S1282 S1044 S1330 S90 S530 S651 S343 S36 S510 S1162 S1477 S1219 S149 S624 S14 S61 S67 S578 S171 S117 S1269 S327 S1288 S875 S245 S2 S516 S108 T1041 S2 S1253 S381 S3 S1178 S3 S914 S2 S201 S552 S8 S336 T337 S191 S31 S1025 S66 S44 S19 S272

AC C

P27816 Q96T23 P46019 Q9Y6Q9 O14646 O60504 Q96JM3 Q8N556 P04075 P27816 Q5T1M5 Q96QT4 Q6R327 P40855 Q92625 Q9H1E3 P51798 Q99081 Q92619 Q9NR30 Q96AY2 Q9UPT8 Q92560 Q9NZN5 Q8IYB7 O95801 Q03135 P49790 Q8WW12 P46019 Q02539 P46013 O95817 Q8TBZ6 O15027 P67870 O95425 P17096 Q9BSJ6 Q06124 Q9P1Q0 Q8N556 Q8N556 Q9UNF1 Q86VX9 P00533 Q9NS39 P05783 P49116 Q13501

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.861363 0.861682 0.86338 0.866122 0.870101 0.870359 0.870565 0.871511 0.873666 0.874237 0.879935 0.880129 0.88598 0.886719 0.886747 0.889358 0.890163 0.892768 0.897369 0.898231 0.898231 0.899484 0.904759 0.905213 0.906121 0.906649 0.908085 0.908523 0.908523 0.908523 0.908523 0.908523 0.908523 0.908845 0.910516 0.910933 0.910953 0.912492 0.913595 0.91584 0.916675 0.91682 0.917755 0.919159 0.920418 0.92062 0.922304 0.92302 0.92312 0.924068

EP

S10 S42 S22 S139 S105 S256 S14 S1698 T379 T235 S413 S435 S350 S189 S2 S403 S425 S62 S17 S397 S391 T989 S1577 S395 S2382 S1216 S4 S137 S138 S138 S138 S138 S745 S771 S9 S283 S652 S225 S520 S910 S432 S21 S386 S1413 S910 S992 S522 T198 S422 S633

AC C

Q3YBR2 P05783 Q9NVD7 Q5T3I0 Q9NUQ3 P42356 Q9H4Z3 Q9H1H9 Q86X10 P17676 Q8TBB5 O15119 Q6KC79 Q15365 P20340 Q8N1F8 Q96AP0 Q9NPI6 Q13263 Q15139 O94806 Q9H7N4 P38398 Q86WB0 Q9UQ35 P39880 P67870 O15320 A4D2H0 Q8IX94 P0CG41 Q86UF2 Q96PC5 O75170 Q9HCD5 P18583 P02545 Q9Y3Q8 Q9BST9 O14974 Q8N3X1 C9JLW8 O95817 Q7Z2Z1 Q8TF72 O75694 Q14195 Q13561 O60318 Q7Z4V5

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.92459 0.92486 0.924872 0.926357 0.928272 0.928932 0.92986 0.931931 0.932766 0.932981 0.93358 0.933785 0.93391 0.934109 0.934279 0.934333 0.93477 0.935694 0.936704 0.938209 0.93873 0.938948 0.940649 0.941992 0.942984 0.944327 0.945613 0.945813 0.946414 0.947824 0.949309 0.950612 0.953492 0.95464 0.95508 0.955124 0.955307 0.95589 0.956564 0.956679 0.957711 0.958265 0.96105 0.961567 0.961994 0.964337 0.964662 0.965628 0.966306 0.966538

EP

S199 S173 S14 S1256 S1944 S712 S510 S395 T780 S313 S2 S397 S13 S774 S877 S488 S552 S608 S202 S757 S375 S211 S26 S132 S235 S11 S173 S60 S27 T336 S31 S2046 S1099 S616 T273 S18 S25 S522 S2828 S261 S934 S15 S238 S2 S1278 Y36 S130 T70 T550 S874

AC C

Q9Y657 O95817 Q9H814 Q6P0Q8 Q8WYP5 Q9C0C2 Q9Y6G9 Q12802 Q13435 Q3T8J9 P16401 P46937 P49736 O94762 Q5T200 Q8N108 Q12888 Q96JM7 Q8N573 O60343 Q08499 Q8NI08 Q13263 Q9NQG5 Q6ZW31 P54274 Q9NR30 Q7L2J0 Q8NHH9 Q13671 P05783 Q9HCK8 Q5VZ89 Q8NDX5 Q7Z2W4 Q9Y383 O00178 Q16555 P46013 Q06210 P52948 Q9NQC3 Q9H019 P10412 Q5VZ89 P05783 Q5TAQ9 Q13541 Q96KR1 Q6ZU35

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.966547 0.966874 0.967591 0.967983 0.968411 0.96873 0.970552 0.971109 0.972319 0.974004 0.97405 0.974065 0.974261 0.974514 0.975337 0.97642 0.97642 0.97642 0.977148 0.977441 0.977911 0.978342 0.978615 0.978788 0.978922 0.97908 0.979485 0.979528 0.979626 0.979918 0.980358 0.981353 0.981511 0.98157 0.982559 0.983234 0.983371 0.983811 0.984564 0.985203 0.985235 0.985263 0.985291 0.985453 0.985767 0.986487 0.986862 0.987207 0.987323 0.98745

EP

S436 S244 T273 S50 S10 T19 S97 S3927 S129 S459 S325 S492 S523 S319 S2209 S532 S305 S405 S423 S122 S176 S704 S6 S613 S92 S225 S1722 S884 S136 S131 S107 S975 S400 S259 S1409 S2 S8 T484 S1100 S679 S312 S541 S17 S8 S876 S674 S449 S594 S968 S14

AC C

P55197 Q9HB20 Q99460 Q12986 A6NFI3 P02545 P18206 Q9UPN3 P31749 Q7Z5K2 P08670 Q9NUL3 Q9UPQ0 P49585 P15924 P08238 Q58FF8 Q58FF7 Q9UNS2 Q9NYF3 O43159 Q8WWI1 Q9BRR8 Q13615 P46100 Q96HH9 Q9HCD6 Q9NZM3 Q8N9T8 Q9BSJ6 Q7Z422 Q9NRY4 P27448 Q9UFC0 O43432 P16403 Q9BRR8 Q8N163 Q9Y4H2 Q8N556 Q14432 Q8IVT2 P60468 Q9NVD7 Q9UQ35 Q96T37 Q13330 P46100 Q5VZ89 Q13263

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.987557 0.987939 0.988032 0.988032 0.988127 0.988378 0.988979 0.989162 0.989741 0.989748 0.99006 0.990469 0.990863 0.990987 0.99135 0.991712 0.99195 0.992065 0.992134 0.992463 0.992505 0.992628 0.992756 0.992756 0.993005 0.993066 0.993103 0.993171 0.993331 0.993612 0.993619 0.993896 0.993943 0.99408 0.99417 0.994251 0.994271 0.994352 0.994362 0.99458 0.994614 0.994962 0.995056 0.995144 0.995257 0.995331 0.995361 0.995523 0.995604 0.995717

EP

S9 S92 S802 S800 S591 Y67 S183 S5 S19 S418 T723 S333 S240 S741 S382 T83 T11 S99 S728 T9 S709 S14 S127 S127 S785 S347 S430 S210 S815 S1222 S72 S20 S201 S384 S1270 S1067 S856 S14 S4267 S1318 S373 S251 S483 S526 S494 S566 S1029 S296 S815 S7

AC C

Q9H0S4 Q5QP82 Q641Q2 Q9Y4E1 Q9ULF5 P35251 Q8IZP0 P17096 P49450 Q8TBB5 Q5VT52 Q13671 P22059 Q5VZ89 Q12906 P83731 P16401 P13861 Q4AC94 Q96KB5 Q9H2P0 Q9NVD7 A6NMY6 P07355 Q6ZRV2 P49585 Q86UU1 P78347 O94762 Q8WYP5 P53365 Q07666 Q8N573 Q69YQ0 Q5SW79 Q9UQE7 Q15262 Q96EB6 Q8NEZ4 Q92538 Q01167 Q9UFC0 Q8N108 P28715 P78362 P51116 Q5THK1 Q15642 Q8IWX8 Q96QK1

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.995956 0.995964 0.996038 0.996051 0.996244 0.996252 0.996358 0.996389 0.996707 0.996869 0.996869 0.997197 0.997197 0.997206 0.997209 0.997287 0.997367 0.997373 0.997376 0.997405 0.997424 0.997504 0.997513 0.997517 0.997545 0.997617 0.997673 0.997697 0.997749 0.997752 0.997796 0.997874 0.998003 0.998023 0.998113 0.998127 0.998148 0.99816 0.998177 0.998202 0.998222 0.998334 0.998334 0.998336 0.998348 0.998381 0.998408 0.998486 0.998503 0.998558

EP

S657 S226 S1202 T145 S12 S1581 S5782 S384 S514 S344 S343 S1225 S1227 T21 S22 S466 S641 S338 S2321 S1400 S739 S108 S729 S1404 S29 S449 S4960 S47 S235 S2486 S991 S1454 S1124 S452 S2077 S19 S375 S48 S369 S463 S502 S215 S216 S513 T488 T139 S718 S507 S2234 S601

AC C

Q9UKV3 Q14694 Q9H6S0 O75781 Q9BRT9 Q14160 Q09666 Q9BSQ5 Q9Y2X3 Q15424 Q14151 O95239 Q2VIQ3 Q09161 Q09161 Q14C86 Q8N4C8 Q9Y3F4 O95359 Q02880 Q12789 Q9H6Z4 Q66K74 Q9UQ35 Q99618 Q9H8N7 Q09666 Q9Y534 Q9H7M9 O95071 P00533 P49815 Q9UQ35 Q9HDC5 Q9Y4A5 Q13263 P30305 O95544 Q01167 P30414 Q68E01 O14646 O14646 Q14684 Q9NUL3 Q96MW1 P00519 O14974 Q9Y618 Q765P7

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.998609 0.998659 0.998692 0.998709 0.998768 0.998861 0.998871 0.998873 0.998941 0.998942 0.999029 0.999038 0.999148 0.999148 0.999185 0.999194 0.999196 0.999226 0.999237 0.999249 0.999269 0.999281 0.999282 0.999282 0.999335 0.999397 0.999431 0.999442 0.999448 0.99946 0.99946 0.999526 0.999562 0.999568 0.999569 0.99957 0.999605 0.999611 0.999624 0.999624 0.999626 0.999626 0.999652 0.999658 0.999661 0.999665 0.999679 0.99968 0.999693 0.999695

EP

S343 S525 S152 S247 S308 S2 S211 S400 S15 S677 T331 S973 S355 S378 S110 S16 S1164 S335 S5780 S61 S489 S751 S275 S731 S67 S42 S127 S507 S435 S401 T2204 S169 S2344 S1191 S2424 S771 S246 S383 S200 S100 S363 T587 S511 S217 S492 S15 S695 S166 S127 T301

AC C

O75676 Q8N3V7 Q7Z434 Q92890 Q9BUA3 P13489 O00308 Q8N1F8 Q9HB90 P46100 Q9BVL2 Q5VZ89 A8CG34 Q96HA1 O00161 Q9BRT9 Q5T1M5 Q9Y3F4 Q09666 P50395 Q86SQ0 Q08J23 Q7Z2W4 Q66K74 O15042 Q8NEM2 P26358 Q96JM3 Q2VPK5 Q9C0C9 P49327 Q14980 P46013 Q8N1G0 Q9Y618 Q15596 Q8WWI1 O75717 Q9Y3E7 Q14258 O14497 Q3KR37 Q09666 Q9UPQ0 Q86YR5 Q8NDC0 Q9Y487 Q14134 Q5T8P6 Q14676

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.999717 0.99976 0.999764 0.999771 0.999794 0.999797 0.9998 0.999808 0.999809 0.99982 0.999827 0.99983 0.999845 0.999858 0.999869 0.999879 0.999879 0.999884 0.999887 0.99989 0.999894 0.999895 0.999898 0.999903 0.999904 0.999906 0.999912 0.99992 0.999928 0.99993 0.99993 0.99993 0.999931 0.999934 0.999935 0.999939 0.999946 0.999948 0.999951 0.999953 0.999956 0.999956 0.999957 0.999957 0.999959 0.99996 0.99996 0.999963 0.999963 0.999963

EP

S503 S299 S525 S76 S1017 S307 S104 S112 S21 Y822 S336 S377 S1208 S1158 S2 S115 S1212 S36 S1874 S985 S398 S684 S315 S420 S743 S1290 S1094 T15 S5 S181 S1055 S130 S30 S672 T54 S469 S422 S679 S21 S18 S69 S116 S372 S1099 S11 S271 S470 T94 T94 T79

AC C

Q9NVU0 Q14676 Q9BWT3 Q96MH2 Q86UU0 Q15054 O00512 Q9BX95 Q9H6F5 P18206 Q58WW2 O95817 Q5T200 P15822 P68402 P18615 Q8NI35 Q9BTL3 P42858 Q9NRY4 Q8N1F8 Q9BWT3 P49585 Q96ST2 Q08J23 Q13459 Q12888 Q9H3U1 Q99733 Q92945 O15014 Q9NXE4 Q9H4Z3 Q9C0C2 Q9UK76 P27448 Q96ST2 Q9H694 Q96FF9 Q9UID3 Q7L2J0 Q8N3X1 Q5T200 Q76FK4 Q9BQG0 Q00839 Q86UU1 P22392 P15531 O60361

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.999963 0.999963 0.999963 0.999966 0.999968 0.999968 0.999969 0.999969 0.999971 0.999971 0.999972 0.999978 0.999978 0.999978 0.999979 0.999979 0.999982 0.999983 0.999983 0.999984 0.999987 0.999988 0.999988 0.999989 0.999989 0.999989 0.99999 0.999991 0.999992 0.999992 0.999992 0.999993 0.999993 0.999994 0.999995 0.999995 0.999996 0.999996 0.999997 0.999997 0.999998 0.999998 0.999998 0.999998 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999

EP

S91 S321 S519 S54 S1320 S1318 S34 S550 S507 S76 S23 S370 S1314 S674 S62 S308 S10 S256 S842 T153 S257 S114 S111 S813 S150 S496 T596 S1155 S259 S635 S347 S254 S388 S426 S588 S2 S428 S138 S487 S149 S140 S90 S496 S329 S18 S614 S347 S146 T448 S954

AC C

O94826 A8MUU9 Q9UF83 Q9NQW6 Q9UQ35 Q9UQ35 P05783 Q3L8U1 P27816 A1L390 Q13085 Q5T200 Q9HBL0 Q9BPX3 O43159 P46013 Q8WXF7 Q13427 Q9Y2H5 Q86UP2 Q13427 P05187 P10696 O94885 Q86U42 Q8NEN9 Q9UJX2 O15085 Q13427 Q92878 O75676 Q13427 Q9Y4H2 Q9BUZ4 O60343 Q01130 P85037 P02765 Q86VM9 Q9H9L4 P49759 O00151 Q9NYF8 Q86X27 P16401 Q9H7N4 Q8TAQ2 Q8N6H7 Q9HDC5 Q9UQ35

TE D

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

RI PT

ACCEPTED MANUSCRIPT X!Tandem

0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

EP

S1688 S2 S9 S498 S14 S361 S2 S324 S147 T731 S87 S89 S131 S648 S254 S562 S3 S168 S415 T588 S12 S69 S4 S111 S66 S2708 S125 S1283 S1281 S1068 T609 S474 S9 S466 S11 S89 S85 S832 S6 S196 S199 S63 S65 S205 S377 S1232 S358 S169 S391 S174

AC C

Q5UIP0 P06454 Q05D32 Q9Y613 Q8IY67 O95677 P46940 O75909 Q9H9L4 Q9NRL2 Q9C0C9 Q9C0C9 Q96F86 Q9NYF8 P08729 Q8IYB3 P23528 Q14676 Q96ST2 P49790 O43399 Q9H1B7 P11388 P09923 O60264 P46013 P06748 Q8WWQ0 Q8WWQ0 Q09666 Q8NDX5 Q13098 Q9NYM9 Q5T0W9 P18754 Q96RS0 Q96RS0 Q96ST3 Q96ER3 Q9BW71 Q9BW71 Q6NXT1 Q96S55 Q58FF7 Q96ST2 Q8WYP5 P27816 Q9H4L4 Q9Y4H2 P16383

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 X!Tandem

EP

S560 S456 S2 S149 S612 S546 S213 S82 S2 S66 S480 S1064 S569 S187 S183 S2120 S103 S181 S7 S819 S1131 S721 S391 S230 S138 S3 S19 S381 S688 S714 S585 S198 S196 S2 S11 S13 S2 S328 S32 T2104 S914 S356 S330 T4430 S423 S5099 S940 S39 S100 S532

AC C

Q8IYB3 Q7KZI7 Q92597 Q16890 Q9H7N4 Q9P275 Q8N565 Q9BWU0 Q13177 Q8IU81 Q5JSZ5 P00533 Q3MIN7 Q8WUF5 Q8WUF5 O75376 Q9H019 Q9H4L4 Q9NQC3 Q09666 P46013 P18206 O43463 Q96S82 Q9HAZ1 Q16576 Q6PK04 Q9H307 Q8IY81 P26358 Q9NVU7 Q96ST2 Q96ST2 O43752 O75822 O75822 Q92522 Q9UKV3 Q9H7L9 Q9UQ35 Q96PE2 Q13427 P05787 Q09666 Q9NYV4 Q09666 P35658 Q04695 Q01433 Q9BYW2

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 X!Tandem

EP

S198 S18 S157 S154 T358 S1362 S952 S1461 T206 S251 S502 S103 S125 S22 S194 S180 S94 S500 S87 S685 S21 S942 S354 S160 S1814 S1812 S186 S172 S212 S88 S314 S316 S427 S215 S804 S406 S796 S283 S124 S2152 S713 T18 S670 S279 S256 S416 S1213 S491 T172 S578

AC C

Q5T200 O00418 Q96A47 Q96A47 Q13427 Q12888 Q9UQ35 O94986 Q96PK6 P78346 Q9NPQ8 P78347 Q9BW71 Q4KMP7 Q9BUJ2 P16383 P18583 Q12888 Q9BW71 Q8N3V7 O60832 O60763 Q16576 Q8WUY9 Q9Y4B5 Q9Y4B5 P41227 Q5PRF9 P22626 Q9UID6 Q13247 Q13247 Q8TB61 O95391 Q7L014 Q5TCZ1 P19634 P49761 Q14671 P21333 Q8N9B5 P10412 Q96T37 Q9Y3Q8 Q9HC52 Q96JM3 P11388 O15014 Q13838 Q8N3F8

SC

M AN U

X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem X!Tandem

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1 X!Tandem

EP

S3 S321 S16 S15 S218 S13 S64 S260 T84 S339 S452 S279 S317 S3426 S136 S352 S2 S251 S780 S312 S181 S434 S173 S612 S2 S179 S847 S27 S13 S428 S1268 S424 S422 S2 S964 S82 S283 S114 S502 S6 S8 S537 S604 S456 S20 S83 S616 S6 S106 S104

AC C

P60981 Q86WB0 Q9BVG9 Q9NS69 Q9UJX6 Q14566 O43159 P06748 Q9BW71 Q8NCN4 Q96JM3 P51948 P41229 Q09666 Q5VUA4 P38159 P20042 P17275 P23921 Q9BWU0 P61006 Q05519 Q5VUA4 Q765P7 Q9UQ80 Q86WR7 Q5M775 Q9UBP6 Q9H0C8 Q9UBF8 Q96T58 Q9NTZ6 Q9NTZ6 P63165 P46379 P98174 Q92576 Q9UNZ2 Q9Y2X3 Q96QR8 Q96QR8 Q02040 Q96T23 Q05519 Q14493 Q8N8A6 O00429 Q9H9E3 O43159 O43159

SC M AN U

TE D

0.152612 0.152612 0.152612 0.152612 0.152612 0.181523 0.227317 0.231221 0.232163 0.232267 0.232268 0.232507 0.232968 0.232968 0.233318 0.240495 0.240495 0.240994 0.240994 0.240994 0.24239 0.243589 0.245885 0.245885 0.247454 0.24917 0.249507 0.249541 0.249541 0.253674 0.253674 0.255711 0.255711 0.255711 0.257291 0.257291 0.259903 0.261085 0.263085 0.265392 0.26992 0.26992 0.26992 0.274828 0.279722 0.279722 0.279722 0.282383 0.283982

RI PT

ACCEPTED MANUSCRIPT 1 X!Tandem

EP

S5 S619 S618 S617 S616 T623 S318 S1544 T164 S41 T36 S34 S40 S56 S60 T155 S109 S108 T449 S448 S450 S261 S1666 S747 S748 T752 S262 S165 T79 S78 T208 T209 T763 S765 S766 S325 S324 S88 S1601 S317 S680 S502 S501 S500 T207 T1678 S1677 S1675 T245 T7246

AC C

Q96GM8 Q12872 Q12872 Q12872 Q12872 Q12872 Q92538 Q14839 Q8N9M1 Q9BQI9 Q9BQI9 Q9BQI9 Q9BQI9 Q8NDF8 Q8NDF8 Q8N9M1 Q9BXK1 Q9BXK1 Q92794 Q92794 Q92794 Q96QF0 Q9C0D5 P46100 P46100 P46100 Q12948 Q8N9M1 Q9HAW8 Q9HAW8 Q9NUA8 Q9NUA8 Q5VT52 Q5VT52 Q5VT52 P50552 P50552 O95155 Q6WRI0 Q9UQ35 Q9H7N4 Q15642 Q15642 Q15642 Q9NQS7 Q9NR48 Q9NR48 Q9NR48 P85037 Q9UPN3

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.283982 0.284664 0.285238 0.285238 0.285238 0.285619 0.287546 0.29808 0.298632 0.299111 0.299111 0.299187 0.301502 0.301516 0.301779 0.303898 0.303898 0.303898 0.307105 0.308098 0.308098 0.308404 0.308404 0.31001 0.310777 0.313178 0.314852 0.315221 0.315426 0.315724 0.316168 0.317436 0.317436 0.317436 0.3175 0.3175 0.317952 0.318331 0.318331 0.318904 0.318904 0.318904 0.319562 0.319672 0.321368 0.322394 0.322394 0.322612 0.323211 0.326278

EP

S7247 S1538 S1145 S1146 S1143 T81 S394 S103 S186 T1151 T1152 S319 S290 T1540 S1170 S101 S103 S102 S992 S230 S231 T493 T495 S23 S98 S335 S480 S478 S1026 S1027 S853 T108 S110 S109 S450 T451 T1032 Y203 Y204 S456 S455 S454 S333 T1444 Y1839 T1597 T1598 S534 S1315 S257

AC C

Q9UPN3 Q12873 Q9UPU5 Q9UPU5 Q9UPU5 Q8TDD1 Q8NC51 Q9BXK1 Q9Y388 A7E2V4 A7E2V4 Q8NBU5 Q99460 Q12873 Q92797 Q8N5C8 Q8N5C8 Q8N5C8 Q9H7N4 Q53LP3 Q53LP3 Q8N163 Q8N163 Q9H4Z3 Q9H4L7 Q5T200 Q86WS4 Q86WS4 Q15648 Q15648 Q6PKG0 O43752 O43752 O43752 P51116 P51116 Q15648 P40261 P40261 P26045 P26045 P26045 Q99590 Q14676 P24928 Q6WRI0 Q6WRI0 Q9P2N6 Q8TEQ6 Q96CP6

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.326617 0.328069 0.328069 0.328879 0.329527 0.329527 0.32967 0.32967 0.330533 0.330841 0.331535 0.331535 0.332507 0.332632 0.332632 0.332632 0.3331 0.333138 0.333273 0.333273 0.333299 0.333333 0.333333 0.333333 0.333333 0.333333 0.333333 0.333333 0.333333 0.333333 0.333333 0.333333 0.334306 0.334757 0.334757 0.335966 0.336099 0.338435 0.339171 0.339171 0.339612 0.339626 0.339626 0.341632 0.341847 0.342054 0.342645 0.342929 0.344303 0.344303

EP

T160 S26 S25 T159 S477 S474 S1226 S1225 S241 S711 S164 S160 S463 S184 S183 S182 S274 S293 T680 S679 T734 S125 S126 S348 S347 T127 T172 T171 S350 S1278 S1277 S1218 T675 S423 S424 T533 S1739 Y25 S282 S283 S341 S275 S276 S231 S654 S92 S512 S414 S108 T109

AC C

Q5JSH3 Q9UN81 Q9UN81 Q6UUV9 Q6VMQ6 Q6VMQ6 Q14160 Q14160 Q92733 P48553 Q13428 Q13428 Q7Z5L9 Q9Y2W1 Q9Y2W1 Q9Y2W1 P49454 Q8IVH2 Q9P275 Q9P275 Q5VT52 O15234 O15234 O95149 O95149 O15234 Q96KQ7 Q96KQ7 O95149 Q9C0J8 Q9C0J8 Q9C0J8 O15164 Q8WWM7 Q8WWM7 P35612 Q5JRA6 Q13303 Q13501 Q13501 Q9BYJ9 P49454 P49454 P17676 O15085 Q9Y2J2 Q96D09 Q86SQ0 P57768 P57768

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.345357 0.346111 0.346111 0.346254 0.346314 0.346314 0.347951 0.347951 0.349877 0.349941 0.349941 0.350044 0.351472 0.351472 0.351537 0.35228 0.353503 0.35515 0.355335 0.356468 0.35831 0.358586 0.358586 0.362597 0.362805 0.363045 0.363045 0.3631 0.363738 0.363738 0.364232 0.364232 0.364874 0.364874 0.365918 0.368339 0.368339 0.369255 0.370663 0.370932 0.371294 0.371531 0.372401 0.372401 0.372587 0.372891 0.373557 0.373557 0.373572 0.373828

EP

S113 S240 S241 S1681 S232 S233 T568 S571 T374 T555 S556 S466 S395 S398 S373 S182 S292 S665 S230 T563 S935 T365 S362 T349 T239 T313 S315 T393 T54 S53 S87 S88 S332 S331 S1219 S307 T305 S1935 S12 T1385 S365 S108 S337 S336 S3411 S228 T556 S552 S259 T611

AC C

O43182 P07910 P07910 Q9NR48 Q8NEC7 Q8NEC7 Q9Y4E1 Q9Y4E1 Q15424 P29350 P29350 Q76I76 Q9C0B5 Q9C0B5 Q15424 O43741 O43310 Q8N556 P17676 A8K7I4 Q9Y4E6 Q8ND30 Q8ND30 Q9H3M7 Q92733 Q8TCC7 Q8TCC7 Q12802 Q7Z3D4 Q7Z3D4 Q13439 Q13439 Q8TD19 Q8TD19 Q8NI27 P15336 P15336 P35580 P49736 Q13428 P09651 Q6Q0C0 Q14202 Q14202 Q70CQ2 P11831 P35222 P35222 Q12948 Q13263

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.375687 0.375755 0.375755 0.37761 0.378299 0.378299 0.379149 0.379769 0.379769 0.382123 0.382529 0.382529 0.382922 0.383768 0.384456 0.384544 0.384544 0.384544 0.384715 0.384715 0.384924 0.386313 0.388589 0.389232 0.389321 0.389321 0.38966 0.389822 0.389822 0.390373 0.391169 0.391169 0.392749 0.398183 0.398183 0.399562 0.399839 0.40126 0.401503 0.402536 0.404159 0.404159 0.405857 0.405857 0.406726 0.406908 0.40751 0.40924 0.410383 0.412061

EP

S17 T331 S332 S452 S699 S697 Y567 S750 S749 S512 S1160 S1156 S571 S117 T5 T180 S181 S182 T9 S8 S1244 S37 S308 S203 S320 T319 S296 S1193 S1194 S612 S510 T508 S388 S188 S187 S383 T1230 T57 T1205 T385 T2504 S2505 T117 S118 S1087 S532 T373 T520 S772 T414

AC C

Q01196 P49915 P49915 O15231 Q9P246 Q9P246 P17812 P46100 P46100 Q56NI9 Q8TDM6 Q8TDM6 Q96PK6 O60238 Q9BT92 O94842 O94842 O94842 Q86SQ7 Q86SQ7 P46821 Q9UHW9 P15408 Q8IWE2 P24723 P24723 Q9NZN5 O15027 O15027 Q13263 Q99569 Q99569 Q99081 Q9Y388 Q9Y388 Q9NUP7 P39880 Q8TAD8 Q9H6S0 Q9Y3X0 P46013 P46013 Q12888 Q12888 Q8N1G0 P35612 Q99575 P49790 Q13111 Q9Y5B0

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.412061 0.41222 0.41222 0.412944 0.413023 0.413037 0.413359 0.413769 0.414079 0.414144 0.415135 0.415829 0.415829 0.41702 0.41702 0.417514 0.418384 0.420152 0.420283 0.42051 0.421736 0.422437 0.422669 0.422669 0.42277 0.423008 0.423008 0.424084 0.424286 0.425025 0.425331 0.426841 0.427084 0.427084 0.427934 0.427934 0.428188 0.429788 0.429788 0.430923 0.432549 0.432549 0.433563 0.433751 0.433829 0.43401 0.434518 0.434518 0.434786 0.43511

EP

S415 S360 S361 T710 T48 Y3393 S528 T58 S661 T2746 S435 S865 S864 Y7 Y8 S1029 T1222 S23 S738 S1845 T549 S225 S145 S147 T636 S406 S409 S751 S570 S235 S178 S154 S1108 S1110 S500 S502 T528 S120 S122 S169 S194 S195 S131 S20 T18 S274 T191 S192 S106 S300

AC C

Q9Y5B0 Q8N568 Q8N568 Q9C0C2 Q13620 O75592 Q9BWU0 Q7L592 Q96S38 Q7Z6Z7 Q9ULJ3 O75128 O75128 P53779 P53779 Q7Z6B7 Q9C0C9 P46821 O75152 P24928 Q9GZU1 Q9Y4E8 Q96PE2 Q96PE2 Q2M3G0 Q9C0B5 Q9C0B5 Q9NRA8 Q76L83 Q9Y4L1 Q8IZ21 Q8IZ21 Q7Z5J4 Q7Z5J4 Q8NI08 Q8NI08 Q9NPI6 Q9BQE9 Q9BQE9 Q9H773 P78312 P78312 Q5M775 Q13303 Q13303 O75128 Q9NZJ0 Q9NZJ0 Q9NRR5 Q9NQS7

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.43565 0.437091 0.437114 0.437114 0.437212 0.43776 0.438736 0.439425 0.439468 0.439468 0.439468 0.439832 0.439978 0.439986 0.440817 0.441961 0.443109 0.443109 0.444755 0.444965 0.444965 0.445184 0.445184 0.445184 0.445351 0.445547 0.446011 0.446092 0.446092 0.446153 0.446601 0.44813 0.448253 0.448391 0.448679 0.448916 0.448916 0.449026 0.449843 0.450919 0.451014 0.451203 0.451516 0.451732 0.451737 0.451996 0.452979 0.453013 0.453517 0.453671

EP

S596 S916 T339 T337 S160 T75 T517 S215 S34 S35 S33 S487 S516 Y202 S714 S972 S1377 S1376 S281 S1385 S1386 S939 S546 S962 S1217 S183 S1597 S924 S925 S302 S17 T713 S371 S29 S159 S12 S9 T678 S230 S461 S902 S499 S580 T488 T487 T58 S675 S1743 S221 S383

AC C

Q92560 Q12955 Q92777 Q92777 P48634 P06748 Q9ULM3 Q9BQ52 P29084 P29084 P29084 Q9NZJ0 Q03164 P43243 Q9UHC1 Q9UK61 Q9UPN3 Q9UPN3 P01106 P49815 P49815 A8CG34 A6NF01 Q96HA1 Q9C0J8 O43741 Q8WWI1 Q6DN90 Q6DN90 Q9NQS7 Q9H4Z3 Q9UHC1 Q27J81 Q15004 O95292 O60841 O60841 Q9P227 Q9NYF8 Q6ZVD8 Q9UQ35 O75928 Q9P275 O94972 O94972 Q99733 Q9UKV3 O75417 Q96HH9 O75955

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.454703 0.45507 0.45507 0.456138 0.456245 0.456706 0.457001 0.45795 0.45795 0.45799 0.45799 0.458136 0.459513 0.459872 0.459872 0.460407 0.460719 0.461606 0.46195 0.46195 0.462276 0.462276 0.462292 0.462534 0.46267 0.462967 0.462967 0.464821 0.465194 0.465313 0.465376 0.465649 0.465704 0.465781 0.465781 0.466491 0.466832 0.466832 0.466867 0.467006 0.467434 0.46753 0.46753 0.467551 0.467823 0.467868 0.467925 0.467932 0.467966 0.468209

EP

S399 S392 S391 S1031 T4433 T512 S1010 S240 T241 S14 S13 S307 T865 S954 T952 T238 S1043 S582 S167 S166 S2211 T2208 S469 T5539 T426 T469 S468 S193 S3409 S453 S817 T223 S599 S423 S424 S244 S252 T251 S696 S322 T2537 S479 S480 S1463 S319 T40 S2059 S10 S600 S259

AC C

Q9Y2W1 Q8NC51 Q8NC51 Q7Z6B7 Q8IVF4 Q9C0H2 Q9UQ35 P62753 P62753 Q9UK33 Q9UK33 P53350 Q6PKG0 O94804 O94804 Q9Y4L1 P46019 Q92619 Q9UIG0 Q9UIG0 Q12955 Q12955 P19484 Q8IVF2 Q16181 O14545 O14545 Q2M3V2 Q09666 Q14684 O15550 Q9BYG3 P22459 Q16181 Q16181 Q6KC79 Q7Z2Y8 Q7Z2Y8 O95819 Q8NBU5 Q7Z6Z7 O14545 O14545 Q7Z6E9 Q12857 O43741 O75179 Q9H3Z4 P22459 Q3SXY7

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.468209 0.468299 0.468299 0.468783 0.468878 0.468952 0.468953 0.469 0.469342 0.46935 0.469435 0.469435 0.472098 0.472348 0.472567 0.473084 0.473104 0.473104 0.473123 0.473494 0.473494 0.473494 0.473494 0.473654 0.474162 0.474162 0.474505 0.474532 0.475315 0.475542 0.476183 0.47623 0.47623 0.47643 0.47643 0.477141 0.477141 0.477262 0.477299 0.477299 0.477929 0.478066 0.478066 0.478475 0.478648 0.47865 0.479033 0.479467 0.479481 0.479756

EP

T258 T408 S406 S268 S633 S390 S340 T427 S338 T845 S479 S480 S664 S871 T4432 S1135 S312 S505 S313 S44 T57 S56 T45 S294 T429 T433 T1417 S341 S8 S1541 S899 S505 S504 S530 S531 S142 S141 T1115 T72 T70 T205 T732 S730 T1239 S907 S395 T1267 S912 T562 S704

AC C

Q3SXY7 Q6UWZ7 Q6UWZ7 Q9HC52 P25440 Q9ULE0 Q5T200 P35269 Q6WKZ4 Q6PKG0 Q08AE8 Q08AE8 Q96S38 P46100 Q8IVF4 Q5VZ89 P37275 Q8N5C8 P37275 Q16760 Q86XP1 Q86XP1 Q16760 Q99460 Q659A1 Q659A1 Q9Y4B5 Q5T200 Q14151 Q9UQ35 Q68CZ2 O15440 O15440 Q9UPN7 Q9UPN7 Q9H3Q1 Q9H3Q1 Q9UKJ3 P21796 P21796 Q9Y2W1 Q5VT52 Q5VT52 Q9BQG0 Q9UPT8 Q9BXF6 O14686 P49916 O15047 Q7Z2K8

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.479756 0.479757 0.479808 0.479848 0.480114 0.480742 0.481134 0.481965 0.482635 0.482671 0.482947 0.483187 0.483187 0.484048 0.484048 0.484624 0.484624 0.484656 0.484739 0.484928 0.484931 0.484937 0.484993 0.484997 0.48504 0.485338 0.485338 0.485677 0.485682 0.485685 0.485686 0.486415 0.486415 0.486519 0.486519 0.486832 0.487943 0.487943 0.488347 0.488347 0.488438 0.489084 0.489365 0.489387 0.489776 0.490193 0.490325 0.490334 0.490606 0.490726

EP

S706 S619 S9 S582 S459 T10 T261 S1290 T52 T2097 S971 S179 S181 T1111 S1112 S223 S222 S19 S284 S937 S935 T1108 T1112 S1110 S64 S492 S494 S475 T476 S477 S478 S3 S4 S1045 S1044 T305 S408 T406 S243 S244 T498 T74 S703 S1266 S7 S101 T25 S390 S1816 S1144

AC C

Q7Z2K8 Q9Y4H2 Q9Y2I8 Q13428 O75122 Q9Y2I8 Q3SXY7 Q5VZK9 Q86WB0 O75376 Q5SW79 P18615 P18615 Q96ST3 Q96ST3 A1L170 A1L170 Q9H4Z3 Q07157 Q9UQ35 Q9UQ35 P48634 P48634 P48634 Q6P6C2 Q96JG6 Q96JG6 Q08AE8 Q08AE8 Q08AE8 Q08AE8 Q8IWS0 Q8IWS0 P35658 P35658 O14974 Q14432 Q14432 Q8NAP3 Q8NAP3 Q5H9R7 Q96MH2 P46100 Q9ULD2 Q9NWV8 Q14739 Q01130 P27448 P46821 O60244

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.490736 0.491441 0.491776 0.491776 0.492913 0.493294 0.493348 0.493667 0.493667 0.493804 0.493808 0.493824 0.493824 0.494011 0.494021 0.494041 0.494041 0.494161 0.494732 0.494732 0.494758 0.495393 0.495393 0.495628 0.495628 0.495794 0.495794 0.495868 0.495868 0.495964 0.496019 0.496024 0.496206 0.496206 0.496342 0.496705 0.496741 0.496741 0.497067 0.497178 0.497178 0.497333 0.497362 0.497399 0.497522 0.497603 0.497603 0.498225 0.498225 0.498235

EP

S4384 S1907 S142 S141 S39 S588 S384 T11 T12 T1278 S1277 S269 S268 S207 Y183 S1341 S1340 S1025 S151 S148 T335 S742 S744 T407 T404 S330 S329 S164 S161 S122 S424 S425 T231 S232 S394 S1279 S206 S207 S428 S1012 S1013 T632 S8 S943 S181 S34 S21 S1582 S1579 T419

AC C

Q15149 Q9Y485 P18621 P18621 O43491 Q27J81 Q15424 Q9UEY8 Q9UEY8 Q96T23 Q96T23 P49454 P49454 Q9UKV3 P42167 Q6XZF7 Q6XZF7 Q6AWC2 Q9Y2I6 Q9Y2I6 Q16643 Q9BYW2 Q9BYW2 Q16630 Q16630 Q9UIG0 Q9UIG0 Q9P0K8 Q9P0K8 P31749 Q14978 Q14978 Q9UBW8 Q9UBW8 Q9P0L2 Q9H2Y7 Q9Y2H6 Q9Y2H6 P02545 O75122 O75122 P49790 P17096 Q9Y2F5 Q9NYF8 Q8IV48 Q8IV48 Q9HCD6 Q9HCD6 O14974

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.498235 0.49837 0.49837 0.498389 0.498506 0.498506 0.498552 0.498583 0.498906 0.498906 0.498973 0.499042 0.499125 0.499125 0.499165 0.499213 0.499226 0.499226 0.49928 0.49928 0.499294 0.499294 0.499323 0.499379 0.499379 0.499379 0.499379 0.499379 0.499459 0.49946 0.49953 0.49953 0.499589 0.499589 0.499713 0.499713 0.499722 0.499731 0.499731 0.49976 0.49976 0.499805 0.499828 0.499828 0.4999 0.499901 0.499901 0.499912 0.499912 0.49992

EP

S422 S127 S128 S631 S1222 S1224 T4238 T4239 S17 S16 S100 S4385 T771 S772 S260 S161 Y309 Y310 S172 S173 S10 T7 T105 S2250 S1275 S1274 S1275 S1274 T719 T1253 S38 S39 S21 S19 S411 T410 S1146 S264 S265 S77 S78 T2514 S291 S290 S484 S604 S597 S551 T552 T45

AC C

O14974 Q96T37 Q96T37 Q9ULT8 O95239 Q2VIQ3 Q2LD37 Q2LD37 Q99502 Q99502 P57682 Q15149 Q99700 Q99700 O75128 Q9BUL9 Q6UWR7 Q6UWR7 O95208 O95208 P62888 P62888 Q6P1L5 P49792 Q7Z3J3 Q99666 A6NKT7 O14715 P18206 Q5VZK9 Q16658 Q16658 Q99502 Q99502 P20810 P20810 Q14004 Q9Y4C1 Q9Y4C1 Q13085 Q13085 P21359 Q8TDN4 Q8TDN4 Q9P2B4 Q12873 Q12873 Q9P242 Q9P242 P0DP57

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.49992 0.499935 0.499935 0.499937 0.499962 0.499962 0.499962 0.499962 0.499965 0.499965 0.499972 0.499977 0.499977 0.49999 0.499992 0.499993 0.499993 0.499994 0.499994 0.499994 0.499995 0.499995 0.499995 0.499996 0.499996 0.499997 0.499997 0.499998 0.499999 0.499999 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5

EP

S44 S70 S71 S862 S1782 S1783 S502 S501 S110 S111 T119 S344 S345 T350 S141 T778 S774 S470 S468 S328 T501 S18 S152 T490 S489 S173 S171 S276 T824 S825 S643 T204 S140 S642 S505 S504 S363 S182 S717 S716 S493 S786 T1487 S962 S1489 T638 T362 S446 S139 S1389

AC C

P0DP57 Q9UK76 Q9UK76 O75420 Q9Y618 Q9Y618 Q9NXP7 Q9NXP7 Q86UE8 Q86UE8 Q13105 Q9Y6M4 Q9Y6M4 P50750 P26599 Q9BY89 Q9BY89 Q9NZN4 Q9NZN4 Q8NC51 O75928 P40222 Q92530 Q92558 Q92558 P50402 P50402 Q15345 P56192 P56192 Q5T200 Q13595 Q86UF2 Q5T200 P29590 P29590 P49674 Q8ND56 Q13427 Q13427 Q15758 O14646 O95602 O75128 O95602 Q14692 P49674 O15231 O15320 P46821

SC M AN U

TE D

0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.500016 0.500016 0.50004 0.50004 0.500059 0.500059 0.500059 0.500095 0.500095 0.500139 0.500146 0.500556 0.500811 0.500811 0.500867 0.500867

RI PT

ACCEPTED MANUSCRIPT 0.5

EP

S1387 S86 S118 S140 S15 S529 T963 S3042 S3041 S365 T637 S787 T494 T15 S864 S140 S741 S742 S747 T596 S90 S636 S595 S639 S309 S308 S140 S822 S114 S115 S357 S358 S140 S821 S72 S73 S1181 S1182 S274 S273 S1690 Y202 Y204 S443 S445 S1064 S112 S114 S111 S110

AC C

P46821 Q92993 Q5R372 A4FU28 Q9GZR2 Q6WKZ4 O75128 P46013 P46013 Q9Y4H2 O95071 O14646 Q15758 P39687 P29374 Q8IX94 Q3KQU3 Q3KQU3 Q96PC5 Q7KZI7 Q92993 O95071 Q7KZI7 Q14692 O43164 O43164 P0CG41 Q58F21 Q5TCX8 Q5TCX8 Q8WUF5 Q8WUF5 A4D2H0 Q58F21 P58004 P58004 A6H8Y1 A6H8Y1 Q96S07 Q96S07 Q9UQ35 Q9NW82 Q9NW82 Q9BVV6 Q9BVV6 Q9UQ35 Q6ZNC4 Q6ZNC4 Q9H9C1 Q9H9C1

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.500917 0.501311 0.50185 0.502163 0.502405 0.502405 0.502432 0.502746 0.502746 0.502849 0.503165 0.503377 0.50354 0.503622 0.503622 0.503629 0.503629 0.504655 0.505373 0.505449 0.506063 0.506541 0.506588 0.506632 0.507794 0.507883 0.508352 0.508352 0.508359 0.508955 0.509314 0.510179 0.510984 0.511552 0.511552 0.511607 0.513338 0.513931 0.51419 0.514307 0.515033 0.515725 0.515944 0.516261 0.516911 0.516934 0.517669 0.517977 0.518097 0.518194

EP

S579 S176 S175 S298 S180 S181 S514 S18 T19 S1142 S13 S245 S92 S663 S664 S157 S158 S1065 T1299 S73 T124 T190 S240 S228 S634 S632 S2081 S2080 S252 S20 S738 T1175 S1366 S324 S323 S357 S884 S140 S1061 S1062 S738 S1625 T414 S1218 T175 T176 S850 T220 T817 S36

AC C

Q9NXD2 Q8IUD6 Q8IUD6 O43493 Q9NWS9 Q9NWS9 Q6ZRV2 P29084 P29084 O60244 Q15311 O15085 Q8WYQ5 O15164 O15164 Q5VYS4 Q5VYS4 Q8N3U4 Q7Z2Z1 Q03188 Q15477 P32519 Q96C92 Q1KMD3 Q2M3G0 Q9ULT8 Q9UPU5 Q9UPU5 Q17RY0 P78549 A0FGR8 A6H8Y1 Q9NTI5 Q9H0C1 Q9H0C1 Q04656 Q96FS4 Q96RL1 Q8TEK3 Q8TEK3 Q7Z3C6 Q7Z6E9 Q7Z6B7 Q15648 O94842 O94842 P10071 Q9BYG3 P48960 P29084

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.518738 0.518868 0.519185 0.519682 0.520049 0.520175 0.520881 0.521334 0.521699 0.523469 0.523515 0.523823 0.523966 0.524691 0.524691 0.525595 0.525771 0.526147 0.526756 0.526985 0.527029 0.528086 0.528086 0.528894 0.529335 0.529476 0.529488 0.529596 0.529729 0.530216 0.530316 0.531039 0.531244 0.531684 0.531908 0.532003 0.532174 0.532175 0.532256 0.532329 0.532398 0.532518 0.532546 0.532833 0.533296 0.534625 0.534984 0.535213 0.535221 0.536377

EP

S154 Y8 S512 T2680 S537 S1512 S95 S18 T299 T561 T218 S231 S228 T358 T359 T433 T5796 S251 S708 S293 T1604 S335 Y336 S138 S1218 S479 S491 S4368 S590 S387 S353 T1177 T242 S68 T1537 S554 S1021 S905 S116 S267 T99 S311 Y124 S39 S385 S317 S1290 S346 S1216 T628

AC C

Q8N9M1 Q01718 Q6DN90 P15822 Q9NZT2 Q15751 Q7Z5K2 Q9UJF2 Q68DY1 Q96I24 Q15008 Q8NCF5 Q9NYF8 Q9H6B4 Q9H6B4 Q15139 Q09666 Q9NYF3 P48553 O43310 Q9Y623 Q9UN76 Q9UN76 Q8NC44 Q8WYP5 Q96PU5 P49916 Q14204 Q9BZ95 Q9ULE0 Q86U86 O75592 O14490 Q8NFG4 Q12873 Q9Y618 Q9P2D0 Q12879 O75475 Q96CP6 Q09666 Q8IVT5 P0C629 Q15004 O95817 P15408 Q12888 Q9H3M7 P20020 Q96T23

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.536857 0.536999 0.537724 0.537724 0.537838 0.537971 0.538558 0.538663 0.53889 0.539183 0.541423 0.541792 0.542329 0.542438 0.542689 0.54287 0.543 0.543405 0.544491 0.545529 0.545651 0.546319 0.546963 0.547459 0.547459 0.547799 0.548278 0.548292 0.548637 0.548742 0.548911 0.549108 0.5492 0.549256 0.549686 0.550305 0.550408 0.550795 0.550851 0.551802 0.552881 0.552939 0.555171 0.555368 0.555923 0.555926 0.556218 0.556499 0.557625 0.558251

EP

S1862 S519 T2209 S2210 S24 S2601 S26 T929 S1014 S101 S572 S617 S100 S595 S142 S923 T334 S1125 S1390 S299 S1407 T408 S629 T49 T50 S425 T1719 T128 T106 S178 T948 S213 S928 S356 T268 S381 S4400 S731 S316 S508 S1028 S265 S1309 S1307 S284 S181 S94 S1045 S1542 S831

AC C

Q5T5U3 Q9NZT2 Q12955 Q12955 O00178 P21359 Q9BUR4 P82094 Q7Z7G8 Q8NCY6 Q14185 P42684 Q14669 Q9Y2A7 Q9P0U4 Q5T5U3 Q969V6 Q5VZ89 Q8NI27 Q96NN9 Q13428 Q7Z6B7 Q96T23 P0DP57 P0DP57 Q6PCD5 Q9BTC0 Q8NEY8 P49736 P18615 O60879 Q9NRA8 P82094 Q5SW79 P59797 P86452 Q15149 Q9Y4H2 O95197 O15047 Q9P2D0 Q9NR19 Q7Z4S6 Q7Z4S6 Q6KC79 Q8IUD6 O43399 P28290 Q5UIP0 Q12888

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.558601 0.558693 0.558703 0.559288 0.559382 0.559513 0.55966 0.561035 0.561247 0.561554 0.561888 0.562536 0.562911 0.562952 0.563232 0.563419 0.563479 0.563723 0.56442 0.564517 0.564889 0.564892 0.566741 0.567026 0.56703 0.567091 0.567146 0.567447 0.567574 0.567615 0.567675 0.568375 0.568623 0.568855 0.569719 0.569731 0.569948 0.570035 0.571712 0.571857 0.571932 0.572048 0.57239 0.572418 0.573322 0.573896 0.574021 0.574418 0.574825 0.574846

EP

S613 T420 S464 S293 S42 S249 T222 S94 S27 T274 S180 S96 S414 T515 S113 S112 S1694 S338 S272 S2915 T515 S917 S554 T529 S196 T1847 T106 S449 T130 S1072 S336 S124 S493 S216 S242 S177 Y1011 S1513 S1035 S135 S107 S16 T187 S922 S277 S276 S26 T683 S497 S384

AC C

Q8TEV9 A0JNW5 Q86W92 P36507 Q99504 Q9HB96 P80723 Q9NX95 Q96EB6 P22314 Q06190 O60220 O96028 Q8NHV4 Q9H6F5 P12004 Q9UQ35 Q9HBL0 P38432 P20929 P49790 Q9Y485 P10636 O60504 Q6UY14 Q9UQ35 Q9H9C1 Q68DK7 Q03188 Q9UQ35 Q15036 Q8N9M1 Q86YR5 Q9P0L0 Q9HB09 Q86W54 Q7Z7G8 Q8WYP5 Q6R327 Q9Y314 Q9H7Z3 Q96FW1 O96013 Q6BDS2 P02545 Q96G46 Q96EB6 Q12959 Q8NC56 Q9NP74

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.575119 0.575228 0.575284 0.575439 0.575462 0.575818 0.576203 0.576455 0.576862 0.576994 0.577629 0.578165 0.578275 0.578343 0.578448 0.578555 0.578555 0.579092 0.579643 0.579669 0.580407 0.580549 0.580825 0.581495 0.581722 0.581771 0.582161 0.582238 0.582254 0.582368 0.584216 0.584711 0.58476 0.584841 0.584937 0.585107 0.585153 0.585153 0.585204 0.585663 0.586206 0.586909 0.587034 0.587059 0.587091 0.587146 0.588514 0.589898 0.590121 0.590316

EP

S1892 S144 S305 T296 T143 T21 S295 S158 T669 S400 S485 S3027 S453 S87 T94 T340 T339 S1174 T170 S47 S418 S431 T1974 S11 S1281 S373 S344 S332 S239 S767 S1030 S2820 S1079 S5706 S1913 S307 S682 S683 S349 S284 S382 T123 S763 S18 S99 S2602 S1445 S2102 T57 S177

AC C

P24928 Q9Y5Q8 P15086 O43493 Q9Y5Q8 P08218 P36507 O95644 P10071 O76021 Q8IZL8 Q03164 Q6TGC4 O43491 Q5JSH3 Q15424 Q14151 Q13136 P50613 Q07960 P23588 P35269 Q9UQ35 Q86WR7 Q9H2Y7 Q9H1A4 Q14202 Q92777 P85037 Q13111 Q7Z6B7 P15924 A1L390 Q8IVF2 P24928 Q9NXR1 Q8N556 Q8N556 Q14004 Q53TN4 O60381 Q8TAC1 Q14676 Q86WR7 Q17RY0 Q9UPU5 Q9HCD6 O75376 Q99504 Q6PJF5

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.591069 0.591533 0.591644 0.591677 0.591854 0.592259 0.592466 0.592501 0.59263 0.593209 0.59347 0.593756 0.594196 0.594378 0.594501 0.594722 0.595067 0.595489 0.595976 0.596136 0.596262 0.596592 0.596853 0.596993 0.596993 0.597045 0.597045 0.597214 0.597529 0.598151 0.598544 0.599495 0.599526 0.59972 0.599969 0.600046 0.600843 0.601062 0.601066 0.601205 0.601272 0.601527 0.601829 0.601847 0.602153 0.602209 0.602454 0.603069 0.603147 0.603688

EP

S2055 S200 S1688 S69 S314 S212 S1012 S33 S50 S1297 S863 S317 T322 T197 S52 S109 T603 T508 S2126 S763 S276 S1120 S768 S933 S233 T157 S158 S1297 Y321 T250 S1568 T199 S1437 S20 S1296 S316 S172 S523 S525 S3919 S299 S1086 S487 T810 Y135 T563 T1529 S49 S22 S152

AC C

Q9Y618 Q9UHD1 P18583 Q6P6C2 Q9BZ72 Q53LP3 Q9UQ35 Q9UGN5 Q9P265 Q12830 P29374 Q9H2U2 Q12857 Q9BVC5 Q9Y6D6 O15205 Q9Y597 Q9Y2X3 Q96T58 Q14149 P59797 Q9Y4G8 Q96JH7 Q6S8J3 P60709 Q96JC9 Q96JC9 Q5VZ89 Q9UN76 Q9Y4L1 Q14789 Q9NQS7 Q14160 Q9Y6X5 Q5VZ89 Q8NGC0 Q9BXB4 Q03164 O75122 Q2LD37 Q96RU3 Q6P0N0 O94913 Q6P3W7 Q96MW1 Q9NZQ8 P46100 O43379 Q9Y6X5 Q96P16

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.603739 0.604251 0.604314 0.604422 0.604422 0.604633 0.604694 0.605818 0.60652 0.606632 0.606968 0.607967 0.608268 0.608924 0.610545 0.610667 0.611039 0.611106 0.611242 0.611295 0.611821 0.611986 0.612567 0.612985 0.612985 0.613364 0.613364 0.613407 0.613409 0.614581 0.615267 0.616468 0.616611 0.616771 0.616996 0.617784 0.61857 0.618786 0.61947 0.619746 0.619763 0.619763 0.620728 0.620728 0.620824 0.620834 0.620834 0.621436 0.621537 0.62178

EP

S86 S213 T45 S320 S321 T365 S1107 S1714 S1254 S106 S3922 T1873 S277 S119 S425 Y236 S301 S1382 T723 T286 T308 S539 S994 S18 S18 S296 S295 S484 S159 S213 T387 S1100 T65 S203 S11 T302 S1579 S608 S204 S18 S1040 S1039 S217 T216 T5798 T147 S144 T1136 S864 S382

AC C

Q7Z402 Q9NX40 P62750 Q5T8I3 Q5T8I3 Q96SD1 Q9Y4D8 Q9BTC0 Q5VZK9 Q8NCY6 Q2LD37 P46013 Q9Y6Y0 Q96MU7 Q9NZJ0 Q96RK4 P38432 O60292 Q9Y6X9 O00712 Q8TAQ2 P35612 Q96JH7 Q5VT79 P13928 P15086 P15086 P16383 Q9NZN8 Q9BQ52 Q9NUP7 Q8TEK3 Q96MW7 Q9Y2H6 Q92685 Q9UPQ0 Q96BY7 Q9H2P0 P30622 P05783 A4UGR9 A4UGR9 Q66PJ3 Q66PJ3 Q09666 P46013 P46013 P42704 P21359 P48730

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.621843 0.622769 0.622783 0.623141 0.623574 0.624087 0.624501 0.624747 0.624747 0.625208 0.625913 0.626142 0.626565 0.626913 0.626995 0.628145 0.628393 0.628596 0.62866 0.629347 0.629347 0.62947 0.629524 0.630468 0.631299 0.631353 0.631538 0.632058 0.632167 0.632198 0.632778 0.632803 0.632886 0.633008 0.63317 0.633874 0.634469 0.634994 0.635537 0.635736 0.635793 0.635956 0.636572 0.638044 0.638158 0.638259 0.638665 0.639499 0.639556 0.640205

EP

T10 T1028 S132 S324 T946 S61 S56 T673 S672 S304 S158 S44 S1446 S304 T18 S410 S211 S143 S224 T15 T15 S1110 S556 S1582 S153 S321 S1366 S664 S135 T141 S105 S524 S1354 T231 S317 S1713 S1593 S383 S161 S1043 T494 S86 S984 T701 S303 S390 T302 Y273 Y307 S638

AC C

B2RD01 Q7Z6B7 Q1ED39 Q9UN76 O60469 Q9P265 P53999 Q9UQP3 Q9UQP3 Q96C36 Q8IZ21 C9J302 Q9HCD6 Q8NFH5 Q01196 Q13547 P11279 P50402 Q9NYB9 P54792 O14640 Q9UQ35 Q8N3E9 Q96BY7 Q92530 Q9BZ72 Q7Z3K3 Q92615 Q15388 P24666 Q9NP66 Q16584 Q13459 Q9NYB9 Q15652 Q9BTC0 Q6WRI0 Q15424 Q8NEY8 Q5TCZ1 P14314 Q9BWF3 Q15811 Q13009 Q12857 Q7KZI7 Q66GS9 P22314 Q4KMP7 Q5TCZ1

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.641057 0.641207 0.641212 0.641286 0.642573 0.642632 0.642837 0.643152 0.643406 0.643453 0.643763 0.643858 0.643956 0.644002 0.644261 0.644261 0.644275 0.644621 0.644756 0.646994 0.647777 0.647777 0.647918 0.648073 0.650078 0.650144 0.652126 0.652984 0.653048 0.653969 0.655605 0.655698 0.656001 0.656368 0.656429 0.65654 0.656696 0.656696 0.656696 0.656696 0.656696 0.6567 0.656936 0.656971 0.657654 0.65779 0.657855 0.657959 0.659423 0.660061

EP

S442 S990 S440 S110 S508 S1099 S21 T1422 T310 T333 S119 Y374 S285 S1874 S448 S447 S80 S348 T1535 S2 S215 S278 S392 S581 S63 S679 S399 T1156 S168 S52 S481 T17 S184 S569 S452 S230 T224 T224 T237 T231 T243 T245 S49 S1081 S2873 S117 S66 T2159 S1368 S161

AC C

Q8WWL2 Q9UQ35 Q9UDY2 Q5T200 Q3MIN7 Q8N1G0 Q9Y6X5 Q70EL1 Q9UPW5 Q86WB0 Q7Z569 Q5T200 O15446 Q9P2D1 Q6K0P9 Q6K0P9 O60930 Q9Y6D5 Q12873 P51397 P49841 P49840 A2A3K4 Q9NXD2 O15042 Q8NEV8 P05783 O94856 P42166 Q8N883 Q9P2B4 Q9H2H9 Q5XG87 Q7KZI7 Q9BZL4 Q9BYG3 P05549 Q7Z6R9 Q92754 Q6VUC0 Q92481 Q92913 Q99567 Q9UQ35 Q9NYQ6 Q92785 O94782 Q01082 Q9UKL3 Q9UIG0

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.660173 0.660173 0.660173 0.660173 0.660395 0.660494 0.660639 0.661021 0.661557 0.661712 0.66227 0.662271 0.662684 0.662704 0.663436 0.663449 0.665065 0.66618 0.667009 0.667274 0.667483 0.667551 0.667591 0.668117 0.668821 0.669329 0.670768 0.670829 0.670931 0.672363 0.672568 0.672568 0.67332 0.675092 0.67548 0.675508 0.675535 0.676032 0.676319 0.676567 0.677511 0.677513 0.677753 0.677928 0.678208 0.678499 0.678728 0.679035 0.679117 0.679306

EP

S22 S22 S22 S22 S1112 T95 S354 S266 T213 T3 S456 T176 S763 S13 S354 T9 S427 S736 T1144 S352 T524 S57 S754 S1415 S61 T198 S87 Y77 S1388 S372 S249 S249 S1105 T818 S358 S364 S1154 S11 T819 S364 S580 S263 Y231 S445 S1102 T2231 S451 T553 S313 T199

AC C

Q9H321 Q9NNX9 Q9H320 Q9H322 Q9UQ35 Q13409 Q96JM2 Q9UM54 Q9NQS7 P20340 Q6ZUM4 Q5XG87 Q9H8M5 Q9NQC3 O60502 P16401 Q9ULU4 Q9Y4D8 O94856 Q9HC52 Q6IS24 Q9Y2D9 Q9C0D7 Q9UQ35 Q16831 Q9BVC5 Q7Z403 Q9HAW8 Q8NI27 Q9ULM3 P38159 Q96E39 Q14C86 P42684 Q9H3M7 Q96SD1 Q76L83 Q8WWH5 P78347 Q5VT25 Q12888 O94906 Q9Y4L1 Q9BVJ6 Q9UQ35 P46013 Q02790 Q9Y618 Q4KMP7 Q86W56

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.679719 0.67991 0.679985 0.680052 0.680773 0.680924 0.681501 0.682603 0.682782 0.683003 0.683322 0.683368 0.683861 0.684127 0.685272 0.685839 0.685868 0.686233 0.686475 0.686661 0.687706 0.688223 0.688268 0.689265 0.689265 0.689265 0.689265 0.689265 0.689265 0.690047 0.690166 0.690261 0.69096 0.691417 0.691417 0.692247 0.692762 0.692989 0.694019 0.694132 0.694132 0.694218 0.694218 0.694312 0.694687 0.694763 0.6949 0.695861 0.695972 0.69598

EP

T1244 T526 S17 S4023 Y300 Y235 S1398 S11 S1033 T168 T3921 S541 S41 T331 T613 S2672 T244 S160 Y100 S300 S461 S1264 T394 S356 S356 S356 S356 S356 S356 S14 S908 S276 S484 S433 S431 S370 S2160 S308 S234 S65 S65 Y61 Y61 S1146 Y282 T1304 S138 S146 S1311 S266

AC C

Q9NYV4 Q6IMN6 P78344 P08519 P26640 O14490 Q9UQ35 Q9Y3B9 Q9UKJ3 Q9HCD6 Q2LD37 Q9ULD2 Q86WR7 Q99590 Q9Y4W2 Q6KC79 Q9BXS6 Q9UIG0 Q9NUQ3 Q8WVC0 Q76I76 Q92610 P36507 P30447 P05534 P10316 P01891 P01892 Q09160 P60468 Q9UPT8 O00712 Q8N3F8 P12036 P12036 Q8IWF2 Q01082 Q86VV8 Q9Y2W1 Q6IF00 Q8NGX2 Q6IF00 Q8NGX2 Q8TDM6 Q6ZSJ9 Q15648 Q9P0U4 Q8N9M1 P42694 Q99504

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.696589 0.696943 0.696987 0.696987 0.697085 0.697097 0.697537 0.697667 0.697686 0.697725 0.698236 0.699128 0.700283 0.700346 0.700979 0.70105 0.701326 0.701754 0.701764 0.701771 0.701923 0.702107 0.702208 0.702359 0.70246 0.703319 0.704124 0.70423 0.704389 0.704452 0.70465 0.705149 0.705461 0.705729 0.705882 0.706531 0.706758 0.707221 0.707664 0.707664 0.707895 0.707917 0.708475 0.70868 0.7089 0.709343 0.7096 0.709952 0.710215 0.710215

EP

S407 S460 S750 S749 S352 S4 T541 S855 Y173 S2790 S1115 S125 S157 S560 S318 S730 S188 S128 T1034 T191 S597 S196 Y121 S95 S96 S789 S411 S54 S263 S665 S431 S2912 S49 S1171 S306 S312 T118 S325 S828 S830 T422 S788 S300 S1891 S55 S1106 S273 S41 Y415 Y414

AC C

Q9NVI1 Q96K21 Q8IYB3 Q8IYB3 O60716 Q00839 Q92502 P10071 Q8IWF9 Q6ZRS2 Q13459 Q6NS38 Q7Z434 Q96S38 Q8TD16 Q8TEW8 Q9BRD0 Q14966 Q7Z6B7 Q96GY3 Q99700 O00470 P01031 Q9H9C1 Q9H9C1 Q05682 Q68D10 Q96P50 O95425 Q9H1B7 P35611 P20929 P17096 Q92797 Q8TAQ2 O43293 P27540 Q9H330 Q8IWX8 Q8IWX8 Q15139 P46100 Q765P7 Q9Y2F5 Q96FS4 P48634 Q6P1L5 Q99504 Q99550 Q99550

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.710609 0.711349 0.711349 0.711349 0.71217 0.712196 0.71295 0.71352 0.713563 0.71396 0.714337 0.715032 0.715323 0.715382 0.715405 0.715812 0.715835 0.716203 0.716242 0.718318 0.719255 0.719454 0.719864 0.720055 0.720366 0.721166 0.721546 0.72156 0.721963 0.723155 0.723438 0.723534 0.724113 0.724238 0.72429 0.724346 0.724848 0.724848 0.725366 0.725752 0.725929 0.726042 0.726137 0.726279 0.72648 0.726975 0.727286 0.728098 0.728274 0.728305

EP

S13 T500 T497 T514 S604 S1462 T567 S575 S361 S440 S361 S1081 S760 S173 S7 S1562 T1869 S2075 S2131 S413 T208 S155 S339 T2667 S1295 Y254 S16 S206 T946 S480 S432 S437 S1738 S7 S869 S511 S1789 S1788 S648 S785 S228 S201 S2161 S1691 S549 S1030 S1293 T1179 S525 S15

AC C

Q9H295 P05771 P17252 P05129 Q99700 Q9UQ35 Q02447 P20810 Q9H3M7 Q96RT1 Q9UQ80 P46379 Q9ULD2 Q96RK0 P08729 P11137 P46013 O95359 Q4AC94 Q68D10 Q14694 Q9BTA9 P08670 Q6KC79 Q8WYP5 Q7L266 P08218 O95297 Q9UQ35 O94966 Q14978 P10636 P42694 P08047 Q6DN12 O15344 Q14980 Q14980 Q9BWT3 O76024 Q5T8I3 P35580 Q01082 Q9UQ35 Q15849 P00533 Q5VZ89 Q9Y493 Q9P2N6 Q13188

EP

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.72878 0.72878 0.728907 0.729642 0.730303 0.730506 0.730563 0.73064 0.731079 0.731254 0.73139 0.731641 0.731669 0.731745 0.731848 0.731939 0.731946 0.731971 0.732204 0.732422 0.732805 0.73285 0.733373 0.73343 0.733631 0.733721 0.733903 0.734408 0.734592 0.7346 0.735229 0.735274 0.735515 0.73572 0.735731 0.735909 0.736281 0.736526 0.736661 0.73709 0.737341 0.737537 0.737838 0.737977 0.738247 0.738345 0.738837 0.739142 0.73932 0.739776

AC C

Q6IF00 T58 Q8NGX2 T58 Q8N5Y2 S367 Q9H334 S290 Q9HCM3 S1398 O75376 S157 Q9BY89 T1706 P51610 S598 Q7L804 S227 C9J302 T47 Q99733 S309 Q9UQ35 S892 Q16322 S493 Q8IY17 T110 Q9H0W8 S53 C9J302 T46 Q9Y2I6 S138 Q8WYP5 S1283 A4D1E1 T1011 Q13472 S513 Q9NZM1 S729 Q9H2Y7 S641 Q9ULD2 S540 P55211 S307 Q14004 S395 Q12778 T467 Q8TEQ6 T1320 Q9NZB2 S513 Q96T58 S2124 A0A0J9YWL9 S834 Q07157 S275 Q9H1K6 S5 Q96PU4 S93 P54259 T651 O60674 Y266 Q92994 S548 Q9H9E3 S11 A9YTQ3 S101 Q8N7Z5 S1672 Q6ZN30 S903 Q8N7Z5 S1671 P15086 Y300 Q9NQZ2 T362 Q3KQU3 S125 Q9UQ35 S1401 Q8WXG6 S1059 Q3MIN7 S511 O60469 S954 Q9P270 S58 Q9ULD2 S544

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.7401 0.740108 0.74034 0.740407 0.740758 0.740802 0.741619 0.741669 0.741905 0.741976 0.742013 0.742013 0.742185 0.742243 0.742243 0.742787 0.742938 0.743373 0.743863 0.743949 0.744226 0.744478 0.745098 0.745104 0.745104 0.745659 0.745855 0.745909 0.746756 0.74692 0.747198 0.747562 0.747856 0.748789 0.748803 0.748926 0.748997 0.74902 0.749679 0.750168 0.750536 0.751071 0.751074 0.751265 0.751489 0.752008 0.752117 0.752821 0.753153 0.753176

EP

S953 T502 S2900 S1301 S1839 S306 T273 S1435 S1978 T945 T123 T123 S238 S266 S270 T234 S336 T513 S1978 S502 S212 S1152 T229 S96 S95 S118 S372 S519 S1673 S238 S323 S227 S296 T332 T1094 S107 S338 T629 S49 S427 S557 S1281 S78 T223 S349 S63 S580 S29 S992 S680

AC C

O60469 Q99549 P08F94 Q5VZ89 Q8TD26 P78310 Q96DL1 Q9Y6N7 Q9HCK8 Q9UQ35 A6NMY6 P07355 Q7Z589 Q13595 P62995 Q9NYF8 Q92597 O15440 O94915 Q14160 Q96T37 Q7Z401 Q13153 Q9H4L7 Q9H4L7 Q6P1N0 Q9UK58 P49790 Q8N7Z5 Q5T200 Q6PJF5 Q8N1G0 Q8NAT2 Q6T4R5 Q08999 Q8IY17 Q9NYV4 P25440 Q99543 Q5T0W9 O60318 Q9NRL2 O75815 Q15008 Q6KC79 Q9NS39 Q9NYZ3 P29084 Q9UQ35 Q8WWM7

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.753243 0.75357 0.753724 0.754173 0.754363 0.754551 0.754584 0.754685 0.754824 0.754827 0.755135 0.755177 0.75533 0.755583 0.755625 0.755716 0.756004 0.756442 0.756589 0.756854 0.756872 0.75688 0.757841 0.758053 0.758212 0.758243 0.758271 0.75858 0.759114 0.759158 0.759228 0.75951 0.759643 0.759643 0.75996 0.760138 0.760196 0.760736 0.760815 0.761113 0.761242 0.761348 0.76136 0.762741 0.762926 0.763155 0.763357 0.763503 0.763649 0.76366

EP

S206 S468 S55 Y143 S423 S142 S8 S988 S1674 S1676 Y104 S479 S488 S2806 Y204 T903 S856 T555 S1450 S344 Y470 S44 S386 S2014 S52 S281 S685 S1504 S620 S1567 S74 S44 S785 S787 T4027 T401 S1326 S1037 S1064 S12 S2902 S132 S244 S17 S254 S30 S322 S954 S489 S320

AC C

Q9BX63 Q13098 Q9NUJ3 P46013 Q14978 Q12792 Q86WR7 Q9UQ35 Q8N7Z5 Q8N7Z5 C9JRZ8 Q9HDC5 P14672 O75592 Q9HAV4 Q9UQ35 P10071 Q04726 Q8NI27 Q5JSH3 A6NKB5 Q9BZF3 Q9Y3X0 Q92614 Q14135 Q15345 Q7RTP6 Q96QT4 Q5T4S7 P11137 O60930 O43741 Q9Y4E1 Q641Q2 P08519 P82094 P46821 A1L390 Q8N3U4 Q04695 P08F94 Q9P0U3 Q92913 Q7L4I2 Q9NYF3 Q9H8T0 P37275 Q9UJF2 Q14134 Q86VR2

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.763843 0.763891 0.764389 0.764514 0.764542 0.764978 0.765739 0.765739 0.766144 0.766169 0.766266 0.766405 0.766446 0.766654 0.767132 0.76764 0.767662 0.767698 0.767838 0.767895 0.768363 0.768528 0.768817 0.76924 0.769495 0.76982 0.769827 0.76986 0.769969 0.77002 0.770046 0.770253 0.770491 0.770533 0.770562 0.770616 0.770933 0.770975 0.772054 0.772054 0.772054 0.772054 0.772054 0.772054 0.772054 0.774035 0.774197 0.774392 0.774496 0.774498

EP

S355 S1571 Y278 Y923 S624 S430 T1200 T592 S61 S133 S1496 S41 S930 S803 T1576 S110 S1042 S179 S420 S1254 S459 T3 S334 S540 S298 S129 S196 S123 S28 S12 S940 S418 T517 S146 T128 S210 S1149 S134 S1456 S1471 S2447 S1471 S1464 S1472 S1472 S38 S347 S71 S645 S23

AC C

Q86U86 Q14789 Q96DL1 Q12955 Q9BYW2 P08670 Q96PC5 O15320 Q8WVV9 Q15477 P38398 Q9H2S5 P33527 O95696 P11137 Q9H6F5 Q15648 Q8WTV1 Q15139 Q8TDM6 P08670 Q9NVD7 Q14498 Q15849 O94875 P40692 Q9Y657 P50402 P29084 Q9H3F6 Q9Y4E6 A0JNW5 Q6IS24 Q76L83 Q6NS38 P49916 O15027 P0C629 P0DJD0 Q99666 P49792 O14715 P0DJD1 Q7Z3J3 A6NKT7 O95361 Q9Y2U5 Q8NDH2 P21580 P56211

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.77482 0.774874 0.775111 0.776851 0.777182 0.77726 0.777303 0.777397 0.777433 0.777717 0.77802 0.778745 0.779337 0.779508 0.780167 0.780211 0.780606 0.780893 0.781022 0.781989 0.782039 0.78245 0.782519 0.782688 0.782695 0.782969 0.782969 0.783362 0.78392 0.784308 0.785004 0.785027 0.785732 0.785904 0.786134 0.786244 0.786371 0.78661 0.786749 0.787091 0.787204 0.787798 0.787809 0.788517 0.78895 0.789096 0.789749 0.78978 0.790068 0.790135

EP

Q96RK4 Q86YS7 O95674 Q9UJA5 Q92560 Q8N1G2 P15374 Q32MZ4 Q9UQ35 Q12955 P11171 Q969R5 Q969R5 Q96JG6 Q14676 Q96FS4 Q9NS39 Q5T3Y7 Q8ND56 Q3SXY7 Q8NHX9 O95785 P52799 P17535 P02794 Q96DL1 Q9H2U1 Q8IYB7 Q9H2H9 Q9NXG2 A8K7I4 P11279 Q15906 Q53TN4 Q12906 Q5T8I3

S141 S602 S178 S391 S3 S518 S190 S178 S442 T537 T1553 Y73 S16 T T234 S295 S21 Y62 S597 S51 S130 S124 S939 S918 S188 S689 S688 S498 T1081 S837 T64 T11 S183 S255 S385 S1127 T264 S255 S183 S280 S161 S139 T54 T79 T580 S209 S127 S260 S810 S317

AC C

O43294 P22459 O94842 Q6UUV7 P33991 Q16555 Q01433 Q07157 P35269 Q9ULD2 Q14789 P19224 P15408

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.790152 0.790174 0.790204 0.790258 0.790333 0.790342 0.790605 0.790689 0.79089 0.791244 0.79156 0.793255 0.793412 0.793412 0.793417 0.793607 0.794354 0.794841 0.795089 0.795349 0.795351 0.797175 0.797324 0.797948 0.797999 0.798241 0.798252 0.798453 0.79878 0.798803 0.799205 0.799258 0.799315 0.799528 0.79972 0.799879 0.800164 0.800175 0.800389 0.800646 0.800911 0.801034 0.80126 0.80145 0.801498 0.801978 0.802123 0.802333 0.802847 0.803183

EP

T507 S1025 T160 Y1150 T224 S128 T1126 S983 S366 S1105 S596 S847 S1773 S1779 S172 T91 T501 S425 S243 S42 S940 Y223 T19 S242 T1202 S445 S415 T1124 S140 S1036 S1010 S84 S93 S623 T1143 S887 S159 Y355 S158 T226 S245 T504 T621 T114 S48 S251 T450 S363 T706 S243

AC C

Q96L34 Q6ZRV2 P42575 O94856 Q9Y4L1 P20813 Q8NET4 O95785 Q15910 Q5JTC6 P46100 Q6PKG0 O60229 O75962 O75376 P98175 Q5H9R7 Q5M775 Q68CP4 P08670 Q9UKL3 Q8NHM5 P49792 Q8N1G0 Q13459 Q9Y4C1 Q6ZW76 Q8NET4 O43294 Q9H792 Q7Z7G8 P46100 Q15651 Q9ULD5 Q9P260 Q9NZM3 Q9UPT8 Q8IZA0 O75376 Q13416 Q9UBP0 Q13472 Q9Y4B5 Q6NS38 Q13309 Q5T9C2 O94941 Q99728 Q9UHC1 Q6KC79

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.803596 0.804155 0.804169 0.804455 0.804557 0.80507 0.805489 0.805846 0.805911 0.806145 0.806215 0.806466 0.806545 0.806778 0.807291 0.807611 0.807913 0.807994 0.807994 0.808146 0.808146 0.808375 0.808488 0.808945 0.808989 0.809118 0.809472 0.809551 0.809688 0.809688 0.810775 0.811626 0.811766 0.812019 0.812524 0.812605 0.81266 0.812681 0.812835 0.813186 0.813251 0.813534 0.813564 0.814177 0.814319 0.814727 0.814936 0.814973 0.815103 0.815514

EP

S325 S829 S1545 S638 S127 S858 S227 S948 S165 S294 S2399 S109 S341 Y317 S725 S161 S414 S179 S179 T200 T199 S345 S630 S752 S433 S218 S154 S638 T649 T674 S243 S604 S2777 S341 S177 S261 S471 S210 S2827 S457 S453 S631 S57 S151 S232 S2989 S142 S655 S371 S1009

AC C

Q6PJF5 O14617 Q12873 O75420 Q5XKK7 Q9H8V3 A6NDX5 Q86U86 Q96JC9 Q9H6B4 Q8TDJ6 Q8IY17 Q99590 Q9H0C1 Q9Y6X9 Q92523 Q659A1 P0CAP2 Q9BZD3 P11279 P11279 Q9ULJ3 Q86TV6 Q9C0D7 Q96AP0 P11279 Q9BTE3 Q9NS15 P54792 O14640 Q00013 Q9Y2W2 Q9NYQ6 P22626 P42167 O95425 P30414 Q3KQV3 P46013 Q9BZ95 Q9Y2T3 Q13614 Q9H410 Q99607 P08559 P49454 P16220 P42684 Q8N6H7 A4D1E1

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.816987 0.817323 0.817403 0.817435 0.817616 0.81782 0.818303 0.818353 0.819002 0.819074 0.819143 0.819687 0.819851 0.820026 0.820194 0.820789 0.821366 0.821736 0.821756 0.822011 0.82234 0.822892 0.822998 0.823541 0.823804 0.824087 0.824498 0.824953 0.825033 0.82508 0.825089 0.826303 0.826369 0.828334 0.828397 0.828483 0.828759 0.828949 0.828988 0.829017 0.829036 0.829156 0.829878 0.829987 0.830181 0.830209 0.830804 0.830963 0.83128 0.831615

EP

S675 S807 T140 S578 T519 S76 T68 S343 S605 S1293 S66 S504 S327 S13 S165 S2077 S97 S453 S297 S385 S790 S882 S913 S18 S233 S394 S214 S218 S1040 S202 S180 T132 T185 S157 T359 S89 T131 S199 S815 T646 T110 S89 S187 S320 S219 S489 T461 S744 S264 S572

AC C

Q8TC07 P06400 Q5M775 Q13523 Q6IS24 P40222 Q13541 Q13435 Q659A1 Q7Z4S6 Q9C0D5 Q14160 Q9P206 P60468 Q8IV13 Q9UPU5 Q9Y2J2 O43719 Q9H6B4 Q9C0B0 O76024 Q14152 P49916 Q7Z3C6 Q9H3P2 Q86WB0 Q7RTT9 Q9NXE8 A1L390 P51858 Q86X02 Q8TAC1 O15537 Q15742 Q15418 Q96GX9 P20813 Q9GZU5 Q9HCE1 Q8TDY2 P27540 Q05655 P46777 Q6ZW76 Q8NC51 Q5T5X7 P42681 Q8IWB9 O00712 A8K7I4

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.831652 0.832086 0.832254 0.832647 0.833308 0.833377 0.833635 0.833635 0.8342 0.834862 0.834873 0.835269 0.835366 0.835859 0.8361 0.836575 0.837261 0.837332 0.83759 0.83773 0.838234 0.838676 0.839504 0.839573 0.840281 0.840337 0.8411 0.841323 0.841774 0.842173 0.842326 0.842976 0.843246 0.843523 0.843568 0.843972 0.843972 0.843973 0.844072 0.844082 0.844609 0.845206 0.845206 0.845366 0.84559 0.845716 0.845807 0.846089 0.846123 0.846455

EP

S152 S36 T598 S1360 S22 S224 S19 S19 S437 Y4018 T766 S152 T36 S509 S558 T352 S190 T438 Y137 S969 S1463 S299 S849 S1074 S187 S1069 T160 S676 S102 S1818 S462 S368 S580 S313 S430 S381 S358 S27 T115 S324 T327 S2435 S252 S582 S12 S518 S1422 S911 S398 S130

AC C

P27815 Q6VN20 O60885 P25054 Q6ZS17 Q7L804 Q5VT79 P13928 O94941 P08519 Q8N1F7 Q9H6H4 Q7L804 Q9Y2X3 Q9NZJ0 O60502 Q96T58 O94941 Q86U06 Q9HCE1 Q9UQ35 P26640 O60341 Q92628 Q6UY14 Q9UQ35 P27815 Q8NEV8 Q96FQ6 P46821 P46013 Q9NYB9 Q13523 Q6PJF5 Q8N1F7 Q96HA1 A8CG34 P08218 Q12959 Q12873 Q9P289 Q8WZ42 O43896 Q9H0B6 O00178 Q12888 P51532 O15438 Q9HCD6 O00255

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.846682 0.846702 0.847118 0.847159 0.847296 0.847346 0.84736 0.847469 0.847527 0.848104 0.848151 0.84931 0.849611 0.849753 0.85039 0.850494 0.850599 0.850627 0.851087 0.851305 0.851324 0.851461 0.852264 0.852309 0.852491 0.852593 0.852646 0.854022 0.854539 0.855584 0.855689 0.855716 0.856359 0.857197 0.857333 0.857355 0.857604 0.857907 0.858103 0.858319 0.858546 0.85988 0.860171 0.860498 0.86109 0.861524 0.861603 0.862202 0.863657 0.863683

EP

S1633 S742 T1385 T1844 S13 S135 S232 S521 T51 T65 Y130 Y146 T1317 Y683 S258 S405 S459 S5790 S694 S376 S415 S2 S104 S1549 S223 T45 S112 T19 T24 S164 T376 S4 S153 S805 S671 S831 S596 S863 S71 S316 S1401 T52 S276 S830 S321 T297 S515 S942 S664 S681

AC C

Q9HCM2 Q14C86 Q8NI27 Q9UQ35 Q04695 Q9UIF9 O75381 Q8NEN9 Q99733 P21796 P40692 Q9Y5Q8 Q92538 Q9P107 O43896 Q9H013 Q9Y2H5 Q09666 P38398 Q5T200 Q86SQ0 O95487 Q13409 Q12873 Q7Z4S6 Q86WH2 Q9NVM6 P20700 Q9C0F3 P43243 Q9NPR2 Q5T3Y7 Q6KC79 Q8IY63 Q9UQP3 Q9HCG8 O75122 Q99700 Q5U3C3 P46100 Q14966 P0DP57 P22314 Q9UHF7 Q4KMP7 Q66GS9 Q5TCZ1 Q15652 P54259 Q9UEY8

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.863751 0.863908 0.864029 0.864338 0.864662 0.865054 0.86538 0.865405 0.865405 0.865422 0.86556 0.865599 0.865779 0.866079 0.866331 0.866331 0.866473 0.86649 0.86687 0.867094 0.868054 0.86817 0.868457 0.869026 0.86944 0.869442 0.869608 0.870071 0.870141 0.870197 0.871132 0.871466 0.871987 0.872045 0.872111 0.872312 0.872738 0.872762 0.87304 0.873057 0.87325 0.87325 0.874062 0.874224 0.874639 0.874722 0.874842 0.874936 0.875458 0.876014

EP

S107 S43 S1146 T518 S363 S2 S760 T213 T214 S54 S300 S908 S14839 T106 Y264 Y382 S99 S891 S118 S1081 S1888 S303 S407 S79 S1106 S105 S108 T627 S195 S1099 S904 S151 S180 S64 S560 Y312 S965 S1076 S4 S161 S62 S62 S445 S1652 Y1621 S695 S2184 T673 S832 S1493

AC C

P54259 Q96FJ0 Q6ZT12 Q9BST9 Q15910 Q9Y5A9 Q14676 Q7Z4S6 Q7Z4S6 Q07352 O00712 Q9UQ35 Q8WZ42 P27540 Q9NR20 Q92630 Q13185 P07814 P29692 Q9UKJ3 Q9BYW2 Q8N6T7 P15151 O43915 Q5JTC6 P46937 Q9H9C1 O95819 P43243 Q9UQ35 Q6ZN30 Q8N9M1 O15537 Q9BXB5 Q13467 Q16849 Q5VZ89 Q9UKJ3 P17096 Q9NZN8 P01106 P04198 Q92667 Q9Y4I1 Q9HCM2 Q5VT06 O15018 Q7Z3C6 Q69YQ0 Q8WWI1

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.876223 0.87684 0.877291 0.877297 0.877559 0.878251 0.878332 0.878506 0.878653 0.878771 0.878891 0.879032 0.879127 0.879154 0.879182 0.879422 0.879571 0.879873 0.879942 0.880161 0.880292 0.880348 0.88091 0.880957 0.881076 0.881552 0.881991 0.882023 0.882492 0.882709 0.882939 0.883033 0.883039 0.884277 0.884449 0.884663 0.885318 0.885341 0.885382 0.885415 0.885578 0.885634 0.885742 0.886047 0.886584 0.887105 0.887205 0.887651 0.888172 0.888207

EP

T55 T1097 S642 S781 S616 S12 S1689 S730 S574 Y1528 S108 T504 S485 S301 S175 T96 S59 S197 S120 S609 S247 Y825 S582 S87 S19 S136 T163 Y1726 S2188 S782 S1673 S21 S389 T495 S548 T975 S379 S861 S227 S1600 S598 S239 S921 S664 S433 T254 S2030 T1261 S135 T676

AC C

Q99504 Q08999 P04049 P49792 Q5T8P6 P38919 Q9NQT8 O60271 Q9Y446 Q9HCD6 Q9H7Z3 Q13769 O15042 P26640 Q5XG87 Q8N5Y8 Q9UBB9 Q9NQS7 P15531 Q9NSK0 Q96C92 A6NI28 Q96PK6 P62995 Q9NVD7 Q9P0U4 O43399 A3KMH1 O15018 Q14126 Q12888 O75420 Q9C0B0 P14314 Q3KQU3 Q5VZ89 Q9H0K1 P10071 Q9NRS6 Q9Y623 O43491 Q13136 Q9H2P0 Q9Y597 Q14978 O15085 Q5VUA4 O14686 Q9Y2I6 Q9UQP3

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.88825 0.888281 0.889028 0.889477 0.889546 0.88984 0.89038 0.890408 0.890409 0.890954 0.891325 0.891348 0.891608 0.891909 0.891979 0.89248 0.892628 0.893738 0.89384 0.894268 0.894953 0.895215 0.895215 0.895574 0.895621 0.895987 0.896202 0.896839 0.897104 0.897439 0.897491 0.89781 0.897993 0.898119 0.898678 0.898678 0.898868 0.898916 0.899092 0.899374 0.900544 0.900708 0.900907 0.901159 0.901234 0.901343 0.902212 0.902221 0.90236 0.902456

EP

Y225 S255 S1521 S328 S89 S560 S1586 T209 S130 S220 S733 T557 S561 S225 T173 S3036 S274 T176 S172 Y956 S1051 S852 S3 S351 S498 S141 Y486 S2426 S923 S140 T732 T834 S160 S124 S326 S324 T699 S439 S1085 S137 T813 S1168 S3207 S434 S319 S2391 S508 S141 T398 Y38

AC C

Q15008 Q9UQR0 Q15751 P35212 O94761 Q9P1Z9 Q12955 Q9BUJ2 Q5T3I0 Q9BST9 Q6ZSS7 Q04726 Q9P1Z9 Q8IZP0 Q13428 Q03164 P59797 Q9H501 Q9P0K8 O60469 O60885 O95696 P55072 O60502 Q13472 Q5TAQ9 P16383 O75962 Q6PJG2 P01031 Q9Y4D8 Q9UHB7 Q70UQ0 Q9H4L7 P35212 P35212 P48357 P48651 Q9UQ35 Q8NH18 Q6P3W7 Q92797 P49792 P07814 Q9UPW5 Q03164 Q14978 Q16643 P37288 Q9H2S5

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.902475 0.903442 0.90383 0.904742 0.90482 0.904909 0.905267 0.905301 0.905311 0.905356 0.905412 0.905555 0.905637 0.905778 0.905933 0.906145 0.906168 0.906569 0.906628 0.907059 0.907211 0.907581 0.907775 0.908158 0.908291 0.908422 0.908523 0.908744 0.909079 0.909238 0.909368 0.909564 0.91016 0.910378 0.910998 0.911098 0.911122 0.91118 0.911198 0.911259 0.911639 0.911661 0.911811 0.912166 0.912276 0.912779 0.913009 0.913223 0.913336 0.913458

EP

S15 S297 S125 T20 T926 S80 S221 S957 T955 S134 S166 S393 S251 S589 Y631 T517 S939 S1311 S386 S1494 S275 S102 S286 S267 S1175 S1237 S138 T279 Y46 S587 S325 S957 S402 S410 S2899 S279 S171 S1028 S512 T265 S48 S419 S214 T32 S603 S741 S2164 S1975 S9 T1577

AC C

Q9H3Z4 Q8NAT2 Q5XKK7 P20700 P52732 P45985 Q66PJ3 O60469 O60469 Q9NQG5 P48634 Q9UIS9 O15085 Q9NXD2 O60241 Q13586 Q9Y2W1 Q6UB98 Q99081 Q8TEU7 Q9UJU6 P62995 Q9P0K7 Q9UQR0 Q92797 P39880 A4FU28 Q6ZSJ9 P21815 Q9BZ95 P35212 Q9UQ35 A6NKF1 Q7Z6B7 P08F94 P08651 P55327 Q12888 Q9BPZ7 Q96T37 Q15311 Q86UU1 Q9NQS7 Q3KR37 O14776 Q6IN85 Q01082 Q9UQ35 Q03135 P11137

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.913654 0.913819 0.914494 0.914549 0.914552 0.914639 0.91479 0.914955 0.915004 0.915482 0.916093 0.916247 0.9167 0.917193 0.917405 0.917467 0.917552 0.917996 0.918012 0.918078 0.918582 0.918634 0.918799 0.918917 0.919005 0.919005 0.919211 0.919524 0.920021 0.920104 0.920311 0.920556 0.920657 0.920853 0.921286 0.921335 0.921354 0.921865 0.922614 0.922647 0.923511 0.923511 0.923764 0.924033 0.924138 0.924218 0.924263 0.924648 0.924995 0.925041

EP

S386 S150 S1925 Y91 S338 T766 S52 Y148 S19 S95 S772 S1035 T1087 S1526 S140 T910 S93 S148 T539 S318 S442 S1854 T39 S485 Y74 Y74 S365 T422 S164 S743 S1786 T137 T174 S19 S485 S4434 S1558 S1023 S1089 S983 Y225 Y225 S1319 S763 S672 S1089 S420 Y266 S472 S463

AC C

Q9UKV3 Q12986 Q92576 Q9NY35 Q9Y6Y0 Q13201 Q9BQI9 Q9BTA9 P02745 Q12986 Q7Z6E9 Q9UKJ3 P48634 Q5SRE5 P16104 Q9UHN6 Q9H9C1 Q9UHW9 Q15849 Q4KMP7 Q5T5U3 Q9UQ35 Q9H2S5 Q9NZJ0 Q8NGX2 Q6IF00 Q9NQZ2 P85037 P50613 A0FGR8 Q9Y618 Q9NRN9 Q9NUM4 P78347 P06127 Q8IVF4 Q9C0C2 P52948 Q6PKG0 O75369 Q96E39 P38159 Q08AD1 Q13136 Q96NR3 P48634 Q9NTZ6 Q96T37 Q96JM3 A6NKB5

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.925041 0.925668 0.925673 0.925728 0.926217 0.926344 0.926555 0.926751 0.927384 0.927548 0.927753 0.927951 0.928191 0.928282 0.928376 0.928558 0.928822 0.928857 0.928857 0.928857 0.929051 0.929051 0.929279 0.92928 0.929513 0.929923 0.930088 0.930111 0.930303 0.930434 0.930649 0.931058 0.931379 0.931659 0.931666 0.931865 0.932012 0.932337 0.932584 0.932992 0.933142 0.933348 0.933767 0.933804 0.934133 0.934371 0.934561 0.934615 0.934931 0.934934

EP

T464 T659 S2437 S451 S500 S146 S540 T1132 S143 T246 S973 Y37 S2043 T439 S37 S441 T1190 S151 S143 S145 S223 T224 S1257 S328 S6 T856 S621 S84 S2392 S1891 S256 S503 S189 S346 S40 S18 T110 S35 S57 S306 S429 S1185 S1016 S768 S43 T606 S131 S496 S577 T531

AC C

A6NKB5 Q96S38 Q8WZ42 Q15459 Q6UN15 Q14847 Q86W92 O15438 O43294 Q96B36 Q96EV2 Q7L804 Q92614 Q9H0E3 Q8IUD2 P85037 Q9Y493 O75592 O75592 O75592 Q66PJ3 Q66PJ3 Q9NTI5 Q12851 Q5VV41 Q6PKG0 O76094 Q9NR30 Q03164 Q13315 Q8IVL1 Q13472 Q15366 Q5T200 Q6NZI2 Q9Y6X5 Q8TAP9 P05787 P21796 Q9UQR1 P02545 Q6P1X5 Q6WCQ1 Q32MZ4 P05787 Q2M2I8 Q86TC9 Q96JG6 Q9NZT2 Q9NPI6

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.935017 0.935023 0.935171 0.935548 0.935562 0.935743 0.935926 0.935993 0.936653 0.936833 0.93708 0.938239 0.938368 0.938532 0.938601 0.938693 0.938839 0.938856 0.938966 0.939053 0.939089 0.939089 0.939634 0.940004 0.940368 0.940574 0.940695 0.940762 0.940784 0.941001 0.941466 0.94151 0.941628 0.942035 0.942363 0.942399 0.942591 0.942629 0.942782 0.942911 0.943067 0.943076 0.943143 0.943246 0.943305 0.943352 0.943358 0.943433 0.943453 0.943492

EP

S2077 S214 S890 S33 T317 Y146 S274 T550 S270 S197 S764 S965 S933 S227 S27 S256 S1078 S284 S661 T228 S963 S964 S419 S521 Y1590 Y668 S224 T12 T1220 S1124 S69 S554 S7 S617 S539 S5 S152 S10 S107 S421 S327 T554 T995 T349 S5 S382 T238 S745 S168 S870

AC C

Q14980 A3KN83 Q86VS3 Q99598 Q9Y608 Q9BTA9 Q7Z2Y8 Q9Y618 Q96RS6 Q92734 Q9UQ35 Q6P1M3 P82094 Q9NYB9 Q9BWE0 Q08357 Q92628 P22314 P54259 P17301 Q8N3X1 Q8N3X1 Q9Y6G9 Q15057 Q12955 Q9UGP8 P11831 Q5T3Y7 O43426 Q9P1Y6 Q969T9 Q92609 Q9Y2I8 Q13576 Q641Q2 Q9Y6I3 Q14181 Q9NVD7 Q9BUQ8 Q5TCZ1 O14545 Q3KQU3 Q9NWH9 Q9BXS6 Q9Y2I8 O14497 Q9BYG3 Q13427 Q92523 O75128

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.943657 0.943713 0.943953 0.943955 0.94402 0.94402 0.944225 0.944423 0.944611 0.944758 0.945184 0.945191 0.945259 0.945297 0.945347 0.945401 0.945446 0.945845 0.946335 0.946818 0.946944 0.947441 0.947585 0.947743 0.94779 0.947888 0.94801 0.948247 0.94831 0.948533 0.949323 0.949681 0.949709 0.9498 0.95005 0.950073 0.950119 0.950166 0.950204 0.95044 0.95059 0.950604 0.950604 0.95066 0.95066 0.950829 0.95097 0.951489 0.951877 0.951889

EP

T328 S334 S450 S1083 T329 S330 S1085 S719 S634 S1603 S410 S160 S549 T1346 S366 S500 T685 S1564 S49 S416 S1602 T393 S981 S344 Y64 S365 S367 S1213 S888 S280 S43 S1476 S764 T1741 S753 Y35 S13 S532 S544 S625 T439 T231 T231 S93 S94 S15 S2993 T53 S1355 S664

AC C

Q9P289 Q9UN76 Q12774 Q9NYV4 Q9UHV7 Q9UHV7 P48634 Q9P246 Q13129 Q9Y623 Q6P9A1 O95292 O60583 P01024 Q8TEW8 Q96JG6 Q9P107 Q14789 Q12986 Q14157 Q14839 Q9UKV3 Q70EL4 P22626 O15305 Q9H6B4 Q9H6B4 Q5T200 Q96N67 Q96PK6 Q86U44 P11388 Q5T0W9 O75691 Q8TF05 Q9H3R0 P84098 O95235 Q9H4G0 Q9NXH9 Q13523 Q96E39 P38159 Q8N9T8 Q8N9T8 Q9UK33 P49454 P17096 Q5T9S5 A4D2H0

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.951889 0.951892 0.951899 0.951962 0.952042 0.952042 0.952343 0.952603 0.952706 0.952904 0.952943 0.953096 0.953133 0.953536 0.953659 0.953736 0.953903 0.954171 0.954418 0.954573 0.95491 0.954913 0.955137 0.955596 0.955788 0.955936 0.955966 0.956086 0.956192 0.9563 0.956399 0.95641 0.956523 0.956537 0.956588 0.956719 0.95676 0.956809 0.956818 0.956865 0.956921 0.957131 0.957202 0.957386 0.957472 0.957543 0.957558 0.957568 0.957786 0.957921

EP

S664 S226 S497 S854 S965 S966 Y495 Y441 S839 Y1220 S2161 Y1028 S179 S92 S467 S207 T302 S293 S868 S368 S583 S99 Y O75925 S488 P11387 S10 Q5H8C1 S279 Q9UQ35 T1856 Q2TAL5 S141 Q12789 S1856 Q8IWV8 S734 P52799 S268 Q6UUV7 S396 P11137 S1570 Q7L804 T38 Q5T200 S381 Q9NQW6 S323 Q92805 S760 Q8NC44 S344 Q00887 T119 Q70EL4 S975 Q9Y493 S1189 Q86T82 T233 P27540 S113 Q96QC0 S313 Q9ULD2 T531 Q9UQ35 S1014 Q96S66 S509 Q9UKV3 S561 P00533 S995 Q96MH2 S29

AC C

Q86UF2 Q9NYD6 Q96BY7 Q03112 Q8N3X1 Q8N3X1 Q8NBF2 Q9UK17 Q96FS4 P54296 Q5UIP0 Q9P227 Q8TBN0 P57682 P30414 Q8IXZ2 Q68DY1 P01106 Q6PKG0 Q8TEW8 Q71RC2 P62995

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.957956 0.958019 0.958032 0.958092 0.958131 0.958157 0.958264 0.958431 0.958475 0.958515 0.958556 0.958574 0.958735 0.958793 0.958835 0.958862 0.958882 0.958909 0.958915 0.959077 0.959276 0.959373 0.959562 0.959568 0.960185 0.960197 0.960464 0.960479 0.960486 0.960922 0.960923 0.960929 0.960929 0.960929 0.960929 0.960992 0.961141 0.961187 0.961378 0.961382 0.961519 0.9617 0.961866 0.962068 0.962215 0.962332 0.962332 0.962335 0.962597 0.962617

EP

S1800 S640 S2207 S290 T301 S521 S908 Y556 S437 S6361 S397 T328 S468 S563 S24 S442 S67 S2909 S1211 S925 S518 S12 Y701 S312 S117 S131 S106 T360 S241 S264 S978 S24 S24 S24 S24 S46 S50 Y154 S500 S1001 Y519 S508 S1754 S339 S105 S654 S679 S361 S347 S1196

AC C

Q0VDD8 Q9Y6Q9 P15924 Q99569 Q68DY1 Q6PKG0 O15438 Q13467 Q13523 Q8WXH0 Q14004 O75533 P30414 Q86UU1 Q9UJY1 Q9H2K8 Q15386 Q8NFC6 Q2KHR3 P82094 Q6IMN6 Q00536 Q86Z14 Q9UPS8 Q9HAN9 P18615 O75475 Q9UQB8 O14979 Q8IVL1 Q70EL4 Q9H321 Q9NNX9 Q9H320 Q9H322 O95544 Q9NX63 P27815 Q9ULU8 Q8TEK3 Q6ZRH7 Q5SWA1 Q9ULL4 Q8WWM7 O75475 P54792 O14640 Q9H6B4 Q8NC44 O75376

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.962649 0.962972 0.963044 0.963142 0.963199 0.963215 0.963252 0.963416 0.963473 0.96357 0.96357 0.963578 0.963614 0.96372 0.963847 0.963897 0.963958 0.964433 0.964569 0.964776 0.964912 0.965243 0.965414 0.965607 0.965657 0.965925 0.965998 0.966098 0.966112 0.966293 0.966399 0.966489 0.966628 0.966813 0.966982 0.967082 0.967317 0.967384 0.967567 0.967587 0.967712 0.967847 0.967892 0.967934 0.967957 0.967978 0.968008 0.968102 0.968126 0.968758

EP

S378 S259 S624 S293 S149 S461 S640 S1381 T693 S405 S406 S470 Y609 S544 T231 S365 Y62 S127 S47 S123 T460 S1223 S365 S1571 S13 S704 Y103 S1300 S108 Y181 S373 T205 S4022 S2 S63 S831 S1136 T185 T89 S259 T1306 S713 S123 S81 S860 T1310 S570 S295 S267 S247

AC C

Q7Z2W4 Q8IVL1 O60353 P22314 Q6UB98 Q7Z5K2 Q66K74 Q9NQT8 Q9ULT0 Q68D10 Q68D10 Q9NV70 Q13576 Q3KQU3 P08559 Q14694 P21796 Q9H4L7 Q99543 Q9UPR0 Q9H7T0 Q14160 Q9UKV3 P11137 O95487 P46100 Q9HBG7 Q68CP9 P49736 Q99759 P20810 Q3KQV3 P08519 P53779 Q9C0D5 Q13206 O60244 Q9NUM4 O43491 Q08357 Q86UR5 Q9P275 Q9NX40 Q969X1 P10071 Q9NTI5 Q96T23 Q5T0N5 Q15942 Q8NB78

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.968881 0.969133 0.969317 0.969517 0.969551 0.969619 0.969619 0.96962 0.969629 0.969674 0.969707 0.969823 0.969983 0.969988 0.970039 0.97018 0.970304 0.970405 0.970501 0.97062 0.970651 0.970719 0.970813 0.970853 0.971217 0.971244 0.971263 0.971365 0.97137 0.971394 0.971428 0.971441 0.971447 0.971639 0.97175 0.971755 0.971864 0.971935 0.972 0.972015 0.972033 0.972257 0.972278 0.972359 0.972785 0.972811 0.972946 0.97298 0.973241 0.973289

EP

S675 S735 S139 Y177 S337 S119 S118 S1442 S186 S16 S457 S706 S260 T269 S243 S825 S609 S636 S530 S1073 S461 S196 S246 S1059 S312 S197 S457 S569 S4 S161 S243 S901 S1021 S56 S470 Y632 Y353 S3360 S588 S95 S185 T918 T60 S257 S32 S1239 T461 S211 S234 S95

AC C

Q9NRH2 Q96PE2 Q9Y266 Q13426 Q6PL18 Q9H808 Q9H808 Q9Y6N7 P62070 Q96EB6 P35611 Q14684 Q8IVL1 Q13501 P85037 P55265 Q8NDT2 Q9Y520 Q9BW71 Q9UQ35 Q9H7T0 O60841 Q5R372 Q8TEK3 P40123 Q14119 Q9H7T0 Q14C86 P55103 Q8IUD6 P06748 Q8WUA4 Q8TDM6 P28066 P30414 O60241 Q92777 Q09666 P51825 Q13185 Q9BRD0 Q7Z333 P21796 Q13523 Q96C90 Q7Z4S6 Q9HDC5 Q53HC0 Q07955 P78317

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.973334 0.973584 0.973698 0.973751 0.973833 0.973881 0.973911 0.973917 0.974135 0.974148 0.97421 0.974343 0.974553 0.974564 0.97486 0.975256 0.975412 0.975563 0.975656 0.976013 0.976109 0.976182 0.976194 0.97623 0.976327 0.976327 0.976344 0.976469 0.976546 0.976853 0.976856 0.976973 0.977005 0.97704 0.977339 0.977391 0.977394 0.977425 0.977634 0.97774 0.977768 0.977817 0.977854 0.977879 0.978098 0.978116 0.978136 0.978207 0.978276 0.978277

EP

T286 S373 S783 S1906 T580 S375 S436 S129 S1101 S1527 S449 T265 S633 S404 S764 S9 S181 S581 S224 S447 S132 T302 S184 S243 S231 S229 S60 S148 S99 S1220 S145 S188 S128 S396 Y459 S1588 T110 S3623 S836 S740 S9 S15 T971 S2165 T171 S61 T74 S263 S42 S352

AC C

Q00839 P49354 Q9UQ35 Q5JRA6 O60504 Q9C0B0 P35269 O75475 Q12888 P46100 Q8WWM7 P52799 O60241 Q68D10 P48634 O60762 Q6UY14 Q58EX2 Q76L83 Q99569 Q13177 Q6NZI2 Q9BVC5 Q96C92 Q13243 Q13243 Q99543 O75145 P17096 P20020 Q9BRG2 P43243 Q8NH18 O76021 Q9H7T0 Q12955 Q9HBG7 P11532 Q8IYA2 Q96T58 Q14146 Q9UHB6 Q6ZU35 Q01082 Q92523 Q9UJA5 P19224 Q96IF1 Q9Y5S9 Q9NRF2

EP

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.978645 0.978705 0.978871 0.978872 0.97888 0.978926 0.978974 0.979156 0.979186 0.979203 0.979213 0.979271 0.979396 0.979396 0.979452 0.979485 0.979572 0.979595 0.979645 0.979687 0.979715 0.979774 0.97983 0.979847 0.979899 0.979922 0.979968 0.980102 0.980222 0.980234 0.980255 0.980446 0.980446 0.98048 0.98053 0.980558 0.980576 0.980599 0.980604 0.980642 0.980642 0.980659 0.980729 0.980743 0.980867 0.980994 0.981065 0.981071 0.981188 0.98127

AC C

A0A0J9YWL9 S832 Q8N883 S46 Q7Z3K3 S1364 P59797 Y279 P14314 T492 Q9HDC5 S473 P82094 S72 Q9BY12 S86 Q9HA47 S253 Q7Z3T8 S939 Q99504 S50 Q9C0A6 S1020 Q6IF00 S68 Q8NGX2 S68 Q7L266 S257 Q99543 S63 Q5R372 S119 Q13112 S538 Q2TBE0 S479 P01024 S1343 Q96T23 S622 Q9NP61 S331 Q9H9A7 S284 Q9NW75 S54 Q8IWF9 T180 Q14103 S190 Q9HDC5 S478 Q96SD1 Y369 P06400 S811 P27816 S1002 Q5JSH3 T349 P60983 Y104 O60234 Y104 Q96T58 S1918 Q15020 S8 P62995 S2 O00159 S408 Q9NYF8 T566 Q96R06 S10 Q8NGX2 T72 Q6IF00 T72 Q8NDX5 S266 Q13428 S503 Q1MSJ5 S85 Q8N9T8 S95 P37837 S3 Q6ZW33 S197 Q96JH7 S998 P52799 T266 P15924 S165

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.98141 0.981499 0.981574 0.981669 0.981759 0.981825 0.981869 0.982097 0.982113 0.982123 0.982173 0.982525 0.982614 0.982641 0.982724 0.98289 0.982904 0.982912 0.983064 0.983139 0.983196 0.983306 0.983428 0.983438 0.983604 0.983745 0.983852 0.98393 0.984004 0.984182 0.984198 0.984338 0.98451 0.984563 0.984696 0.984724 0.984739 0.984807 0.984893 0.984911 0.984912 0.984926 0.985024 0.985076 0.985078 0.985097 0.985185 0.985287 0.985441 0.985527

EP

S288 S447 S514 S35 S157 S56 S7 S315 S161 S13 S585 S505 S104 T1880 S602 S71 T496 S495 S64 S694 S1457 S977 S349 S451 S274 S166 S263 S373 S6 S262 T256 T748 S156 T117 S156 S546 S3 S23 S208 S569 S101 S208 T2 S43 T1307 T480 S192 S524 S73 S698

AC C

Q99961 P42681 Q6IMN6 Q99567 P28715 Q9BRS8 P05114 Q8NDX5 O95644 Q99250 Q9BZ95 Q08AG5 P21796 Q9UQ35 Q96QE3 Q86SQ0 Q08AE8 Q08AE8 O95394 Q14156 Q9UBG0 Q6WCQ1 Q9UIG0 P49321 Q92945 P15924 Q8IVL1 Q8IWF2 Q7Z3Y7 Q5JSH3 O43854 Q13427 O95684 P0C629 P28715 Q15022 P55103 Q9H609 Q04727 Q14185 P54259 Q8NI08 Q8TDU6 Q86WR7 Q9NTI5 P10071 Q16629 Q9NYJ8 Q9UJA5 Q8N3V7

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.985627 0.985648 0.98569 0.985825 0.985909 0.986017 0.986033 0.986068 0.986073 0.986077 0.986086 0.986142 0.986347 0.986386 0.986618 0.986805 0.986819 0.986823 0.986923 0.98693 0.986965 0.987005 0.987017 0.987104 0.987147 0.987198 0.987221 0.987273 0.987342 0.987367 0.987397 0.987428 0.987428 0.987456 0.987564 0.987624 0.987829 0.987862 0.987951 0.988016 0.988035 0.98807 0.988203 0.988225 0.98839 0.988424 0.988429 0.988431 0.988492 0.988538

EP

T82 T2 S373 S546 S147 T340 S234 S1424 T546 S58 S1056 T180 S107 S907 S201 Y52 T4 S1366 S377 S2 T78 S493 S561 T1120 S388 T1738 S10 S184 T343 S1298 S667 S345 S312 T1031 S318 S270 S257 S1181 S1315 S226 S782 S1474 S419 Y30462 S86 S30 S351 S99 S445 S14

AC C

Q13541 P55103 O14686 Q13427 Q8TF76 Q9UQB8 Q9NYF3 Q02880 Q04726 Q9BRS8 O75151 Q16539 O60361 P19838 Q8IWW6 P21815 Q9C0F3 Q9BY89 Q9UPQ0 P09651 Q7Z403 P14314 O75864 Q8NET4 Q8NHX9 O75417 Q9C0F3 Q9BRD0 O15226 Q7Z4S6 O15164 Q8NFJ5 Q0JRZ9 Q9P227 Q8NGC0 Q5BKZ1 Q13115 O15027 Q96M86 Q9H3N1 Q5UIP0 P11388 P27448 Q8WZ42 P05114 Q9BUR4 O95263 Q14847 Q7L7X3 P27816

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.988548 0.988555 0.98858 0.988606 0.988649 0.988817 0.988838 0.988841 0.988843 0.98886 0.988891 0.988931 0.98896 0.989025 0.989099 0.989118 0.989126 0.989128 0.989132 0.989156 0.989297 0.989338 0.989483 0.989483 0.989611 0.989612 0.989612 0.989629 0.989649 0.989662 0.989681 0.989694 0.989694 0.989694 0.989694 0.989694 0.989694 0.989694 0.98973 0.989782 0.989829 0.989866 0.990074 0.990095 0.990097 0.990237 0.990243 0.990271 0.990317 0.99033

EP

S88 S1322 S548 S748 S801 S7 T241 S213 S106 S653 S201 S17 S171 S46 S52 S92 T122 S362 S453 S343 S51 S880 S465 S463 S176 T211 S122 T1604 S1972 T436 S474 S789 S788 S787 S789 S788 S788 S779 S263 S1014 T199 T408 S331 S151 S618 T670 S644 S803 S9 S577

AC C

Q14738 Q9UGU0 Q9H1K0 Q8IYB3 O95239 P13489 Q86T82 Q9Y2H6 P26373 Q8IYB3 Q07955 Q6W2J9 Q13428 O95425 Q5T5P2 Q86XQ3 O75475 Q15910 Q96GX5 Q6PJT7 O43741 Q5VZK9 O15198 Q15797 Q13185 Q3KQV3 O00255 Q6WRI0 Q9UQ35 P85037 Q86WS4 Q7Z3J3 O14715 P0DJD1 A6NKT7 Q99666 P49792 P0DJD0 Q9Y661 Q9UKJ3 P40199 Q96T23 Q9UHR4 P25685 Q96PK6 P35658 Q7L590 O95155 Q7Z3Y7 Q9Y4H2

EP

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.990361 0.990375 0.990454 0.990461 0.990528 0.990533 0.990549 0.990549 0.990575 0.990614 0.990677 0.990694 0.9907 0.990715 0.990732 0.99081 0.990845 0.990845 0.990889 0.990941 0.99095 0.990951 0.990973 0.991005 0.991009 0.991014 0.991111 0.991137 0.991148 0.99116 0.991206 0.991209 0.991228 0.991236 0.99124 0.991254 0.991271 0.991352 0.991408 0.991585 0.991595 0.991608 0.991632 0.991634 0.991652 0.991656 0.991721 0.991767 0.991779 0.991871

AC C

P38398 S1189 Q8N9T8 S97 Q7RTT9 T204 Q01130 S26 O14490 S251 Q9Y618 S1869 Q9NQW6 T515 Q5T4S7 S178 Q00536 T14 Q6ZRH7 Y507 Q9NSK0 S565 Q86VM9 S492 Q8NB78 S17 Q14244 S315 A0A0B4J1V2T89 Q9NTI5 S1383 Q7RTT9 S207 Q7RTT9 T208 Q9Y2W1 S268 O95425 S968 P52799 T271 Q12888 S523 Q86WB0 S329 Q9UBT2 S207 Q702N8 S127 P15056 S729 Q9NQ75 T522 Q5R372 Y245 Q3B726 T322 Q8NHM5 T212 Q86Z14 T690 Q9BRS8 S409 Q15648 S1223 Q9UPS8 S314 P02745 T22 P27815 S162 C9JRZ8 Y108 Q14004 S340 P06748 S139 Q7RTP6 S649 P52888 S16 Q86U86 S1405 P48681 S1155 P49792 S21 O43915 S76 Q16539 Y182 Q15849 S537 Q9NY35 T83 Q8IV13 T169 Q9UIS9 S399

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.991894 0.991901 0.991904 0.99191 0.991962 0.992 0.992084 0.992126 0.992137 0.992141 0.992143 0.99215 0.992153 0.992216 0.992313 0.992375 0.992403 0.992439 0.992552 0.992578 0.992579 0.992617 0.99262 0.992667 0.992678 0.992845 0.992855 0.993025 0.993042 0.99306 0.993148 0.993155 0.993185 0.993204 0.993288 0.993642 0.993662 0.993703 0.993716 0.993874 0.993874 0.993876 0.993899 0.994019 0.99402 0.994073 0.99419 0.994192 0.994208 0.994231

EP

S687 S209 S655 S890 T155 S304 S1173 S89 S811 S533 Y167 S500 S649 Y229 S2169 S210 S13 S9 S294 S620 S647 S150 S438 T88 S188 T863 T30464 S604 S85 S42 S2035 S831 S1187 S5 S608 S1180 S477 S1319 S878 S203 S1160 S7 S23 T1181 S137 S1308 T494 S1033 S167 S2041

AC C

Q13427 Q6P4R8 O14639 Q9UHV7 Q07002 Q8TAQ2 Q92797 Q14738 O15164 Q9Y2F5 Q92523 Q9UHI6 Q58WW2 P17301 Q01082 Q6P4R8 Q6W2J9 Q9Y2A7 Q13523 Q96PK6 Q9HCX3 Q9H6H4 P49757 Q13595 Q15366 O75128 Q8WZ42 Q8TEP8 P62995 Q86VQ6 Q5VUA4 P48960 Q04637 Q14872 Q13586 O14686 Q8IZL8 P52746 Q9Y520 Q00G26 Q5SW79 P05783 Q9H3F6 O75592 Q7Z309 Q86UR5 Q16322 A4UGR9 Q6NZI2 Q92614

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.994237 0.994273 0.994281 0.994293 0.994306 0.994326 0.994333 0.994468 0.994468 0.994468 0.994468 0.994468 0.994524 0.994593 0.994609 0.994635 0.994662 0.994671 0.994685 0.994717 0.994717 0.994722 0.99473 0.994768 0.994821 0.994837 0.994838 0.99484 0.994855 0.994855 0.994855 0.994881 0.994946 0.995027 0.995029 0.995104 0.99512 0.995148 0.995174 0.995176 0.995182 0.995199 0.995208 0.995214 0.995225 0.995235 0.995251 0.995258 0.995275 0.995309

EP

Y41 S182 S58 S673 S181 T395 S1545 S58 S58 S58 S58 S57 S424 S37 T36 S1104 S907 S163 S49 S222 S220 S188 S2728 Y181 S241 S546 Y194 S99 Y565 Y556 Y562 S188 S56 S27 S763 S1335 Y444 S5 S332 S225 T155 S295 S862 S60 T2286 S832 S120 S1068 T1874 S291

AC C

Q8N883 Q8IUD2 P56180 P52948 Q8IUD2 O94759 Q9Y520 Q71DI3 P84243 P68431 Q16695 Q6NXT2 P42166 Q15004 Q15004 Q8WX93 Q9UPQ0 Q5VYS4 Q6ZMJ4 O00763 O00763 Q9NWS9 Q12802 Q5XG87 P40925 Q96PE2 P35580 Q8N5Y8 P15311 P26038 P35241 Q6UY14 Q9H2H9 P06733 Q9UQ35 Q15154 Q6TGC4 Q9H3F6 Q9HB21 Q66PJ3 O60565 Q12874 Q08AD1 Q659C4 Q8NEZ4 P46821 Q9ULM3 Q8IZF0 O15018 O00257

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.995315 0.995348 0.995367 0.995384 0.995402 0.995515 0.995532 0.995548 0.995562 0.995564 0.995585 0.995603 0.995627 0.995629 0.99563 0.995649 0.995652 0.995676 0.995696 0.995721 0.995745 0.995761 0.995771 0.995809 0.99581 0.995819 0.995827 0.995851 0.995857 0.995866 0.995937 0.995976 0.995983 0.995999 0.996 0.996007 0.996016 0.996077 0.996122 0.996151 0.996158 0.99617 0.99617 0.996171 0.996177 0.99618 0.996181 0.996203 0.996224 0.996229

EP

S35 S338 T326 S201 T1691 T1605 S79 Y834 S181 S83 T201 S813 S368 T178 S485 S495 S623 T511 S281 S404 S417 S165 S923 S4 S128 Y53 S912 S294 T178 S129 S422 S255 S191 S1857 S473 S51 S335 S70 S199 S270 S151 S405 S458 S633 S8 S4 S179 S1413 S1029 S2119

AC C

Q15004 O00443 O75533 Q6ZW33 P18583 Q6WRI0 Q8NDH2 Q8IYA2 Q8IW40 P62995 P40199 Q8IWX8 P09651 Q9NYB9 Q14676 Q14676 Q08050 Q6IMN6 Q9P0K7 Q9HCD6 Q8TEV9 Q92508 Q71F56 P43243 Q9BY89 Q9UJA5 Q12879 Q12888 Q8IZP0 O75533 Q15223 Q96BY7 Q5VV41 Q9UQ35 Q9UL54 P18858 Q8TAF3 Q9UJA5 Q9BQ52 P52799 P15056 A2A3N6 Q99755 Q9Y520 P50402 Q8N1N4 P02794 Q9NRL2 Q7Z7G8 Q07954

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.996229 0.996233 0.996238 0.996247 0.996269 0.996303 0.996331 0.996365 0.996381 0.996384 0.996433 0.996465 0.996519 0.996524 0.996539 0.99654 0.99656 0.996569 0.99657 0.996596 0.996619 0.996622 0.996633 0.996684 0.996717 0.996723 0.99675 0.996757 0.996763 0.996769 0.99679 0.996811 0.996857 0.996897 0.996949 0.996949 0.996958 0.996969 0.996994 0.997005 0.997005 0.997005 0.997005 0.997006 0.997035 0.997059 0.997094 0.997099 0.997113 0.997145

EP

S215 S102 S217 S79 S565 S473 S388 T1528 S550 S1214 S339 S2120 S636 S1970 S1134 S1019 S95 S573 S659 S97 S1421 T14827 S140 S498 S814 T764 S16 S330 S178 S86 S324 S438 S204 S380 Y742 Y740 S236 T325 S350 S57 S57 S57 S57 S491 T406 T14829 S835 T121 S166 T69

AC C

Q9HAV4 Q8WUF5 P49790 P50747 Q15596 A2RRP1 Q6T4R5 Q86XA9 Q3KR37 Q8WYP5 P17612 Q96T58 P17480 Q9UQ35 Q07889 Q9BTC0 Q9H7Z7 Q58EX2 Q08945 P62995 Q9Y4B5 Q8WZ42 P26599 Q14676 Q9P1Y6 Q9ULU4 P28066 P40425 Q13057 Q9UJN7 Q96II8 Q96S66 P40199 P48634 Q8TF05 Q8TF05 Q86T82 P49585 Q5D1E8 P62979 P62987 P0CG48 P0CG47 P16383 Q9H211 Q8WZ42 Q14160 Q9UPR0 Q99759 Q9UJA5

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.997148 0.997169 0.997169 0.997244 0.997252 0.99726 0.997275 0.997285 0.99729 0.997293 0.997302 0.997322 0.997333 0.997341 0.997341 0.997343 0.997348 0.997374 0.997425 0.997481 0.997487 0.997509 0.99753 0.997566 0.997583 0.997602 0.997618 0.997636 0.997647 0.997673 0.997675 0.997683 0.997709 0.997729 0.997763 0.997776 0.997815 0.997817 0.997833 0.99784 0.997847 0.997847 0.99788 0.997919 0.997952 0.997963 0.997965 0.997981 0.998003 0.998006

EP

S1531 S531 S3 T257 S143 S167 T327 S1785 T171 S808 S1077 S180 S469 S333 S334 S412 S1158 Y177 S180 S1632 S695 S290 Y310 S596 S1646 S187 S625 S468 S405 S119 Y254 S225 S128 S211 S39 S162 S819 S223 S100 S406 S467 S465 S116 S116 S182 S1608 S517 S233 S14 S155

AC C

Q8NFC6 O43353 Q9Y281 Q9NYF8 P54578 Q9H4A3 Q9UJZ1 P46821 Q8IV13 P48634 Q8NFC6 Q9BRG2 Q96NU1 Q9NYV4 Q9NYV4 P49407 Q9P260 Q5XG87 Q8IUD2 Q12789 P51532 O75152 A2A2Y4 Q6ZT98 Q92508 Q8WTV1 Q7Z4V5 Q9Y2W1 Q03252 Q96N64 O60674 Q9NQW6 O95696 Q6ZVD7 Q9Y5A9 Q14693 P46100 Q9BW71 Q13595 O95886 O15198 Q15797 O60264 Q96N64 Q9ULT0 Q6WRI0 Q6PKG0 Q13243 B2RD01 Q9GZY8

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.998014 0.998027 0.998028 0.998028 0.998028 0.998046 0.998052 0.998052 0.998052 0.99806 0.998071 0.998076 0.998081 0.998088 0.998106 0.99811 0.998125 0.998128 0.998138 0.998157 0.99816 0.998203 0.998229 0.998251 0.998269 0.998284 0.998287 0.998308 0.99833 0.998337 0.998341 0.998357 0.998361 0.998401 0.998425 0.998435 0.998439 0.998441 0.998445 0.998475 0.998495 0.998517 0.998527 0.998528 0.998537 0.998537 0.998537 0.998553 0.998581 0.998603

EP

S825 S2194 S1157 S1180 S147 S496 S60 S391 S391 S598 Y164 S1273 S200 T635 S525 S431 S278 T234 S138 S38 S82 S544 S41 S216 S199 S56 S817 S225 S768 Y395 S858 T17 S901 S720 T75 S143 T1443 S547 S110 S342 S465 S227 S618 S433 S266 S279 S240 T507 S409 S976

AC C

Q9UKV3 O15018 Q9Y4E1 Q641Q2 Q5SRD0 Q16322 Q5T5P2 P00367 P49448 P43243 Q5VYS4 Q8N3D4 Q8NAP3 Q9NS15 Q12888 Q8N1G4 Q9H5Z6 Q9BYG3 Q9H3Q1 Q9H3R0 Q05655 Q13427 Q09666 Q7Z4S6 Q9UQN3 P56180 A6NI28 Q96L33 P48681 Q9ULE0 Q8WXE0 Q96R06 Q9UQ35 Q9Y2D5 O43915 Q96D71 Q8NI27 Q9ULD2 Q6ZNC4 Q14004 O15231 Q15008 Q9Y4B5 P35269 P56524 Q9UQL6 Q9UKV0 Q5H9R7 P23588 Q9UKJ3

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.998604 0.998604 0.99863 0.998635 0.998658 0.998669 0.998672 0.998675 0.998675 0.998676 0.99868 0.998699 0.998703 0.998706 0.998708 0.998708 0.998717 0.998742 0.998758 0.998758 0.998758 0.998758 0.998758 0.998758 0.998758 0.998758 0.998759 0.998771 0.998775 0.998788 0.998801 0.998806 0.998807 0.998807 0.998816 0.998819 0.99883 0.998857 0.998858 0.998863 0.998865 0.998868 0.998873 0.998875 0.998878 0.998878 0.99888 0.99888 0.998896 0.998898

EP

T27 S23 S101 S102 S614 S11 S474 T58 T58 S446 S334 S76 S466 S517 S1185 T178 S190 S1861 S1471 S2454 S1478 S1478 S1463 S1479 S32 S1479 S946 S201 S3 S689 S2694 S332 S475 S71 S1872 S862 S838 T516 S861 S346 T13 S614 S182 S431 S419 S1955 S866 S604 S232 S328

AC C

P59036 P59036 Q13228 Q13228 P46821 Q8TDU6 O00418 P01106 P04198 Q8IZT6 Q9H1B7 Q6L8Q7 Q86W92 Q8WVR3 Q04637 Q9Y446 Q00587 P46013 P0DJD1 P49792 Q99666 O14715 P0DJD0 Q7Z3J3 Q96A65 A6NKT7 Q7Z3T8 Q9UPQ0 Q13601 P55197 Q9UQ35 Q9NYV4 A2RRP1 Q9Y6A5 Q9Y618 O75448 Q9ULV3 Q86UU1 Q9H2Y7 Q9UQ35 P15924 A1L390 Q9BVC5 O95232 Q16204 Q96JI7 P30414 P43243 Q9NYF3 Q6PJF5

EP

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.998906 0.998911 0.998919 0.99894 0.998942 0.998943 0.998959 0.99897 0.998985 0.998986 0.999003 0.999003 0.999009 0.999013 0.999017 0.999022 0.999024 0.999031 0.999044 0.999044 0.999044 0.999053 0.999076 0.999078 0.99908 0.999084 0.999092 0.999113 0.999123 0.999133 0.99914 0.999142 0.999159 0.999161 0.999167 0.99917 0.999181 0.999183 0.999195 0.999201 0.999204 0.999206 0.999215 0.99922 0.99922 0.999234 0.999234 0.999239 0.999256 0.999262

AC C

Q9Y580 S136 Q9P206 S971 O15018 S2192 Q14676 S793 Q5VUA4 S1971 Q6P0N0 T1089 P46013 S2588 Q9NYV4 S276 Q9Y4I1 Y828 Q8IWB9 S736 O43765 S77 O43765 T81 Q8N3U4 S1061 Q9NRF2 T343 O75376 S2436 Q07157 S175 Q15048 T82 Q8IWC1 S229 Q641Q2 S1179 Q5SRD0 S146 Q9Y4E1 S1156 Q5SSJ5 T51 O15438 Y1129 Q9UKV3 T420 Q5T1M5 S1114 O75145 T134 Q5VTL8 S529 Q9UNF1 S247 Q96MR6 Y809 A0A0B4J1V2S91 O14828 S76 Q9Y2F5 S1903 Q13115 Y265 Q13242 S204 Q9UNS2 S410 Q13769 Y509 O94759 T393 P02787 Y242 Q9HDC5 S465 Q9NTI5 T1381 Q9UQ35 S1132 Q5T0W9 T470 Q9UBB9 S2 A2A2Y4 S314 A2A2Y4 S313 Q99996 T3380 Q99567 T525 Q9Y217 S561 Q7Z2Z1 T1307 Q9C026 T357

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999268 0.99928 0.999283 0.999294 0.999295 0.999309 0.999313 0.999317 0.999338 0.99934 0.999353 0.999357 0.999366 0.999372 0.999373 0.999386 0.999394 0.999398 0.999405 0.999407 0.999408 0.999415 0.99942 0.999422 0.999423 0.999423 0.999423 0.999425 0.99943 0.999431 0.999436 0.999444 0.999445 0.999445 0.999446 0.999447 0.999451 0.999456 0.999458 0.999467 0.999471 0.999471 0.999479 0.999479 0.99948 0.99948 0.999481 0.999493 0.999493 0.999502

EP

T121 T1619 S325 S1800 S84 S143 S403 S1014 S1501 S346 S71 Y1188 S302 S40 S324 S236 S160 S810 S507 Y325 Y270 T746 T323 S238 S993 S80 S563 S309 S1364 S359 S405 S2 S1701 S825 S1663 S169 S107 S727 S2986 Y114 S198 S81 S2022 Y53 S87 S731 S253 S187 S191 S1216

AC C

O15205 O75037 Q9NYV4 Q14980 Q15048 Q96KR4 Q9P0L2 Q9NWH9 Q9UQ35 O60716 Q96C34 O75592 Q8TAQ2 Q5VU43 O75128 P62753 O95684 Q9HAW4 Q08AG5 Q14202 P20933 Q9C0D7 Q14202 Q07955 Q6WCQ1 Q13085 Q8NFF5 Q66GS9 Q5T200 Q5SW79 Q96JM3 Q7Z3Y7 Q7RTP6 P27816 Q7Z333 Q9UPQ0 P22234 O94762 Q8NFC6 O75794 Q8NCF5 Q15048 P25054 Q6ZMJ4 Q8N5Y8 Q5JU85 Q9Y2W1 O15083 Q8IUD2 Q8WYP5

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999508 0.999511 0.999511 0.999518 0.999519 0.999527 0.999534 0.999535 0.999536 0.999549 0.999552 0.999552 0.999558 0.999559 0.99956 0.99956 0.999561 0.999574 0.999579 0.999583 0.999587 0.999592 0.999595 0.999598 0.9996 0.999606 0.99961 0.999611 0.999613 0.999616 0.999617 0.999618 0.999622 0.999627 0.99964 0.999643 0.99965 0.999657 0.99966 0.999666 0.999666 0.999666 0.999674 0.999678 0.999683 0.999685 0.999685 0.999692 0.999693 0.999693

EP

S135 T128 S1228 S359 S244 T672 S7 S975 T2715 S4253 T1099 S54 S1126 S1053 S563 S489 S205 S395 S177 S10 S331 T200 T1982 S825 S43 S412 S62 S4251 S2284 Y235 S383 Y1348 T2912 S831 S86 T958 S273 S238 S8 S73 S817 S184 S75 T1422 T893 S741 S1325 S96 S2471 S397

AC C

P98174 Q9H694 Q9BYW2 O95747 P07911 Q9UGP8 Q9C0J8 Q6ZU35 Q5T4S7 Q2LD37 Q08999 Q9H1E3 Q8NB49 P28290 Q8TDC3 Q8IWQ3 Q9UBU7 P78344 Q15024 Q15020 P49585 Q3KQV3 Q8IVF2 Q9NPR2 Q96AQ6 Q5FWF5 Q96Q45 Q2LD37 Q8NEZ4 A6NDX5 Q8TEW0 P01024 P08F94 P46821 Q86XQ3 Q16513 Q9NYF3 Q92913 Q96R06 O43915 Q92547 Q8IW40 Q96C34 Q76I76 Q6ZN30 Q96T37 Q5VZ89 Q8IXM2 Q96L73 O60934

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999695 0.999696 0.999698 0.999699 0.999702 0.999704 0.999705 0.999707 0.999708 0.999709 0.999713 0.999718 0.999718 0.999722 0.999727 0.999729 0.999734 0.999736 0.999744 0.999746 0.99975 0.99975 0.999757 0.999757 0.99976 0.999764 0.999766 0.999767 0.999769 0.999769 0.99977 0.999776 0.999779 0.999786 0.99979 0.999793 0.999797 0.999799 0.9998 0.999802 0.999805 0.999808 0.99981 0.999814 0.999815 0.999815 0.999815 0.999817 0.999821 0.999823

EP

T367 S1878 S398 S1189 S32 T548 S257 S1792 S778 S226 S19 S2692 S158 S155 S693 S195 S690 S571 S1709 S296 S29 S292 Y1027 S104 S233 S18 Y130 S569 S259 Y490 S918 S204 S852 T514 S1101 S634 T785 S343 S359 S673 S573 S291 T199 S529 S1366 S1487 S4 S165 S365 S84

AC C

Q15910 Q9UQ35 P38398 O75592 P49450 P10636 Q96T37 Q6UB99 Q14289 P08621 Q03393 Q9UQ35 Q8N6N3 Q8WUI4 Q92609 Q9UHY8 Q9ULT0 P29322 O75179 Q8WVC0 Q16695 Q9H9A7 A4UGR9 P46778 Q9UGP4 O15083 Q8TAC1 P00519 Q96T37 Q8NBF2 Q9ULH0 Q4KMQ1 Q86YS7 Q16555 Q8WX93 Q765P7 Q6PKG0 Q86X27 P26045 Q9NRH2 Q3MIN7 Q96NN9 Q9NW82 O75122 Q7Z333 Q9Y618 Q99250 P08195 Q76FK4 Q13595

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999825 0.999828 0.999828 0.999832 0.999833 0.999833 0.999833 0.999833 0.999833 0.999835 0.999835 0.999836 0.999838 0.999838 0.999843 0.999844 0.999845 0.999847 0.999848 0.99985 0.999851 0.999856 0.999857 0.999857 0.999857 0.999858 0.999858 0.99986 0.999862 0.999862 0.999862 0.999864 0.999866 0.999868 0.999869 0.999871 0.999871 0.999873 0.999873 0.999874 0.999874 0.999875 0.999875 0.999875 0.999876 0.999876 0.999876 0.999878 0.99988 0.99988

EP

S1110 S895 S443 S821 S919 S918 S919 S918 S1894 S14 S407 S68 S419 S395 S333 S436 S532 S269 T277 S202 S816 S1211 Y31 S228 Y31 S1653 S1034 S1091 S141 S230 S690 S94 S536 S655 S1505 S223 T434 S8305 S2177 S384 S1122 Y33 T983 T118 S429 T217 S2 S122 T314 S118

AC C

Q5JTC6 Q8WWI1 Q01804 Q6P3W7 Q7Z3J3 Q99666 A6NKT7 O14715 P49792 Q14146 Q9UBB5 Q99618 Q2VPK5 P38398 Q58FF7 Q9BVV6 Q4G112 P20933 Q9H5Z6 Q4KMQ1 A6NI28 O43933 Q5VT79 Q92913 P13928 P46821 Q9BSJ8 Q9NSV4 Q7Z309 Q92913 Q9H307 P78317 Q9UQ35 Q9HCX3 O75369 P85037 Q9BVV6 Q8NF91 O95613 O94759 Q13459 Q8N883 Q9UQ35 C9JRZ8 Q8IYB3 Q7Z4S6 Q8N6S5 P12268 Q8TB03 Q86UU0

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.99988 0.999881 0.999882 0.999882 0.999882 0.999885 0.999886 0.999886 0.999887 0.999889 0.999889 0.999889 0.999892 0.999892 0.999893 0.999895 0.999896 0.999897 0.999898 0.999899 0.999904 0.999904 0.999905 0.999905 0.999907 0.999909 0.999912 0.999912 0.999912 0.999916 0.999917 0.999917 0.999918 0.999918 0.999918 0.99992 0.999921 0.999921 0.999921 0.999922 0.999922 0.999926 0.999926 0.999927 0.999927 0.999928 0.999928 0.999928 0.99993 0.999932

EP

S650 S199 S277 S1442 T315 Y251 S167 S95 S506 S600 S1341 S223 S109 S86 S936 S132 T243 S80 S1093 S466 S186 Y364 S551 S2 T367 S915 T479 S333 S333 S397 S182 S460 S189 S1513 S86 S688 S1704 S165 S766 T65 T126 T165 T206 S93 T172 S77 S1031 S1029 S104 S103

AC C

A6ND36 Q07955 Q96S07 Q9HCD6 O00512 Q13145 Q96GV9 P62995 A0MZ66 Q9Y2W2 Q13464 Q96NZ8 Q9BUQ8 Q9NXG2 Q9P1Y6 O75152 Q7L266 O00479 Q9NSV4 Q96EP0 P31152 Q8IWF2 Q9Y6Q9 Q16539 P45983 Q9Y4H2 P49916 Q9H7F4 Q8NFB2 Q13427 Q8TB72 Q14562 Q01130 Q5T5U3 Q13595 Q9P2M4 Q7RTP6 P30291 Q9H694 Q8NDH2 Q9H808 O60565 Q4KMQ1 Q13185 P48634 Q1MSJ5 Q8NHM5 Q8NHM5 O43399 O43399

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999933 0.999933 0.999934 0.999934 0.999935 0.999935 0.999936 0.999936 0.999938 0.999938 0.999941 0.999941 0.999943 0.999943 0.999943 0.999946 0.999946 0.999947 0.999948 0.999948 0.99995 0.99995 0.99995 0.999951 0.999952 0.999953 0.999953 0.999953 0.999953 0.999956 0.999956 0.999956 0.999956 0.999959 0.999959 0.99996 0.999961 0.999961 0.999962 0.999962 0.999962 0.999962 0.999963 0.999964 0.999964 0.999964 0.999965 0.999965 0.999966 0.999966

EP

S102 S494 S329 S30470 S470 S243 S334 S274 S621 S582 S383 S191 S619 S274 S1726 S242 S372 S664 Y411 S134 S631 S913 S476 S472 T200 S170 S41 S92 S887 S76 S839 S1290 S508 T234 S52 S725 S357 S252 T29 T29 S770 T788 S375 T277 T1470 S1975 S531 S761 S231 S375

AC C

Q6ZNC4 O94913 Q86W50 Q8WZ42 O00418 Q86T82 O95678 P05787 P04049 P10398 Q5T9C2 Q01130 O43395 Q9NYV4 O75417 Q6UWB4 Q9P227 Q7Z4V5 Q96L91 P12004 Q9ULJ1 Q12879 P49916 P49916 Q4KMQ1 P29966 Q96P50 Q5JRC9 Q92625 Q8IVF5 P58107 Q9BQG0 Q14966 Q7L266 Q9Y2V2 Q9UP83 P26045 Q13145 Q5VT79 P13928 P18084 Q6PKG0 Q8TEW8 Q8NG27 P11388 P35580 Q9NYF8 Q9UQ35 Q8IZP0 P20700

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999967 0.999967 0.999967 0.999968 0.999968 0.999969 0.999969 0.99997 0.999971 0.999971 0.999972 0.999973 0.999973 0.999974 0.999974 0.999974 0.999975 0.999975 0.999975 0.999975 0.999975 0.999975 0.999976 0.999976 0.999977 0.999978 0.999978 0.999978 0.999978 0.99998 0.99998 0.999981 0.999981 0.999981 0.999981 0.999982 0.999982 0.999983 0.999983 0.999985 0.999985 0.999985 0.999986 0.999986 0.999987 0.999987 0.999987 0.999987 0.999987 0.999988

EP

S639 S694 T14 S80 S60 S2438 T338 S441 Y290 Y133 S442 S406 S294 S636 S780 Y48 S703 T325 S951 Y106 S21 S242 S233 S510 S695 Y726 S61 S44 S974 S198 S60 S404 Y400 S98 S2 T326 S45 Y841 S518 S538 T14 Y285 S732 S32 S29 S1031 S763 S475 S24 S609

AC C

Q8N9T8 Q13009 Q01196 Q8ND82 P58004 O75376 Q4G0J3 Q6TGC4 Q96NN9 P12004 Q6TGC4 Q9Y2W1 Q8WVC0 P27816 Q14676 Q86WH2 P19634 Q05519 Q9NRA8 O43399 Q9H0X4 Q86T82 Q8NHM5 Q14966 Q13009 Q9UP83 P63027 Q15836 Q9UKJ3 Q9H501 O00629 P37288 Q9ULE0 Q13595 P08729 Q86X27 Q8N7K0 P58107 Q92834 Q03188 Q01718 Q5H8C1 Q8IWB9 Q04695 Q9BVJ6 O95466 Q8N4C8 O94972 Q8IV50 Q99700

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999988 0.999988 0.999988 0.999988 0.999988 0.999989 0.999989 0.999989 0.999989 0.99999 0.99999 0.99999 0.99999 0.99999 0.99999 0.999991 0.999991 0.999991 0.999991 0.999991 0.999992 0.999992 0.999992 0.999992 0.999992 0.999992 0.999992 0.999993 0.999993 0.999993 0.999993 0.999993 0.999993 0.999994 0.999994 0.999994 0.999994 0.999994 0.999994 0.999994 0.999994 0.999994 0.999994 0.999994 0.999995 0.999995 0.999995 0.999995 0.999995 0.999995

EP

S35 S47 S658 S276 S478 Y327 S588 S337 T827 S213 S1534 S276 S133 S742 T1257 S195 S263 S261 S16 Y76 S187 S342 S188 S431 S113 S13 S17 S121 S120 S915 S2690 S71 Y1346 S609 S1225 S3150 T669 T402 S657 S727 T69 S1068 T610 S103 S254 S77 T575 S323 T21 S208

AC C

Q14160 P30419 Q6NZY4 O00203 O94972 Q9NYV4 Q9UJX2 Q4G0J3 Q5VVW2 P85037 Q9HCD6 Q92504 O95295 Q9C0D7 Q92797 Q6NYC8 P61247 Q14247 Q96MY7 O15305 Q01130 Q6PL18 O95218 Q8IYB3 Q92785 O75607 P49450 O75794 O75794 Q9NXL9 Q9UQ35 Q9NR30 Q6XZF7 Q9UHB6 Q7Z401 P49454 Q12884 Q9H211 Q66K74 Q9NYL2 Q96MW7 Q12789 Q99700 Q8N5J2 P06733 P27540 P20700 Q05519 Q8IWV7 P38159

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999995 0.999995 0.999995 0.999995 0.999995 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999996 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999997 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999998 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999

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S208 S475 S960 S16 S759 S485 S469 S527 S162 S594 S1202 T571 S1486 S639 S1923 S251 S780 S205 S392 S188 S364 S736 S1284 S24 S22 S27 T668 S843 S571 S1531 S19 S326 S356 S358 S71 S1194 T364 S297 S9 T215 S266 S204 S96 S1055 S42 S21 S693 S2124 S2223 S697

AC C

Q96E39 Q9HDC5 Q15154 O75607 Q9UQ35 O60832 Q9HDC5 P29590 Q15742 Q8NHQ9 Q9P1Y6 Q9NZQ8 Q8NI27 O95819 Q9UQ35 Q6ZT52 Q9UQ35 Q07955 O76021 Q14653 Q8IZA0 Q96T58 Q6Q759 O15083 O60610 Q8IUD2 O15085 P58107 Q15911 Q14839 Q9NUE0 P23511 O15226 O15226 Q02543 Q96T58 Q9C0C6 Q96JM3 P62273 Q9NX40 Q9UDY2 Q8NCF5 Q13595 Q9Y6N7 Q1ED39 Q53H80 Q8NCN4 Q07954 P46013 Q92541

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 0.999999 1 1 1 1 1 1 1 1 1 1 1 1 1

EP

S14 S1259 S1348 S4 S259 S1876 S78 S137 S270 T550 S131 S Q9Y2W1 S408 Q96HE9 S40 Q09666 S93 Q5TKA1 S65 Q709C8 S3641 Q8NDT2 T532 Q86XL3 S268 Q9BVJ6 S31 P37837 S237 Q9NXG2 S88 Q9H501 S153 Q9NS91 S158 P42704 T1129 Q9UNL2 S11 O14640 Y8 Q15311 S62 P62753 S235 O15085 T672 O60290 T182 Q71UM5 S78 O60493 S72 O60290 Y181 P54792 Y8 Q12923 S240 Q02241 S867 Q9BXP5 S74 Q14152 S1336 Q92545 T1509 Q9NYP3 S326 Q9UEW8 S371 P18084 T667 Q1MSJ5 S966 Q15424 S288 Q9BRD0 S201 Q8IYB3 S465 Q8IYB3 S463 P05787 S104 Q15287 S251

AC C

O15172 Q92797 P46100 Q9BXP5 O95425 Q9UQ35 P42677 O43294 O95425 Q9NS15 O75494

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S860 S663 S287 S105 S295 S1454 S315 S66 S1054 Y57 T363 S419 S1730 S300 S87 T131 S571 S1144 T2034 S2 S13609 S5 S909 S635 S293 S432 S1223 S1221 S563 S406 S163 S284 S196 T458 S797 S795 S791 S6 S278 S1483 S1508 S1732 S719 S147 S544 S159 T110 S956 S351 S251

AC C

Q96ST3 P16615 Q14151 Q9Y6K1 P36578 Q5UIP0 Q9Y5K3 P18858 Q96KR1 Q5M9N0 Q9Y5I0 P06733 Q15154 Q5JTW2 Q8TAP8 P63208 Q8IZC4 P78312 Q9UQ35 O43768 Q8WZ42 P84103 Q4KMQ2 Q6MZP7 P78562 Q96JM3 Q86YA3 Q86YA3 Q9BUH8 P23588 Q14241 P61978 Q01546 O60832 Q8IYB3 Q8IYB3 Q8IYB3 Q9BW19 Q8IXT5 Q9UQ35 Q14160 Q9UQ35 Q96HA7 P84077 Q13144 P29966 Q9BWG6 Q9Y618 Q9C086 P56693

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S499 S2543 S173 S263 S2771 S2 S254 S250 S1731 S126 T793 S3 S445 S94 Y282 S726 Y114 S376 S366 S1012 S752 S756 S754 S2150 S443 S135 S25 S67 S951 S64 T559 S222 S777 T379 S2032 Y243 S242 S254 S391 S395 S493 S3408 S147 S621 S809 S237 S235 S1042 S139 S1133

AC C

P23471 P21359 Q66LE6 Q9NQS7 O15417 P62879 Q8IXT5 Q8IXT5 Q9UQ35 P15735 Q8IYB3 Q8NAQ8 Q9UK58 Q01831 Q7L0R7 P35611 A6NCN2 Q9BXT5 Q13523 Q14687 Q8IYB3 Q8IYB3 Q8IYB3 Q5VUA4 Q86UU1 Q5U5Z8 Q8NC51 A6NFU8 Q8NHM5 P56180 Q5T5P2 Q9UQ88 Q9UJX5 Q9BXT5 Q9UQ35 Q13416 Q9Y6M7 Q99808 Q96DF8 Q96DF8 Q9BXP5 Q8IVF2 P18085 P98194 Q92598 Q96ST2 Q96ST2 O15164 P29353 Q92576

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S131 S103 S102 S245 S713 T247 S259 S779 S1974 S1970 Y244 T4 S63 S523 S118 S552 S29 S325 S284 S145 S1497 S2 T2484 S327 S1061 S155 S151 Y46 S328 S427 S2 T220 S991 S263 S173 S120 Y4261 T292 S159 S379 Y2 S6 S163 T4266 S54 S830 S76 T220 S389 S504

AC C

Q8N4S0 P17096 P17096 Q9Y696 P35612 P56693 Q9H0H0 Q9UJX5 Q92614 Q92614 Q9Y696 O14640 P16949 Q9Y613 Q92934 Q14966 Q9H1K1 Q9BRD0 Q5HYI7 Q86Y46 Q9UQ35 Q5T3J3 Q8TD57 Q9UKT4 P46100 Q99959 Q99959 Q96KA5 Q3B726 Q13523 P47756 Q9BVH7 Q9P1Y6 P28562 Q69YN4 P33991 P20929 P78385 Q9BW71 O15013 Q8NAQ8 O15541 Q9BRD0 P20929 Q99741 P52701 P34932 Q96PZ2 Q9HCS5 P23471

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S502 S22 Y214 T578 S708 S24 S27 S1894 S667 S666 S1113 S2 S710 S1219 T561 S366 S209 S483 S178 S338 S5 S8 S2013 S2011 S175 S1168 S143 T279 T580 S110 Y374 S171 S115 S117 S606 S471 S562 S382 S477 T610 S37 S30 S32 S42 S104 Y118 S2226 S158 T100 S300

AC C

P23471 Q9NTJ3 Q96PZ2 Q8IZC4 Q13136 Q15435 Q15435 Q14839 Q14624 Q14624 Q9UPR0 Q9HAV0 Q9UKV3 Q9H9J4 P53350 Q9Y5I0 Q8NAV1 Q05519 Q9NSB2 Q96RY5 O95661 O95661 P18583 P18583 Q9BRJ6 O60841 Q3SY84 Q7L0R7 Q8IZC4 Q15154 Q9BXT5 Q96PY5 Q9NW75 Q9NW75 P33897 O95163 P17812 Q5T1R4 P40692 Q14978 Q14160 Q9Y2V2 Q9Y2V2 Q9P0B6 O96013 P15735 O95359 O75494 Q9BWG6 Q969H4

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S573 S104 T1927 S234 S138 S2397 S885 S164 S37 S136 S160 S1320 S5 S75 S76 S79 S74 S14 S1417 S1415 S1413 S99 S139 S395 Y1331 S378 T202 S332 S520 S355 T650 S112 S195 S321 S932 S698 S275 S676 T214 S211 S692 S237 T4 S1499 S246 S537 T1322 S673 S191 T1955

AC C

Q14738 P49006 Q9UQ35 P21127 Q14CN4 Q09666 O75400 P19013 Q9BTT6 Q14498 Q9BW71 Q13129 Q8NC56 P50502 P50502 P50502 P31947 P42696 Q9BYW2 Q9BYW2 Q9BYW2 P05114 Q5U5Z8 Q68DQ2 Q13129 P18031 Q9H1E3 Q9Y6R0 P12956 Q8N412 Q9UI36 A6NFI3 O15375 Q08211 Q92974 Q9Y2W1 Q92504 O43719 Q5W041 P12035 Q9Y2K7 Q9Y2W2 P54792 Q9UQ35 Q8NCX0 P50990 Q13129 Q6VMQ6 P35908 E9PAV3

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

T1952 T92 T95 S1537 T208 T49 T1958 S153 Y763 S540 S250 S37 S608 S353 S38 Y172 S467 S944 Y206 S181 S133 S2785 S687 S582 T200 S2067 Y13612 S84 S216 S67 S18 Y81 S599 S343 S950 S163 Y318 S2 S7 S626 S628 S104 S42 T122 T176 T381 S525 S1503 S514 S813

AC C

E9PAV3 Q13765 Q13765 O43149 P35523 Q15003 E9PAV3 Q6ZNE5 Q5H8A4 Q99567 Q13416 Q96KA5 P52948 Q9BZJ8 P30050 P48995 P23381 Q00341 P35523 P13647 O75494 Q4LDE5 P49790 Q8TD16 O15375 Q9UQ35 Q8WZ42 Q9UJV3 Q9Y2D9 P20042 Q53H80 Q9UJV3 P17017 O95340 Q9UQ35 P29966 Q9UKT4 O15182 O15182 Q8IYB3 Q8IYB3 O15173 L0R819 P38432 P48995 Q92628 O75153 Q92545 Q9UK59 Q6EKJ0

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S817 S318 Y366 T1512 S1297 S510 S1119 S333 S387 S118 S1515 S310 T1423 S1092 S1526 S1552 T1193 S440 T333 S1482 S37 S153 S17 S147 S63 T58 S596 S593 S67 S815 S152 S682 S237 S236 S13610 T440 T524 S2601 S100 S644 T576 T508 T503 S76 Y258 Y252 S649 S176 S625 T770

AC C

Q6EKJ0 Q6KC79 Q6SJ96 Q92545 Q07864 Q9H4G0 Q9UPN9 Q9NYP3 Q9Y6K9 Q9H3Q1 Q13129 Q92922 Q9NR16 O43896 Q5T5U3 Q02880 P46013 P20810 Q9Y6R0 Q9UQ35 Q03135 Q7RTS7 Q9NTM9 P61204 Q5M9N0 Q7KZI7 P40145 P40145 Q9BXP5 O75128 Q7L2J0 Q9ULU4 Q13416 Q6Y7W6 Q8WZ42 Q99549 O75153 O75691 P17535 Q8IY81 Q8IZC4 P23471 P23471 P18858 A6NHJ4 A6NHJ4 P26374 P04259 O75151 Q6ZMZ3

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

T418 S2651 S2071 T289 S1027 S247 S1565 S777 T374 S654 S1729 S1727 S4 S690 T14 S1217 S1218 S58 S82 S248 S544 S6 S409 S1925 S1117 T265 S60 S656 S362 T292 S2046 S162 S176 S1642 S199 S375 S836 T112 S545 Y562 T208 T372 S1005 S1007 S1214 S259 T2069 S2 S175 T671

AC C

Q8IVW6 A4UGR9 Q9UQ35 Q969H4 Q92673 Q9BZD4 Q12802 O94913 P19835 Q9NW15 Q9UQ35 Q9UQ35 Q96IY1 Q9NYF8 P06493 Q86YA3 Q86YA3 Q9H6F5 Q53GS9 Q9Y2W1 Q8NHQ9 Q9BQ52 Q6PJT7 Q9UQ35 O60885 Q14982 Q86YV9 Q05682 Q96ST2 P78562 Q9UQ35 O95678 P48668 Q92576 P19429 Q63ZY3 Q9Y4R8 Q14671 Q16798 P53350 P42167 P19835 Q14687 Q14687 Q14571 O94875 Q9UQ35 Q13595 C9JI98 P18084

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S1706 S184 S1766 Y517 Y152 S58 S738 T1008 T21 S653 S914 S2226 S2222 S2044 S254 T206 S1435 S56 S356 S278 S888 T312 S436 T100 S565 T498 S1510 S1182 S526 T219 S455 S15 S17 S120 S237 S413 T1492 S737 S1130 T119 S431 S613 S1486 S999 S991 S995 S486 Y287 S1514 S283

AC C

Q7LBC6 P48995 Q9H7D0 O75153 Q6ZNE5 P46087 Q9UKW4 Q14687 P51957 P53618 Q6ZRV2 Q8WYP5 Q8WYP5 Q9UQ35 P43699 P51948 Q15149 Q9H267 Q6SJ96 Q7L0R7 O75400 P01008 Q96JM3 Q12852 P56524 P23471 Q13129 P55196 Q8WUF5 Q5TEJ8 Q9H3H1 A2AJT9 A2AJT9 Q9Y3P9 Q9P209 Q9P270 Q9UQ35 Q9P2G1 Q71F56 A6NCN2 Q13523 Q14151 Q14160 O15417 O15417 O15417 Q9ULW0 P78385 Q9Y4B5 Q9UJU6

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S1550 S348 S267 S265 S908 S753 T4 T120 S380 T323 S210 T610 S705 S1181 S709 S441 S476 S260 S119 S544 S1118 S146 S1116 S12 S1266 S197 S291 Y727 T772 T774 T142 S176 S104 S601 S393 T194 S37 S667 Y297 S528 T293 S63 S1888 S167 S608 S601 S600 Y1224 S2 S1378

AC C

Q02880 Q9Y2T1 Q8NDT2 Q8NDT2 Q7Z4H7 Q9NXE4 Q9P278 P15735 Q92628 Q9UKT4 Q5W0B1 P17017 O75151 Q5VZL5 Q5VUA4 Q8N5J2 Q96JM3 O96017 O43187 P42285 Q8WX93 Q9NZ09 Q8WX93 P78345 Q9Y4C1 Q9BRD0 P05787 O14638 Q5H8A4 Q5H8A4 O75533 P02538 P08729 Q15424 Q9HCS5 O15375 Q96NZ9 Q96PU4 P78562 Q5TCX8 Q969H4 Q01105 Q14839 P63151 P17017 P17017 P17017 Q14571 O60499 Q14160

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S349 S1226 S1222 S56 S373 S375 S183 Y87 S579 S1089 S33 Y356 S748 S233 S2009 S29 S25 S21 S204 S14 S508 S76 S22 Y822 T247 S391 S27 S382 S14 S513 S511 S13 S89 T252 S280 T236 S370 S1540 S1441 S205 S76 S2928 S194 T133 S664 T577 S201 S1319 S233 S2040

AC C

Q15696 Q9H9J4 Q9H9J4 Q9UKB5 Q9Y5I0 Q9Y5I0 O15372 Q9NX40 O43719 Q92610 P58012 Q8N412 Q96T23 P49585 P18583 Q9GZP8 Q86UU0 Q86UU0 Q9H1E3 Q9H1K1 Q9UQ35 Q8N9E0 Q9NZN5 Q6EKJ0 Q8NCX0 P57081 Q8WUM0 O94876 P51991 Q96ST2 Q96ST2 Q8NAQ8 Q9NR30 Q9Y696 Q8IXT5 Q13416 Q9UEW8 O43149 Q68CZ2 P51948 Q96E09 O95714 Q53T59 Q5U5Z8 Q5T0W9 P23470 Q9Y232 Q13129 Q9Y5K3 Q9Y490

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S1389 S73 S23 S385 S1478 S71 S1099 S16 S693 S86 S85 T159 S596 S1072 S1071 S383 S369 T28 S160 S155 S17 T89 S144 T546 S368 S415 S883 S4026 S170 Y618 S510 S778 S77 T61 S249 S248 S551 S135 S1310 T31 T30 S681 Y208 T574 T572 T599 S507 S310 S262 S1604

AC C

Q96RK0 P05412 Q14493 Q5T1R4 Q9UQ35 Q13637 P49750 P51957 Q9UEY8 O95983 O95983 Q9BRD0 Q3YEC7 P29400 P29400 Q9Y4P1 P19835 Q8WUM0 O75494 Q5XKE5 P0DKB6 Q13765 Q96K21 P42285 Q13523 Q8NCE2 O75400 P78527 P09543 P98194 Q9UQ35 Q9UQ35 Q15061 P27448 Q13416 Q13416 Q92502 P62826 Q7RTP6 P36404 P36404 Q0P6D6 Q5TEJ8 Q8IYB3 Q8IYB3 Q3YEC7 Q16584 Q8N3D4 Q9Y5B6 Q5VT25

SC M AN U

TE D

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

RI PT

ACCEPTED MANUSCRIPT 1

EP

S177 S2 S730 S612 S994 S575 S1469 S906 Y83 Y746 Y745 S1898 Y17 S50 S1352 T1316 S227 S658 S26 Y359 S87 S44 T97 S156 S1100 S314 S636 S638 T108 S1515 S1513 T607 S168

AC C

Q7Z794 P26368 O14638 P52948 P55011 Q8IXT5 P11388 Q7Z6B7 O95983 Q9UKW4 Q9UKW4 Q92576 P51957 Q5JSH3 P46100 Q13129 Q9BW71 O14617 P78563 Q6SJ96 Q96JM3 Q8NDX6 O95983 O75494 Q14966 Q8TEB9 Q8IYB3 Q8IYB3 Q9BWG6 Q92545 Q92545 Q14978 Q8TDN4

SC

RI PT

MANUSCRIPT

M AN U

ACCEPTED Overlap MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

Expect value 2.20E-10 8.60E-10 2.10E-09 2.50E-09 2.60E-09 9.50E-09 1.80E-08 3.20E-08 4.40E-08 5.00E-08 1.20E-07 1.20E-07 1.90E-07 2.10E-07 3.00E-07 3.10E-07 3.10E-07 3.40E-07 4.00E-07 4.20E-07 4.90E-07 5.00E-07 6.00E-07 6.20E-07 7.60E-07 8.10E-07 8.40E-07 8.90E-07 9.50E-07 1.30E-06 1.30E-06 1.40E-06 1.40E-06 1.50E-06 2.00E-06 2.10E-06 2.10E-06 2.10E-06 2.20E-06 2.20E-06 2.50E-06 2.60E-06 2.80E-06 2.80E-06 3.40E-06 3.60E-06 4.20E-06 4.30E-06 4.90E-06

EP

Site S245 S1009 S778 S166 S863 T363 S2708 S492 S1874 S860 S1227 S1225 S395 S1651 S18 S386 S550 S712 S1212 S1409 S635 S100 T11 S7 S302 S397 S181 S140 S100 S172 T1650 S721 S349 S523 S9 S1400 S651 S652 S337 S209 S13 S347 T179 S75 S85 S5 T9 S201 S82

AC C

Protein O95801 Q8WWI1 Q13435 Q14134 O75448 Q9Y4H2 P46013 Q86YR5 P42858 P55201 Q2VIQ3 O95239 Q12802 Q9Y4I1 Q9UID3 O95817 Q3L8U1 Q9C0C2 Q8NI35 O43432 Q92878 Q01433 P27816 Q96QK1 P49023 P46937 Q92945 P49759 Q14258 Q5PRF9 Q9Y4I1 P18206 O75533 Q9UPQ0 Q9HCD5 Q02880 Q96JM3 Q96JM3 Q16643 Q9NXV6 Q14566 Q8TAQ2 Q96A73 Q8TDD1 Q99549 Q96GM8 Q96KB5 Q8N573 P98174

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

5.00E-06 5.10E-06 5.40E-06 5.40E-06 5.50E-06 6.10E-06 6.60E-06 6.80E-06 8.00E-06 8.00E-06 9.40E-06 9.40E-06 9.40E-06 9.80E-06 1.10E-05 1.20E-05 1.40E-05 1.40E-05 1.50E-05 1.50E-05 1.60E-05 1.70E-05 1.80E-05 1.80E-05 1.90E-05 2.00E-05 2.10E-05 2.20E-05 2.30E-05 2.40E-05 2.60E-05 2.90E-05 3.20E-05 3.20E-05 3.30E-05 3.50E-05 3.60E-05 3.70E-05 4.30E-05 4.30E-05 4.60E-05 4.60E-05 4.60E-05 4.60E-05 4.60E-05 4.60E-05 4.90E-05 5.20E-05 5.30E-05 5.50E-05

EP

S1270 S1314 S15 S804 T54 S934 S9 S5 S751 S754 S601 S713 S136 S11 T18 T989 S183 S3503 S432 S256 T360 S566 S796 S2 S106 S244 S19 S428 S2 S466 S97 S200 S1850 T2381 S496 S107 S815 S1099 S704 S1906 S137 S745 S138 S138 S138 S138 S679 S771 S56 S125

AC C

Q5SW79 Q9HBL0 Q8NDC0 Q9UPP1 Q9UK76 P52948 Q9H0S4 Q99733 O60343 O60343 Q765P7 Q8N9B5 Q8N9T8 Q9BQG0 P10412 Q9H7N4 P48382 Q03164 Q8N3X1 P42356 Q5T4S7 P51116 P19634 P20340 Q6P1L5 Q9HB20 P40222 Q9UBF8 P10412 Q14C86 P18206 Q9Y3E7 P24928 Q9UQ35 Q8NEN9 Q7Z422 O94762 Q76FK4 Q8WWI1 P24928 O15320 Q96PC5 A4D2H0 Q8IX94 P0CG41 Q86UF2 Q9H694 O75170 O60503 Q9NRF2

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

5.50E-05 5.50E-05 5.60E-05 5.70E-05 5.90E-05 5.90E-05 6.20E-05 6.20E-05 6.30E-05 6.60E-05 6.60E-05 6.60E-05 7.20E-05 7.30E-05 7.50E-05 7.50E-05 7.70E-05 7.70E-05 8.90E-05 9.00E-05 9.20E-05 9.20E-05 9.40E-05 9.60E-05 1.10E-04 1.10E-04 1.20E-04 1.20E-04 1.20E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.40E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04

EP

S323 S322 S71 S842 S168 S1917 S39 S952 S106 S1161 S1164 S1162 S426 S1318 S1317 S1316 S728 S578 S1282 S509 S1202 S1201 S467 S884 S714 S38 S112 S612 S4267 T84 S1278 S1191 S87 S2515 S205 S474 S333 S2 S248 S222 S13 S757 S272 S127 S57 S578 S1158 S138 T379 S127

AC C

P50552 P50552 O43493 Q9Y2H5 Q14134 P24928 Q9Y657 Q9UQ35 P49023 Q5T1M5 Q5T1M5 Q5T1M5 Q9BUZ4 Q92538 Q12888 Q12888 Q4AC94 Q8N3F8 Q96T23 Q9UQ84 Q9H6S0 Q9H6S0 O15014 Q9NZM3 P26358 O43491 Q9BX95 Q765P7 Q8NEZ4 Q9BW71 Q5VZ89 Q8N1G0 Q9BW71 P21359 Q8NEY8 Q13098 Q13671 P17096 Q9HB20 Q96I25 Q9H0C8 O60343 Q96G46 A6NMY6 Q7L2J0 Q92619 P15822 Q9HAZ1 Q86X10 P07355

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.80E-04 1.90E-04 2.00E-04 2.00E-04 2.00E-04 2.00E-04 2.00E-04 2.00E-04 2.20E-04 2.20E-04 2.20E-04 2.30E-04 2.30E-04 2.30E-04 2.30E-04 2.40E-04 2.50E-04 2.50E-04 2.50E-04 2.60E-04 2.60E-04 2.80E-04 2.80E-04 2.80E-04 2.90E-04 3.00E-04 3.00E-04 3.00E-04 3.10E-04 3.20E-04 3.20E-04 3.30E-04 3.40E-04 3.40E-04 3.60E-04 3.70E-04 3.70E-04 3.80E-04 3.90E-04 4.00E-04 4.10E-04 4.20E-04 4.20E-04 4.30E-04 4.30E-04 4.50E-04 4.50E-04 4.50E-04 4.50E-04 4.70E-04

EP

S27 S674 S1698 S343 S388 S391 S103 S240 T119 T116 S54 S8 S343 S347 S460 S317 S87 S89 S1017 Y352 Y361 S509 S106 S104 S105 S308 S225 T220 S893 S942 S995 S1219 S176 S283 T83 S160 S1219 S169 S325 S7 S36 S1671 S547 S39 S987 S265 S312 S422 S1477 S251

AC C

Q9UN81 Q9BPX3 Q9H1H9 Q8N556 Q9Y4H2 Q9Y4H2 P78347 Q86TN4 P05187 P10696 Q9NQW6 Q9NVD7 P49585 P49585 Q9BTU6 P41229 Q9C0C9 Q9C0C9 Q86UU0 Q86Z02 Q9H2X6 Q8N5C8 O43159 O43159 Q7Z422 P46013 Q96HH9 Q96HH9 Q8WUA4 O60763 Q14676 Q6R327 O43159 P49761 P83731 Q8WUY9 Q9C0J8 Q14980 P08670 Q99733 P04075 Q5T5U3 Q9GZU1 Q04695 Q4ADV7 Q8N556 Q9BWU0 O60318 Q96QT4 P78346

TE D

M AN U

SC

RI PT

ACCEPTED MANUSCRIPT

MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

EP

4.70E-04 4.70E-04 4.90E-04 4.90E-04 5.00E-04 5.00E-04 5.10E-04 5.10E-04 5.10E-04 5.10E-04 5.10E-04 5.20E-04 5.20E-04 5.20E-04 5.20E-04 5.30E-04 5.30E-04 5.40E-04 5.40E-04 5.40E-04 5.40E-04 5.40E-04 5.60E-04 5.60E-04 5.60E-04 5.60E-04 5.70E-04 5.70E-04 5.80E-04 5.80E-04 5.80E-04 5.90E-04 5.90E-04 5.90E-04 6.00E-04 6.10E-04 6.20E-04 6.30E-04 6.30E-04 6.50E-04 6.50E-04 6.50E-04 6.50E-04 6.60E-04 6.70E-04 6.70E-04 6.80E-04 6.90E-04 6.90E-04 6.90E-04

AC C

O43399 S12 Q13501 S272 Q7Z6Z7 S2917 Q7Z434 S152 Q01167 S373 Q01167 S369 P27816 S507 P27816 S510 Q96A73 S183 O14646 S216 O14646 S215 Q9HC52 S256 P22059 S240 Q9H8N7 S449 Q9ULF5 S591 Q9H7M9 S235 Q6P0Q8 S1256 Q15139 T400 O94806 S391 O94806 T394 Q15139 S397 Q96AY2 S117 Q8N556 T341 Q09666 S1068 Q9ULD2 T1204 Q8N556 S342 Q58FF7 S205 Q6NZY4 S598 Q8NEM2 S42 Q9UMZ2 S935 P16403 S2 Q8NG31 S1690 Q9Y534 S47 Q12797 S29 Q9UFC0 S259 Q8WYP5 S1222 O75717 S383 Q7Z5K2 S459 Q9UFC0 S251 Q13085 S23 O14974 S507 P18615 S115 Q01130 S2 Q9HCK8 S2046 Q9H6Z4 S108 O15042 S67 Q9Y4H2 S620 O15027 S391 Q9BVL2 T331 Q5VZK9 S1291

M AN U

SC

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ACCEPTED MANUSCRIPT

MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

6.90E-04 7.00E-04 7.00E-04 7.20E-04 7.20E-04 7.30E-04 7.40E-04 7.50E-04 7.60E-04 7.60E-04 7.70E-04 7.80E-04 7.90E-04 8.10E-04 8.20E-04 8.30E-04 8.40E-04 8.40E-04 8.40E-04 8.50E-04 8.50E-04 8.50E-04 8.60E-04 8.60E-04 8.60E-04 8.60E-04 8.60E-04 9.10E-04 9.20E-04 9.20E-04 9.30E-04 9.50E-04 9.50E-04 9.60E-04 9.80E-04 9.80E-04 1.00E-03 1.00E-03 1.00E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03

EP

S436 S685 S110 S48 S201 S173 S624 S709 S21 S5 S1587 S183 S124 S14 S2 S122 S565 S191 S534 S691 S157 S154 T402 S270 S271 T272 S92 S463 S151 S1279 S2828 S63 S184 S613 S65 S66 S11 S13 S589 S718 S4960 T1041 S327 S1283 S321 S31 S1281 S31 S34 S874

AC C

P55197 Q8N3V7 O00161 O95544 Q14244 Q5VUA4 Q92625 Q9H2P0 O60832 Q5JSH3 Q7Z401 Q9NYB9 Q14671 Q9NVD7 P46940 Q9NYF3 O15047 Q9UNF1 O15047 O60303 Q96A47 Q96A47 Q9NYF8 Q9Y6Y0 Q9Y6Y0 Q9Y6Y0 Q5QP82 P30414 Q92667 Q9C0J8 P46013 Q6NXT1 Q9HB19 Q13615 Q9NS39 Q9NS39 P54274 O14579 Q27J81 P00519 Q09666 P46019 Q92560 Q8WWQ0 Q86WB0 P05783 Q8WWQ0 O95361 O95361 Q6ZU35

M AN U

SC

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ACCEPTED MANUSCRIPT

MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03

EP

S254 T780 S298 S296 S297 S10 S316 S242 S238 S487 S488 S314 S784 S400 S48 S398 S381 T609 S477 S475 S403 S522 S616 S1029 S7 S453 S1025 S998 S6 S1000 S525 S571 T570 T569 T11 S940 S572 S27 S498 S96 T731 S211 T479 S507 S1181 T4430 T15 T47 T479 S513

AC C

P08729 Q13435 P08240 P08240 P08240 Q8WXF7 Q13247 Q9NYB9 Q9H019 Q86VM9 Q8N108 Q13247 P46100 Q8N1F8 O14686 Q8N1F8 Q9H307 Q8NDX5 P12956 P12956 Q8N1F8 Q16555 Q8NDX5 Q5THK1 Q9NQC3 Q9H7N4 P00533 P07814 Q9H9E3 P07814 Q8N3V7 Q92841 Q92841 Q92841 P16401 P35658 Q92841 Q8NHH9 Q9Y613 O15344 Q9NRL2 Q8NI08 Q641Q2 Q96JM3 O43933 Q09666 Q9H3U1 Q96AQ6 Q9Y4E1 Q14684

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03

EP

S687 S31 S127 S225 S876 S17 S15 S62 T686 S15 T689 S511 S9 S679 S247 S428 S780 S113 S1944 S92 S10 S2234 S1178 T596 S3927 S20 S975 S231 S76 S985 T19 S650 S125 S1722 S19 S187 S183 S296 S391 S2486 S1574 S1573 S90 S802 S269 S169 S1374 S800 S51 S50

AC C

Q8N556 Q86VX9 P26358 Q9Y3Q8 Q9UQ35 Q6UB98 Q6UB98 Q9NPI6 Q8N556 Q9HB90 Q8N556 Q09666 P17096 Q8N556 Q92890 P10636 P23921 Q6VMQ6 Q8WYP5 P46100 A6NFI3 Q9Y618 O15027 Q9UJX2 Q9UPN3 Q14493 Q9NRY4 Q9UPQ0 Q96MH2 Q9NRY4 P02545 Q9UKJ3 Q9BW71 Q9HCD6 P49116 Q8WUF5 Q8WUF5 Q15642 O43463 O95071 Q9BY89 Q9BY89 O00151 Q641Q2 Q96A49 Q9H4L4 P11388 Q9Y4E1 Q9UP95 Q12986

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

2.10E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.70E-03 2.70E-03 2.80E-03 2.80E-03 2.80E-03 2.90E-03

EP

S875 S968 T994 S973 S90 S998 S997 S8 S1663 S633 S2424 S427 S180 S181 S67 S146 S279 T587 T271 S14 S251 T837 T875 S836 T835 S834 S516 S5 S819 S1131 S6 S19 S2152 S1099 S690 S8 S689 S641 S1404 S181 S633 S2077 S79 S300 S6 S8 S20 S2 T550 S69

AC C

Q8IYB7 Q5VZ89 Q9H7N4 Q5VZ89 O14646 Q9H7N4 Q9H7N4 Q9P1Q0 Q9C0D5 Q7Z4V5 Q9Y618 Q8TB61 Q9Y478 Q9Y478 Q99081 Q8N6H7 Q9Y3Q8 Q3KR37 Q96G46 Q8IY67 P17275 Q641Q2 Q6ZU35 Q641Q2 Q9Y4E1 Q9Y4E1 P49790 P17096 Q09666 P46013 Q9BRR8 Q6PK04 P21333 Q5VZ89 Q15398 Q9BRR8 Q15398 Q8N4C8 Q9UQ35 Q9H4L4 P49790 Q9Y4A5 O95155 Q12857 Q96QR8 Q96QR8 Q07666 Q03135 Q96KR1 Q9H1B7

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

2.90E-03 2.90E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.10E-03 3.10E-03 3.10E-03 3.10E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.30E-03 3.30E-03 3.30E-03 3.30E-03 3.30E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03

EP

S308 S1268 S1100 S72 S815 S2 S1889 S350 S88 S149 S147 S423 S289 S914 S288 S361 S1413 S149 S384 S385 S189 S12 S16 S832 S480 S771 S103 S319 T382 S61 S124 S315 S336 S261 S173 S401 T301 S847 S937 S17 T521 S1208 T79 T94 S36 S416 S532 S190 S25 S405

AC C

Q9BUA3 Q96T58 Q99569 P53365 Q8IWX8 Q92597 Q96SN8 Q6KC79 Q9UID6 Q9H9L4 Q9H9L4 Q9UNS2 Q99959 Q96PE2 Q99959 O95677 Q7Z2Z1 Q16890 Q69YQ0 Q69YQ0 Q15365 Q9BRT9 Q9BRT9 Q96ST3 Q5JSZ5 Q15596 Q9H019 P49585 Q6Y7W6 P50395 O95251 P49585 Q58WW2 Q06210 Q9NR30 Q9C0C9 Q14676 Q5M775 Q8WYL5 Q13263 Q16555 Q5T200 O60361 P22392 Q9BTL3 Q96JM3 P08238 Q9UNF1 O00178 Q58FF7

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

3.70E-03 3.70E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 4.00E-03 4.00E-03 4.00E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.30E-03 4.30E-03 4.30E-03 4.30E-03 4.30E-03 4.30E-03 4.40E-03 4.40E-03 4.40E-03 4.50E-03 4.50E-03 4.50E-03 4.50E-03

EP

T94 S305 S275 S1554 T273 S13 S12 T145 S2 S1290 S3426 T178 S456 T1286 S2 S1288 S470 S18 S50 S502 S435 S195 T2204 S194 S327 S672 S615 S594 S598 T599 S596 T488 S600 S486 S601 T70 S492 S173 S22 S856 S217 S299 S695 S1454 S682 S94 S173 T68 S9 S1213

AC C

P15531 Q58FF8 Q7Z2W4 Q9C0C2 Q7Z2W4 Q86U86 Q86U86 O75781 P63165 Q13459 Q09666 Q96A73 Q05519 Q9NZN5 Q92522 Q9NZN5 Q86UU1 Q9Y383 O95251 Q9NPQ8 Q2VPK5 O95817 P49327 O95817 Q9NQA3 Q9C0C2 Q7Z2K8 Q13263 Q13263 Q13263 Q13263 Q9NUL3 Q13263 Q9NUL3 Q13263 Q13541 Q9NUL3 O95817 Q9NVD7 Q15262 Q9UPQ0 Q14676 Q9Y487 P49815 Q9P275 P18583 Q96KQ7 Q6PKG0 Q9NYM9 P11388

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

4.60E-03 4.60E-03 4.60E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.80E-03 4.90E-03 4.90E-03 4.90E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.20E-03 5.20E-03 5.20E-03 5.30E-03 5.30E-03 5.30E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.60E-03 5.60E-03 5.70E-03 5.70E-03 5.70E-03 5.70E-03 5.80E-03 5.80E-03

EP

S1100 S352 S494 S525 S226 S1885 S1318 S51 S1320 S3 S648 S731 S729 S30 S2 S14 S209 S491 S237 S790 S652 S1461 T238 S594 S598 S131 S355 S520 S378 S64 S62 S184 S29 S128 S375 S4 S279 S17 S684 S537 S210 S171 S372 S413 S469 S199 S162 S483 S741 S201

AC C

Q9Y4H2 Q92538 P78362 Q9BWT3 Q14694 Q9BYW2 Q9UQ35 Q9P258 Q9UQ35 Q8TBZ6 Q9NYF8 Q66K74 Q66K74 Q9H4Z3 O43752 Q9H4Z3 Q86YC2 O15014 Q8TDY2 Q8N137 P02545 O94986 Q8TDY2 P46100 P46100 Q96F86 A8CG34 Q9BST9 Q96HA1 O43159 O43159 O43741 Q99618 P46013 P30305 P11388 P51948 P60468 Q9BWT3 Q02040 P78347 Q9NR30 O94763 Q8TBB5 Q9UPQ0 Q9Y657 Q9BUL9 Q8N108 Q5VZ89 Q9BSJ6

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

5.80E-03 5.80E-03 5.80E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.10E-03 6.10E-03 6.10E-03 6.20E-03 6.20E-03 6.20E-03 6.20E-03 6.20E-03 6.30E-03 6.30E-03 6.40E-03 6.50E-03 6.50E-03 6.50E-03 6.50E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03 6.70E-03 6.70E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 7.00E-03

EP

S391 S312 S489 S512 S500 S2 S813 S1253 T203 T153 S202 S1812 S1814 S182 S19 S372 S532 S3 S5099 S321 S519 S460 S954 S246 S1082 T350 T336 S863 T273 S211 S642 S283 S425 S860 S22 S469 S14 S475 T46 T47 S14 S1218 S31 S100 S198 S196 T1315 S99 S2344 S1026

AC C

Q8N3F8 Q14432 Q86SQ0 Q3MIN7 Q12888 P13489 O94885 P46013 Q8N573 Q86UP2 Q8N573 Q9Y4B5 Q9Y4B5 Q9Y478 Q6Y7W6 Q27J81 Q9BYW2 P60981 Q09666 A8MUU9 Q9UF83 Q14157 Q9UQ35 Q8WWI1 Q9NYV4 O75533 Q13671 O75420 Q99460 O00308 Q8NCD3 P18583 Q96AP0 P43246 Q4KMP7 P27448 Q9GZR2 Q14157 Q9UKT5 Q9UKT5 Q96EB6 P39880 O95155 O95251 Q96ST2 Q96ST2 Q12888 O95251 P46013 P00533

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

7.00E-03 7.00E-03 7.00E-03 7.10E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.30E-03 7.30E-03 7.40E-03 7.40E-03 7.50E-03 7.50E-03 7.50E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.80E-03 7.90E-03 7.90E-03 7.90E-03 7.90E-03 8.10E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.30E-03 8.30E-03 8.30E-03 8.40E-03 8.40E-03 8.40E-03

EP

S449 S136 S518 S14 S336 T337 S2120 S179 S992 S14 S10 S354 S546 S330 S347 S343 Y822 S1269 S1124 S141 S140 S530 S42 S377 S1065 S1067 S381 S215 S91 S1362 S66 S149 T198 S1763 S18 S612 S614 T235 S1232 S21 S2 S18 S375 S230 S514 S502 S848 S2321 S69 S671

AC C

Q13330 Q5VUA4 P49790 Q9H1E3 Q8N556 Q8N556 O75376 Q86WR7 O75694 Q86U86 Q86U86 Q16576 Q9P275 P05787 O75676 O75676 P18206 Q9UPT8 Q9UQ35 P24534 P24534 O60504 P05783 O95817 Q9UQE7 Q9UQE7 O95817 O95391 O94826 Q12888 Q8IU81 P40855 Q13561 P42694 O00418 Q9H7N4 Q9H7N4 P17676 Q8WYP5 C9JLW8 P16401 P16401 Q08499 Q96S82 Q9Y2X3 Q9Y2X3 Q99700 O95359 Q7L2J0 Q8N163

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

8.40E-03 8.40E-03 8.50E-03 8.50E-03 8.50E-03 8.60E-03 8.60E-03 8.60E-03 8.60E-03 8.70E-03 8.80E-03 8.80E-03 8.80E-03 8.90E-03 8.90E-03 8.90E-03 9.00E-03 9.00E-03 9.00E-03 9.00E-03 9.10E-03 9.10E-03 9.10E-03 9.10E-03 9.20E-03 9.20E-03 9.20E-03 9.30E-03 9.30E-03 9.30E-03 9.30E-03 9.30E-03 9.40E-03 9.40E-03 9.40E-03 9.40E-03 9.50E-03 9.50E-03 9.60E-03 9.60E-03 9.60E-03 9.60E-03 9.60E-03 9.60E-03 9.70E-03 9.70E-03 9.70E-03 9.80E-03 9.80E-03 9.80E-03

EP

S552 S60 S588 S15 S569 S363 S2 S804 S50 T139 S186 S13 S21 S111 S257 S150 S11 T588 S785 S384 S66 S76 S324 S502 S183 S139 S329 S428 S2382 S268 S526 S269 S356 T358 S503 S1581 S3 T723 S608 S10 S283 S1765 S616 S19 S108 S212 S9 S339 S65 S134

AC C

Q06124 Q7L2J0 O60343 Q9NQC3 Q3MIN7 O14497 Q02539 Q7L014 Q9P258 Q96MW1 P41227 P49736 Q96FF9 P09923 P10398 Q86U42 P18754 P49790 Q6ZRV2 Q9BSQ5 O60264 A1L390 O75909 Q68E01 Q8IZP0 Q5T3I0 Q86X27 P85037 Q9UQ35 Q9Y6Y0 P28715 Q9Y6Y0 Q13427 Q13427 Q9NVU0 Q14160 P23528 Q5VT52 Q96JM7 Q3YBR2 Q92576 Q15154 O00429 P49450 Q8WW12 P22626 Q05D32 Q8NCN4 Q96S55 Q9UIF9

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

9.80E-03 9.80E-03 9.90E-03 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02

EP

S1055 S104 S13 S1330 T24 S127 S2 S213 S198 S552 S328 S434 S1044 T1542 T1545 S99 S338 S259 S254 S256 S257 S32 T2104 S335 S430 S435 S424 S422 S291 S292 S362 S364 S452 Y67 S31 S629 S198 S363 S688 S1552 S11 S406 S6 S181 T32 S21 S358 S423 S496 S782

AC C

O15014 O00512 O75822 Q9Y6Q9 Q9H2V7 Q5T8P6 P68402 Q8N565 Q5T200 Q12888 Q9UKV3 Q05519 P46019 Q14839 Q14839 P13861 Q9Y3F4 Q13427 Q13427 Q13427 Q13427 Q9H7L9 Q9UQ35 Q9Y3F4 Q86UU1 O15119 Q9NTZ6 Q9NTZ6 Q8IVH2 Q8IVH2 P09651 P09651 Q96JM3 P35251 O14874 Q13393 Q9BZL6 P09651 Q8IY81 Q9C0C2 O75822 Q5TCZ1 Q96ER3 P61006 O14874 Q9H6F5 P27816 Q9NYV4 Q9NYF8 Q12888

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02

EP

S670 S674 S60 S61 S1042 S456 S131 S2 S541 S1064 T1041 T572 S130 S3 S1688 S415 T21 S395 S585 S235 S422 S420 S372 S418 S130 S44 S944 S22 S129 S739 S370 S400 S14 S19 T172 S774 S132 S751 S2209 S14 S16 S168 T484 S743 S197 S1155 S352 S8 S89 S344

AC C

Q96T37 Q96T37 P51798 P51798 P00533 Q7KZI7 Q9BSJ6 Q13177 Q8IVT2 P00533 P00533 Q96PK6 Q5TAQ9 Q16576 Q5UIP0 Q96ST2 Q09161 Q86WB0 Q9NVU7 Q6ZW31 Q96ST2 Q96ST2 Q5T200 Q8TBB5 Q9NXE4 P05783 Q9Y2F5 Q09161 Q5TAQ9 Q12789 Q5T200 P27448 Q13263 Q13263 Q13838 O94762 Q9NQG5 Q08J23 P15924 Q9H814 Q9H814 Q14676 Q8N163 Q08J23 Q32P44 O15085 P38159 Q9NWV8 Q96RS0 Q15424

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant

TE D

1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02

EP

S1577 S343 S991 S657 S196 S199 S910 S233 S27 S452 S4108 S85 S105 S307 T411 Y36 T448 S114 S849 S82 S604 T206 S850 S910 S914 S4 S3 S2 S16 S218 S5784 S413 S5782 S5780 S277 S382 T273 S194 S1094 S114 S124 S129 S260 S2 S125 S313 S510 S2 S2 S2

AC C

P38398 Q14151 P00533 Q9UKV3 Q9BW71 Q9BW71 Q8TF72 Q9UPQ0 Q9UBP6 Q9HDC5 Q8WXH0 Q96RS0 Q9NUQ3 Q15054 Q9C0B5 P05783 Q9HDC5 Q9UNZ2 Q99700 Q9BWU0 Q96T23 Q96PK6 Q99700 O14974 O95425 P67870 P67870 P67870 Q9BVG9 Q9UJX6 Q09666 Q9Y4P8 Q09666 Q09666 Q96G46 Q12906 Q96G46 Q9BUJ2 Q12888 P05187 P31749 P31749 P06748 P20042 P06748 Q3T8J9 Q9Y6G9 A6NMY6 P07355 Q9UQ80

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MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant MaxQuant PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 3.30E-13 4.40E-10 5.10E-09 7.30E-09 8.30E-09 1.00E-08 1.80E-08 1.80E-08 1.80E-08 2.30E-08 2.70E-08 4.50E-08 4.50E-08 4.50E-08 5.60E-08 5.70E-08 8.20E-08 9.50E-08 1.30E-07 1.70E-07 2.40E-07 2.40E-07 3.10E-07

EP

S677 S26 S138 S174 S560 S562 S466 S156 S34 S30 T3 S557 S1216 S1215 S3175 S116 S180 T3 S111 S877 S83 S377 S522 S964 S2 S271 S15 S15 S214 Y717 S99 S372 S358 S403 S401 S404 S2519 S1691 S372 S375 S368 S347 S716 S432 S18 Y161 S205 S288 S114 S216

AC C

P46100 Q13263 P02765 P16383 Q8IYB3 Q8IYB3 Q5T0W9 Q5SSJ5 P05783 P05783 P07355 Q7Z460 P39880 P39880 P49454 Q8N3X1 P16383 A6NMY6 P10696 Q5T200 Q8N8A6 Q96ST2 Q14195 P46379 P06454 Q00839 Q9NS69 O00458 Q9Y232 P40818 Q5TAQ9 A8CG34 P51991 Q8NBJ9 Q8NBJ9 Q8NBJ9 Q9HCK8 Q9NQT8 Q15018 Q15018 Q15018 Q9BWW4 P40818 Q8TBZ3 Q5XUX1 Q9NQG5 Q96EV2 O14745 Q9NRR5 Q7L2J0

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

3.20E-07 6.00E-07 8.40E-07 8.70E-07 8.90E-07 1.20E-06 1.20E-06 1.30E-06 1.50E-06 1.70E-06 2.20E-06 2.40E-06 2.80E-06 3.30E-06 4.10E-06 4.10E-06 5.10E-06 5.10E-06 5.10E-06 6.20E-06 7.20E-06 7.30E-06 1.00E-05 1.00E-05 1.00E-05 1.10E-05 1.10E-05 1.30E-05 1.30E-05 1.40E-05 1.70E-05 1.80E-05 1.80E-05 2.00E-05 2.00E-05 2.10E-05 2.50E-05 2.50E-05 2.80E-05 2.80E-05 2.80E-05 2.80E-05 2.80E-05 2.90E-05 3.00E-05 3.10E-05 3.10E-05 3.10E-05 3.40E-05 3.50E-05

EP

S276 S469 S349 S282 S740 S740 S1934 Y401 S226 S687 S474 S1110 S138 S137 S399 S684 S1082 S1083 S1084 S856 Y480 Y850 S261 S259 Y258 S397 S390 T18 S21 S3518 S77 S366 S462 S757 S960 S84 S854 S855 S896 S883 S884 T1028 S234 S64 Y441 S284 S286 S305 S1091 T267

AC C

O75410 Q9UMZ2 Q9Y6D5 Q12872 Q5T5Y3 Q7Z6Z7 P24928 Q92560 P78345 Q12959 Q9UJX6 Q9UPT8 Q53GA4 Q86W56 Q9UNF0 Q9C0B5 Q76FK4 Q76FK4 Q76FK4 Q9H9J4 Q8NFC6 O95425 Q9Y2U8 Q9Y2U8 Q9Y2U8 Q14676 Q6PJT7 P43487 P43487 Q03164 P41236 P49768 Q08AD1 Q13263 Q5T1M5 O95155 Q7Z4S6 Q7Z4S6 Q96N67 Q01831 Q01831 Q9UHW9 Q13573 Q8WVB6 Q08945 P08651 P08651 P08651 Q7Z460 Q9Y385

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

3.60E-05 3.90E-05 4.00E-05 4.10E-05 4.20E-05 4.20E-05 4.20E-05 4.80E-05 5.00E-05 5.30E-05 5.30E-05 5.40E-05 5.70E-05 6.20E-05 6.20E-05 6.20E-05 6.40E-05 6.50E-05 6.60E-05 7.00E-05 7.20E-05 7.30E-05 7.30E-05 8.00E-05 8.00E-05 8.00E-05 8.10E-05 8.30E-05 8.50E-05 1.00E-04 1.00E-04 1.10E-04 1.20E-04 1.30E-04 1.40E-04 1.40E-04 1.50E-04 1.50E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.70E-04 1.70E-04 1.70E-04 1.80E-04 1.80E-04 1.80E-04 1.90E-04

EP

S355 S566 Y219 S1779 T124 T1102 S1105 S395 T31 S395 Y394 T615 S2643 S1242 T1241 T1256 S169 S202 S1996 Y75 S5749 S193 S194 S986 S967 S24 S350 S1917 S2599 T913 S506 S185 T319 S17 S622 T355 S202 Y506 T335 S127 S125 S128 S94 S689 S688 S340 T257 S468 Y321 T266

AC C

Q9BWW4 Q92613 Q9NYF8 Q92538 Q9H6Z4 Q9UPN9 Q9UPN9 Q13425 O95674 Q92560 Q92560 Q9UPN6 O75592 Q01814 Q01814 P20020 Q9BZ23 Q96GY3 P46100 P41236 Q09666 Q8NAV1 Q8NAV1 Q5T200 Q5VZK9 O95361 Q9BYJ9 P46821 P21359 Q02241 Q8N5C8 Q8IWC1 Q9H501 Q96AY2 Q8N9T8 P42167 Q04323 Q9UQR0 Q8TD19 O14730 O14730 O14730 Q9NQS1 P49959 P49959 Q658Y4 Q4G0J3 Q86SQ0 O60716 O94906

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

2.00E-04 2.10E-04 2.30E-04 2.30E-04 2.40E-04 2.40E-04 2.50E-04 2.60E-04 2.70E-04 2.80E-04 2.80E-04 2.80E-04 2.90E-04 3.00E-04 3.00E-04 3.00E-04 3.30E-04 3.40E-04 3.40E-04 3.50E-04 3.60E-04 3.80E-04 3.80E-04 4.00E-04 4.20E-04 4.20E-04 4.20E-04 4.20E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.40E-04 4.40E-04 4.40E-04 4.40E-04 4.80E-04 5.00E-04 5.00E-04 5.20E-04 5.30E-04 5.40E-04 6.00E-04 6.10E-04 6.70E-04

EP

S1301 S173 S12 S286 T331 T331 S58 T351 S275 S883 S884 S880 T1331 T26 S576 T1370 S1591 S1277 S2405 T1007 S619 S310 S311 T220 S88 S683 T87 S681 S245 T245 T244 S162 S161 T996 S13 S473 S246 S647 T779 S504 Y780 S1132 S393 S395 T1587 S195 Y932 S114 S100 Y383

AC C

O60293 P04920 Q96AY2 Q8TF01 Q641Q2 Q9Y4E1 Q8TF76 Q658Y4 Q5PRF9 Q96HP0 Q96HP0 Q96HP0 Q15021 A2RU67 Q14694 Q9NTI5 Q8IVL1 Q9P2E9 O75179 Q8WWI1 Q8N3F8 O15143 O15143 Q5JTV8 O75376 Q6ZW31 O75376 Q6ZW31 Q14151 Q15424 Q14151 Q9NVU0 Q9NVU0 Q4ADV7 Q8IVP5 Q9UMZ2 Q15424 Q71RC2 Q13111 Q9C0C2 Q13111 O75116 Q96HA1 Q96HA1 O75592 Q15424 Q9UDY2 P98174 Q8NFH5 Q9Y2X7

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

6.80E-04 6.90E-04 6.90E-04 6.90E-04 6.90E-04 7.30E-04 7.40E-04 7.40E-04 7.50E-04 7.50E-04 7.60E-04 8.20E-04 8.20E-04 8.30E-04 8.50E-04 8.50E-04 8.60E-04 8.80E-04 9.00E-04 9.40E-04 9.70E-04 9.80E-04 1.00E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.40E-03 1.40E-03 1.40E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.60E-03 1.60E-03 1.60E-03

EP

T897 S519 S518 S520 S196 T526 T5845 T265 S124 S830 S4390 S154 T466 Y438 S1105 S1102 S283 S167 S453 T185 S203 S1015 S291 Y80 S134 S352 S770 S1164 S157 S301 T156 T1231 S1232 S274 S276 T848 S122 S857 S1384 S170 S418 S173 S352 S676 T679 T861 S674 T244 S934 S313

AC C

Q9HC35 Q13523 Q13523 Q13523 Q8TEA8 Q6PKG0 Q09666 Q96QF0 Q15185 Q5VYK3 Q15149 Q5JTV8 Q9UJX6 Q08945 Q13464 Q13464 O95817 P67809 Q14676 Q13153 Q9NYB0 Q7Z401 O95817 O15541 Q5M775 Q9BWW4 Q8IW35 Q86SQ4 Q9UNF1 Q13247 Q9Y618 Q9UQ35 Q9UQ35 Q96ST2 Q96ST2 Q9UQ35 Q01831 Q9UQ35 O14646 Q8NI08 Q659A1 Q8NI08 P46013 Q68EM7 Q68EM7 P35606 Q68EM7 P49916 Q9H0A0 Q9H501

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 2.00E-03 2.00E-03 2.00E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.20E-03 2.20E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.40E-03 2.40E-03 2.40E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.60E-03 2.60E-03 2.60E-03 2.90E-03 2.90E-03 3.10E-03

EP

S312 S759 T311 S53 S830 T832 Y155 T829 S19 T674 S431 T277 T966 S91 T602 S430 S1792 T204 S2597 S44 S1228 S447 T38 S255 S1295 S228 S425 T501 S525 S692 S174 S164 S983 S267 S263 S369 S620 Y137 S735 T343 S459 T434 S1445 S342 T117 S83 S129 S1269 S32 S875

AC C

Q9H501 O75152 Q9H501 P49736 Q14008 Q14008 P49761 Q14008 Q96QD8 Q9H2J7 Q9C0C9 O94875 Q14676 P16333 Q86W92 P16383 P46821 Q9Y5J1 P21359 Q9BTU6 Q2KHR3 P15056 Q09666 Q86TC9 Q14160 Q8NE71 O95747 Q9C0C2 Q5VTR2 Q96TA1 Q9NZM1 Q9Y2U5 P78312 Q14202 Q14202 Q15418 P42684 P49736 Q7Z3C6 Q16643 Q9H6S3 P35658 Q14160 Q16643 Q01831 O95155 Q01831 Q9HBL0 P35659 Q6P2E9

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

3.10E-03 3.40E-03 3.40E-03 3.40E-03 3.50E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.80E-03 3.90E-03 3.90E-03 4.00E-03 4.00E-03 4.00E-03 4.10E-03 4.20E-03 4.20E-03 4.20E-03 4.30E-03 4.30E-03 4.30E-03 4.40E-03 4.50E-03 4.60E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.90E-03 4.90E-03 5.00E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.20E-03

EP

S21 S428 S98 S525 T147 S307 S314 S312 T444 S397 T9 T2571 Y11 S1329 S50 T261 S597 S598 S480 S278 S317 S545 S246 Y228 T445 T3510 S165 S370 S482 T89 T1161 T441 S87 S436 S258 S1260 S1262 S260 S1263 S1257 S588 S4889 S456 S115 S203 S202 Y210 S304 S358 S385

AC C

P49840 Q96GM8 Q9BW71 Q9BTA9 P29692 Q13769 Q13769 Q13769 O43318 Q9NYF8 Q9UH99 O95359 Q9UH99 Q14669 Q13610 Q92733 Q8WWM7 Q8WWM7 Q9H6S3 O94888 Q8NBU5 Q96QC0 Q9NVT9 O60716 P35269 Q03164 Q9NZN8 Q5F1R6 Q5T5U3 P41236 Q9BQG0 Q9NPQ8 P41236 Q9NPQ8 Q86VR2 Q15154 Q15154 Q86VR2 Q15154 Q15154 Q6ZRV2 Q9NU22 Q08J23 Q9P287 Q6NZI2 Q6NZI2 O15173 Q9H4L5 Q96HB5 P35269

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

5.20E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.60E-03 5.70E-03 5.70E-03 5.70E-03 5.80E-03 5.80E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 6.00E-03 6.00E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.40E-03 6.40E-03 6.50E-03 6.50E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03

EP

S391 S90 S148 S97 S151 S704 Y705 S202 S296 S54 S153 S145 T722 S550 S242 T713 Y708 S688 S446 S829 S830 S135 S444 S335 S333 S336 S2115 S263 S1825 S142 S668 S156 S184 Y89 S246 S247 S249 S182 S181 S96 S622 S1177 S1176 S72 S14 T1392 S264 S1386 T73 S711

AC C

P35269 Q9H5H4 Q15185 Q9H5H4 Q15185 P25205 P25205 Q96B36 O75808 Q8TAD8 P19338 P19338 P25205 Q9NWH9 O00566 P25205 P25205 A0FGR8 Q13428 Q7Z3B3 Q7Z3B3 Q8NHG8 Q08945 Q8IY81 Q8IY81 Q8IY81 Q9UQ35 Q15059 Q5T011 Q8NEJ9 Q8N556 Q9P2K3 P19338 P46100 Q8IU60 Q8IU60 Q8IU60 Q8NI08 Q8NI08 Q86XP3 Q92625 Q9NTI5 Q9NTI5 P41236 Q2M2I8 Q5SYE7 Q9UNF1 Q5SYE7 P41236 P25205

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass

TE D

6.70E-03 6.70E-03 6.80E-03 6.80E-03 6.80E-03 7.00E-03 7.10E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.30E-03 7.40E-03 7.60E-03 7.70E-03 7.80E-03 8.00E-03 8.00E-03 8.00E-03 8.00E-03 8.40E-03 8.50E-03 8.50E-03 8.50E-03 8.50E-03 8.70E-03 9.00E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.30E-03 9.40E-03 9.80E-03 9.80E-03 9.80E-03 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02

EP

S205 S470 S106 S723 S726 T24 S585 S132 S133 T128 S125 S759 S438 S797 S274 S155 S245 S1168 S219 S494 S467 S250 T162 S125 S122 S118 T120 S46 S296 Y119 S87 Y119 S463 S528 S259 S420 S419 S423 S440 Y732 Y238 S733 S1757 S114 S443 S238 T157 S60 T23 S58

AC C

Q8N684 O60885 P24534 Q99590 Q99590 Q13200 Q6ZRV2 P55081 P55081 Q9H6Z4 Q9H6Z4 Q05682 Q9NZN4 Q6GYQ0 Q5PRF9 Q8IVT2 Q68CP4 Q8N3D4 Q6L8Q7 A0MZ66 Q6GQQ9 P25788 P54727 Q9HAF1 Q9HAF1 Q9HAF1 Q9HAF1 O95400 P04049 Q8N0Y7 Q96GX9 P18669 Q9H6S3 Q8N1G4 P22626 Q9P2I0 Q9P2I0 Q9P2I0 O14578 P98175 Q9H7N4 P98175 Q14980 Q8WUZ0 Q96JM3 Q9Y446 Q13765 P0DJ93 O43399 P0DJ93

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PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.10E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 6.60E-11 8.30E-11 2.20E-10 3.60E-10 3.80E-10 5.10E-10 5.10E-10 1.10E-09 1.70E-09 2.40E-09 4.20E-09 5.50E-09 8.30E-09 1.40E-08 2.10E-08 2.10E-08

EP

T2020 Y446 T5729 Y804 S672 T428 T93 S532 S362 T24 S1317 S429 Y449 S1322 Y1325 T531 Y305 Y509 S861 T109 S225 Y134 S435 Y183 S112 S428 S206 S38 S629 S27 T114 S394 S396 S25 S27 S30 S57 T734 S224 S277 S278 S82 Y427 S720 S239 S137 S373 S60 S928 S1096

AC C

E9PAV3 O14974 Q09666 Q8WWI1 P25205 P16383 Q53EL6 Q9BTA9 Q9Y2X7 Q9Y4F1 Q14669 P16383 Q13263 Q14669 Q15021 Q9BTA9 Q9NY61 Q8N1G4 Q5T5U3 Q9P287 Q9UPQ0 O60841 Q86VR2 Q86XP3 Q9P287 Q13112 P19338 O43314 Q03701 O60678 P46937 Q9Y6D6 Q9Y6D6 O60678 P29966 Q15311 O00264 Q86X10 Q6WCQ1 Q96RK0 Q96RK0 Q9GZR7 P29353 Q86X10 O95671 Q96IF1 A8CG34 O95361 Q86TC9 Q14C86

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.90E-08 3.40E-08 3.50E-08 3.80E-08 3.90E-08 7.00E-08 1.20E-07 1.30E-07 1.30E-07 1.30E-07 1.50E-07 2.00E-07 2.20E-07 2.40E-07 2.70E-07 3.10E-07 3.70E-07 4.00E-07 5.00E-07 5.40E-07 5.40E-07 5.80E-07 5.80E-07 6.00E-07 6.10E-07 7.80E-07 8.40E-07 8.50E-07 8.70E-07 8.80E-07 8.80E-07 9.50E-07 9.50E-07 9.60E-07 1.10E-06 1.20E-06 1.20E-06 1.20E-06 1.30E-06 1.40E-06 1.50E-06 1.50E-06 1.50E-06 1.50E-06 1.50E-06 1.50E-06 1.70E-06 1.80E-06 1.80E-06 2.00E-06

EP

S718 S2372 T1237 S358 S203 S218 S2068 S439 S110 S159 T1989 S628 T270 S290 S56 S853 T227 T1885 S226 S1017 S93 S956 T2645 S467 S429 S642 S254 S430 S283 S468 T36 S1106 T1101 S355 S9 S199 S310 S1920 T4100 S190 S380 S48 S48 S48 S48 S48 S292 T1867 S1298 S332

AC C

P40818 Q7Z6Z7 Q8WXG6 P35611 Q9H0H5 Q6WCQ1 Q9Y618 O43318 Q13425 Q96AC1 P46100 P02545 O75475 O14745 P08670 Q7Z4S6 Q9UN86 Q13315 A0JLT2 Q4ADV7 Q9GZR7 Q5T1M5 O75592 Q9UMZ2 Q13112 O43719 Q86TC9 Q9UBB4 Q12872 Q96D46 P80723 Q6BDS2 Q6BDS2 Q658Y4 Q96AY2 Q04323 P53667 P24928 Q09666 Q12906 Q9C0B5 Q13748 P68363 Q6PEY2 Q71U36 Q9BQE3 Q04727 Q6ZNJ1 Q14160 Q66PJ3

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.00E-06 2.10E-06 2.30E-06 2.30E-06 2.30E-06 2.40E-06 2.50E-06 2.50E-06 2.60E-06 2.70E-06 2.70E-06 2.80E-06 2.90E-06 3.00E-06 3.10E-06 3.20E-06 3.40E-06 3.50E-06 3.60E-06 3.60E-06 3.70E-06 3.70E-06 3.70E-06 3.80E-06 3.90E-06 3.90E-06 3.90E-06 4.20E-06 4.30E-06 4.50E-06 4.60E-06 4.60E-06 4.60E-06 4.80E-06 4.90E-06 5.10E-06 6.10E-06 6.40E-06 6.50E-06 6.80E-06 6.90E-06 6.90E-06 6.90E-06 7.00E-06 7.20E-06 7.60E-06 8.20E-06 8.60E-06 9.10E-06 9.10E-06

EP

T90 S370 S17 S15 S844 T25 S1586 S280 S495 S567 S338 S210 S397 S173 S415 S740 S716 S46 S2887 S543 S546 S43 S94 S487 T251 S744 T196 S393 S649 S12 T796 S1621 S1620 S439 S95 S75 S868 S1045 S335 T199 S105 S89 S12 S1084 S484 S2065 S101 S1047 S165 T580

AC C

Q9UKI2 A8CG34 P53999 P53999 Q8WY36 O75167 Q8WWI1 O14757 P23588 Q5TCZ1 Q86WB0 Q9Y5J1 Q96BT3 O75367 Q9UER7 Q9UKJ3 Q92738 Q96TC7 Q7Z6Z7 Q9ULH7 Q01804 Q9UHR5 Q9GZR7 Q8WUI4 Q86TC9 Q8TEW8 P80723 Q13425 Q7Z460 P35611 Q86VM9 Q9C0C2 Q9C0C2 O94887 O15258 Q56NI9 O75717 Q9P2D0 Q5VSL9 Q8IWE2 P20042 P05114 P02545 P21333 Q8NFC6 Q9Y618 P29966 P41252 P67809 Q86UU1

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

9.10E-06 9.30E-06 9.40E-06 9.40E-06 9.50E-06 9.90E-06 9.90E-06 1.00E-05 1.10E-05 1.10E-05 1.10E-05 1.20E-05 1.20E-05 1.20E-05 1.30E-05 1.40E-05 1.40E-05 1.40E-05 1.50E-05 1.50E-05 1.50E-05 1.50E-05 1.50E-05 1.60E-05 1.60E-05 1.70E-05 1.70E-05 1.80E-05 1.80E-05 1.90E-05 1.90E-05 1.90E-05 2.00E-05 2.00E-05 2.00E-05 2.10E-05 2.10E-05 2.10E-05 2.20E-05 2.20E-05 2.30E-05 2.50E-05 2.60E-05 2.70E-05 2.70E-05 2.70E-05 2.70E-05 2.80E-05 2.80E-05 2.90E-05

EP

S578 S359 S45 S52 S98 S532 S536 S282 T389 S468 S201 S511 S584 T111 S163 S1067 S414 S144 S202 S548 S87 T925 S215 S1797 S2449 S206 S1113 S367 S742 S2359 S983 S736 S435 S135 S696 S120 S395 S427 S314 S230 S77 S1179 S15 S209 S121 S127 S121 S898 S621 S265

AC C

Q86UU1 Q9NQ55 Q8TAP8 Q8TAP8 Q13895 Q9Y2L9 Q9Y2L9 Q96EZ8 Q6PJT7 O15047 Q9ULX3 Q5F1R6 P46013 Q8WUZ0 O00566 Q9UDY2 Q9UHR4 Q9Y2U8 Q86X95 Q9H7N4 Q96AY2 Q6PD62 Q9Y618 P46821 Q9UQ35 P43243 Q12888 P49768 Q6PJG6 O95359 Q9C0C2 P98175 Q66K14 Q9BXS6 O14497 Q13105 Q9UQ35 O76021 Q99569 Q96B97 Q9Y4B5 Q9Y4F5 O00193 Q14244 Q969E4 Q5H9L2 Q6IPX3 Q96N67 Q8N3F8 Q9UNF1

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.90E-05 3.00E-05 3.10E-05 3.10E-05 3.30E-05 3.50E-05 3.50E-05 3.50E-05 3.60E-05 3.60E-05 3.90E-05 3.90E-05 3.90E-05 4.00E-05 4.10E-05 4.10E-05 4.30E-05 4.50E-05 4.50E-05 4.50E-05 4.50E-05 4.60E-05 4.70E-05 4.70E-05 4.80E-05 4.80E-05 4.90E-05 5.00E-05 5.00E-05 5.50E-05 5.60E-05 5.60E-05 5.70E-05 5.70E-05 5.70E-05 5.80E-05 5.90E-05 5.90E-05 6.00E-05 6.00E-05 6.20E-05 6.40E-05 6.40E-05 6.50E-05 6.60E-05 6.60E-05 6.60E-05 6.60E-05 6.60E-05 6.70E-05

EP

S159 S325 S338 S334 S2559 S266 S1137 S292 S176 S638 T899 S112 S379 S1965 S624 S1780 S764 S131 S174 S170 S22 S161 S362 S473 S21 S545 S292 S1156 S33 S126 S575 S286 S593 S2649 S2833 S1038 S332 S137 S244 S518 S1257 S587 S168 S128 S557 S1992 S1990 S1991 S158 S62

AC C

Q92733 Q14678 P49790 P49790 Q9P2D1 Q9Y385 O75116 Q96T37 Q96CX2 Q9NW82 Q9HC35 Q7Z417 P12270 P46821 P52756 Q92538 Q6NWY9 Q9NXV6 Q96D71 Q96D71 Q8NE71 Q6SPF0 Q9H6X2 Q9HCH0 Q96GN5 Q9P206 Q6WCQ1 O43432 O95674 Q9NRF2 Q8IVT2 Q04726 Q5VT52 O75592 O75592 Q5TCZ1 O00712 P52701 Q16204 Q03164 P20020 Q96B97 Q9BZ23 Q96CB8 O95453 P46100 P46100 P46100 O95292 P52292

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

6.70E-05 6.70E-05 6.80E-05 6.80E-05 6.90E-05 6.90E-05 7.00E-05 7.20E-05 7.30E-05 7.30E-05 7.40E-05 7.40E-05 7.50E-05 7.50E-05 7.70E-05 8.10E-05 8.40E-05 8.60E-05 8.70E-05 8.80E-05 8.90E-05 9.00E-05 9.10E-05 9.20E-05 9.40E-05 9.50E-05 9.70E-05 9.90E-05 9.90E-05 1.00E-04 1.00E-04 1.10E-04 1.10E-04 1.10E-04 1.10E-04 1.10E-04 1.10E-04 1.10E-04 1.10E-04 1.10E-04 1.20E-04 1.20E-04 1.20E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04 1.30E-04

EP

S630 S1348 S778 S470 S567 T693 S229 S5752 S996 S1432 S731 T724 S114 S636 S212 S1443 S1195 S143 S1644 S420 S2047 S280 S481 S613 S245 S85 S1156 S326 T327 S912 S462 S296 S183 T470 S74 S515 T745 S1003 S31 S1377 S600 S1793 S1166 S260 S7 S121 S2401 S893 S168 S290

AC C

Q96AE4 Q03468 Q8N4C8 O15047 Q8WUF5 P00533 Q13033 Q09666 Q6PJG2 Q96N67 P46100 P46100 Q12982 P02545 Q7Z417 P46821 Q13017 P26358 Q9NQT8 Q96PE2 O75179 P27816 Q8IZL8 P51532 Q14684 P49023 Q15648 Q15345 Q15345 Q02241 Q9BZZ5 Q99460 Q8IWC1 Q96D46 Q96C19 P40222 Q8IZL8 Q9ULJ3 Q16637 P51531 Q7Z460 P46821 P00533 Q9HC77 Q96AY2 Q9Y5J1 O75179 Q8WX93 Q8TBN0 P18206

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.30E-04 1.30E-04 1.40E-04 1.40E-04 1.40E-04 1.40E-04 1.40E-04 1.40E-04 1.40E-04 1.40E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.60E-04 1.60E-04 1.60E-04 1.70E-04 1.70E-04 1.70E-04 1.70E-04 1.70E-04 1.70E-04 1.70E-04 1.70E-04 1.80E-04 1.80E-04 1.80E-04 1.80E-04 1.80E-04 1.90E-04 1.90E-04 1.90E-04 1.90E-04 1.90E-04 2.00E-04 2.00E-04 2.00E-04 2.10E-04 2.10E-04 2.10E-04 2.10E-04 2.20E-04 2.20E-04 2.20E-04 2.20E-04 2.30E-04

EP

S221 S466 T330 S278 S459 S1579 S2229 S2567 T165 S448 S102 S351 S225 S224 T2000 S271 T364 S341 T1466 S660 S793 S5763 S558 S796 S171 S172 T563 S557 S662 S297 S295 S258 S335 T918 S1062 S930 S1063 S152 S1304 S1303 T150 S57 S1466 S261 S287 S441 S431 S441 S22 S15

AC C

Q9UKX7 O60825 Q8NC44 Q6IQ49 Q96JM3 Q69YN4 Q9BV73 O95359 Q1KMD3 Q9H0D6 P54105 Q96NB3 O75643 Q8WXE1 Q14980 Q5PRF9 Q9NQW6 Q6WKZ4 Q14676 Q68CZ2 Q9Y597 Q09666 Q9Y5B6 Q99590 Q63ZY3 Q63ZY3 Q9Y5B6 Q9Y5B6 Q86XL3 Q9UQ35 Q9UQ35 Q4G0J3 Q9UGV2 Q9BX63 Q12789 Q9BX63 Q12789 Q9Y2D5 O60293 O60293 P29966 Q13442 Q02880 Q4G0J3 Q9NYF8 Q641Q2 O14639 Q9Y4E1 Q9UBN7 Q96AY2

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.30E-04 2.30E-04 2.30E-04 2.30E-04 2.40E-04 2.40E-04 2.40E-04 2.50E-04 2.50E-04 2.50E-04 2.50E-04 2.50E-04 2.50E-04 2.60E-04 2.60E-04 2.60E-04 2.60E-04 2.60E-04 2.60E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.80E-04 2.80E-04 2.80E-04 2.80E-04 2.80E-04 2.80E-04 2.80E-04 2.80E-04 2.90E-04 2.90E-04 2.90E-04 2.90E-04 2.90E-04 2.90E-04 2.90E-04 2.90E-04 3.00E-04 3.00E-04 3.00E-04 3.00E-04 3.00E-04 3.00E-04 3.00E-04 3.00E-04

EP

S6 S601 S187 S31 S445 S80 S370 S559 S1179 S229 S411 S657 S663 S451 S2273 S857 T711 S329 S483 S41 S1438 S21 S236 T778 S23 S883 S1939 T1011 S878 S28 S1345 S1012 S1010 T445 S53 S51 S611 S316 S354 S28 S107 S4396 S171 S167 S1358 T400 T275 S43 S531 S259

AC C

Q96AY2 Q92615 Q96CX2 Q9NWW5 Q8NHM5 P51608 O75122 Q6VMQ6 Q9NRY4 Q96P48 Q66K14 Q9H501 Q9H501 O60832 Q63HN8 Q9UPP1 P98174 P21731 P42568 Q13439 P46821 Q9UJV9 Q96G46 Q8IYB3 Q9UJV9 P07814 O14578 Q8WWI1 Q96HP0 Q05D32 Q96T23 Q8WWI1 Q8WWI1 Q9NPF5 Q96MH2 Q96MH2 Q9UKN8 P98082 Q86WB0 Q16637 Q86YP4 Q15149 O00566 O00566 Q9NTI5 Q9UQ35 O75410 Q9Y5Q9 Q6VY07 Q15942

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

3.10E-04 3.10E-04 3.10E-04 3.10E-04 3.10E-04 3.20E-04 3.20E-04 3.30E-04 3.40E-04 3.40E-04 3.40E-04 3.40E-04 3.50E-04 3.50E-04 3.50E-04 3.50E-04 3.50E-04 3.50E-04 3.50E-04 3.50E-04 3.60E-04 3.60E-04 3.60E-04 3.70E-04 3.70E-04 3.80E-04 3.80E-04 3.80E-04 3.80E-04 3.80E-04 3.80E-04 3.90E-04 3.90E-04 3.90E-04 3.90E-04 3.90E-04 3.90E-04 4.00E-04 4.00E-04 4.00E-04 4.00E-04 4.00E-04 4.00E-04 4.00E-04 4.10E-04 4.20E-04 4.20E-04 4.20E-04 4.20E-04 4.20E-04

EP

S525 S337 S253 S2102 S713 S344 S323 S752 S113 S230 S231 S897 S1166 T1438 S1858 S174 S29 S25 S214 S410 S230 S42 S109 T447 S415 T401 S506 S216 S1601 S1605 S1556 S300 S102 S84 S85 S1283 S1586 S67 S66 T521 S133 S47 S52 S412 S854 S111 S181 S406 S460 S2739

AC C

Q14004 P12694 P05787 Q01082 Q12873 P82094 O75674 Q9UMZ2 O60841 Q13283 Q13283 P29317 Q9NTI5 P25054 Q03164 P67809 Q13085 Q13085 Q9Y6Q9 Q13112 P15408 Q92917 Q8WXX5 O15231 Q9Y5T5 Q14247 Q9BY44 Q13242 Q12873 Q12873 P18583 Q5JTD0 O75351 Q96AY2 Q96AY2 Q9NTI5 O75592 Q96B23 Q96B23 P27816 P29692 Q9UPN4 Q8TAD8 Q9UQR1 Q9UPP1 Q96HC4 Q96AC1 Q9BTX1 Q9NSK0 Q6ZNJ1

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

4.30E-04 4.30E-04 4.40E-04 4.40E-04 4.50E-04 4.50E-04 4.50E-04 4.50E-04 4.50E-04 4.60E-04 4.60E-04 4.60E-04 4.60E-04 4.60E-04 4.70E-04 4.70E-04 4.70E-04 4.70E-04 4.80E-04 4.80E-04 4.90E-04 4.90E-04 4.90E-04 4.90E-04 5.00E-04 5.10E-04 5.10E-04 5.20E-04 5.20E-04 5.20E-04 5.20E-04 5.30E-04 5.30E-04 5.40E-04 5.40E-04 5.40E-04 5.40E-04 5.50E-04 5.50E-04 5.50E-04 5.50E-04 5.50E-04 5.50E-04 5.50E-04 5.50E-04 5.50E-04 5.60E-04 5.60E-04 5.60E-04 5.60E-04

EP

S155 S21 S306 S421 S405 S119 S212 S281 T399 T285 S458 S374 S1220 S122 S547 S95 T97 T96 S164 S138 S312 S530 S1666 S344 S396 S333 S333 S79 S75 T5 S1174 S268 S196 S180 S179 S178 T933 S836 S240 S1002 S1005 S1004 T1147 S169 S1146 S12 S1203 S125 S131 S129

AC C

Q8IX90 Q8IUD2 Q9Y4H2 Q7L7X3 Q14247 P29692 Q86WR7 O43572 Q14247 Q02952 P02545 Q9UHB6 Q14160 Q8WUZ0 Q5TCZ1 Q13425 Q9NQL2 Q9HB90 P80723 Q5VTR2 Q9H8G2 Q96EN8 Q9C0C2 Q15942 Q96HA1 Q9Y4E1 Q641Q2 Q9H1E3 Q9H1E3 Q9BQA1 Q9Y4H2 Q9NYF8 Q15424 Q9UHB7 Q9UHB7 Q9UHB7 Q9UDY2 Q9C0C2 Q7Z5L9 Q12965 Q12965 Q12965 Q14004 O43598 Q53SF7 Q9NP87 Q9ULD2 Q07157 Q07157 Q8WXI9

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

5.70E-04 5.70E-04 5.70E-04 5.70E-04 5.70E-04 5.80E-04 5.90E-04 5.90E-04 5.90E-04 6.00E-04 6.00E-04 6.00E-04 6.10E-04 6.10E-04 6.20E-04 6.20E-04 6.20E-04 6.40E-04 6.40E-04 6.40E-04 6.40E-04 6.50E-04 6.50E-04 6.50E-04 6.50E-04 6.70E-04 6.80E-04 6.90E-04 7.00E-04 7.10E-04 7.10E-04 7.10E-04 7.10E-04 7.20E-04 7.20E-04 7.20E-04 7.30E-04 7.30E-04 7.40E-04 7.40E-04 7.60E-04 7.60E-04 7.60E-04 7.70E-04 7.70E-04 7.90E-04 7.90E-04 7.90E-04 8.00E-04 8.20E-04

EP

T1845 S226 S1837 S65 S4386 S304 T2409 S99 S100 S83 T111 T443 T106 S326 S307 S330 T1274 S1241 S312 S1260 S212 S857 S91 S220 S183 S521 S646 S197 S661 S50 S996 S1006 S294 T163 S366 S365 S1783 S244 S555 S608 S347 S4389 S346 S445 S601 S5110 S1032 S1035 S244 Y114

AC C

Q03164 P08238 Q03164 Q15154 Q15149 Q05655 Q9UQ35 Q96SB3 Q96SB3 Q9H5H4 P20042 O14974 Q8NFH5 Q8ND76 Q00613 Q92597 Q7Z6E9 Q9BQG0 O00273 P46821 Q9UFC0 Q9Y6Q9 Q9H6F5 Q6L8Q7 O60271 Q9C0E2 Q7Z460 Q8TEA8 Q86YS7 Q86U44 O95785 O43314 Q96T37 Q5JSH3 Q13501 Q13501 Q8WWQ0 Q9UDY2 Q9NPH3 Q99590 Q01831 Q15149 Q01831 Q96JM3 Q9C0C2 Q09666 Q9UMN6 Q9UMN6 Q7Z5L9 O95218

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

8.20E-04 8.40E-04 8.50E-04 8.50E-04 8.50E-04 8.50E-04 8.60E-04 8.60E-04 8.60E-04 8.60E-04 8.70E-04 8.80E-04 8.90E-04 8.90E-04 8.90E-04 8.90E-04 9.00E-04 9.00E-04 9.00E-04 9.10E-04 9.10E-04 9.10E-04 9.40E-04 9.40E-04 9.50E-04 9.60E-04 9.60E-04 9.60E-04 9.60E-04 9.70E-04 9.90E-04 9.90E-04 9.90E-04 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03

EP

S25 S882 S194 S132 T1101 S152 S284 S289 S22 S18 S362 S715 S453 S516 T329 S153 S269 S222 T455 S234 S235 S135 T157 S156 S268 S1133 S1134 S490 S247 S432 S332 S293 S291 S296 S187 S294 S719 S631 S90 S85 S258 S425 S176 S1452 S1305 S114 S929 S3527 S209 S833

AC C

Q53F19 P07814 O95400 O15357 Q13464 Q9Y618 O95817 O95817 Q9UHR5 Q9UHR5 P35613 P51812 O15231 P10636 Q9H330 Q96S55 Q9UJU6 Q9NYF8 Q14676 Q14151 Q15424 Q8WXI9 Q8IVT2 Q8IVT2 O60716 O75116 O75116 Q9UHB6 Q9H3N1 Q8NDI1 P78310 P08559 P29803 Q96RU3 Q9Y520 Q53SF7 Q9H7N4 P42684 Q9BUR4 Q9BUR4 P05787 Q96IG2 P67809 P51532 Q29RF7 Q9P035 Q9P206 Q03164 Q7Z589 O60524

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.30E-03 1.40E-03 1.40E-03 1.40E-03

EP

S84 S646 S641 S1834 T417 S589 S149 S436 S250 T778 S248 S777 S332 S241 S214 T412 S457 S1258 S175 T431 T2289 S333 T176 S284 S97 S434 S410 S411 S1233 S518 S329 S15 S21 S267 T285 S117 S22 S266 S156 S137 S243 S1385 S1387 S738 S53 S50 S51 S456 T13 T15

AC C

O15541 Q96TA1 Q96TA1 Q9H7D0 Q96IG2 Q9NRY4 Q9Y618 Q8IU81 Q96ST2 Q13111 Q96ST2 Q13111 Q13501 P18887 Q5VUA4 Q6UUV7 Q7Z5L9 Q63HN8 Q63ZY3 Q9ULJ3 Q9UQ35 O00712 Q63ZY3 Q6IBW4 Q96NY9 Q9ULJ3 Q6UUV7 Q6UUV7 Q9UQ35 Q8N1G4 Q8ND30 P04792 Q9BRS2 Q92733 O95817 Q9BVV8 Q9BRS2 P18887 O95292 O75396 Q9UFC0 O14646 O14646 Q5T5Y3 O43818 O43818 O43818 Q9H4M9 P43487 P43487

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03

EP

S790 S123 T793 S171 S77 S4986 S732 S1103 S51 S14 S201 S202 S418 S416 S125 S733 S354 S14 S1377 S174 S388 S280 S287 Y389 S755 S758 S630 S331 T753 S653 S425 S467 S231 S242 S438 S494 S657 S132 S772 S97 S14 S445 S31 S134 S758 S725 S540 S95 S677 T654

AC C

Q4LE39 P54725 Q4LE39 Q8NI08 Q7Z5K2 Q09666 O60271 Q9UQ35 Q99549 P43487 Q6ZUT6 Q6WKZ4 Q14247 Q659A1 Q8N8S7 O60271 Q96K21 Q02363 P11388 Q5VV41 Q5T0W9 Q12857 Q12857 Q5T0W9 A0FGR8 A0FGR8 Q8WVC0 Q9UGV2 A0FGR8 Q96RL1 Q96GM8 Q14157 P07900 P49916 Q96ST2 O60832 Q58WW2 Q9Y2K6 Q8N1F8 Q9H910 O00458 Q8NB49 Q92522 Q9Y2K6 O75152 Q9H7N4 Q9Y2J4 Q96NY9 P49756 Q58WW2

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.60E-03 1.60E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 2.00E-03

EP

S149 S440 S144 S146 S218 S227 T420 S775 S37 S78 S282 S51 S480 S968 S828 S286 S221 S70 S675 S227 S495 S1094 S785 S251 S1217 S248 S888 S18 S17 S750 S749 S964 S854 S118 S2398 S39 S22 S877 T86 S592 S333 S23 S374 S40 S1275 S205 S206 S886 S39 S214

AC C

Q13283 Q96ST2 Q9HC35 Q9HC35 Q9Y6D5 Q9Y6D5 P23588 Q13111 P14618 P13861 Q96JM3 P18615 O60583 Q5VZK9 Q14008 Q96JM3 Q7Z5K2 P10809 Q9H2J7 P52701 Q9UER7 Q5VZK9 P19634 Q9BUA3 Q13813 Q9BUA3 P52948 Q96QD8 Q96QD8 Q14147 Q14147 Q14676 Q9UQ35 P29966 Q9UQ35 B5ME19 P02545 Q8N122 Q15029 Q9Y2X7 Q9H6Z4 P13051 Q5VT52 Q96BD0 Q9UPT8 Q9Y5J1 Q9Y5J1 P07814 Q99613 Q9P0L0

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.20E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03 2.30E-03

EP

S337 S512 T118 S446 S182 S1231 S1230 S1138 S77 S180 S678 S673 S448 S210 S315 S135 S511 T503 S669 S662 S427 S41 S527 S47 S48 T1215 S153 S92 T139 S48 S557 S51 S216 S200 S643 S522 S524 S696 S30 S33 S539 S401 S1172 S19 S37 S659 S93 S662 S18 S694

AC C

Q99569 Q9NYF8 Q96T60 P15056 Q96GY3 Q2KHR3 Q2KHR3 Q9C0C2 Q9NWB6 P0C1Z6 P35658 Q9P206 Q9NPF5 Q9UBB9 Q5SQI0 Q9UKM9 Q9UQR0 Q9UQR0 Q9P206 O14523 O95747 Q9NTJ3 O94979 Q9ULG1 Q9ULG1 Q15648 Q16666 P05455 Q8WW12 O76080 Q8WWM7 Q9ULG1 Q8ND56 P15408 Q6AI08 Q5VTR2 Q5VTR2 Q96TA1 A2RU67 A2RU67 Q9Y4E1 P98082 Q13136 P10155 O95674 Q86YS7 Q15154 Q86YS7 Q07666 Q9C0B5

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.30E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.40E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.60E-03 2.70E-03 2.70E-03 2.70E-03 2.70E-03 2.70E-03 2.70E-03 2.80E-03 2.80E-03 2.80E-03 2.80E-03 2.80E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03

EP

S709 S859 T333 S122 S765 S781 T598 S63 S619 S363 S955 S27 S1329 S773 S40 S177 S874 T872 S21 S364 S5731 S362 T437 S658 S143 S465 S347 S78 S691 S203 S1712 S2012 S242 S76 T2884 S822 S823 S316 S1329 S81 S328 S83 S157 S119 S224 S2484 S596 S732 Y598 S1330

AC C

Q14671 P35606 Q8TD19 Q5VZL5 Q96EV2 Q8IYB3 P51116 Q9C086 P19338 Q15418 P49792 Q6IAA8 Q9UQ35 Q8IYB3 Q5VUA4 Q9NYF8 Q8IYB3 Q8IYB3 Q6IQ22 Q92597 Q09666 Q92597 P35658 Q9H1B7 Q12792 Q9BY89 P50750 O95155 Q12996 Q9H8G2 Q5T5U3 Q9H4A3 Q5T200 Q96C19 Q5T4S7 Q8IWX8 Q8IWX8 Q3B726 Q6T4R5 Q9H410 Q9Y608 Q14103 Q92733 O14737 O75376 P11717 Q9Y2X7 P46087 Q9Y2X7 Q15021

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

2.90E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.10E-03 3.10E-03 3.10E-03 3.10E-03 3.10E-03 3.10E-03 3.10E-03 3.10E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.20E-03 3.30E-03 3.30E-03 3.30E-03 3.30E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03

EP

S90 S195 S2209 S255 S817 S204 S559 S617 T819 S330 S779 S2211 S69 S879 S64 S105 S461 T19 S450 S20 S171 S1156 S116 S435 S320 S2272 S898 S1106 S165 S626 S628 S151 S85 S1547 S353 S302 S520 S403 S404 S641 S315 S275 S332 S442 S1859 S17 S161 S100 S2016 S868

AC C

O15173 O95400 P46821 Q9UBC2 Q8IWX8 Q96JM3 Q8WWM7 Q5H9R7 Q8IWX8 Q8NC51 Q7LBC6 P46821 P35251 Q6P2E9 Q9H3Q1 O95155 Q86UU1 P49840 Q8IYB3 P49840 Q8N9T8 A7E2V4 P98174 O94776 O60716 Q9UQ35 Q9BTC0 P11388 Q7Z434 Q92625 Q92625 Q9BWH2 P55884 Q14160 Q8N5D0 O94875 Q8N1G4 P02545 P02545 P35221 Q9H788 O75475 Q9H330 P48651 P27708 P39687 Q1KMD3 Q9BW71 Q9Y618 Q8TD19

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03 3.60E-03 3.60E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.70E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.80E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 4.00E-03 4.00E-03 4.00E-03

EP

S407 S406 S303 S1309 T120 S130 S334 S122 T128 S503 S1510 S485 S616 S573 S571 S2569 S1086 Y333 S632 S1779 S60 S12 S427 T1003 S455 S332 S331 S398 S387 S1468 S315 S377 T9 S413 S234 S237 T213 S237 S315 S217 T110 S109 S2749 S527 S1057 S208 S425 T696 S214 S701

AC C

P02545 P02545 Q00613 Q14160 Q8WXI9 Q9UDY2 Q86SQ0 Q8WXI9 O95251 Q9BY44 Q8WWI1 Q8IWZ8 Q13586 P17812 P17812 O95359 Q14676 Q68CZ2 P02545 P46821 O00505 Q9UH99 Q96JM3 Q9UQ35 Q7Z5L9 Q68CZ2 O00499 Q9UQ35 Q9UQ35 Q9UIG0 Q9NZT2 Q9UQ35 Q86U86 Q6UUV7 Q9H7L9 Q9H7L9 Q7L2J0 Q9BTK6 O00273 Q7L2J0 P46937 P46937 O75592 O60318 Q8N1G0 O15173 Q7Z3K3 O14974 O60841 O43150

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.10E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.30E-03 4.30E-03 4.30E-03 4.30E-03 4.30E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.50E-03 4.50E-03 4.50E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.70E-03 4.80E-03 4.80E-03

EP

S1361 S1362 S280 S241 S1374 S437 S285 S727 S916 T25 S422 S1423 S1697 S542 Y73 S298 S3010 T48 T446 S181 S481 S230 S212 S259 T255 S874 S260 T219 S210 S256 S100 S153 S786 S328 S214 S271 S692 S487 S2280 S160 S473 S507 S155 S477 S1305 S210 S657 S659 S133 S1093

AC C

Q9NTI5 Q9NTI5 O94888 Q9UNX4 Q7Z5J4 Q9BVJ6 Q9NYF8 P13807 Q16512 Q96A57 P23588 Q8WWI1 P18583 Q96QC0 Q15029 Q9BTE3 Q14789 P36915 P35269 Q5T4S7 P53396 O60716 Q09666 P17275 P17275 Q9H7N4 Q8IYB3 Q9BU76 Q09666 Q15477 P23193 O95218 P46087 P15336 Q96JM3 Q9BRD0 Q9UHB6 Q15361 P49792 P54727 Q13263 P43007 Q96I25 Q14157 Q7Z3J3 Q9UKV3 Q9H1B7 Q9H1B7 P54725 Q5VZK9

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.90E-03 4.90E-03 4.90E-03 4.90E-03 4.90E-03 4.90E-03 4.90E-03 4.90E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.00E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.20E-03 5.20E-03 5.20E-03 5.20E-03 5.20E-03 5.20E-03 5.20E-03 5.20E-03 5.20E-03 5.30E-03 5.30E-03 5.30E-03 5.40E-03

EP

S225 S594 T202 S90 T49 S1448 Y204 S1099 S75 T207 S141 S544 S545 S434 S100 S547 S652 S1207 S601 S695 T19 S727 S64 S194 S694 T19 S333 S334 T50 S782 T762 S161 S162 T211 S761 S247 S575 S56 S480 S49 S659 S181 S1075 S1126 T302 S466 S303 S904 S135 S203

AC C

P22626 Q8WWM7 P27361 Q6PKG0 Q13620 Q14160 P27361 Q5VT52 Q6PKG0 P27361 Q5QJE6 O60504 O60504 Q8TBZ3 Q9H307 Q9H1B7 Q7Z417 Q15648 P51116 Q8IYB3 P07355 P42224 O75496 O43237 Q8IYB3 A6NMY6 Q8WXI9 Q8WXI9 P36915 Q8TDD1 O75152 Q5JSH3 Q5JSH3 O15173 O75152 P25490 Q9Y2W1 Q9Y3T9 Q9NR09 Q9Y3T9 Q86V48 O00264 Q9UMZ2 Q12774 Q9GZR7 Q9BWU0 Q13247 Q15811 Q09666 Q96B36

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.70E-03 5.70E-03 5.70E-03 5.70E-03 5.70E-03 5.70E-03 5.70E-03 5.80E-03 5.80E-03 5.80E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.10E-03 6.10E-03 6.10E-03

EP

S143 S216 S516 S1784 S212 S49 S208 S738 S583 S988 S196 S551 S991 Y67 S563 S504 S273 S271 S183 S240 S856 T272 S6 S827 S119 S479 S307 S759 T828 S328 S787 S1222 S861 S621 S1472 S619 S2123 S397 S522 S828 S157 S156 S52 S26 S30 S312 T25 S1306 S1300 S269

AC C

Q5JTV8 Q9UKV3 Q9Y6G9 Q92538 Q96B36 Q8TAD8 Q9UKV3 Q9ULW0 P27824 Q8WWI1 Q8IWE2 Q9NWH9 Q8WWI1 P06748 P19338 P23588 O75475 O75475 Q9NYF8 Q16204 Q5T5U3 O75475 P09651 Q7Z3B3 Q15390 Q9H6S3 Q9Y2I7 Q66K74 Q7Z3B3 O00712 P27816 Q96T58 Q15154 Q9HBL0 O75376 Q9HBL0 Q9UQ35 Q8IVT2 Q13330 Q7Z3C6 Q5JTV8 Q5JTV8 P30086 Q6Y7W6 Q6Y7W6 Q14669 Q16637 Q14160 Q14160 O75128

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.10E-03 6.20E-03 6.20E-03 6.20E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.30E-03 6.40E-03 6.40E-03 6.40E-03 6.40E-03 6.50E-03 6.50E-03 6.50E-03 6.50E-03 6.50E-03 6.50E-03 6.60E-03 6.60E-03 6.60E-03 6.70E-03 6.70E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03

EP

S143 S355 S203 S526 S36 S320 S37 S36 S113 S334 T175 T174 S170 S799 S21 S357 T461 S1267 S979 S492 S181 S775 S777 S769 S1114 T358 S127 S126 S630 S267 Y231 S597 S233 S352 S354 T522 T203 S298 S80 S384 S557 S367 S765 S556 S1231 S48 S681 S340 S615 S1320

AC C

Q8NEJ9 Q09028 Q8NEF9 O95365 P16403 Q9Y2W1 P16402 P10412 Q15185 Q9UGV2 O75367 O75367 O75367 O94979 Q96CP2 P46013 Q14157 Q9BQG0 Q9P206 Q6UN15 P52594 Q8IYB3 Q8IYB3 Q8IYB3 Q12888 O76021 Q14137 Q14137 Q9UJA3 Q8TF74 Q96P48 Q8IYB3 P07910 Q9UK58 Q9NZL4 Q8N1G4 Q8N684 O00499 Q9Y3X0 Q8IU81 Q9NPH3 P46937 Q8WUA4 Q9NPH3 Q04637 Q9UKT5 Q8N163 O75909 Q9Y6X9 Q12888

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

6.90E-03 6.90E-03 7.00E-03 7.00E-03 7.00E-03 7.00E-03 7.10E-03 7.10E-03 7.10E-03 7.10E-03 7.10E-03 7.10E-03 7.10E-03 7.10E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.20E-03 7.30E-03 7.30E-03 7.30E-03 7.30E-03 7.40E-03 7.40E-03 7.40E-03 7.40E-03 7.40E-03 7.50E-03 7.50E-03 7.50E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.60E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.80E-03

EP

T1319 S24 S53 S1370 S52 S1040 S2029 S2027 T390 S2032 S295 S609 S2155 S445 S323 S144 S141 S126 S220 T888 S499 S525 S501 S490 S1163 S1381 S906 S696 S3467 S713 S717 T514 S454 S289 S427 S506 S292 T200 S201 S752 S740 S494 T5839 S902 S333 S120 S29 S339 S497 S105

AC C

Q12888 O00193 P55081 Q9H2Y7 P55081 Q9BTC0 Q9H4A3 Q9H4A3 P49841 Q9H4A3 Q9GZR7 Q14157 P12270 P85037 Q63ZY3 Q53GA4 Q53GA4 Q9H6Z4 Q6WCQ1 P07814 Q9H0D6 Q9NPI6 Q9H0D6 Q9UKV3 Q9BQG0 Q9HBL0 Q13428 Q8IYB3 O75592 P10636 P10636 Q86V48 Q14157 P46937 Q9Y4F1 Q3MII6 Q03111 Q8NEY8 Q8NEY8 P21127 Q9UQ88 Q9HCH0 Q09666 Q14C86 P08651 Q9BVV8 Q15311 P08651 P23588 P05387

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

7.80E-03 7.80E-03 7.90E-03 7.90E-03 7.90E-03 7.90E-03 7.90E-03 7.90E-03 7.90E-03 8.00E-03 8.00E-03 8.00E-03 8.00E-03 8.10E-03 8.10E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.30E-03 8.30E-03 8.30E-03 8.30E-03 8.30E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.50E-03 8.50E-03 8.50E-03 8.50E-03 8.50E-03 8.50E-03 8.50E-03 8.60E-03 8.60E-03 8.60E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03

EP

S104 S1380 S18 S179 T366 S121 S367 S30 S205 S58 S464 S61 S132 S703 S986 T190 S162 Y187 S838 S221 S541 S123 S471 S460 S299 S1247 S298 S187 S675 S678 S1265 S354 S2317 S1256 S686 S295 S970 S361 S1114 S97 S2047 T701 S736 S738 S118 S116 T404 S402 S27 S166

AC C

P05386 P51532 O75569 Q86TB9 Q92597 Q9NR30 Q92597 O75379 P80723 Q9H1E3 Q6GQQ9 Q9H1E3 Q9UHB6 Q9UHB7 Q9UDY2 P28482 P29692 P28482 Q9UKV3 O95425 Q9ULH7 Q01664 Q8IVT2 Q7Z5L9 Q4G0J3 P11388 Q4G0J3 P05549 Q8N163 Q8N163 P46821 O60293 O95359 P46821 Q9UHB6 O00712 Q6PD62 O76021 Q9UPT8 Q17RY0 Q9UPU5 A0FGR8 Q9H2P0 Q9H2P0 P55081 P55081 Q14676 Q14676 Q9NTJ3 Q9NQG5

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.90E-03 8.90E-03 8.90E-03 9.00E-03 9.00E-03 9.00E-03 9.00E-03 9.00E-03 9.00E-03 9.00E-03 9.10E-03 9.10E-03 9.10E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.30E-03 9.30E-03 9.30E-03 9.30E-03 9.30E-03 9.30E-03 9.40E-03 9.40E-03 9.40E-03 9.50E-03 9.50E-03 9.50E-03 9.50E-03

EP

S1522 S397 S1526 S49 S1524 S96 T267 S574 S575 S351 S145 S232 S498 S499 S14 S592 S38 S1298 S453 S47 S301 S165 S27 S136 S304 S21 S329 S392 S455 S453 S1023 S674 S1024 S394 S395 S394 S24 S673 S672 S695 S766 S692 S774 S817 S160 S199 S66 S166 S265 S193

AC C

Q02880 Q14978 Q02880 O95400 Q02880 Q5JSH3 P55081 P17812 P17812 P22059 P29966 Q13283 Q8TCJ2 Q8TCJ2 Q5SW96 Q9NYZ3 P16949 Q92538 Q8IU81 Q9H6F5 P04049 P51858 P49736 Q8TB72 P17706 Q6R327 O75909 P02545 O60832 O60832 Q01804 Q8WWQ0 Q01804 Q9UDY2 Q8IVT2 Q8IVT2 Q96A57 Q9Y3T9 Q9Y3T9 Q8TEW0 Q6PKG0 Q8TEW0 Q6PKG0 Q9H7F0 Q02241 Q6WKZ4 Q9H307 O60341 Q5T200 P22059

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ACCEPTED MANUSCRIPT

PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

9.50E-03 9.50E-03 9.50E-03 9.50E-03 9.60E-03 9.60E-03 9.60E-03 9.60E-03 9.60E-03 9.70E-03 9.70E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.90E-03 9.90E-03 9.90E-03 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02

EP

S190 T263 S459 S579 S177 S1193 S3808 S3816 S1471 S83 S141 S216 S37 T614 S682 S616 S131 S138 S398 S400 S601 T74 S366 S738 S1017 S59 S60 S261 S104 T332 S394 T329 S233 S245 S163 S1080 S80 S310 S738 S312 S113 S1228 S447 S333 T74 S82 S461 S2105 S360 S443

AC C

P22059 Q5T200 P11274 Q86W92 Q09666 P20020 Q7Z6Z7 Q7Z6Z7 P11388 P10644 Q9UQC2 Q09666 Q9NQZ2 Q8IYB3 Q9Y2W1 Q8IYB3 O75446 O75446 Q96ST2 Q96ST2 Q86W92 P42166 P20810 Q8IYB3 O95785 Q00839 Q13442 Q9NZ63 P31943 Q9UGV2 Q92769 Q9UGV2 Q13428 O95425 Q9Y2U5 Q5JTH9 P13861 Q01518 P98175 Q9NQS7 P46379 Q13428 P18887 Q9UGV2 P42167 Q14103 Q6PJG2 Q9Y520 Q7Z5L9 Q9H307

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02

EP

S194 S16 S188 S104 T453 S308 S697 T160 T75 S519 S328 S411 S158 S159 S156 T646 S18 S21 S330 Y256 S628 T161 S71 S139 S381 S2044 S62 T160 T1156 S304 S674 S1709 S114 S156 S159 S158 S289 S176 S261 S1021 T118 S224 S314 S304 S211 S1717 S100 S232 S520 T257

AC C

Q9NQX3 Q13200 Q9NQX3 P55795 P18887 Q01518 Q96HA1 P42167 Q3MHD2 O00567 Q92922 Q8IY17 P42166 P42166 P42166 O15439 Q9H6F5 O43399 Q92922 O00401 Q8N9T8 Q13765 P35251 P49736 Q13428 O75179 A2RU67 P42166 P49792 P05388 A8CG34 Q5SRE5 Q86YP4 P42167 P42167 P42167 Q9NWH9 P55327 Q9UHR4 Q9UPP1 Q8WUZ0 Q13573 P67809 Q8NHW5 Q8TF01 Q5SRE5 Q86YP4 Q13573 O00567 Q9UHR4

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02

EP

S126 S3205 S1759 S185 S1160 T2024 S183 S380 S255 S402 S400 S105 T108 S4521 S307 S214 S467 S231 T186 S70 S63 S445 S364 T3716 S564 S41 S67 S1905 S109 S805 S1179 S307 S2362 T925 S366 S207 S436 S426 S455 S1333 S1002 S2151 S1456 S290 S17 S856 T1151 S200 T674 S177

AC C

Q8WUZ0 P78527 Q12888 P61006 P49792 E9PAV3 Q6FI81 Q12888 P08238 Q99590 Q99590 Q8NE71 Q8NE71 Q9UPN3 P05388 Q9H1E3 P53985 Q6ZW31 Q8IWC1 P06748 Q13442 O14974 O60502 Q09666 Q9C0I1 Q9Y2V2 P46087 O15027 Q8NE71 Q8WWI1 Q9UQ35 Q8NHW5 Q7Z6Z7 Q9UDY2 P05455 Q9Y2W1 Q8NDI1 Q8NDI1 P53396 Q15021 Q9NWH9 O75376 Q9BTC0 Q9NYF8 O00193 Q13045 Q9H792 Q04323 P25205 Q58FF8

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02

EP

S88 S1459 S166 S165 S920 S62 S766 S498 S494 S181 S7 S56 S398 T227 S520 S282 S143 S147 S762 S1155 S644 S185 S553 T1521 S118 T440 S471 S1073 S316 S156 S2132 S226 S2409 S518 S87 T220 S135 S137 S436 S433 S458 S425 S118 T310 S26 S575 S1518 S529 S528 S83

AC C

Q9UK76 P21333 Q969G5 Q969G5 Q9UDY2 P56211 Q32MZ4 Q9C0C2 Q9C0C2 Q9H1E3 Q01105 Q9Y5S9 Q9UDY2 O75533 Q86UU1 Q6IBW4 Q96E09 Q96E09 Q14566 Q15648 Q86TC9 Q1KMD3 Q9NWH9 O43149 P18669 Q86VR2 P48681 P27816 Q9NY61 P07199 Q9UQ35 Q9UPQ0 P11717 Q86UU1 Q9UK76 Q8IYB3 O60841 O60841 Q86VR2 Q86VR2 Q96NT5 Q8IZT6 Q8N0Y7 Q9NY61 Q6IAA8 Q68EM7 O43149 Q6VY07 Q6VY07 Q96JP5

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02

EP

T510 S324 S323 S185 S211 S67 S400 S284 S323 S500 T406 S691 S420 S284 S80 S402 S66 S67 S303 S415 S35 S218 S132 S133 S2101 S440 S207 S51 S362 S369 S1943 S498 S393 S19 S693 S25 S47 S67 S66 S181 S4 S435 S554 S82 S376 S2501 S155 T469 S240 S243

AC C

Q8N1G4 Q9H2K8 P08651 Q86XP3 Q13242 O43768 Q9UDY2 Q641Q2 Q9UQ35 Q9H7N4 Q8IYB3 A0FGR8 P85037 Q9Y4E1 Q15637 Q8IYB3 P42167 P42167 O00499 O14545 Q8TAD8 Q15019 P51858 P51858 Q5VUA4 Q9UQ35 Q9Y6G9 Q9BTU6 Q9UHB6 Q9UHB6 P35579 Q9H7N4 Q13547 Q9H1E3 A0FGR8 P16949 Q9BTU6 P42166 P42166 Q9NZI8 P09651 Q9UQ35 P27824 Q15637 Q8IVT2 Q8NFC6 Q8TBF4 Q9H6S3 Q9UKV3 Q9UKV3

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PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant PhoPepMass;MaxQuant

TE D

1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02 4.10E-11 4.10E-11 1.30E-09 1.30E-09 2.40E-09 2.00E-08 3.20E-08 6.80E-08 6.80E-08 1.10E-07 1.40E-07 1.40E-07 1.50E-07 1.70E-07 2.30E-07 2.30E-07 2.30E-07 4.00E-07

EP

T60 S64 Y13 S16 S50 S1690 S1693 S119 S416 S253 S436 S437 S426 S26 S111 S51 S107 S89 S311 S440 S121 S122 S30 S122 S121 S2029 S1004 S439 S437 S5841 S114 S166 S347 S346 S54 T58 T718 S89 S94 S27 S31 S28 Y35 T40 S205 S416 T599 S593 S609 T1209

AC C

P13051 P13051 Q9H1E3 P16949 Q96AT1 Q9Y5S2 Q9Y5S2 P55884 P85037 O15541 Q9UQ35 Q9UQ35 Q2TB10 Q92466 Q5T3F8 P36915 Q5VV41 P98175 Q8N5Y2 Q13263 Q6NXS1 Q6NXS1 Q9UHD8 P41236 P41236 E9PAV3 Q9UKV3 Q13263 Q13263 Q09666 Q5T3F8 Q13765 Q658Y4 Q658Y4 Q9NXX6 Q9NXX6 Q86X10 Q147X3 Q13409 O00418 O00418 Q8TD19 P30273 P30273 Q9HAW4 Q9UNF0 Q9UER7 Q9UER7 Q9UER7 Q8NI35

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TE D

5.90E-07 6.00E-07 6.00E-07 6.00E-07 6.00E-07 6.30E-07 6.40E-07 8.10E-07 9.20E-07 9.20E-07 1.10E-06 1.10E-06 1.10E-06 1.10E-06 1.10E-06 1.10E-06 1.10E-06 1.20E-06 1.20E-06 1.20E-06 1.30E-06 1.30E-06 1.40E-06 1.40E-06 1.50E-06 1.60E-06 1.60E-06 1.60E-06 1.60E-06 1.60E-06 1.80E-06 2.10E-06 2.10E-06 2.20E-06 2.30E-06 2.30E-06 2.40E-06 2.40E-06 2.80E-06 2.80E-06 2.80E-06 3.00E-06 3.00E-06 3.00E-06 3.00E-06 3.30E-06 3.30E-06 3.30E-06 3.30E-06 3.30E-06

EP

S312 T521 T520 S526 S517 Y86 S362 T398 T653 Y654 T348 S381 S382 S81 S409 S410 T99 T63 S718 S65 S705 S699 S382 S381 S668 S206 S577 S578 T203 T198 S343 T10 S653 S87 Y14 Y15 S38 Y22 T268 S71 T74 S16 S17 S19 T2 S51 T866 T873 T53 T47

AC C

Q86WR7 Q9BVP2 Q9BVP2 Q9BVP2 Q9BVP2 Q9Y232 P23497 P46937 Q8IWY4 Q8IWY4 Q9NYJ8 A4D1P6 A4D1P6 Q1L6U9 A4D1P6 A4D1P6 Q1L6U9 Q6QNY0 Q7Z6Z7 Q6QNY0 Q9UIG0 Q9UIG0 Q92625 Q92625 P25205 P27918 Q96N64 Q96N64 P27918 P27918 Q9BYU1 Q9H1K6 Q96JM3 Q9Y4B5 Q8IXH7 Q8IXH7 Q14CZ8 Q14CZ8 O43347 Q8TDD1 Q8TDD1 P16383 P16383 P16383 P51686 P17020 Q92887 Q92887 P17020 P17020

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TE D

3.40E-06 3.90E-06 4.10E-06 4.10E-06 4.10E-06 4.20E-06 4.20E-06 4.20E-06 4.60E-06 4.60E-06 4.70E-06 4.70E-06 5.30E-06 5.30E-06 5.50E-06 5.60E-06 5.60E-06 5.60E-06 5.90E-06 6.20E-06 6.20E-06 6.50E-06 6.50E-06 6.50E-06 7.20E-06 7.30E-06 7.30E-06 7.80E-06 7.80E-06 8.00E-06 8.30E-06 8.30E-06 8.30E-06 8.90E-06 8.90E-06 9.30E-06 1.00E-05 1.00E-05 1.00E-05 1.00E-05 1.00E-05 1.10E-05 1.10E-05 1.10E-05 1.20E-05 1.30E-05 1.30E-05 1.40E-05 1.40E-05 1.40E-05

EP

T84 S12 T2003 T2016 S1990 S282 S302 Y262 S199 S203 Y229 T735 S673 T672 T263 S942 S926 S938 Y519 T9 T2743 S85 T100 S77 Y481 T1322 S1325 T492 Y491 T752 S255 T294 S254 S38 Y24 T153 S389 T388 S390 T408 S492 S519 T387 S1406 S770 T593 S564 S851 S3502 Y915

AC C

Q99549 Q9NQC3 O95071 O95071 O95071 Q9NPY3 Q9NPY3 Q9NPY3 Q8IXJ9 Q8IXJ9 Q6ZW31 Q9P0K1 O95425 O95425 O43347 Q9HC35 Q9HC35 Q9HC35 P54278 P49736 P49792 Q9UQF2 Q9UQF2 Q9UQF2 Q8NFC6 Q14767 Q14767 P24821 P24821 O60343 Q8IXS6 Q8IXS6 Q8IXS6 P68366 P68366 Q2M3C6 Q12765 Q12765 Q12765 Q12765 Q8N108 Q12872 Q6PJT7 Q9UBG0 O75170 P18084 P18084 Q6PKG0 Q03164 O95373

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TE D

1.40E-05 1.50E-05 1.50E-05 1.50E-05 1.50E-05 1.50E-05 1.50E-05 1.50E-05 1.60E-05 1.60E-05 1.60E-05 1.60E-05 1.60E-05 1.60E-05 1.70E-05 1.70E-05 1.70E-05 1.70E-05 1.70E-05 1.70E-05 1.70E-05 1.80E-05 1.80E-05 1.90E-05 1.90E-05 1.90E-05 1.90E-05 2.00E-05 2.00E-05 2.00E-05 2.10E-05 2.20E-05 2.20E-05 2.20E-05 2.20E-05 2.20E-05 2.20E-05 2.30E-05 2.30E-05 2.60E-05 2.80E-05 2.90E-05 3.00E-05 3.00E-05 3.20E-05 3.20E-05 3.20E-05 3.20E-05 3.20E-05 3.20E-05

EP

S299 Y278 S965 S274 S981 S280 T996 S194 S65 T64 T79 Y81 S82 S80 T312 T313 S323 S119 S16 T118 S310 S199 T198 S154 S152 S20 S11 Y243 Y339 T242 T267 T224 S942 Y218 S974 S964 S219 S746 T4 S468 S60 S550 S63 S61 Y18 S1277 T1279 T1273 S1283 S16

AC C

Q99733 P50502 P14735 P50502 P14735 P50502 P14735 Q8TEA8 Q92764 Q92764 Q92764 Q92764 Q92764 Q92764 P35556 P35556 P35556 Q8IYP9 Q9UJF2 Q8IYP9 P35556 P43489 P43489 P55884 P55884 Q9P260 Q9P260 Q9HB20 Q9HBL0 Q9HB20 O75475 O43852 Q75N90 O43852 Q75N90 Q75N90 O43852 Q14C86 P10412 Q12778 Q8TF76 Q9H1C4 Q9NXX6 Q9NXX6 Q3LHN1 P56715 P56715 P56715 P56715 Q3LHN1

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TE D

3.50E-05 3.80E-05 4.00E-05 4.10E-05 4.40E-05 4.70E-05 4.90E-05 4.90E-05 5.40E-05 5.80E-05 5.90E-05 6.00E-05 6.00E-05 6.00E-05 6.20E-05 6.30E-05 6.60E-05 6.60E-05 6.60E-05 6.60E-05 6.60E-05 6.70E-05 6.80E-05 6.80E-05 7.00E-05 7.00E-05 7.10E-05 7.10E-05 7.10E-05 7.60E-05 7.60E-05 7.80E-05 7.80E-05 8.40E-05 8.40E-05 8.40E-05 8.80E-05 8.90E-05 9.60E-05 1.00E-04 1.00E-04 1.00E-04 1.00E-04 1.00E-04 1.10E-04 1.10E-04 1.20E-04 1.20E-04 1.20E-04 1.20E-04

EP

S886 S40 T665 S1778 S1145 Y4611 Y963 S962 S128 S80 S1931 T526 S514 S534 S38 S1819 S344 S365 S369 Y367 S337 Y876 S338 S41 T8 Y5 T210 Y41 S237 S1465 T1482 T228 T232 T764 S765 S786 T211 Y1281 S889 T530 S507 T519 T518 S260 S2114 S2113 S333 S130 S121 Y618

AC C

O95373 Q9Y6I9 Q6ZMP0 Q92538 Q53SF7 Q15149 P98164 P98164 P51692 Q0ZGT2 P24928 Q12872 Q12872 Q12872 Q9Y657 P46821 P32314 P32314 P32314 P32314 P32314 O95373 Q99590 Q03701 P36269 P36269 Q96C92 P30419 Q96C92 Q7Z7M0 Q7Z7M0 Q12948 Q12948 O00203 O00203 O00203 Q04637 Q96T23 Q9NZM3 O75129 Q8N5C8 O75129 O75129 Q9UKL0 Q86YZ3 Q86YZ3 Q969V6 P48547 P48547 Q765P7

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TE D

1.20E-04 1.20E-04 1.30E-04 1.40E-04 1.40E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.50E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.60E-04 1.70E-04 1.70E-04 1.70E-04 1.70E-04 1.80E-04 1.90E-04 1.90E-04 1.90E-04 1.90E-04 2.00E-04 2.00E-04 2.00E-04 2.00E-04 2.20E-04 2.20E-04 2.50E-04 2.60E-04 2.60E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.70E-04 2.80E-04 2.80E-04 2.80E-04 2.80E-04 2.90E-04 2.90E-04 3.00E-04

EP

S142 S14 S263 S414 S214 S693 S697 S367 S365 S700 S144 S369 S310 S570 T749 S750 S304 S329 S731 S791 S100 S101 S380 S36 S24 S241 S235 T32 T1441 S306 S305 S210 S374 S41 S339 S15 S17 Y279 S55 S60 S62 S367 Y216 S126 Y512 S882 S175 S25 S169 T441

AC C

P48547 Q9H6Y2 Q9H0J9 P20810 Q9NUA8 Q16787 Q16787 Q12874 Q12874 Q16787 Q9H1E3 Q12874 P55211 Q09666 O60343 O60343 Q99733 Q99569 Q9NZM1 Q9Y597 Q7Z5K2 Q7Z5K2 O60381 O95361 Q9BQ75 Q12948 Q12948 Q9BQ75 Q9Y6N7 Q86YS7 Q86YS7 O95297 O75717 O94806 O95747 Q9NZ63 Q9NZ63 P49840 Q8NHG8 Q8NHG8 Q8NHG8 Q99575 P49841 P31749 Q8N5C8 Q96HP0 Q9Y6A5 P46821 Q9HCD6 Q9H0E3

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TE D

3.10E-04 3.10E-04 3.10E-04 3.10E-04 3.20E-04 3.20E-04 3.20E-04 3.20E-04 3.30E-04 3.30E-04 3.30E-04 3.40E-04 3.40E-04 3.40E-04 3.40E-04 3.50E-04 3.50E-04 3.70E-04 3.70E-04 4.00E-04 4.00E-04 4.00E-04 4.00E-04 4.10E-04 4.10E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.30E-04 4.40E-04 4.50E-04 4.50E-04 4.60E-04 4.90E-04 4.90E-04 5.00E-04 5.00E-04 5.00E-04 5.10E-04 5.10E-04 5.20E-04 5.40E-04 5.40E-04 5.40E-04 5.40E-04 5.40E-04 5.60E-04 5.60E-04

EP

Y541 T683 S243 S547 S263 S393 S231 S243 T45 T1222 S1217 S34 T2956 S2406 S2954 T1326 T21 S457 S284 S398 S33 S11 S37 S450 T451 T426 T489 T488 S156 S152 T151 S26 T423 S1476 T169 S397 S396 S1388 T1813 T1811 S1204 S596 S88 S176 S393 S9 S399 S10 Y353 T9

AC C

Q9H1C4 Q8WWM7 O95801 Q9H1C4 Q86YV5 Q99590 Q86YV5 Q86YV5 Q10589 Q6R327 Q6R327 Q8IXH7 Q8NFC6 O75179 Q8NFC6 Q8TEQ6 Q96LA8 O15231 Q7Z2W4 P05783 Q96SB4 Q9NQC3 Q96SB4 O14639 O14639 P08670 Q8N163 Q8N163 Q9BTC0 Q9BTC0 Q9BTC0 Q99871 O60318 Q96QT4 P04920 Q9BXF6 Q9BXF6 P49815 P46821 P46821 Q96PC5 O15320 Q9Y232 Q9UHB7 O94806 Q12797 Q15139 Q12797 O43251 Q9NZT2

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TE D

5.60E-04 5.60E-04 5.60E-04 5.80E-04 5.80E-04 5.80E-04 5.80E-04 5.80E-04 5.90E-04 5.90E-04 6.00E-04 6.00E-04 6.00E-04 6.20E-04 6.30E-04 6.30E-04 6.30E-04 6.30E-04 6.40E-04 6.70E-04 6.70E-04 6.70E-04 6.70E-04 6.70E-04 6.70E-04 6.70E-04 7.00E-04 7.10E-04 7.20E-04 7.40E-04 7.50E-04 7.60E-04 7.60E-04 7.70E-04 7.80E-04 7.80E-04 7.80E-04 7.90E-04 8.00E-04 8.00E-04 8.00E-04 8.00E-04 8.00E-04 8.00E-04 8.00E-04 8.00E-04 8.10E-04 8.10E-04 8.10E-04 8.20E-04

EP

Y349 Y132 S8 T4 S74 S932 T931 S72 T1692 S284 S562 S565 T569 T1413 Y15 Y452 S16 S14 S1254 S280 S101 S375 T100 S762 S761 S96 S1209 T1323 S727 T298 S517 S3 T7 S230 T10 Y1888 S22 S114 S23 S15 S327 S15 S23 T17 T17 S120 T377 S51 S39 S463

AC C

O43251 Q07157 Q9NZT2 P16403 Q92614 Q9UMZ2 Q9UMZ2 Q92614 Q8NG31 Q13501 A9YTQ3 A9YTQ3 A9YTQ3 Q9UQ35 Q7Z3C6 Q7Z5K2 Q7Z3C6 Q7Z3C6 P46821 Q6KC79 Q9H6Z4 Q9Y2X7 Q9NQ92 Q8NDX5 Q8NDX5 Q9H6Z4 O43933 Q8TEQ6 P47712 Q9NQS7 P54278 Q5JSH3 Q5JSH3 Q8TEU7 Q96IK1 P24928 Q96IK1 Q9NU19 P63241 Q6IS14 Q6PJT7 P63241 Q6IS14 Q6IS14 P63241 P55201 O15013 Q96SB4 Q96SB4 Q9UJX6

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TE D

8.20E-04 8.30E-04 8.40E-04 8.40E-04 8.80E-04 9.00E-04 9.00E-04 9.00E-04 9.00E-04 9.10E-04 9.20E-04 9.20E-04 9.20E-04 9.60E-04 9.60E-04 9.60E-04 9.60E-04 9.60E-04 9.60E-04 9.60E-04 9.80E-04 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.00E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.10E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.20E-03 1.30E-03 1.30E-03

EP

S494 T35 T631 S532 S12 S516 Y785 S761 S759 T117 S336 S353 S349 T37 S6 S4 S156 Y614 S36 S16 T85 T471 S87 S10 S243 T469 T473 S82 S559 S412 S1129 S351 S213 T352 S664 S1163 T243 S1162 S654 S184 T256 T188 T199 S200 S655 T213 S664 T284 S124 S1110

AC C

Q9UJX6 Q8IUD2 Q9NW82 O15047 Q99733 Q8N612 Q7Z3C6 Q7Z3C6 Q7Z3C6 Q9NRR5 P08581 P08581 P08581 Q12962 Q12962 Q12962 Q96P16 Q13615 Q12962 Q12962 Q96S55 Q9UM82 Q9UD57 O14579 Q92539 Q9UM82 Q9UM82 Q9UD57 Q9UGU0 Q9UER7 O95785 Q92994 Q53LP3 Q92994 Q15648 Q86SQ4 Q8NB78 Q86SQ4 Q8WUY3 Q96JP5 Q99700 Q96JP5 Q9BZL6 Q9BZL6 Q8WUY3 Q9P2F6 Q8WUY3 P08240 Q9NRG0 Q9Y4D8

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TE D

1.30E-03 1.30E-03 1.30E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.40E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.50E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.60E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.70E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03 1.80E-03

EP

S385 S86 S517 S1391 S1395 T1386 S172 S296 S295 S999 T1623 S91 S92 S1626 S870 S874 S954 T30 T749 S703 S51 S7 S246 S34 S256 S745 T494 S2051 T1179 S2028 T1246 Y133 T9 T7 S486 S1637 T1627 S366 S40 S700 S1625 S149 S99 S438 T1636 T148 T603 S439 S634 S727

AC C

Q9NP74 P83731 Q16555 Q9HC10 Q9HC10 Q9HC10 Q8NI08 Q7L014 Q7L014 P07814 Q13129 Q96S55 Q96S55 Q13129 Q8N9H8 Q8N9H8 P26358 Q96A65 Q9UBY0 Q9UHI6 P51397 Q9H4A4 Q8IXH7 Q03701 Q8IXH7 Q9UBY0 Q9NYF8 P35556 O43933 P35556 Q14004 Q9UN86 A6NNZ2 A6NNZ2 Q8N3F8 Q5UIP0 Q5UIP0 Q9C0H5 A6NNZ2 Q9P2Y4 Q5UIP0 Q9UN86 Q9BXK1 P10636 Q5UIP0 P0C862 Q86W92 Q9C0C9 Q7Z4V5 P40763

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TE D

1.80E-03 1.80E-03 1.80E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 1.90E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.00E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.10E-03 2.20E-03 2.20E-03 2.30E-03 2.30E-03 2.30E-03 2.40E-03 2.40E-03 2.40E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03

EP

S492 S490 S1225 S26 S25 S1565 S337 S419 S338 S3777 S255 T1112 S201 S254 S253 T236 S3771 T1343 S248 T1912 T1926 S56 S148 S152 S130 S34 S73 S716 S540 S63 S28 Y501 S732 Y62 T710 T854 S499 S16 S12 S406 S982 S1598 S194 T143 S30 S6 S2118 S1654 S1856 Y28

AC C

Q99501 Q99501 Q5VZ89 Q6NZI2 Q6NZI2 O43426 P09651 P16383 P09651 Q07954 Q9H0G5 P11388 Q07021 Q9H0G5 P05997 P05997 Q07954 P11388 Q9H0G5 P24928 P24928 Q9BXB5 Q9BUA3 Q9BUA3 O00151 Q9UGN5 Q14766 Q9UIG0 Q8TF72 Q14766 Q9Y4X0 Q8TF72 Q8TEW8 Q14766 Q9UIG0 Q15262 Q8TF72 P78347 Q12948 P15151 P78312 Q9UQ35 Q9UNF1 Q9P260 Q53F19 P17096 Q09666 Q09666 Q09666 Q9BUW7

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TE D

2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.50E-03 2.60E-03 2.70E-03 2.70E-03 2.70E-03 2.70E-03 2.70E-03 2.70E-03 2.80E-03 2.80E-03 2.80E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 2.90E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.00E-03 3.10E-03 3.20E-03 3.20E-03 3.20E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.40E-03 3.50E-03 3.50E-03 3.50E-03 3.50E-03

EP

S523 S2 S183 S770 S763 S1196 S1990 S1923 S33 S1452 S1109 S234 T1115 S1103 T479 T485 S16 S911 S46 S549 T341 T358 S1130 S686 T601 S551 S342 S603 T1135 S1340 S1344 Y364 S320 S1342 S104 S17 S1336 S26 Y422 T516 S518 S620 T1472 T1471 S1457 S523 S173 S322 S1036 S1045

AC C

Q9P2N6 Q9BUW7 P80723 O14529 O14529 Q09666 Q09666 Q09666 Q9BUW7 P49815 Q14980 Q8NCF5 Q14980 Q14980 Q6NZY4 Q6NZY4 Q9Y4X0 Q02241 Q86VM9 Q8IYB3 Q6XZF7 Q6XZF7 Q15047 P16070 Q9Y2X7 Q8IYB3 Q6XZF7 Q9Y2X7 Q15047 Q02880 Q02880 Q14694 Q9H330 Q02880 Q86XP3 Q9H6S3 Q02880 P29966 Q9UNS2 O60934 O60934 Q99501 Q9H251 Q9H251 Q9H251 Q9BTA9 P53621 P49585 P00533 P00533

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3.50E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.60E-03 3.70E-03 3.70E-03 3.80E-03 3.90E-03 3.90E-03 3.90E-03 3.90E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.00E-03 4.10E-03 4.10E-03 4.10E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.20E-03 4.30E-03 4.30E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.40E-03 4.50E-03

EP

S321 T1039 S274 S276 S272 T545 T311 S4908 T460 T1011 T55 S155 T355 S451 Y457 S687 S1126 S423 S421 S308 S679 S348 S253 S260 T1091 S105 S320 S331 S165 S146 T149 S556 S558 S540 S222 S221 S537 T22 S1294 S2726 S300 S265 S239 S61 S325 S1449 S278 S55 S43 S364

AC C

P49585 Q27J81 Q9NYF8 Q9NYF8 Q9NYF8 Q9ULH7 Q14432 Q09666 Q9HCS7 Q27J81 O95361 Q5SSJ5 Q9BWG4 Q9UBV2 Q9UBV2 Q9H2J7 Q5VZ89 Q13547 Q13547 P54274 Q9P227 Q9BYU1 P07910 P07910 Q6PKG0 A9YTQ3 P08621 Q9BYU1 P14651 P14651 P14651 Q96D71 Q96D71 Q96D71 O15047 O15047 Q96D71 Q9Y2W7 Q96RK0 Q03164 Q9NZN5 P56524 Q9UKV0 Q96M83 Q92560 P49815 Q9UQL6 Q96M83 Q86SR1 Q5M775

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4.50E-03 4.50E-03 4.50E-03 4.50E-03 4.50E-03 4.50E-03 4.50E-03 4.50E-03 4.50E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.60E-03 4.70E-03 4.70E-03 4.70E-03 4.80E-03 4.80E-03 4.80E-03 4.80E-03 4.90E-03 4.90E-03 5.00E-03 5.00E-03 5.00E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.10E-03 5.20E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.30E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.40E-03 5.50E-03

EP

S1600 S21 S22 S20 S19 S1601 S30 S360 T15 S264 S25 S349 S345 S347 S28 T418 S416 S220 Y1316 T253 Y1468 S1472 S1476 S1083 S80 S1219 T557 S267 Y543 S2 S21 T7 S856 S322 S15 T684 T684 T684 T683 T681 T682 T686 T682 S229 S127 S555 S58 S689 T796 S64

AC C

Q9UQ35 Q12791 Q12791 Q9BQ75 Q9BQ75 Q9UQ35 Q86VQ1 Q5M775 Q9BQ75 Q8N556 Q96BU1 Q92538 Q92538 Q92538 Q96BU1 Q8IZW8 Q8IZW8 Q14694 Q92538 Q9NZ63 Q5TGY3 Q5TGY3 Q5TGY3 Q9UQ35 Q8N6S5 Q15648 Q5T6X5 Q96A49 Q5T6X5 P78543 P78543 P78543 Q9UPN9 Q9H330 Q7Z4Q2 P12882 Q9Y623 Q9UKX2 P13535 P13535 P12882 Q9UKX2 Q9Y623 Q7L804 P46013 Q96PK6 O43159 O00512 Q9P2N6 Q92841

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5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.50E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.60E-03 5.70E-03 5.70E-03 5.80E-03 5.80E-03 5.80E-03 5.80E-03 5.80E-03 5.80E-03 5.80E-03 5.80E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 5.90E-03 6.00E-03 6.00E-03 6.00E-03 6.00E-03 6.10E-03 6.10E-03 6.10E-03 6.20E-03 6.20E-03 6.20E-03 6.20E-03 6.30E-03 6.30E-03 6.40E-03 6.40E-03 6.40E-03 6.40E-03 6.40E-03 6.40E-03 6.50E-03

EP

Y21 S23 Y10 Y11 T22 S18 T16 S95 S946 S44 T373 S407 T23 T25 T26 S821 S491 S644 S185 S188 S239 S240 S199 S2741 Y187 T622 T628 T630 S199 S20 T263 T1815 T192 S173 S812 T167 S135 T253 S1644 S1646 S402 S190 T177 S1448 T1452 S2 S3 S1454 T610 S168

AC C

P35414 Q9HC29 P35414 P35414 P35414 Q8IVY1 Q8IVY1 Q8WYQ5 Q9HC35 Q9UBB5 O94763 Q8TBB5 Q9NQZ2 Q9NQZ2 Q8IVY1 P78347 Q8N108 Q5TCZ1 Q9BSJ6 Q9BSJ6 P28356 P28356 Q9BSJ6 P49792 Q9BSJ6 Q5VTJ3 Q5VTJ3 Q5VTJ3 Q14699 O75822 Q06210 Q5T011 Q6ZS94 Q6ZS94 Q13563 Q92508 Q8NEJ9 Q02078 P46821 P46821 A8MUU9 Q15365 Q8NI08 Q96KV7 Q96KV7 O60264 O60264 Q96KV7 Q9P2E9 Q9NR30

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6.50E-03 6.50E-03 6.50E-03 6.60E-03 6.60E-03 6.60E-03 6.60E-03 6.70E-03 6.70E-03 6.70E-03 6.70E-03 6.70E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.80E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 6.90E-03 7.10E-03 7.10E-03 7.20E-03 7.30E-03 7.30E-03 7.30E-03 7.30E-03 7.30E-03 7.30E-03 7.30E-03 7.40E-03 7.40E-03 7.40E-03 7.40E-03 7.40E-03 7.50E-03 7.60E-03 7.60E-03 7.60E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03 7.70E-03

EP

T23 Y1187 S164 S206 S9 S361 S358 T105 T100 S1435 S1434 S1023 T5794 S268 S278 S277 S300 S296 S94 S272 S1523 T97 T303 T584 S428 S312 Y586 S70 S1455 S365 S471 S124 S367 T472 S247 S251 S441 S47 S44 S18 S379 S502 S4 T15 S10 S147 T10 S141 T138 S12

AC C

Q96FF9 Q9NTI5 Q9NR30 O75475 Q13263 O15014 O15014 Q9BTC0 Q9BTC0 O15027 O15027 P35658 Q09666 Q8TF45 Q8N556 Q8N556 Q8TF45 Q8TF45 Q99618 Q8TF45 Q5SRE5 O95251 Q96RK0 Q7Z4H7 Q14432 Q96RK0 Q6ZRV2 O14562 Q9UBG0 Q6VN20 Q9UPQ0 Q9ULR3 Q6VN20 Q9UPQ0 Q9UF83 Q9UF83 Q5SNT2 O00178 O00178 Q93009 Q9Y2W1 Q96JM3 P06748 Q9Y4X4 P06748 P40855 Q9NWV8 Q8IXQ4 Q8IXQ4 P52926

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7.70E-03 7.70E-03 7.80E-03 7.80E-03 7.80E-03 7.80E-03 7.80E-03 7.80E-03 7.90E-03 7.90E-03 8.00E-03 8.00E-03 8.00E-03 8.00E-03 8.10E-03 8.10E-03 8.10E-03 8.10E-03 8.10E-03 8.10E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.20E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.40E-03 8.50E-03 8.50E-03 8.50E-03 8.50E-03 8.60E-03 8.60E-03 8.60E-03 8.60E-03

EP

S140 S454 S55 T207 T205 S56 S1764 S54 S218 S572 S114 T2 S122 S109 Y784 T365 S186 S384 S71 S198 T536 S173 S750 T832 S736 S27 S828 T207 S374 S831 S734 S427 S23 T4 T130 T146 S225 Y551 S707 S134 S220 S708 T797 S808 T6 T124 T4 S445 S45 S1398

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Q8IXQ4 O94972 Q96ER3 Q04637 Q04637 Q96ER3 P42694 Q96ER3 P17676 Q9H792 P19484 Q9HCE3 P19484 P19484 Q14112 Q92994 Q6ZSB9 Q6Y7W6 Q8N6S5 Q6ZSB9 Q9ULH7 O15355 Q9UPN9 Q9NQS7 Q9UPN9 A6NIR3 Q9NQS7 O15355 Q08499 Q9NQS7 Q9UPN9 P35611 A6NIR3 P16401 Q9BZK7 Q9BZK7 Q9HAW4 Q06124 Q13751 P04150 Q14156 Q13751 Q86V48 Q68EM7 Q9H2V7 Q9HAF1 Q02539 Q86T13 Q9P258 Q9Y6Q9

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8.60E-03 8.60E-03 8.60E-03 8.60E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.70E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.80E-03 8.90E-03 8.90E-03 8.90E-03 9.10E-03 9.10E-03 9.10E-03 9.10E-03 9.10E-03 9.10E-03 9.20E-03 9.20E-03 9.20E-03 9.20E-03 9.30E-03 9.30E-03 9.40E-03 9.40E-03 9.50E-03 9.50E-03 9.50E-03 9.60E-03 9.60E-03 9.60E-03 9.60E-03 9.70E-03 9.70E-03 9.70E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03 9.80E-03

EP

T626 S43 S44 S46 S1776 S337 S63 S554 S177 S1149 S548 S674 S16 S538 S544 S99 S269 T260 S263 S1376 S2871 S235 S34 S40 T42 S5 S19 T23 S22 S211 S3 S1579 S59 S102 T993 S366 S132 T279 S1768 S973 T106 S903 T898 S1098 S1066 S1061 S1069 S1067 S165 S705

AC C

Q13586 Q9P258 Q9P258 Q9P258 Q15154 Q96F63 Q5JTZ9 Q9C0B5 Q643R3 O60307 Q53SF7 P78347 Q9UMX0 Q53SF7 Q53SF7 P27816 O95359 O95359 O95359 Q13428 Q9NYQ6 Q9UPQ0 P10588 P10588 Q7KZI7 Q9BQ08 Q15029 Q9BQ08 Q9BQ08 Q92925 P51397 Q14160 Q8WVV9 O95251 P00533 Q8NEC7 Q6P158 Q8NAP3 Q15154 Q5SW79 Q8WW12 O95373 O95373 P20930 P20930 P20930 P20930 P20930 P25490 Q9UJ99

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9.80E-03 9.80E-03 9.80E-03 9.90E-03 9.90E-03 9.90E-03 9.90E-03 9.90E-03 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.00E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02

EP

S277 S714 S732 S226 S222 S599 S324 S327 S61 S786 S1010 S60 S411 S3 S409 T347 S300 S298 S507 S36 T776 S111 S109 S168 S35 S18 T405 S1620 S6 S780 S576 S59 S520 S3 T347 S212 T114 S3 S802 T2946 S384 S213 S548 S784 S1039 S29 T1022 S28 S1037 S2943

AC C

Q99460 Q9UJ99 Q9UJ99 Q9BRD0 Q9BRD0 Q86W92 P43304 P43304 P46937 Q9C0D6 O95785 Q9HB90 Q15788 Q8WTS6 Q15788 Q9Y4E1 Q8IVH2 Q15642 Q05209 P45985 Q9C0D6 Q86XP3 Q86XP3 Q01433 P45985 P45985 Q15788 P46821 P68402 Q9C0D6 Q13330 Q9HB90 Q7RTY8 A0MZ66 Q641Q2 Q17RH7 P10696 Q13635 O60293 Q02505 P27816 Q17RH7 Q9H6Z4 Q12888 P00533 P08670 Q7Z3B3 Q96JN8 P00533 Q02505

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1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02 1.10E-02

EP

S567 T69 T244 S610 Y431 S206 S771 S564 S608 T117 S582 S97 S98 S276 S30 Y600 S1918 S786 T1282 S158 T607 S214 T71 S18 S257 S190 S19 S131 T434 T801 S1280 T28 S24 S539 Y533 S553 S16 Y188 S113 T23 S386 S40 T192 S18 S565 S205 S522 S521 S552 S803

AC C

O75553 Q12834 P15121 P19827 Q15642 Q17RH7 Q12888 O75553 P19827 P05187 Q7L576 O94992 O94992 P08651 Q96JN8 P19827 P35580 Q12888 O60346 Q96P16 P19827 Q17RH7 Q70SY1 Q12797 Q13033 P51451 P60468 P46013 Q15642 O60293 O60346 Q8IZ21 Q8NHH9 Q9H6Z4 Q6TDP4 Q92994 Q12797 P51451 Q9H1E3 Q8NHH9 P23258 P30419 Q7Z417 Q13635 O75553 Q17RH7 Q6TDP4 Q6TDP4 O75553 O60293

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1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02

EP

S244 S156 T158 S245 S34 S1337 T569 T80 S2265 Y29 Y1247 S211 S2247 T556 S254 S279 T162 S392 T248 S75 T3 S31 S656 S12 S156 T158 S670 S223 Y87 T234 S156 T1241 S11 S304 S1332 T216 T643 T1327 S126 S11 S197 T158 S37 T210 T11 S1863 S633 S631 S132 S130

AC C

Q6ZW31 P01892 P10316 Q8NB59 Q96F45 P11388 P98160 Q9NUB1 Q93008 Q96C90 Q8TEQ6 Q8WU20 Q93008 P98160 P28356 Q8TD16 Q8N1V2 Q99590 Q96A49 Q86UP2 Q9BY89 P30419 Q6N022 Q6PKC3 P10316 P01892 O60716 Q13153 Q9NUB1 P28356 P01891 Q8TEQ6 Q6PKC3 Q0JRZ9 P11388 P13637 Q6N022 P11388 Q8N9M1 P78358 P13637 P01891 Q96F45 Q8WU20 Q9BY89 Q8NDV7 P15502 P15502 Q9H1E3 Q9H1E3

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1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.20E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02

EP

T209 S143 S567 S1865 S1869 S568 Y1112 T343 S339 S336 Y1113 T63 S1509 S191 T1363 S545 S908 S783 T187 Y466 S19 S2394 S1360 T174 S1540 S1125 S785 S340 Y512 Y4111 S337 T102 S4110 T461 Y196 T1144 S428 S162 S667 S861 S1496 S646 T1539 S30 S1522 Y92 S536 S539 S538 S1734

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P13637 Q6PKG0 P98160 Q8NDV7 Q8NDV7 P98160 Q8TEW8 O94885 O94885 O60346 Q8TEW8 P14866 Q9UPZ6 P30101 Q14643 P51003 O14974 P45974 P30101 Q9BZE4 O43399 O95359 Q14643 P49640 Q9Y5S2 Q8TEW8 P45974 O94885 Q96JJ6 Q8WXH0 O94885 Q9NUQ3 Q8WXH0 Q9BZE4 P30101 P49792 Q6IBW4 P49640 Q0VG06 Q99700 Q9UPZ6 Q14149 Q9Y5S2 Q9NR19 Q9UPZ6 P14866 Q96JJ6 Q96JJ6 Q96JJ6 O75691

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1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.30E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02

EP

S1732 S820 S30 S338 S913 S468 S614 S244 T400 T533 S18 S500 S34 T49 S45 S4 T25 T300 T21 S904 S913 S906 S41 S559 S602 S264 S58 S416 T432 S555 S556 S605 S82 S217 S214 S13 S95 S397 S124 S128 S242 S31 S252 S253 S30 S894 S31 T883 T5 S522

AC C

O75691 P78347 Q9HC29 O94885 O95425 Q9BZE4 Q9UQF2 Q9UKM9 Q9Y6D6 O43526 Q9H814 Q8IYB3 Q12946 Q9H7L9 Q9H7L9 Q9NV39 Q9NV39 Q3T8J9 Q9H814 Q5VZL5 P18858 Q5VZL5 Q16600 Q7Z460 Q9ULK2 Q9UKM9 P13861 Q01804 Q96MY7 Q7Z460 Q7Z460 Q9ULK2 Q53H54 Q13905 Q13905 Q9UMX0 Q53H54 Q9Y6D6 Q7Z6L0 Q7Z6L0 O43847 Q12946 Q9UKM9 Q9UKM9 Q12946 Q5VZL5 Q9UMX0 Q5VZL5 P10244 O43526

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1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.40E-02 1.50E-02 1.50E-02 1.50E-02 1.50E-02

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S53 S1497 S1316 S499 S22 S27 S223 Y113 S558 S27 S498 S494 S492 S493 S7 S911 S607 S36 S32 S210 T4 S3412 S437 T242 T3 S698 S236

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Q9H7L9 P38398 Q5SYE7 Q8IYB3 Q9NV39 Q9UHB9 Q96ET8 Q8N3X1 Q7Z460 Q8IZL2 Q8IYB3 Q8IYB3 Q8IYB3 Q8IYB3 Q9UMX0 P18858 Q9UQF2 O00267 O00267 O43847 Q8IZL2 Q09666 Q96MY7 Q14108 Q9NR09 Q9P2Y4 Q14108

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